JP2019527239A5 - - Google Patents

Download PDF

Info

Publication number
JP2019527239A5
JP2019527239A5 JP2019519608A JP2019519608A JP2019527239A5 JP 2019527239 A5 JP2019527239 A5 JP 2019527239A5 JP 2019519608 A JP2019519608 A JP 2019519608A JP 2019519608 A JP2019519608 A JP 2019519608A JP 2019527239 A5 JP2019527239 A5 JP 2019527239A5
Authority
JP
Japan
Prior art keywords
cancer
formula
acute
independently
leukemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019519608A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019527239A (ja
JP7013453B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/038697 external-priority patent/WO2017223284A1/en
Publication of JP2019527239A publication Critical patent/JP2019527239A/ja
Publication of JP2019527239A5 publication Critical patent/JP2019527239A5/ja
Priority to JP2022006150A priority Critical patent/JP7372993B2/ja
Application granted granted Critical
Publication of JP7013453B2 publication Critical patent/JP7013453B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019519608A 2016-06-23 2017-06-22 内皮安定化及び抗炎症活性を有する非触媒基質選択的p38α特異的MAPK阻害剤、及びその使用方法 Active JP7013453B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022006150A JP7372993B2 (ja) 2016-06-23 2022-01-19 内皮安定化及び抗炎症活性を有する非触媒基質選択的p38α特異的MAPK阻害剤、及びその使用方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662353856P 2016-06-23 2016-06-23
US62/353,856 2016-06-23
US201762469913P 2017-03-10 2017-03-10
US62/469,913 2017-03-10
PCT/US2017/038697 WO2017223284A1 (en) 2016-06-23 2017-06-22 NON-CATALYTIC SUBSTRATE-SELECTIVE P38α-SPECIFIC MAPK INHIBITORS WITH ENDOTHELIAL-STABILIZING AND ANTI-INFLAMMATORY ACTIVITY, AND METHODS OF USE THEREOF

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022006150A Division JP7372993B2 (ja) 2016-06-23 2022-01-19 内皮安定化及び抗炎症活性を有する非触媒基質選択的p38α特異的MAPK阻害剤、及びその使用方法

Publications (3)

Publication Number Publication Date
JP2019527239A JP2019527239A (ja) 2019-09-26
JP2019527239A5 true JP2019527239A5 (enExample) 2020-07-30
JP7013453B2 JP7013453B2 (ja) 2022-01-31

Family

ID=60784745

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019519608A Active JP7013453B2 (ja) 2016-06-23 2017-06-22 内皮安定化及び抗炎症活性を有する非触媒基質選択的p38α特異的MAPK阻害剤、及びその使用方法
JP2022006150A Active JP7372993B2 (ja) 2016-06-23 2022-01-19 内皮安定化及び抗炎症活性を有する非触媒基質選択的p38α特異的MAPK阻害剤、及びその使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022006150A Active JP7372993B2 (ja) 2016-06-23 2022-01-19 内皮安定化及び抗炎症活性を有する非触媒基質選択的p38α特異的MAPK阻害剤、及びその使用方法

Country Status (6)

Country Link
US (5) US20190151324A1 (enExample)
EP (1) EP3474835B1 (enExample)
JP (2) JP7013453B2 (enExample)
CN (2) CN109640970B (enExample)
AU (4) AU2017281222B2 (enExample)
WO (1) WO2017223284A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7013453B2 (ja) * 2016-06-23 2022-01-31 ユニバーシティ・オブ・メリーランド・ボルティモア 内皮安定化及び抗炎症活性を有する非触媒基質選択的p38α特異的MAPK阻害剤、及びその使用方法
JP7594787B2 (ja) 2018-12-07 2024-12-05 ユニバーシティ オブ メリーランド、ボルチモア 非ATP/触媒部位p38マイトジェン活性化プロテインキナーゼ阻害剤
IL298366A (en) * 2020-05-18 2023-01-01 Gen1E Lifesciences Inc P38 alpha mitogen-activated protein kinase inhibitors, compositions comprising same and uses thereof
JP2023546835A (ja) * 2020-10-29 2023-11-08 ジーニー ライフサイエンシズ インコーポレイテッド 結晶性5-(ジメチルアミノ)-n-(4-(モルホリノメチル)フェニル)ナフタレン-1-スルホンアミド二塩酸塩二水和物
IL306101A (en) 2021-03-23 2023-11-01 Gen1E Lifesciences Inc Naphthyl-mutated p38 alpha mitogen-activated protein kinase inhibitors
CN113304267B (zh) * 2021-06-11 2022-03-15 河南大学 肺癌的治疗靶点及其应用
EP4374157A4 (en) * 2021-07-22 2025-07-09 Massachusetts Gen Hospital Fret-based assays

