JP2019528255A5 - - Google Patents
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- JP2019528255A5 JP2019528255A5 JP2019503247A JP2019503247A JP2019528255A5 JP 2019528255 A5 JP2019528255 A5 JP 2019528255A5 JP 2019503247 A JP2019503247 A JP 2019503247A JP 2019503247 A JP2019503247 A JP 2019503247A JP 2019528255 A5 JP2019528255 A5 JP 2019528255A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- optionally
- elution buffer
- temperature
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022096278A JP7411020B2 (ja) | 2016-07-22 | 2022-06-15 | Ｆｃ含有タンパク質を精製する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662365943P | 2016-07-22 | 2016-07-22 | |
| US62/365,943 | 2016-07-22 | ||
| PCT/US2017/043384 WO2018018011A2 (en) | 2016-07-22 | 2017-07-21 | Methods of purifying fc-containing proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022096278A Division JP7411020B2 (ja) | 2016-07-22 | 2022-06-15 | Ｆｃ含有タンパク質を精製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528255A JP2019528255A (ja) | 2019-10-10 |
| JP2019528255A5 true JP2019528255A5 (enExample) | 2020-07-27 |
| JP7092744B2 JP7092744B2 (ja) | 2022-06-28 |
Family
ID=59656168
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503247A Active JP7092744B2 (ja) | 2016-07-22 | 2017-07-21 | Ｆｃ含有タンパク質を精製する方法 |
| JP2022096278A Active JP7411020B2 (ja) | 2016-07-22 | 2022-06-15 | Ｆｃ含有タンパク質を精製する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022096278A Active JP7411020B2 (ja) | 2016-07-22 | 2022-06-15 | Ｆｃ含有タンパク質を精製する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11312745B2 (enExample) |
| EP (1) | EP3487867B1 (enExample) |
| JP (2) | JP7092744B2 (enExample) |
| KR (2) | KR102435801B1 (enExample) |
| CN (2) | CN115925780B (enExample) |
| AU (2) | AU2017298984B2 (enExample) |
| CA (2) | CA3031469C (enExample) |
| IL (2) | IL285146B (enExample) |
| MA (1) | MA45721A (enExample) |
| MX (2) | MX2019000903A (enExample) |
| SG (1) | SG11201900573UA (enExample) |
| WO (1) | WO2018018011A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019343053B2 (en) * | 2018-09-21 | 2026-04-30 | Teneobio, Inc. | Methods for purifying heterodimeric, multispecific antibodies |
| AR117650A1 (es) * | 2018-10-11 | 2021-08-18 | Amgen Inc | Procesamiento posterior de constructos de anticuerpos biespecíficos |
| BR112021011194A2 (pt) * | 2019-01-16 | 2021-08-31 | Regeneron Pharmaceuticals, Inc. | Método e sistema de identificar e quantificar a fragmentação do anticorpo |
| KR102286892B1 (ko) | 2019-07-08 | 2021-08-06 | 삼천당제약주식회사 | 안과용 단백질 제제의 정제방법 |
| CN110724204B (zh) * | 2019-11-18 | 2021-10-22 | 广东菲鹏制药股份有限公司 | Fc融合蛋白的纯化方法 |
| CN112881675A (zh) * | 2019-11-29 | 2021-06-01 | 广东菲鹏生物有限公司 | IgM抗体检测稀释液 |
| CA3174665A1 (en) | 2020-04-09 | 2021-10-14 | Cytomx Therapeutics, Inc. | Compositions containing activatable antibodies |
| CN116056775B (zh) * | 2020-09-16 | 2025-12-02 | 沃特世科技公司 | 在尺寸排阻色谱流动相中使用低浓度氨基酸的改善尺寸排阻色谱法 |
| WO2023068740A1 (ko) * | 2021-10-19 | 2023-04-27 | 주식회사 알테오젠 | Igg fc 도메인을 가지는 융합 단백질의 정제방법 |
| CN113980092B (zh) * | 2021-12-09 | 2024-05-14 | 上海药明生物技术有限公司 | 一种蛋白质亲和纯化方法 |
| CN116165290B (zh) * | 2021-12-17 | 2025-06-27 | 复旦大学 | 一种抗体药物研发流程中工程细胞株的筛选方法 |
| CN116271982B (zh) * | 2022-11-30 | 2024-01-09 | 杭州广科安德生物科技有限公司 | 一种血液高丰度蛋白免疫亲和柱的再生方法 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| ES2284161T3 (es) | 1990-01-12 | 2007-11-01 | Amgen Fremont Inc. | Generacion de anticuerpos xenogenicos. |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US6713610B1 (en) | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| WO1991018982A1 (en) | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
| US5350683A (en) | 1990-06-05 | 1994-09-27 | Immunex Corporation | DNA encoding type II interleukin-1 receptors |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| ES2301158T3 (es) | 1992-07-24 | 2008-06-16 | Amgen Fremont Inc. | Produccion de anticuerpos xenogenicos. |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| EP0822830B1 (en) | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Human anti-IL-8 antibodies, derived from immunized xenomice |
