JP2019527537A5 - - Google Patents
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- JP2019527537A5 JP2019527537A5 JP2018564975A JP2018564975A JP2019527537A5 JP 2019527537 A5 JP2019527537 A5 JP 2019527537A5 JP 2018564975 A JP2018564975 A JP 2018564975A JP 2018564975 A JP2018564975 A JP 2018564975A JP 2019527537 A5 JP2019527537 A5 JP 2019527537A5
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- Prior art keywords
- seq
- car
- domain
- polypeptide
- antigen receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 38
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 210000004027 cell Anatomy 0.000 claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 208000035475 disorder Diseases 0.000 claims 7
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 125000006850 spacer group Chemical group 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 230000000139 costimulatory effect Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000011664 signaling Effects 0.000 claims 5
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 4
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 4
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 210000002865 immune cell Anatomy 0.000 claims 3
- 230000003834 intracellular effect Effects 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010034016 Paronychia Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 101800001707 Spacer peptide Proteins 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 102000046935 human TNFRSF17 Human genes 0.000 claims 1
- 210000003519 mature b lymphocyte Anatomy 0.000 claims 1
- 210000001806 memory b lymphocyte Anatomy 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022106290A JP7646604B2 (ja) | 2016-06-07 | 2022-06-30 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ－ｔ細胞 |
| JP2024154170A JP2024178217A (ja) | 2016-06-07 | 2024-09-06 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ－ｔ細胞 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16173401.7 | 2016-06-07 | ||
| EP16173401 | 2016-06-07 | ||
| PCT/EP2017/063862 WO2017211900A1 (en) | 2016-06-07 | 2017-06-07 | Chimeric antigen receptor and car-t cells that bind bcma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022106290A Division JP7646604B2 (ja) | 2016-06-07 | 2022-06-30 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ－ｔ細胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019527537A JP2019527537A (ja) | 2019-10-03 |
| JP2019527537A5 true JP2019527537A5 (OSRAM) | 2020-06-11 |
Family
ID=56112891
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018564975A Pending JP2019527537A (ja) | 2016-06-07 | 2017-06-07 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ−ｔ細胞 |
| JP2022106290A Active JP7646604B2 (ja) | 2016-06-07 | 2022-06-30 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ－ｔ細胞 |
| JP2024154170A Pending JP2024178217A (ja) | 2016-06-07 | 2024-09-06 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ－ｔ細胞 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022106290A Active JP7646604B2 (ja) | 2016-06-07 | 2022-06-30 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ－ｔ細胞 |
| JP2024154170A Pending JP2024178217A (ja) | 2016-06-07 | 2024-09-06 | キメラ抗原受容体と、ｂｃｍａに結合するｃａｒ－ｔ細胞 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12048718B2 (OSRAM) |
