JP2019534891A5 - - Google Patents

Info

Publication number

JP2019534891A5

JP2019534891A5 JP2019529466A JP2019529466A JP2019534891A5 JP 2019534891 A5 JP2019534891 A5 JP 2019534891A5 JP 2019529466 A JP2019529466 A JP 2019529466A JP 2019529466 A JP2019529466 A JP 2019529466A JP 2019534891 A5 JP2019534891 A5 JP 2019534891A5

Authority

JP

Japan

Prior art keywords

hiv

subject

antibody

seq

antibodies

Prior art date

2017-08-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 210000004027 cell Anatomy 0.000 claims 12
• 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 10
• 150000001413 amino acids Chemical group 0.000 claims 8
• 238000011225 antiretroviral therapy Methods 0.000 claims 8
• 230000003612 virological effect Effects 0.000 claims 4
• 229940122313 Nucleoside reverse transcriptase inhibitor Drugs 0.000 claims 3
• 239000003112 inhibitor Substances 0.000 claims 3
• 230000009545 invasion Effects 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 210000003289 regulatory T cell Anatomy 0.000 claims 3
• 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 3
• 108020005544 Antisense RNA Proteins 0.000 claims 2
• 108010041397 CD4 Antigens Proteins 0.000 claims 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
• 229940123527 Nucleotide reverse transcriptase inhibitor Drugs 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical group P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 239000002953 phosphate buffered saline Substances 0.000 claims 2
• 230000008685 targeting Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 239000004471 Glycine Substances 0.000 claims 1
• 208000031886 HIV Infections Diseases 0.000 claims 1
• 208000037357 HIV infectious disease Diseases 0.000 claims 1
• 102100034343 Integrase Human genes 0.000 claims 1
• 108010061833 Integrases Proteins 0.000 claims 1
• 229920001213 Polysorbate 20 Polymers 0.000 claims 1
• 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
• 238000009825 accumulation Methods 0.000 claims 1
• 239000002259 anti human immunodeficiency virus agent Substances 0.000 claims 1
• 230000000840 anti-viral effect Effects 0.000 claims 1
• 239000003443 antiviral agent Substances 0.000 claims 1
• 230000005540 biological transmission Effects 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 230000001413 cellular effect Effects 0.000 claims 1
• 230000006957 competitive inhibition Effects 0.000 claims 1
• 239000003184 complementary RNA Substances 0.000 claims 1
• 238000004132 cross linking Methods 0.000 claims 1
• 229940125777 fusion inhibitor Drugs 0.000 claims 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
• 229940042402 non-nucleoside reverse transcriptase inhibitor Drugs 0.000 claims 1
• 239000002726 nonnucleoside reverse transcriptase inhibitor Substances 0.000 claims 1
• 230000002085 persistent effect Effects 0.000 claims 1
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
• 229940068977 polysorbate 20 Drugs 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 230000002062 proliferating effect Effects 0.000 claims 1
• 230000010076 replication Effects 0.000 claims 1
• 230000000638 stimulation Effects 0.000 claims 1
• 230000006433 tumor necrosis factor production Effects 0.000 claims 1
• 239000013598 vector Substances 0.000 claims 1
• 230000029302 virus maturation Effects 0.000 claims 1
• 230000003442 weekly effect Effects 0.000 claims 1