JP2019522459A5 - - Google Patents
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- JP2019522459A5 JP2019522459A5 JP2018554100A JP2018554100A JP2019522459A5 JP 2019522459 A5 JP2019522459 A5 JP 2019522459A5 JP 2018554100 A JP2018554100 A JP 2018554100A JP 2018554100 A JP2018554100 A JP 2018554100A JP 2019522459 A5 JP2019522459 A5 JP 2019522459A5
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- 229920001184 polypeptide Polymers 0.000 claims 121
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 121
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662322036P | 2016-04-13 | 2016-04-13 | |
| US62/322,036 | 2016-04-13 | ||
| US201662331191P | 2016-05-03 | 2016-05-03 | |
| US62/331,191 | 2016-05-03 | ||
| US201662412187P | 2016-10-24 | 2016-10-24 | |
| US62/412,187 | 2016-10-24 | ||
| EP17305298.6 | 2017-03-17 | ||
| EP17305298 | 2017-03-17 | ||
| PCT/US2017/027488 WO2017180913A2 (en) | 2016-04-13 | 2017-04-13 | Trispecific and/or trivalent binding proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019522459A JP2019522459A (ja) | 2019-08-15 |
| JP2019522459A5 true JP2019522459A5 (enExample) | 2020-05-07 |
| JP7195929B2 JP7195929B2 (ja) | 2022-12-26 |
Family
ID=58464471
Family Applications (1)
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Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI743461B (zh) * | 2011-03-28 | 2021-10-21 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| CN120988137A (zh) * | 2015-01-23 | 2025-11-21 | 赛诺菲 | 抗cd3抗体、抗cd123抗体和与cd3和/或cd123特异性结合的双特异性抗体 |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| RS62437B1 (sr) | 2015-10-25 | 2021-11-30 | Sanofi Sa | Trispecifični i/ili trivalentni vezujući proteini za prevenciju ili lečenje hiv infekcije |
| LT3443006T (lt) | 2016-04-13 | 2023-10-25 | Sanofi | Trispecifiniai ir (arba) trivalenčiai rišantieji baltymai |
| CA3020633A1 (en) | 2016-04-13 | 2017-10-19 | Sanofi | Trispecific and/or trivalent binding proteins |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| WO2018151841A1 (en) | 2017-02-17 | 2018-08-23 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
| KR102654105B1 (ko) | 2017-02-17 | 2024-04-04 | 사노피 | 디스트로글리칸 및 라미닌-2에 대한 특이성을 갖는 다중특이적 결합 분자 |
| DK3583126T3 (da) | 2017-02-17 | 2025-11-17 | Sanofi Sa | Multispecifikke bindingsmolekyler med specificitet for dystroglycan og laminin-2 |
| AU2018224094B2 (en) | 2017-02-24 | 2025-04-17 | Macrogenics, Inc. | Bispecific binding molecules that are capable of binding CD137 and tumor antigens, and uses thereof |
| UY37758A (es) * | 2017-06-12 | 2019-01-31 | Novartis Ag | Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos |
| BR112020007002A2 (pt) | 2017-10-10 | 2020-11-17 | Sanofi | anticorpos anti-cd38 e métodos de uso |
| MY205342A (en) * | 2017-11-01 | 2024-10-16 | Hoffmann La Roche | Bispecific 2+1 contorsbodies |
| EP3713959A1 (en) * | 2017-11-21 | 2020-09-30 | Innate Pharma | Multispecific antigen binding proteins |
| AU2018387829B2 (en) | 2017-12-22 | 2024-12-19 | Argenx Bvba | Bispecific antigen binding construct |
| CN109957026A (zh) * | 2017-12-22 | 2019-07-02 | 成都恩沐生物科技有限公司 | 共价多特异性抗体 |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| CN119291194A (zh) * | 2018-01-12 | 2025-01-10 | 建新公司 | 用于定量多肽的方法 |
| JP7337079B2 (ja) | 2018-02-15 | 2023-09-01 | マクロジェニクス,インコーポレーテッド | 変異型cd3結合ドメイン、及び疾患の治療のための併用療法におけるその使用 |
| GB201802487D0 (en) | 2018-02-15 | 2018-04-04 | Argenx Bvba | Cytokine combination therapy |
| CA3089230A1 (en) * | 2018-03-02 | 2019-09-06 | Cdr-Life Ag | Trispecific antigen binding proteins |
| SG11202007055QA (en) * | 2018-03-08 | 2020-09-29 | Phanes Therapeutics Inc | Anti-claudin 18.2 antibodies and uses thereof |