| EP (1) | EP3463396A1 (OSRAM) |
| JP (3) | JP2019527537A (OSRAM) |
| KR (2) | KR102497013B1 (OSRAM) |
| CN (1) | CN109641012A (OSRAM) |
| AU (1) | AU2017276706B2 (OSRAM) |
| CA (1) | CA3026778A1 (OSRAM) |
| SG (2) | SG11201810697QA (OSRAM) |
| WO (1) | WO2017211900A1 (OSRAM) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109641012A (zh) * | 2016-06-07 | 2019-04-16 | 马克思-德布鲁克-分子医学中心亥姆霍兹联合会 | 与bcma结合的嵌合抗原受体和car-t细胞 |
| WO2018209324A2 (en) | 2017-05-11 | 2018-11-15 | The Broad Institute, Inc. | Methods and compositions of use of cd8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| JP7356354B2 (ja) | 2017-05-12 | 2023-10-04 | クリスパー セラピューティクス アクチェンゲゼルシャフト | 細胞の操作のための材料及び方法並びに免疫腫瘍学におけるその使用 |
| WO2018232195A1 (en) | 2017-06-14 | 2018-12-20 | The Broad Institute, Inc. | Compositions and methods targeting complement component 3 for inhibiting tumor growth |
| US12049643B2 (en) | 2017-07-14 | 2024-07-30 | The Broad Institute, Inc. | Methods and compositions for modulating cytotoxic lymphocyte activity |
| EP3695408A4 (en) | 2017-10-02 | 2021-12-15 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING A GENETIC SIGNATURE OF IMMUNOTHERAPY RESISTANCE IN CANCER |
| US12171783B2 (en) | 2017-11-13 | 2024-12-24 | The Broad Institute, Inc. | Methods and compositions for targeting developmental and oncogenic programs in H3K27M gliomas |
| EP3710039A4 (en) | 2017-11-13 | 2021-08-04 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER BY TARGETING THE CLEC2D-KLRB1 PATH |
| US11026975B2 (en) * | 2018-02-01 | 2021-06-08 | Nanjing Iaso Biotherapeutics Co., Ltd. | Chimeric antigen receptor (CAR) binding to BCMA, and uses thereof |
| WO2019149250A1 (zh) | 2018-02-01 | 2019-08-08 | 南京驯鹿医疗技术有限公司 | 一种结合bcma的嵌合抗原受体(car)及其应用 |
| CA3081125C (en) * | 2018-02-01 | 2025-09-16 | Innovent Biologics (Suzhou) Co., Ltd. | All-Human Single-Chain Variable Fragment Anti-Antigen for B Lymphocyte Maturation (BCMA), and Associated Application |
| CN111684062A (zh) | 2018-02-09 | 2020-09-18 | 伊玛提克斯美国公司 | 制造t细胞的方法 |
| SG11202007513PA (en) * | 2018-02-16 | 2020-09-29 | Kite Pharma Inc | Modified pluripotent stem cells and methods of making and use |
| CA3095864A1 (en) * | 2018-04-03 | 2019-10-10 | Promab Biotechnologies, Inc. | Bcma-car-t cells |
| CN116836297A (zh) * | 2018-04-12 | 2023-10-03 | 上海赛比曼生物科技有限公司 | 靶向bcma的嵌合抗原受体及其制法和应用 |
| US11957695B2 (en) | 2018-04-26 | 2024-04-16 | The Broad Institute, Inc. | Methods and compositions targeting glucocorticoid signaling for modulating immune responses |
| SG11202011080QA (en) | 2018-05-11 | 2020-12-30 | Crispr Therapeutics Ag | Methods and compositions for treating cancer |
| GB201807862D0 (en) * | 2018-05-15 | 2018-06-27 | Ucl Business Plc | Chimeric antigen receptor |
| WO2019232542A2 (en) | 2018-06-01 | 2019-12-05 | Massachusetts Institute Of Technology | Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients |
| US12036240B2 (en) | 2018-06-14 | 2024-07-16 | The Broad Institute, Inc. | Compositions and methods targeting complement component 3 for inhibiting tumor growth |
| TWI838389B (zh) | 2018-07-19 | 2024-04-11 | 美商再生元醫藥公司 | 雙特異性抗-BCMAｘ抗-CD3抗體及其用途 |
| PT3823665T (pt) | 2018-07-19 | 2024-02-26 | Regeneron Pharma | Recetores antigénicos quiméricos que possuem uma especificidade para o bcma e utilizações dos mesmos |
