JP2019525897A5 - - Google Patents
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- Publication number
- JP2019525897A5 JP2019525897A5 JP2018563925A JP2018563925A JP2019525897A5 JP 2019525897 A5 JP2019525897 A5 JP 2019525897A5 JP 2018563925 A JP2018563925 A JP 2018563925A JP 2018563925 A JP2018563925 A JP 2018563925A JP 2019525897 A5 JP2019525897 A5 JP 2019525897A5
- Authority
- JP
- Japan
- Prior art keywords
- immunoglobulin
- residue
- amino acid
- item
- binding portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662348410P | 2016-06-10 | 2016-06-10 | |
| US62/348,410 | 2016-06-10 | ||
| PCT/JP2017/021672 WO2017213267A1 (en) | 2016-06-10 | 2017-06-12 | Lysine conjugated immunoglobulins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019525897A JP2019525897A (ja) | 2019-09-12 |
| JP2019525897A5 true JP2019525897A5 (https=) | 2020-07-16 |
| JP7041077B2 JP7041077B2 (ja) | 2022-03-23 |
Family
ID=59315675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018563925A Active JP7041077B2 (ja) | 2016-06-10 | 2017-06-12 | リジン結合体化免疫グロブリン |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US10941431B2 (https=) |
| EP (1) | EP3468614A1 (https=) |
| JP (1) | JP7041077B2 (https=) |
| KR (1) | KR102538866B1 (https=) |
| CN (1) | CN109475642B (https=) |
| AU (1) | AU2017279352B2 (https=) |
| BR (1) | BR112018075253A2 (https=) |
| CA (1) | CA3026991A1 (https=) |
| CL (1) | CL2021003383A1 (https=) |
| CO (1) | CO2018013314A2 (https=) |
| IL (1) | IL263329B (https=) |
| JO (1) | JOP20180118A1 (https=) |
| MX (1) | MX419566B (https=) |
| MY (1) | MY202858A (https=) |
| NZ (1) | NZ748605A (https=) |
| PE (1) | PE20190340A1 (https=) |
| PH (1) | PH12018502594A1 (https=) |
| RU (2) | RU2762939C2 (https=) |
| SG (1) | SG11201810470XA (https=) |
| UA (1) | UA126799C2 (https=) |
| WO (1) | WO2017213267A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11135304B2 (en) | 2015-12-18 | 2021-10-05 | Eisai R&D Management Co., Ltd. | C-terminal lysine conjugated immunoglobulins |
| UA126799C2 (uk) | 2016-06-10 | 2023-02-08 | ЕЙСАЙ Ар ЕНД Ді МЕНЕДЖМЕНТ КО., ЛТД. | Кон'югований імуноглобулін |
| US20210054049A1 (en) * | 2019-05-09 | 2021-02-25 | Merus N.V. | Variant domains for multimerizing proteins and separation thereof |
| GB201907093D0 (en) * | 2019-05-20 | 2019-07-03 | Ucl Business Plc | Antibody functionalisation |
| CN115335406B (zh) * | 2020-02-12 | 2026-01-30 | 伊莱利利公司 | 抗体或抗原-结合片段的结晶 |
| EP4126929A1 (en) * | 2020-03-25 | 2023-02-08 | Eli Lilly and Company | Multispecific binding proteins and methods of developing the same |
| WO2021234593A1 (en) | 2020-05-20 | 2021-11-25 | Janssen Biotech, Inc. | Methods for site specific conjugation of proteins containing glycosylated fc domains |
| WO2022067076A1 (en) * | 2020-09-25 | 2022-03-31 | Epivax, Inc. | Retro-inverso regulatory t cell epitopes |
| MX2024002476A (es) * | 2021-08-27 | 2024-05-20 | Janssen Biotech Inc | Anticuerpos anti-psma y usos de estos. |
| CN115947830B (zh) * | 2022-12-27 | 2023-09-12 | 优洛生物(上海)有限公司 | 一种经改造的抗体、其制备方法及其用途 |
| WO2024182569A2 (en) | 2023-02-28 | 2024-09-06 | Eisai R&D Management Co., Ltd. | Anti-psma antibodies, conjugates, and methods of use |
| WO2024211135A2 (en) * | 2023-04-07 | 2024-10-10 | Regeneron Pharmaceuticals, Inc. | Characterization of crosslinking sites in antibody-drug conjugates |
| WO2025020905A1 (zh) * | 2023-07-26 | 2025-01-30 | 菲鹏生物股份有限公司 | 抗体和抗体缀合物及其用途 |
