CN113784963A - 用作ret激酶抑制剂的化合物及其应用 - Google Patents

用作ret激酶抑制剂的化合物及其应用 Download PDF

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CN113784963A
CN113784963A CN202080032938.5A CN202080032938A CN113784963A CN 113784963 A CN113784963 A CN 113784963A CN 202080032938 A CN202080032938 A CN 202080032938A CN 113784963 A CN113784963 A CN 113784963A
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alkyl
ring
cycloalkyl
alkoxy
heteroalkyl
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CN113784963B (zh
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李钧
郑茂林
牛成山
梁阿朋
吴豫生
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Deuracor Therapeutic Inc
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D513/04—Ortho-condensed systems

Abstract

本发明属于医药技术领域，具体公开了式I'所示的化合物、或其药学上可接受的盐、立体异构体、溶剂化物或前药，其中的各符号如权利要求中所定义。本发明的化合物可用作调节RET激酶活性或治疗RET相关疾病方面的药物，并且具有更好的药代动力学性质。

Description

PCT国内申请，说明书已公开。

Claims (14)

  1. PCT国内申请，权利要求书已公开。
CN202080032938.5A 2019-05-20 2020-05-20 用作ret激酶抑制剂的化合物及其应用 Active CN113784963B (zh)

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WO2022053046A1 (zh) * 2020-09-14 2022-03-17 上海辉启生物医药科技有限公司 吡唑并吡啶类化合物或其盐及其制备方法和用途
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CN113698390A (zh) * 2020-05-20 2021-11-26 浙江同源康医药股份有限公司 用作ret激酶抑制剂的化合物及其应用

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US20220233513A1 (en) 2022-07-28
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