| WO2020072700A1 (en) | 2018-10-02 | 2020-04-09 | Dana-Farber Cancer Institute, Inc. | Hla single allele lines |
| WO2020081730A2 (en) | 2018-10-16 | 2020-04-23 | Massachusetts Institute Of Technology | Methods and compositions for modulating microenvironment |
| US20220170097A1 (en) | 2018-10-29 | 2022-06-02 | The Broad Institute, Inc. | Car t cell transcriptional atlas |
| EP3873539A4 (en) * | 2018-10-31 | 2023-01-18 | The Children's Hospital of Philadelphia | LYMPH-BASED T-CELLS FOR DIAGNOSTIC AND THERAPEUTIC USE |
| PE20211058A1 (es) | 2018-11-01 | 2021-06-07 | Juno Therapeutics Inc | Receptores de antigenos quimericos especificos para el miembro d del grupo 5 de la clase c del receptor acoplado a proteina g (gprc5d) |
| WO2020131586A2 (en) | 2018-12-17 | 2020-06-25 | The Broad Institute, Inc. | Methods for identifying neoantigens |
| US11739156B2 (en) | 2019-01-06 | 2023-08-29 | The Broad Institute, Inc. Massachusetts Institute of Technology | Methods and compositions for overcoming immunosuppression |
| ES2991170T3 (es) | 2019-01-16 | 2024-12-02 | Caribou Biosciences Inc | Anticuerpo BCMA humanizado y células BCMA-CAR-T |
| CN111454358A (zh) * | 2019-01-18 | 2020-07-28 | 四川科伦博泰生物医药股份有限公司 | 一种嵌合抗原受体及其应用 |
| AU2020226401A1 (en) * | 2019-02-18 | 2021-10-14 | Memorial Sloan-Kettering Cancer Center | Combinations of multiple chimeric antigen receptors for immunotherapy |
| US20220154282A1 (en) | 2019-03-12 | 2022-05-19 | The Broad Institute, Inc. | Detection means, compositions and methods for modulating synovial sarcoma cells |
| EP3942023A1 (en) | 2019-03-18 | 2022-01-26 | The Broad Institute, Inc. | Compositions and methods for modulating metabolic regulators of t cell pathogenicity |
| WO2020191346A1 (en) | 2019-03-21 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy |
| ES2967879T3 (es) * | 2019-03-25 | 2024-05-06 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Mejora de la actividad de los linfocitos T citolíticos mediante la inhibición de EBAG9 |
| EP3733707A1 (en) * | 2019-04-30 | 2020-11-04 | Celyad S.A. | Car t-cells targeting bcma and uses thereof |
| JP2022531185A (ja) | 2019-04-30 | 2022-07-06 | クリスパー セラピューティクス アクチェンゲゼルシャフト | 遺伝子改変ｔ細胞を標的化するｃｄ１９を使用するｂ細胞悪性病変の同種細胞療法 |
| CN113784733B (zh) * | 2019-05-07 | 2024-09-06 | 亘喜生物科技（上海）有限公司 | 靶向bcma的工程化免疫细胞及其用途 |
| US20220235340A1 (en) | 2019-05-20 | 2022-07-28 | The Broad Institute, Inc. | Novel crispr-cas systems and uses thereof |
| EP3980458A1 (en) * | 2019-06-05 | 2022-04-13 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) | Chimeric autoantibody receptor (caar) that binds autoantibodies targeting the central nervous system in neurological autoimmune disease |
| US20220257653A1 (en) * | 2019-07-19 | 2022-08-18 | The Children's Hospital Of Philadelphia | Chimeric antigen receptors containing glypican 2 binding domains |
| RS65094B1 (sr) * | 2019-08-02 | 2024-02-29 | Fundacio De Recerca Clinic Barcelona Inst Dinvestigacions Biomediques August Pi I Sunyer Frcb Idibap | Car t-ćelije prema bcma za lečenje multiplog mijeloma |
| WO2021030627A1 (en) | 2019-08-13 | 2021-02-18 | The General Hospital Corporation | Methods for predicting outcomes of checkpoint inhibition and treatment thereof |
