|
GB939516A
(en)
|
1961-05-29 |
1963-10-16 |
British Drug Houses Ltd |
Sulphonyl ureas
|
|
US3702849A
(en)
|
1967-10-26 |
1972-11-14 |
Pfizer |
4-(isoquinolin-1-yl) piperazine-1-carboxylic acid esters
|
|
US3752660A
(en)
|
1971-03-15 |
1973-08-14 |
Allied Chem |
Chlorophenoxyacetyloxazolidone herbicides and preparation thereof
|
|
EP0094498A3
(en)
|
1982-05-06 |
1985-04-03 |
American Cyanamid Company |
Antiatherosclerotic 1-piperazine derivatives
|
|
US4439606A
(en)
|
1982-05-06 |
1984-03-27 |
American Cyanamid Company |
Antiatherosclerotic 1-piperazinecarbonyl compounds
|
|
US4656181A
(en)
|
1982-11-24 |
1987-04-07 |
Cermol S.A. |
Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
|
|
JPS59163372A
(ja)
|
1983-03-09 |
1984-09-14 |
Showa Denko Kk |
ピラゾ−ル誘導体とその製造法及び除草剤
|
|
JPS60193955A
(ja)
|
1984-03-13 |
1985-10-02 |
Mitsui Toatsu Chem Inc |
環式不飽和アミド置換エ−テル化合物及びその製造方法
|
|
JPS6143190A
(ja)
|
1984-08-06 |
1986-03-01 |
Mitsui Petrochem Ind Ltd |
ピリドピリミジン誘導体およびその製法
|
|
US4911920A
(en)
|
1986-07-30 |
1990-03-27 |
Alcon Laboratories, Inc. |
Sustained release, comfort formulation for glaucoma therapy
|
|
FR2588189B1
(fr)
|
1985-10-03 |
1988-12-02 |
Merck Sharp & Dohme |
Composition pharmaceutique de type a transition de phase liquide-gel
|
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
|
US5010175A
(en)
|
1988-05-02 |
1991-04-23 |
The Regents Of The University Of California |
General method for producing and selecting peptides with specific properties
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
US5925525A
(en)
|
1989-06-07 |
1999-07-20 |
Affymetrix, Inc. |
Method of identifying nucleotide differences
|
|
IE66205B1
(en)
|
1990-06-14 |
1995-12-13 |
Paul A Bartlett |
Polypeptide analogs
|
|
US5650489A
(en)
|
1990-07-02 |
1997-07-22 |
The Arizona Board Of Regents |
Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
|
|
ATE141502T1
(de)
|
1991-01-15 |
1996-09-15 |
Alcon Lab Inc |
Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen
|
|
US5212162A
(en)
|
1991-03-27 |
1993-05-18 |
Alcon Laboratories, Inc. |
Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
|
|
US6017696A
(en)
|
1993-11-01 |
2000-01-25 |
Nanogen, Inc. |
Methods for electronic stringency control for molecular biological analysis and diagnostics
|
|
US6051380A
(en)
|
1993-11-01 |
2000-04-18 |
Nanogen, Inc. |
Methods and procedures for molecular biological analysis and diagnostics
|
|
US5573905A
(en)
|
1992-03-30 |
1996-11-12 |
The Scripps Research Institute |
Encoded combinatorial chemical libraries
|
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
|
US5288514A
(en)
|
1992-09-14 |
1994-02-22 |
The Regents Of The University Of California |
Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
US5605798A
(en)
|
1993-01-07 |
1997-02-25 |
Sequenom, Inc. |
DNA diagnostic based on mass spectrometry
|
|
US5858659A
(en)
|
1995-11-29 |
1999-01-12 |
Affymetrix, Inc. |
Polymorphism detection
|
|
US6045996A
(en)
|
1993-10-26 |
2000-04-04 |
Affymetrix, Inc. |
Hybridization assays on oligonucleotide arrays
|
|
US6068818A
(en)
|
1993-11-01 |
2000-05-30 |
Nanogen, Inc. |
Multicomponent devices for molecular biological analysis and diagnostics
|
|
US5538848A
(en)
|
1994-11-16 |
1996-07-23 |
Applied Biosystems Division, Perkin-Elmer Corp. |
