SG11201901203PA - Treatment and sustained virologic remission of hiv infection by antibodies to cd4 in haart stabilized patients - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER (19) World Intellectual Property Organization International Bureau (43) International Publication Date .....0\"\" 22 February 2018 (22.02.2018) WIP0 I PCT THE PATENT COOPERATION TREATY (PCT) 111111111111111111 11111111110111110100111111011100H011111101111111011110111111 (10) International Publication Number WO 2018/035001 Al _ (51) (21) (22) (25) Filing Language: (26) (30) (71) (71) International Patent Classification: C07K 16/28 (2006.01) International Application Number: (72) PCT/US2017/046668 International Filing Date: (74) 13 August 2017 (13.08.2017) English (81) Publication Language: English Priority Data: 62/374,752 13 August 2016 (13.08.2016) US Applicant (for AM, AZ, BY CN, ID, IN, JP, KG, KR, KZ, MD, RU, SG, TH, TJ, TM only): UNITED BIOMEDICAL, INC. [US/US]; 25 Davids Drive, Hauppauge, New York 11788 (US). Applicant (for US only): UBI US HOLDINGS, LLC. [US/US]; 25 Davids Drive, Hauppauge, New York 11788 (84) (US). Applicant (for all designated States except AM, AZ, BY, CN, ID, IN, JP, KG, KR, KZ, RU, SG, TH, TJ, TM): UBI (71) IP HOLDINGS; c/o Stuarts Corporate Services Ltd., P.O. Box 2510, Grand Cayman, KY1-1104 (KY). Inventor: WANG, Chang Yi; 47 Snake Hill Road, Cold Spring Harbor, New York 11724 (US). Agent: FILL, Peter et al.; Locke Lord LLP, 3 World Fi- nancial Center, New York, New York 10281 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW MX, MY MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = = Title: TREATMENT AND SUSTAINED VIROLOGIC REMISSION STABILIZED PATIENTS Figure 21 (54) HAART OF HIV INFECTION BY ANTIBODIES TO CD4 IN = = f Treatment with UB-421-like : .• antibodies = — = T cal, tore HIV- antiapn specific 1 Celt activity Triggeetof latency itctivatitm Reduce reservoirs ---- Prevent esti- Actively fn-cell and infected cell-free Released cells inrk (11011t viral particle U8421 coated cells : The present disclosure is directed to compositions and methods for the prevention, treatment, and/or functional cure of infection. One aspect of the present disclosure relates to monoclonal antibodies directed against CD4, compositions thereof, and employing such compositions for the prevention, treatment, and functional cure of HIV infection. \" methods = = — = = = = — = _ fl fl C= C= 11 in en © ,-1 (57) 0 HIV C [Continued on next page] WO 2018/035001 Al MIDEDIMOMOIDEIREEMODHOMINIMMOVOIME TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a))