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR96352E (fr) 1967-12-29 1972-06-16 Science Union & Cie Nouveaux dérives du spiro (4,5) decane et leur procédé de préparation.
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5001139A (en) 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
US4992445A (en) 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
DE19801646A1 (de) 1998-01-17 1999-07-22 Bayer Ag Substituierte alpha,beta-annellierte Butyrolactone
JPH11269146A (ja) 1998-03-24 1999-10-05 Mitsui Chem Inc 分化誘導剤
PT1537116E (pt) 2002-09-04 2010-09-03 Schering Corp Pirazolopirimidinas adequadas para o tratamento de doenças cancerosas
TW200503994A (en) 2003-01-24 2005-02-01 Novartis Ag Organic compounds
EP1597259B1 (de) 2003-02-13 2008-04-30 Sanofi-Aventis Deutschland GmbH Stickstoff substituierte hexahydro-pyrazino 1,2-a pyrimidin-4,7-dionderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US7297817B2 (en) 2004-04-13 2007-11-20 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
JP2007532615A (ja) 2004-04-13 2007-11-15 アステックス、セラピューティックス、リミテッド 医薬化合物
US20090299063A1 (en) * 2005-03-29 2009-12-03 Paul Shapiro Inhibitors for Extracellular Signal-Regulated Kinase Docking Domains and Uses Therefor
TW200904421A (en) * 2007-05-03 2009-02-01 Astellas Pharma Inc New compounds
ES2427892T3 (es) 2008-02-29 2013-11-04 Chroma Therapeutics Limited Inhibidores de MAP quinasa p38
AU2009313315A1 (en) 2008-11-07 2011-06-30 The Cleveland Clinic Foundation Compounds and methods of promoting oligodendrocyte precursor differentiation
WO2010082912A1 (en) * 2009-01-15 2010-07-22 Avalon Pharmaceuticals Derivatives of multi-ring aromatic compounds and uses as anti-tumor agents
UY32462A (es) * 2009-02-23 2010-09-30 Arrow Therapeutics Ltd Derivados de bifenilo novedosos para el tratamiento de infección por virus de hepatitis c 644
HK1217687A1 (zh) 2013-01-15 2017-01-20 Karl Alex MÜLLER 利用紫外线辐射的氧化物的快速固态反应
EP3004087B1 (en) * 2013-06-06 2017-08-09 CHIESI FARMACEUTICI S.p.A. Derivatives of [1,2,4]triazolo[4,3-a]pyridine as p38-map kinase inhibitors
US9025712B2 (en) 2013-07-30 2015-05-05 Pixart Imaging Inc. Sensor, clock frequency adjusting system and method thereof
US9447076B2 (en) * 2014-02-14 2016-09-20 Respivert Ltd. Inhibitor of p38 map kinase
GB201417168D0 (en) * 2014-09-29 2014-11-12 Univ Hertfordshire Higher Education Corp Compounds
JP2017538676A (ja) * 2014-11-05 2017-12-28 ザ ユニバーシティ オブ カンザス ミトコンドリア透過性遷移孔(mtPTP)の小分子阻害剤
JP7013453B2 (ja) 2016-06-23 2022-01-31 ユニバーシティ・オブ・メリーランド・ボルティモア 内皮安定化及び抗炎症活性を有する非触媒基質選択的p38α特異的MAPK阻害剤、及びその使用方法
TW201829381A (zh) 2016-12-22 2018-08-16 美商拜奧馬林製藥公司 組蛋白脫乙醯基酶抑制劑
JP7594787B2 (ja) 2018-12-07 2024-12-05 ユニバーシティ オブ メリーランド、ボルチモア 非ATP/触媒部位p38マイトジェン活性化プロテインキナーゼ阻害剤
WO2021183970A1 (en) 2020-03-13 2021-09-16 University Of Maryland, Baltimore Non-atp/catalytic site p38 mitogen activated protein kinase inhibitors
IL298366A (en) 2020-05-18 2023-01-01 Gen1E Lifesciences Inc P38 alpha mitogen-activated protein kinase inhibitors, compositions comprising same and uses thereof

Similar Documents

Publication Publication Date Title
JP2019527239A5 (enExample)
AU2015335391B2 (en) Uses of duloxetine HCL medicament in preparing pharmaceutical composition for treatment of cancer
RU2468016C2 (ru) СОЕДИНЕНИЯ И СПОСОБЫ ИНГИБИРОВАНИЯ ВЗАИМОДЕЙСТВИЯ БЕЛКОВ Bcl СО СВЯЗЫВАЮЩИМИ ПАРТНЕРАМИ
JP7058345B2 (ja) Bcl-2阻害剤及びMDM2阻害剤の組合せ製品並びに疾患の予防及び/又治療におけるその使用
JP2013507415A5 (enExample)
JP2016536283A5 (enExample)
JP2017510641A5 (enExample)
EP2916841A1 (en) Combination therapy
TWI726362B (zh) Bcl-2抑制劑與利妥昔單抗和/或苯達莫司汀或Bcl-2抑制劑與CHOP聯合用藥的協同抗腫瘤作用
JP2016506916A5 (enExample)
JP2020515571A5 (enExample)
PH12020500327A1 (en) Macrocyclic mcl-1 inhibitors and methods of use
CN112368281A (zh) 作为pde3/pde4双重抑制剂的三并环类化合物
HRP20192101T1 (hr) Inhibitori ezh2
JP2016513704A5 (enExample)
RU2016122731A (ru) Функционализированные и замещенные индолы в качестве противораковых агентов
JP2010506919A5 (enExample)
WO2013170758A1 (zh) 含稠环结构的苯甲酰胺类化合物及其作为抗肿瘤药物应用
EP3716978A1 (en) Quinoxaline compounds and uses thereof
EP3741748B1 (en) Compound and use thereof in medicine
JP2013528215A5 (enExample)
RU2014128387A (ru) Ингибиторы рi3к для лечения фиброзных заболеваний
JP2016502540A5 (enExample)
CN114423762A (zh) 大环类衍生物及其制备方法和用途
JP2017525777A5 (enExample)