Method for detecting nucleic acid amplification using self-quenching fluorescence probe
|
|
IL111730A
(en)
|
1993-11-29 |
1998-12-06 |
Fujisawa Pharmaceutical Co |
Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them
|
|
CA2182517C
(en)
|
1994-02-07 |
2001-08-21 |
Theo Nikiforov |
Ligase/polymerase-mediated primer extension of single nucleotide polymorphisms and its use in genetic analysis
|
|
US5593853A
(en)
|
1994-02-09 |
1997-01-14 |
Martek Corporation |
Generation and screening of synthetic drug libraries
|
|
US5539083A
(en)
|
1994-02-23 |
1996-07-23 |
Isis Pharmaceuticals, Inc. |
Peptide nucleic acid combinatorial libraries and improved methods of synthesis
|
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
|
AU701127B2
(en)
|
1994-10-27 |
1999-01-21 |
Merck & Co., Inc. |
Muscarine antagonists
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
US5861510A
(en)
|
1995-04-20 |
1999-01-19 |
Pfizer Inc |
Arylsulfonyl hydroxamic acid derivatives as MMP and TNF inhibitors
|
|
FR2734816B1
(fr)
|
1995-05-31 |
1997-07-04 |
Adir |
Nouveaux aryl (alkyl) propylamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
EP2258726A1
(en)
|
1995-06-14 |
2010-12-08 |
The Regents of the University of California |
High affinity human antibodies to c-erbB-2
|
|
ES2183905T3
(es)
|
1995-12-20 |
2003-04-01 |
Hoffmann La Roche |
Inhibidores de metaloproteasa de matriz.
|
|
US6011029A
(en)
|
1996-02-26 |
2000-01-04 |
Bristol-Myers Squibb Company |
Inhibitors of farnesyl protein transferase
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
EP0923585B1
(en)
|
1996-07-18 |
2002-05-08 |
Pfizer Inc. |
Phosphinate based inhibitors of matrix metalloproteases
|
|
CN1228083A
(zh)
|
1996-08-23 |
1999-09-08 |
美国辉瑞有限公司 |
芳基磺酰氨基异羟肟酸衍生物
|
|
US5777324A
(en)
|
1996-09-19 |
1998-07-07 |
Sequenom, Inc. |
Method and apparatus for maldi analysis
|
|
WO1998030566A1
(en)
|
1997-01-06 |
1998-07-16 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
NZ336840A
(en)
|
1997-02-03 |
2001-01-26 |
Pfizer Prod Inc |
Arylsulfonylamino hydroxamic acid derivatives useful in the treatment of tumor necrosis factor and matrix metalloproteinase mediated diseases
|
|
GB9702194D0
(en)
|
1997-02-04 |
1997-03-26 |
Lilly Co Eli |
Sulphonide derivatives
|
|
JP2000507975A
(ja)
|
1997-02-07 |
2000-06-27 |
ファイザー・インク |
Ｎ−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用
|
|
IL131123A0
(en)
|
1997-02-11 |
2001-01-28 |
Pfizer |
Arylsulfonyl hydroxamic acid derivatives
|
|
EP0968201A2
(en)
|
1997-02-17 |
2000-01-05 |
Fujisawa Pharmaceutical Co., Ltd. |
New aminopiperazine derivatives
|
|
UA73073C2
(uk)
|
1997-04-03 |
2005-06-15 |
Уайт Холдінгз Корпорейшн |
Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
|
|
US6002008A
(en)
|
1997-04-03 |
1999-12-14 |
American Cyanamid Company |
Substituted 3-cyano quinolines
|
|
US5919626A
(en)
|
1997-06-06 |
1999-07-06 |
Orchid Bio Computer, Inc. |
Attachment of unmodified nucleic acids to silanized solid phase surfaces
|
|
CA2293706C
(en)
|
1997-06-17 |
2008-11-18 |
Schering Corporation |
N-substituted urea inhibitors of farnesyl-protein transferase
|
|
NZ502309A
(en)
|
1997-08-08 |
2002-02-01 |
Pfizer Prod Inc |
Aryloxyarylsulfonylamino hydroxamic acid derivatives and pharmaceutical use