| WO2025199464A1 (en) | 2024-03-22 | 2025-09-25 | Eisai R&D Management Co., Ltd. | Anti-trop2 antibody-drug conjugates and methods of use |
| CN120779021A (zh) * | 2024-04-08 | 2025-10-14 | 菲鹏生物股份有限公司 | 抗体缀合物及其用途 |
| WO2026044149A2 (en) | 2024-08-21 | 2026-02-26 | Eisai R&D Management Co., Ltd. | Synthesis of drug-linker combinations for antibody-drug conjugates |
| WO2026044039A2 (en) | 2024-08-21 | 2026-02-26 | Eisai R&D Management Co., Ltd. | Anti-cd73 antibodies, conjugates, and methods of use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| EP2033662B1 (en) * | 2004-01-21 | 2012-10-17 | Novo Nordisk Health Care AG | Transglutaminase mediated conjugation of peptides |
| US9676871B2 (en) * | 2010-11-05 | 2017-06-13 | Pfizer Inc. | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| WO2013176516A1 (ko) | 2012-05-24 | 2013-11-28 | 한화케미칼 주식회사 | 트랜스글루타미나아제를 이용하여 제조한 항체-약물 결합체 및 이의 용도 |
| US10036010B2 (en) | 2012-11-09 | 2018-07-31 | Innate Pharma | Recognition tags for TGase-mediated conjugation |
| US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
| JP6744212B2 (ja) * | 2013-06-21 | 2020-08-19 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | ポリペプチドの酵素的結合 |
| EP3019515B1 (en) * | 2013-07-11 | 2019-08-21 | Novartis AG | Lysine-specific chemoenzymatic protein modifications using microbial transglutaminase |
| EP3027224B1 (en) * | 2013-07-31 | 2020-06-03 | Rinat Neuroscience Corp. | Engineered polypeptide conjugates using transglutaminase |
| SI3134127T1 (sl) | 2014-04-25 | 2020-06-30 | Rinat Neuroscience Corp. | Konjugati zdravil s protitelesi z visoko stopnjo zdravila |
| US11135304B2 (en) | 2015-12-18 | 2021-10-05 | Eisai R&D Management Co., Ltd. | C-terminal lysine conjugated immunoglobulins |
| UA126799C2 (uk) | 2016-06-10 | 2023-02-08 | ЕЙСАЙ Ар ЕНД Ді МЕНЕДЖМЕНТ КО., ЛТД. | Кон'югований імуноглобулін |
-
2017
- 2017-06-12 UA UAA201900242A patent/UA126799C2/uk unknown
- 2017-06-12 NZ NZ748605A patent/NZ748605A/en unknown
- 2017-06-12 RU RU2018145507A patent/RU2762939C2/ru active
- 2017-06-12 BR BR112018075253-3A patent/BR112018075253A2/pt unknown
- 2017-06-12 AU AU2017279352A patent/AU2017279352B2/en active Active
- 2017-06-12 CA CA3026991A patent/CA3026991A1/en active Pending
- 2017-06-12 MX MX2018015331A patent/MX419566B/es unknown
- 2017-06-12 JP JP2018563925A patent/JP7041077B2/ja active Active
- 2017-06-12 KR KR1020197000701A patent/KR102538866B1/ko active Active
- 2017-06-12 CN CN201780043485.4A patent/CN109475642B/zh active Active
- 2017-06-12 RU RU2021136863A patent/RU2021136863A/ru unknown
- 2017-06-12 WO PCT/JP2017/021672 patent/WO2017213267A1/en not_active Ceased
- 2017-06-12 SG SG11201810470XA patent/SG11201810470XA/en unknown
- 2017-06-12 EP EP17737890.8A patent/EP3468614A1/en active Pending
- 2017-06-12 MY MYPI2018002415A patent/MY202858A/en unknown
- 2017-06-12 PE PE2018003193A patent/PE20190340A1/es unknown
- 2017-07-28 US US15/662,981 patent/US10941431B2/en active Active
-
2018
- 2018-11-27 IL IL263329A patent/IL263329B/en unknown
- 2018-12-07 CO CONC2018/0013314A patent/CO2018013314A2/es unknown
- 2018-12-09 JO JOP/2018/0118A patent/JOP20180118A1/ar unknown
- 2018-12-10 PH PH12018502594A patent/PH12018502594A1/en unknown
-
2021
- 2021-01-27 US US17/159,655 patent/US11753669B2/en active Active
- 2021-12-16 CL CL2021003383A patent/CL2021003383A1/es unknown
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