| ATE549918T1 (de) | 1996-12-03 | 2012-04-15 | Amgen Fremont Inc | Menschliche antikörper, die ausdrücklich menschliches tnf alpha binden |
| US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
| AU763513B2 (en) * | 1998-04-16 | 2003-07-24 | Genentech Inc. | Secretion of glycosylated proteins using a tissue plasminogen activator pro-sequence |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| SG156672A1 (en) * | 2004-10-22 | 2009-11-26 | Amgen Inc | Methods for refolding of recombinant antibodies |
| BRPI0611600B8 (pt) * | 2005-06-17 | 2021-05-25 | Wyeth Corp | método para purificação de uma proteína tendo uma região fc a partir de um líquido fonte compreendendo a proteína e uma ou mais impurezas, e kit |
| CA2636109A1 (en) * | 2006-01-06 | 2007-07-19 | Amgen Inc. | Methods and systems for isolating target molecules from complex solutions by column-chromatography using eluants containing organic solvents |
| CN105837690A (zh) | 2006-06-12 | 2016-08-10 | 新兴产品开发西雅图有限公司 | 具有效应功能的单链多价结合蛋白 |
| WO2008036600A2 (en) * | 2006-09-18 | 2008-03-27 | Genentech, Inc. | Methods of protein production |
| JP5522723B2 (ja) * | 2007-05-21 | 2014-06-18 | ノマディックバイオサイエンス株式会社 | 新規ポリペプチド，アフィニティークロマトグラフィー用材，及びイムノグロブリンの分離及び／又は精製方法 |
| EP3663318A1 (en) | 2008-01-07 | 2020-06-10 | Amgen Inc. | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
| WO2010019493A1 (en) * | 2008-08-14 | 2010-02-18 | Merck Sharp & Dohme Corp. | Methods for purifying antibodies using protein a affinity chromatography |
| KR101741859B1 (ko) * | 2009-06-22 | 2017-06-15 | 암젠 인크 | 화학적으로 조절된 산화환원 상태를 사용한 단백질의 재폴딩 |
| SI3660032T1 (sl) * | 2009-06-25 | 2026-02-27 | Amgen Inc. | Postopki zajemanja in čiščenja beljakovin, izraženih v nesesalskem sistemu |
| MX2012003396A (es) | 2009-09-16 | 2012-04-10 | Genentech Inc | Complejos de proteina conteniendo helice super-enrollada y/o enlazador tether y usos de los mismos. |
| CN102382190B (zh) * | 2010-09-01 | 2014-04-09 | 山东新时代药业有限公司 | 分离和去除TNFR-Fc融合蛋白中寡聚体的方法 |
| WO2012086837A1 (ja) | 2010-12-24 | 2012-06-28 | 旭化成メディカル株式会社 | 温度応答性プロテインａの固定化方法 |
| JP6280499B2 (ja) * | 2011-07-08 | 2018-02-14 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｆｃ融合タンパク質の精製方法 |
| US10189891B2 (en) | 2012-03-28 | 2019-01-29 | Ge Healthcare Bioprocess R&D Ab | Affinity chromatography matrix |
| EP2889617B1 (en) | 2012-08-27 | 2017-10-11 | Asahi Kasei Medical Co., Ltd. | Antibody purification method by means of temperature-responsive chromatography |
| UY35148A (es) * | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| US20140302037A1 (en) | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| WO2015063339A1 (en) * | 2013-11-04 | 2015-05-07 | Glenmark Pharmaceuticals S.A. | Production of t cell retargeting hetero-dimeric immunoglobulins |
-
2017
- 2017-07-21 KR KR1020197003162A patent/KR102435801B1/ko active Active
- 2017-07-21 MA MA045721A patent/MA45721A/fr unknown
- 2017-07-21 MX MX2019000903A patent/MX2019000903A/es unknown
- 2017-07-21 CN CN202210979746.6A patent/CN115925780B/zh active Active
- 2017-07-21 AU AU2017298984A patent/AU2017298984B2/en active Active
- 2017-07-21 KR KR1020227028721A patent/KR102579850B1/ko active Active
- 2017-07-21 WO PCT/US2017/043384 patent/WO2018018011A2/en not_active Ceased
- 2017-07-21 CA CA3031469A patent/CA3031469C/en active Active
- 2017-07-21 CN CN201780045463.1A patent/CN109563125B/zh active Active
- 2017-07-21 SG SG11201900573UA patent/SG11201900573UA/en unknown
- 2017-07-21 IL IL285146A patent/IL285146B/en unknown
- 2017-07-21 JP JP2019503247A patent/JP7092744B2/ja active Active
- 2017-07-21 EP EP17754514.2A patent/EP3487867B1/en active Active
- 2017-07-21 CA CA3218290A patent/CA3218290A1/en active Pending
- 2017-07-21 US US16/093,994 patent/US11312745B2/en active Active
-
2019
- 2019-01-21 IL IL264375A patent/IL264375B/en unknown
- 2019-01-21 MX MX2023006291A patent/MX2023006291A/es unknown
-
2022
- 2022-06-15 JP JP2022096278A patent/JP7411020B2/ja active Active
-
2023
- 2023-08-31 AU AU2023222915A patent/AU2023222915B2/en active Active
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