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
US6903118B1
(en)
|
1997-12-17 |
2005-06-07 |
Klinge Pharma Gmbh |
Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
|
|
DE19756236A1
(de)
|
1997-12-17 |
1999-07-01 |
Klinge Co Chem Pharm Fab |
Neue piperazinylsubstituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
|
|
CA2314401A1
(en)
|
1997-12-22 |
1999-07-01 |
Du Pont Pharmaceuticals Company |
Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
US7060431B2
(en)
|
1998-06-24 |
2006-06-13 |
Illumina, Inc. |
Method of making and decoding of array sensors with microspheres
|
|
PT1004578E
(pt)
|
1998-11-05 |
2004-06-30 |
Pfizer Prod Inc |
Derivados hidroxamida do acido 5-oxo-pirrolidino-2-carboxilico
|
|
US6429027B1
(en)
|
1998-12-28 |
2002-08-06 |
Illumina, Inc. |
Composite arrays utilizing microspheres
|
|
US6511993B1
(en)
|
1999-06-03 |
2003-01-28 |
Kevin Neil Dack |
Metalloprotease inhibitors
|
|
EP1081137A1
(en)
|
1999-08-12 |
2001-03-07 |
Pfizer Products Inc. |
Selective inhibitors of aggrecanase in osteoarthritis treatment
|
|
DK1218542T3
(da)
|
1999-09-13 |
2004-08-02 |
Nugen Technologies Inc |
Fremgangsmåder og sammensætninger til lineær isotermisk amplifikation af polynukleotidsekvenser
|
|
SK13352002A3
(sk)
|
2000-03-21 |
2003-05-02 |
The Procter & Gamble Company |
Metaloproteázové inhibítory s vedľajším heterocyklickým reťazcom
|
|
EP1289984A4
(en)
|
2000-06-05 |
2004-11-24 |
Dong A Pharm Co Ltd |
NEW OXAZOLIDE DERIVATIVES AND A METHOD FOR THEIR PRODUCTION
|
|
TWI227231B
(en)
|
2000-07-12 |
2005-02-01 |
Novartis Ag |
4-benzoyl-piperidine derivatives for treating conditions mediated by CCR-3
|
|
MXPA03001359A
(es)
|
2000-08-18 |
2004-12-13 |
Millennium Pharm Inc |
Derivados de quinazolina como inhibidores de cinasa.
|
|
US6890747B2
(en)
|
2000-10-23 |
2005-05-10 |
Warner-Lambert Company |
Phosphoinositide 3-kinases
|
|
US7429599B2
(en)
|
2000-12-06 |
2008-09-30 |
Signal Pharmaceuticals, Llc |
Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
|
|
US20020169300A1
(en)
|
2001-01-30 |
2002-11-14 |
Waterman Marian L. |
Method of detection and treatment of colon cancer by analysis of beta-catenin-sensitive isoforms of lymphoid enhancer factor-1
|
|
EP1390034A4
(en)
|
2001-04-03 |
2005-07-13 |
Merck & Co Inc |
NMDA / NR2B NONARYL-HETEROCYCLO AMIDYL N-SUBSTITUTE ANTAGONISTS
|
|
ATE402164T1
(de)
|
2001-04-26 |
2008-08-15 |
Eisai R&D Man Co Ltd |
Stickstoffhaltige verbindung mit kondensiertem ring und pyrazolylgruppe als substituent und medizinische zusammensetzung davon
|
|
ATE449090T1
(de)
|
2001-07-02 |
2009-12-15 |
High Point Pharmaceuticals Llc |
Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren
|
|
EP1348434A1
(en)
|
2002-03-27 |
2003-10-01 |
Fujisawa Deutschland GmbH |
Use of pyridyl amides as inhibitors of angiogenesis
|
|
AU2003269242A1
(en)
|
2002-10-11 |
2004-05-04 |
Astrazeneca Ab |
1,4-disubstituted piperidine derivatives and their use as 11-betahsd1 inhibitors
|
|
JP4608852B2
(ja)
|
2002-10-15 |
2011-01-12 |
チッソ株式会社 |
液晶性ビニルケトン誘導体およびその重合体
|
|
EP1597256A1
(en)
|
2003-02-21 |
2005-11-23 |
Pfizer Inc. |
N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors
|
|
MXPA05009661A
(es)
|
2003-03-12 |
2006-03-08 |
Kudos Pharm Ltd |
Derivados de ftalazinona.