| US12421557B2 (en) | 2019-08-16 | 2025-09-23 | The Broad Institute, Inc. | Methods for predicting outcomes and treating colorectal cancer using a cell atlas |
| CN114222758A (zh) * | 2019-08-20 | 2022-03-22 | 武汉华大吉诺因生物科技有限公司 | 抗bcma抗体及其在car-t领域中的应用 |
| US20220298501A1 (en) | 2019-08-30 | 2022-09-22 | The Broad Institute, Inc. | Crispr-associated mu transposase systems |
| WO2021051390A1 (zh) * | 2019-09-20 | 2021-03-25 | 上海吉倍生物技术有限公司 | 靶向bcma的抗体及嵌合抗原受体 |
| WO2021062281A2 (en) * | 2019-09-25 | 2021-04-01 | Fate Therapeutics, Inc. | Multi-targeting effector cells and use thereof |
| US12297426B2 (en) | 2019-10-01 | 2025-05-13 | The Broad Institute, Inc. | DNA damage response signature guided rational design of CRISPR-based systems and therapies |
| US12394502B2 (en) | 2019-10-02 | 2025-08-19 | The General Hospital Corporation | Method for predicting HLA-binding peptides using protein structural features |
| US12195725B2 (en) | 2019-10-03 | 2025-01-14 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating and detecting tissue specific TH17 cell pathogenicity |
| US11981922B2 (en) | 2019-10-03 | 2024-05-14 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment |
| US11793787B2 (en) | 2019-10-07 | 2023-10-24 | The Broad Institute, Inc. | Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis |
| CN110642953B (zh) * | 2019-10-12 | 2021-09-17 | 华夏源（上海）细胞基因工程股份有限公司 | 一种靶向bcma的t细胞受体融合蛋白和应用 |
| CN110669144B (zh) * | 2019-10-12 | 2021-09-17 | 华夏源（上海）细胞基因工程股份有限公司 | 一种靶向b细胞成熟抗原的嵌合抗原受体及其应用 |
| US11844800B2 (en) | 2019-10-30 | 2023-12-19 | Massachusetts Institute Of Technology | Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia |
| US12165747B2 (en) | 2020-01-23 | 2024-12-10 | The Broad Institute, Inc. | Molecular spatial mapping of metastatic tumor microenvironment |
| US20230114854A1 (en) * | 2020-02-14 | 2023-04-13 | Cellgentek Co., Ltd. | Chimeric antigen receptor targeting b-cell maturation antigen and use thereof |
| BR112022024833A2 (pt) | 2020-06-05 | 2023-02-14 | Eisai R&D Man Co Ltd | Conjugados anticorpo anti-bcma-fármaco e métodos de uso |
| KR102316091B1 (ko) * | 2020-06-17 | 2021-10-25 | 국립암센터 | Bcma를 표적으로 하는 키메라 항원 수용체 및 이의 용도 |
| CN112048481B (zh) * | 2020-09-09 | 2023-02-10 | 广东昭泰体内生物医药科技有限公司 | 一种靶向cd19的嵌合抗原受体nk细胞及其应用 |
| CN112143707A (zh) * | 2020-09-29 | 2020-12-29 | 广东先康达生物科技有限公司 | 一种治疗自身免疫细胞的免疫细胞及其应用 |
| WO2022116086A1 (en) * | 2020-12-03 | 2022-06-09 | Janssen Biotech, Inc. | Bcma-targeted car-t cell therapy for multiple myeloma |
| CN117693519A (zh) | 2021-05-25 | 2024-03-12 | 瓦克斯细胞生物 | 基于单体拟抗体的嵌合抗原受体和包含其的免疫细胞 |
| WO2023284875A1 (zh) * | 2021-07-16 | 2023-01-19 | 克莱格医学有限公司 | 嵌合抗原受体 |
| CN115466331B (zh) * | 2021-11-18 | 2023-05-30 | 合源生物科技(天津)有限公司 | 靶向bcma的嵌合抗原受体及其应用 |
| US20250186495A1 (en) | 2022-03-08 | 2025-06-12 | Vaxcell-Bio Co., Ltd. | Pd-l1-specific chimeric antigen receptor and immune cell comprising same |
| WO2024031091A2 (en) | 2022-08-05 | 2024-02-08 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for gprc5d and bcma |
| KR20250054790A (ko) * | 2022-08-08 | 2025-04-23 | 티크바 알로셀 피티이. 엘티디. | 키메라 항원 수용체 도메인 |
| WO2024077256A1 (en) | 2022-10-07 | 2024-04-11 | The General Hospital Corporation | Methods and compositions for high-throughput discovery ofpeptide-mhc targeting binding proteins |