|
|
US20050119266A1
(en)
|
2003-10-01 |
2005-06-02 |
Yan Shi |
Pyrrolidine and piperidine derivatives as factor Xa inhibitors
|
|
JP4923380B2
(ja)
|
2003-12-22 |
2012-04-25 |
Ｊｎｃ株式会社 |
低屈折率異方性化合物、組成物およびそれらの重合体または重合体組成物
|
|
CN1933839A
(zh)
|
2004-01-23 |
2007-03-21 |
安进公司 |
化合物和使用方法
|
|
WO2005082892A2
(en)
|
2004-02-17 |
2005-09-09 |
Dr. Reddy's Laboratories Ltd. |
Triazole compounds as antibacterial agents and pharmaceutical compositions containing them
|
|
JP4775259B2
(ja)
|
2004-03-31 |
2011-09-21 |
味の素株式会社 |
アニリン誘導体
|
|
US20060167044A1
(en)
|
2004-12-20 |
2006-07-27 |
Arnaiz Damian O |
Piperidine derivatives and their use as anti-inflammatory agents
|
|
GB0428475D0
(en)
|
2004-12-30 |
2005-02-02 |
4 Aza Bioscience Nv |
Pyrido(3,2-D)pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders
|
|
US20090264415A2
(en)
|
2004-12-30 |
2009-10-22 |
Steven De Jonghe |
Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for medical treatment
|
|
CA2599476A1
(en)
|
2005-03-16 |
2006-09-21 |
F. Hoffmann-La Roche Ag |
Cis-2,4,5-triaryl-imidazolines and their use as anti-cancer medicaments
|
|
JP2007016011A
(ja)
|
2005-06-10 |
2007-01-25 |
Nippon Soda Co Ltd |
抗酸化活性を有する新規な含窒素ヘテロ環化合物、及び該化合物を含有する抗酸化薬
|
|
AU2006261607A1
(en)
*
|
2005-06-24 |
2006-12-28 |
Gilead Sciences, Inc. |
Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for treating hepatitis C.
|
|
JP2009513576A
(ja)
|
2005-10-11 |
2009-04-02 |
インターミューン・インコーポレーテッド |
ウィルス複製のインヒビター
|
|
JP2009519349A
(ja)
|
2005-12-15 |
2009-05-14 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Ｃｂ２受容体を変調する化合物
|
|
PE20070978A1
(es)
|
2006-02-14 |
2007-11-15 |
Novartis Ag |
COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
|
|
RU2008143179A
(ru)
|
2006-03-31 |
2010-05-10 |
Новартис АГ (CH) |
Органические соединения
|
|
US20090124636A1
(en)
|
2006-04-12 |
2009-05-14 |
Pfizer Inc. |
Chemical compounds
|
|
CA2655282A1
(en)
|
2006-06-16 |
2007-12-21 |
High Point Pharmaceuticals, Llc |
Pharmaceutical use of substituted piperidine carboxamides
|
|
AU2007263017A1
(en)
|
2006-06-22 |
2007-12-27 |
Biovitrum Ab (Publ) |
Pyridine and pyrazine derivatives as MNK kinase inhibitors
|
|
FR2903101B1
(fr)
|
2006-06-30 |
2008-09-26 |
Servier Lab |
Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US9259426B2
(en)
|
2006-07-20 |
2016-02-16 |
Gilead Sciences, Inc. |
4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
|
|
EP1903038A1
(de)
|
2006-09-07 |
2008-03-26 |
Bayer Schering Pharma Aktiengesellschaft |
N-(1-Hetaryl-piperidin-4-yl)-(het)arylamide als EP2-Rezeptor Modulatoren
|
|
WO2008112440A1
(en)
|
2007-03-09 |
2008-09-18 |
Astrazeneca Ab |
Piperazine and piperidine mglur5 potentiators
|
|
EP2144606A2
(en)
|