| WO2024124044A1 (en) | 2022-12-07 | 2024-06-13 | The Brigham And Women’S Hospital, Inc. | Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression |
| WO2024206884A1 (en) | 2023-03-31 | 2024-10-03 | AbelZeta Inc. | Bispecific chimeric antigen receptors targeting cd20 and bcma |
| WO2025031500A1 (zh) * | 2023-08-10 | 2025-02-13 | 深圳市三启生物技术有限公司 | 含有gprc5d抗体的嵌合抗原受体及其应用 |
| WO2025059533A1 (en) | 2023-09-13 | 2025-03-20 | The Broad Institute, Inc. | Crispr enzymes and systems |
| WO2025097055A2 (en) | 2023-11-02 | 2025-05-08 | The Broad Institute, Inc. | Compositions and methods of use of t cells in immunotherapy |
| WO2025117544A1 (en) | 2023-11-29 | 2025-06-05 | The Broad Institute, Inc. | Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof |
| WO2025160324A2 (en) | 2024-01-26 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for using plasma cell depleting agents and/or b cell depleting agents to suppress host anti-aav antibody response and enable aav transduction and re-dosing |
| US20250242018A1 (en) | 2024-01-26 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Combination immunosuppression for inhibiting an immune response and enabling immunogen administration and re-administration |
| US20250276092A1 (en) | 2024-03-01 | 2025-09-04 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response |
| CN118344480A (zh) * | 2024-03-19 | 2024-07-16 | 浙江康佰裕生物科技有限公司 | 靶向bcma的单域抗体、嵌合抗原受体及其应用 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| CA2078539C (en) | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US6489458B2 (en) | 1997-03-11 | 2002-12-03 | Regents Of The University Of Minnesota | DNA-based transposon system for the introduction of nucleic acid into DNA of a cell |
| WO1999060846A1 (en) | 1998-05-26 | 1999-12-02 | Innogenetics N.V. | Method for expanding primate b cells selectively in immunocompromised mice and producing large numbers of antigen-specific b lymphocytes for the production of primate monoclonal antibodies |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| HK1047770A1 (zh) | 2000-02-24 | 2003-03-07 | Xcyte Therapies, Inc. | 细胞的同时刺激与浓缩 |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US8236523B2 (en) | 2004-08-23 | 2012-08-07 | The Johns Hopkins University | Camp reporters and high throughput assays |
| WO2009003671A2 (en) | 2007-07-04 | 2009-01-08 | Max-Delbrück-Centrum für Molekulare Medizin | Hyperactive variants of the transposase protein of the transposon system sleeping beauty |
| MX2011003380A (es) | 2008-09-30 | 2011-04-21 | Abbott Lab | Genotecas de anticuerpo mejoradas. |
| WO2013075027A2 (en) * | 2011-11-17 | 2013-05-23 | Emergent Product Development Seattle, Llc | Anti-sil6xr complex binding domains and methods of use |
| KR102086874B1 (ko) * | 2012-04-11 | 2020-03-10 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | B-세포 성숙 항원을 표적화하는 키메라 항원 수용체 |
| KR20150038511A (ko) * | 2012-08-02 | 2015-04-08 | 에프. 호프만-라 로슈 아게 | 불활성 면역글로불린 Ｆｃ-영역을 갖는 Ｆｃ-융합체로서의 가용성 ＦｃＲ 의 생산 방법 및 그의 용도 |
| IL293944A (en) | 2012-08-20 | 2022-08-01 | Hutchinson Fred Cancer Res | Method and preparations for cellular immunotherapy |
| JP6694712B2 (ja) | 2012-11-01 | 2020-05-20 | マックス−デルブルック−セントラム フアー モレキュラーレ メデジン | Ｃｄ２６９（ｂｃｍａ）に対する抗体 |