2007-04-05 |
2010-01-20 |
Max-Delbrück-Centrum Für Molekulare Medizin |
Remedy for the treatment of cardio-vascular diseases or disorders
|
|
ES2705599T3
(es)
|
2007-04-16 |
2019-03-26 |
Abbvie Inc |
Indoles sustituidos en la posición 7 como inhibidores de mcl-1
|
|
AU2009229157B2
(en)
|
2008-03-28 |
2015-01-29 |
Pacific Biosciences Of California, Inc. |
Compositions and methods for nucleic acid sequencing
|
|
EP2133334A1
(en)
|
2008-06-09 |
2009-12-16 |
DAC S.r.l. |
Heterocyclic derivatives as HDAC inhibitors
|
|
CA2733533C
(en)
|
2008-08-25 |
2013-12-17 |
Irm Llc |
Hedgehog pathway modulators
|
|
WO2010087399A1
(ja)
|
2009-01-30 |
2010-08-05 |
第一三共株式会社 |
ウロテンシンｉｉ受容体拮抗薬
|
|
EP2421826B1
(en)
|
2009-04-20 |
2013-10-23 |
F.Hoffmann-La Roche Ag |
Proline derivatives as cathepsin inhibitors
|
|
CN102459240A
(zh)
|
2009-04-22 |
2012-05-16 |
詹森药业有限公司 |
作为单酰甘油脂肪酶抑制剂的氮杂环丁烷基二酰胺
|
|
EP2270002A1
(en)
|
2009-06-18 |
2011-01-05 |
Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg |
Quinazoline derivatives as histamine H4-receptor inhibitors for use in the treatment of inflammatory disorders
|
|
WO2011002816A1
(en)
|
2009-06-29 |
2011-01-06 |
Agios Pharmaceuticals, Inc. |
Therapeutic compositions and related methods of use
|
|
WO2011016559A1
(ja)
|
2009-08-07 |
2011-02-10 |
武田薬品工業株式会社 |
複素環化合物およびその用途
|
|
KR101256018B1
(ko)
|
2009-08-20 |
2013-04-18 |
한국과학기술연구원 |
단백질 키나아제 저해활성을 갖는 1,3,6-치환된 인돌 화합물
|
|
CN102625708A
(zh)
|
2009-09-09 |
2012-08-01 |
阿维拉制药公司 |
Pi3激酶抑制剂及其用途
|
|
NZ600954A
(en)
|
2009-12-22 |
2013-11-29 |
|
Isoindolinone inhibitors of phosphatidylinositol 3-kinase
|
|
CA2785738A1
(en)
|
2009-12-30 |
2011-07-07 |
Avila Therapeutics, Inc. |
Ligand-directed covalent modification of protein
|
|
RS53705B1
(en)
|
2010-01-29 |
2015-04-30 |
Otsuka Pharmaceutical Co., Ltd. |
DI-SUBSTITUTED PYRIDINE DERIVATIVES AS ANTICANCERS
|
|
EP2542893A2
(en)
|
2010-03-03 |
2013-01-09 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
WO2011113512A1
(de)
|
2010-03-16 |
2011-09-22 |
Merck Patent Gmbh |
Morpholinylchinazoline
|
|
AU2011246067A1
(en)
|
2010-04-28 |
2012-09-27 |
Daiichi Sankyo Company, Limited |
[5,6] heterocyclic compound
|
|
TW201202230A
(en)
|
2010-05-24 |
2012-01-16 |
Mitsubishi Tanabe Pharma Corp |
Novel quinazoline compound
|
|
WO2011153553A2
(en)
|
2010-06-04 |
2011-12-08 |
The Regents Of The University Of California |
Methods and compositions for kinase inhibition
|
|
CN103119439A
(zh)
|
2010-06-08 |
2013-05-22 |
纽亘技术公司 |
用于多重测序的方法和组合物
|
|
US8658131B2
(en)
|
2010-06-21 |
2014-02-25 |
Washington University |
Compounds comprising 4-benzoylpiperidine as a sigma-1-selective ligand
|
|
ES2565627T3
(es)
|
2010-07-30 |
2016-04-06 |
Oncotherapy Science, Inc. |
Derivados de quinolina e inhibidores de MELK que contienen los mismos
|
|
RU2013114771A
(ru)
|
2010-09-03 |
2014-10-10 |
Янссен Фармацевтика Нв |
Диамиды азетидинила как ингибиторы моноацилглицерол липазы
|
|
WO2012041872A1
(en)
|
2010-09-29 |
2012-04-05 |
Intervet International B.V. |
N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases
|
|
CA2815350A1
(en)
|
2010-10-22 |
2012-04-26 |
Janssen Pharmaceutica Nv |
Piperidin-4-yl-azetidine diamides as monoacylglycerol lipase inhibitors
|
|
JP2014504269A
(ja)
|
2010-11-05 |
2014-02-20 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー２、リミテッド |
化学化合物
|
|
US9260484B2
(en)
|
2011-06-15 |
2016-02-16 |
Ohio State Innovation Foundation |
Small molecule composite surfaces as inhibitors of protein-protein interactions
|
|
AR086798A1
(es)
|
2011-06-29 |
2014-01-22 |
Otsuka Pharma Co Ltd |
Derivados quinazolinicos utiles para tratar trastornos del sistema nervioso central y composiciones farmaceuticas que los contienen
|
|
CN103087077B
(zh)
|
2011-11-03 |
2016-05-18 |
上海希迈医药科技有限公司 |
噻吩并嘧啶和呋喃并嘧啶类衍生物、其制备方法及其在医药上的应用
|
|
JP2013107855A
(ja)
|
2011-11-22 |
2013-06-06 |
Mitsubishi Tanabe Pharma Corp |
医薬組成物
|
|
WO2013096455A1
(en)
|
2011-12-20 |
2013-06-27 |
Dana-Farber Cancer Institute, Inc. |
Methods for diagnosing and treating oncogenic kras-associated cancer
|
|
WO2013096151A1
(en)
|
2011-12-22 |
2013-06-27 |
Glaxosmithkline Llc |
Chemical compounds
|
|
JP6096219B2
(ja)
|
2012-01-13 |
2017-03-15 |
ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ |
キナーゼ阻害剤として有用なトリアゾリルまたはトリアジアゾリル置換されたピリジル化合物
|
|
AU2013237226A1
(en)
|
2012-03-19 |
2014-10-09 |
Emory University |
Quinazoline compounds and their use in therapy
|
|
WO2013155077A1
(en)
|
2012-04-09 |
2013-10-17 |
Board Of Regents,The University Of Texas System |
Response markers for src inhibitor therapies
|
|
EP2836482B1
(en)
|
2012-04-10 |
2019-12-25 |
The Regents of The University of California |
Compositions and methods for treating cancer
|
|
AU2013259387B2
(en)
|
2012-05-09 |
2016-12-15 |
Strike Bio, Inc. |
Bi-functional short-hairpin rna (bi-shrna) specific for single-nucleotide kras mutations
|
|
JO3300B1
(ar)
|
2012-06-06 |
2018-09-16 |
Novartis Ag |
مركبات وتركيبات لتعديل نشاط egfr
|
|
RS62233B1
(sr)
|
2012-07-11 |
2021-09-30 |
Blueprint Medicines Corp |
Inhibitori receptora fibroblast faktora rasta
|
|
US20150299188A1
(en)
|
2012-08-24 |
2015-10-22 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound
|
|
CN202931543U
(zh)
|
2012-10-19 |
2013-05-08 |
深圳Tcl新技术有限公司 |
扬声器
|
|
MX2020009849A
(es)
|
2012-11-01 |
2021-09-13 |
Infinity Pharmaceuticals Inc |
Tratamiento de canceres utilizando moduladores de las isoformas de pi3 cinasa.