| GB201317929D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Chimeric antigen receptor |
| EP3080156A1 (en) * | 2013-12-10 | 2016-10-19 | F. Hoffmann-La Roche AG | Use of the binding domain of a subunit of a multi-subunit structure for targeted delivery of pharmaceutically active entities to the multi-subunit structure |
| CN106414502A (zh) * | 2014-02-27 | 2017-02-15 | Ucl商务股份有限公司 | April变体 |
| MA39502A (fr) * | 2014-02-28 | 2015-09-03 | Glenmark Pharmaceuticals Sa | Constructions d'expression et méthodes de sélection des cellules hôtes exprimant des polypeptides |
| GB201403972D0 (en) * | 2014-03-06 | 2014-04-23 | Ucl Business Plc | Chimeric antigen receptor |
| SI3126381T2 (sl) * | 2014-04-01 | 2022-05-31 | Biontech Cell&Gene Therapies Gmbh | Claudin-6-specifični imunoreceptorji in t-celični epitopi |
| KR102463529B1 (ko) * | 2014-04-10 | 2022-11-07 | 시애틀 칠드런즈 호스피탈 디/비/에이 시애틀 칠드런즈 리서치 인스티튜트 | 약물 관련 트랜스진 발현 |
| AU2015248956B2 (en) * | 2014-04-14 | 2020-06-25 | Cellectis | BCMA (CD269) specific chimeric antigen receptors for cancer immunotherapy |
| MX375800B (es) * | 2014-04-30 | 2025-03-06 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Anticuerpos humanizados contra cd269 (bcma). |
| JP7054622B2 (ja) * | 2014-07-21 | 2022-04-14 | ノバルティス アーゲー | ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置 |
| BR112017000939A2 (pt) * | 2014-07-21 | 2017-11-14 | Novartis Ag | tratamento de câncer usando um receptor antigênico quimérico de cll-1 |
| SG10201900455YA (en) | 2014-07-24 | 2019-02-27 | Bluebird Bio Inc | Bcma chimeric antigen receptors |
| JP6588084B2 (ja) | 2014-08-19 | 2019-10-09 | ミルテニイ バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｓｓｅａ４抗原に特異的なキメラ抗原受容体 |
| TWI805109B (zh) * | 2014-08-28 | 2023-06-11 | 美商奇諾治療有限公司 | 對cd19具專一性之抗體及嵌合抗原受體 |
| IL292650B2 (en) * | 2014-09-19 | 2024-04-01 | Hope City | COSTIMULATORY CHIMERIC ANTIGEN RECEPTOR T CELLS TARGETING IL13Ra2 |
| CN109641012A (zh) * | 2016-06-07 | 2019-04-16 | 马克思-德布鲁克-分子医学中心亥姆霍兹联合会 | 与bcma结合的嵌合抗原受体和car-t细胞 |
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2017
- 2017-06-07 CN CN201780035831.4A patent/CN109641012A/zh active Pending
- 2017-06-07 SG SG11201810697QA patent/SG11201810697QA/en unknown
- 2017-06-07 JP JP2018564975A patent/JP2019527537A/ja active Pending
- 2017-06-07 WO PCT/EP2017/063862 patent/WO2017211900A1/en not_active Ceased
- 2017-06-07 SG SG10202012157QA patent/SG10202012157QA/en unknown
- 2017-06-07 US US16/307,854 patent/US12048718B2/en active Active
- 2017-06-07 AU AU2017276706A patent/AU2017276706B2/en active Active
- 2017-06-07 KR KR1020187038249A patent/KR102497013B1/ko active Active
- 2017-06-07 EP EP17729846.0A patent/EP3463396A1/en active Pending
- 2017-06-07 CA CA3026778A patent/CA3026778A1/en active Pending
- 2017-06-07 KR KR1020237003879A patent/KR20230042703A/ko not_active Ceased
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2022
- 2022-06-30 JP JP2022106290A patent/JP7646604B2/ja active Active
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2024
- 2024-05-17 US US18/667,995 patent/US12351640B2/en active Active
- 2024-09-06 JP JP2024154170A patent/JP2024178217A/ja active Pending
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