|
|
EA201591746A1
(ru)
|
2013-03-14 |
2016-08-31 |
КОНВЕРДЖЕН ЭлЭлСи |
Способы и композиции для ингибирования бромодомен-содержащих белков
|
|
US9227978B2
(en)
|
2013-03-15 |
2016-01-05 |
Araxes Pharma Llc |
Covalent inhibitors of Kras G12C
|
|
JP6473133B2
(ja)
|
2013-03-15 |
2019-02-20 |
アラクセス ファーマ エルエルシー |
Ｋｒａｓｇ１２ｃの共有結合性阻害剤
|
|
US9745319B2
(en)
|
2013-03-15 |
2017-08-29 |
Araxes Pharma Llc |
Irreversible covalent inhibitors of the GTPase K-Ras G12C
|
|
WO2014201435A1
(en)
|
2013-06-13 |
2014-12-18 |
Biodesy, Inc. |
Method of screening candidate biochemical entities targeting a target biochemical entity
|
|
FI3016946T3
(fi)
|
2013-07-03 |
2023-01-13 |
|
Substituoituja bentsofuranyyli- ja bentsoksatsolyyliyhdisteitä ja niiden farmaseuttisia käyttöjä
|
|
LT3049417T
(lt)
|
2013-07-31 |
2019-02-11 |
Merck Patent Gmbh |
Piridinai, pirimidnai ir pirazinai kaip btk inhibitoriai ir jų panaudojimas
|
|
CN104418860B
(zh)
|
2013-08-20 |
2016-09-07 |
中国科学院广州生物医药与健康研究院 |
嘧啶并杂环类化合物及其药用组合物和应用
|
|
JO3805B1
(ar)
*
|
2013-10-10 |
2021-01-31 |
Araxes Pharma Llc |
مثبطات كراس جي12سي
|
|
KR20160076519A
(ko)
*
|
2013-10-10 |
2016-06-30 |
아락세스 파마 엘엘씨 |
Kras g12c 억제제
|
|
US9376559B2
(en)
|
2013-11-22 |
2016-06-28 |
Exxonmobil Chemical Patents Inc. |
Reverse staged impact copolymers
|
|
US9695165B2
(en)
|
2014-01-15 |
2017-07-04 |
Blueprint Medicines Corporation |
Inhibitors of the fibroblast growth factor receptor
|
|
EP3102579B1
(en)
*
|
2014-02-03 |
2019-04-10 |
Cadila Healthcare Limited |
Heterocyclic compounds
|
|
DK3119762T3
(da)
|
2014-03-20 |
2021-08-30 |
Capella Therapeutics Inc |
Benzimidazol-derivater som erbb-tyrosin-kinase-inhibitorer til behandlingen af kræft
|
|
NZ724691A
(en)
|
2014-03-24 |
2018-02-23 |
Guangdong Zhongsheng Pharmaceutical Co Ltd |
Quinoline derivatives as smo inhibitors
|
|
MA40074A
(fr)
|
2014-05-30 |
2015-12-03 |
Univ Columbia |
Composés liant ras multivalents
|
|
JP6640126B2
(ja)
|
2014-06-27 |
2020-02-05 |
セルジーン コーポレイション |
セレブロン及び他のｅ３ユビキチンリガーゼの立体構造の変化を誘導するための組成物及び方法
|
|
JO3556B1
(ar)
|
2014-09-18 |
2020-07-05 |
Araxes Pharma Llc |
علاجات مدمجة لمعالجة السرطان
|
|
US10011600B2
(en)
|
2014-09-25 |
2018-07-03 |
Araxes Pharma Llc |
Methods and compositions for inhibition of Ras
|
|
JP2017528498A
(ja)
|
2014-09-25 |
2017-09-28 |
アラクセス ファーマ エルエルシー |
Ｋｒａｓ ｇ１２ｃ変異体タンパク質のインヒビター
|
|
WO2016049565A1
(en)
|
2014-09-25 |
2016-03-31 |
Araxes Pharma Llc |
Compositions and methods for inhibition of ras
|
|
US20160219959A1
(en)
|
2015-01-23 |
2016-08-04 |
Bella Lash Extensions, Llc |
Tray for holding eyelash extensions and processes for applying eyelash extensions
|
|
JP2018502853A
(ja)
*
|
2015-01-23 |
2018-02-01 |
コンフルエンス・ライフ・サイエンシズ，インコーポレーテッド |
炎症およびがんを処置するための複素環式ｉｔｋ阻害剤
|
|
CN107849022A
(zh)
*
|
2015-04-10 |
2018-03-27 |
亚瑞克西斯制药公司 |
取代的喹唑啉化合物和其使用方法
|
|
EP3283462B1
(en)
|
2015-04-15 |
2020-12-02 |
Araxes Pharma LLC |
Fused-tricyclic inhibitors of kras and methods of use thereof
|
|
WO2017015562A1
(en)
|
2015-07-22 |
2017-01-26 |
Araxes Pharma Llc |
Substituted quinazoline compounds and their use as inhibitors of g12c mutant kras, hras and/or nras proteins
|
|
US10144724B2
(en)
|
2015-07-22 |
2018-12-04 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use thereof
|
|
EP3356354A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
EP3356347A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058792A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
US10689356B2
(en)
|
2015-09-28 |
2020-06-23 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
WO2017058728A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
US10975071B2
(en)
|
2015-09-28 |
2021-04-13 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
EP3356351A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
WO2017070256A2
(en)
|
2015-10-19 |
2017-04-27 |
Araxes Pharma Llc |
Method for screening inhibitors of ras
|
|
EP3365334B1
(en)
|
2015-10-21 |
2024-07-17 |
Otsuka Pharmaceutical Co., Ltd. |
Benzolactam compounds as protein kinase inhibitors
|
|
US10414757B2
(en)
|
2015-11-16 |
2019-09-17 |
Araxes Pharma Llc |
2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof
|
|
US9988357B2
(en)
|
2015-12-09 |
2018-06-05 |
Araxes Pharma Llc |
Methods for preparation of quinazoline derivatives
|
|
WO2017172979A1
(en)
|
2016-03-30 |
2017-10-05 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use
|
|
US10646488B2
(en)
|
2016-07-13 |
2020-05-12 |
Araxes Pharma Llc |
Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
|
|
CN110036010A
(zh)
|
2016-09-29 |
2019-07-19 |
亚瑞克西斯制药公司 |
Kras g12c突变蛋白的抑制剂
|
|
CN110312711A
(zh)
|
2016-10-07 |
2019-10-08 |
亚瑞克西斯制药公司 |
作为ras抑制剂的杂环化合物及其使用方法
|
|
US11358959B2
(en)
|
2017-01-26 |
2022-06-14 |
Araxes Pharma Llc |
Benzothiophene and benzothiazole compounds and methods of use thereof
|
|
US11279689B2
(en)
|
2017-01-26 |
2022-03-22 |
Araxes Pharma Llc |
1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
|
|
EP3573970A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
|
|
WO2018140512A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
|
|
CN110382482A
(zh)
|
2017-01-26 |
2019-10-25 |
亚瑞克西斯制药公司 |
稠合的杂-杂二环化合物及其使用方法
|
|
CN110869358A
(zh)
|
2017-05-25 |
2020-03-06 |
亚瑞克西斯制药公司 |
Kras的共价抑制剂
|
|
TW201906832A
(zh)
|
2017-05-25 |
2019-02-16 |
美商亞瑞克西斯製藥公司 |
用於癌症治療之化合物及其使用方法
|
|
KR20210045998A
(ko)
|
2018-08-01 |
2021-04-27 |
아락세스 파마 엘엘씨 |
헤테로사이클릭 스피로 화합물 및 암 치료를 위한 그의 사용 방법
|