| EP3765517A1 (en) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| EP3765516A2 (en) * | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | Multifunctional molecules and uses thereof |
| SG11202008474QA (en) * | 2018-03-27 | 2020-10-29 | Systimmune Inc | Guidance and navigation control proteins and method of making and using thereof |
| US10633458B2 (en) * | 2018-04-10 | 2020-04-28 | Y-Biologics Inc. | Cell engaging binding molecules |
| CN112384243A (zh) * | 2018-04-17 | 2021-02-19 | 英温拉公司 | 三价三特异性抗体构建体 |
| CN112912103B (zh) * | 2018-05-21 | 2025-08-29 | 广州邦定生物技术有限公司 | 多价蛋白质复合物 |
| CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| EP3833392A4 (en) * | 2018-08-08 | 2022-05-18 | Dragonfly Therapeutics, Inc. | MULTISPECIFIC BINDING PROTEINS FOR BINDING CD33, NKG2D AND CD16 AND METHODS OF USE |
| CA3109513A1 (en) * | 2018-08-23 | 2020-02-27 | Regeneron Pharmaceuticals, Inc. | Anti-fc epsilon-r1 alpha (fcer1a) antibodies, bispecific antigen-binding molecules that bind fcer1a and cd3, and uses thereof |
| JP7462621B2 (ja) * | 2018-10-09 | 2024-04-05 | サノフイ | 三重特異性抗cd38、抗cd28、および抗cd3結合タンパク質ならびにウイルス感染を処置するための使用方法 |
| CN111153988B (zh) * | 2018-11-08 | 2022-11-04 | 中国科学院上海巴斯德研究所 | 广谱抗肠道病毒d68型的中和性单克隆抗体 |
| EP3674316A1 (en) | 2018-12-24 | 2020-07-01 | Sanofi | Multispecific binding proteins with mutant fab domains |
| AU2019412561A1 (en) | 2018-12-24 | 2021-08-12 | Sanofi | Multispecific binding proteins with mutant Fab domains |
| IL319262A (en) | 2018-12-24 | 2025-04-01 | Sanofi Sa | Multispecific FAB pseudoproteins bind |
| CN113646334B (zh) * | 2019-02-20 | 2025-09-16 | 国家儿童医院研究所 | 癌症靶向的、病毒编码的、可调节的t细胞(catvert)或nk细胞(catvern)接头 |
| GB2599228B (en) | 2019-02-21 | 2024-02-07 | Marengo Therapeutics Inc | Multifunctional molecules that bind to T cell related cancer cells and uses thereof |
| CN119039441A (zh) | 2019-02-21 | 2024-11-29 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| TW202104274A (zh) | 2019-04-09 | 2021-02-01 | 法商賽諾菲公司 | 用於治療hiv感染之三特異性及/或三價結合蛋白 |
| EP3953388A1 (en) * | 2019-04-09 | 2022-02-16 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| CN116987197A (zh) * | 2019-06-20 | 2023-11-03 | 成都恩沐生物科技有限公司 | 共价多特异性抗体 |
| CA3147044A1 (en) * | 2019-07-11 | 2021-01-14 | Tavotek Biotherapeutics (Hong Kong) Limited | Agents that interfere with thymic stromal lymphopoietin (tslp)-receptor signaling |
| US20220112258A1 (en) * | 2019-07-25 | 2022-04-14 | I-Mab Biopharma Us Limited | Bifunctional molecules with il-7 activity |
| WO2021080649A1 (en) | 2019-10-25 | 2021-04-29 | Sanofi | Methods for analyzing chain mispairing in multispecific binding proteins |
| MX2022005330A (es) * | 2019-11-05 | 2022-05-26 | Regeneron Pharma | Moleculas de union multiespecificas con scfv en el extremo nterminal. |
| AU2020416273A1 (en) | 2020-01-03 | 2022-07-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| US20230138520A1 (en) * | 2020-01-16 | 2023-05-04 | Caerus Therapeutics, Inc. | Humanized antibodies specific for myeloma and ovarian cancer cells |
| KR20220159989A (ko) | 2020-02-26 | 2022-12-05 | 바이오그래프 55, 인크. | C19 c38 이중특이적 항체 |
| TW202146463A (zh) | 2020-03-05 | 2021-12-16 | 法商賽諾菲公司 | 蛋白酶加工的分子 |
| JP2023519699A (ja) * | 2020-03-30 | 2023-05-12 | サノフイ | スプリットch2ドメイン |
| AU2021295549A1 (en) * | 2020-06-23 | 2022-11-24 | F. Hoffmann-La Roche Ag | Agonistic CD28 antigen binding molecules targeting Her2 |
| JP7620780B2 (ja) * | 2020-06-30 | 2025-01-24 | ノナ・バイオサイエンシーズ・(シャンハイ)・カンパニー・リミテッド | H2L2とHCAb構造を有する結合タンパク質 |
| WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
| MX2023003214A (es) * | 2020-09-18 | 2023-05-24 | Regeneron Pharma | Moleculas de union al antigeno que se unen a cd38 y/o cd28 y usos de las mismas. |
| CN116648463A (zh) | 2020-09-18 | 2023-08-25 | 伊克诺斯科学公司 | Cd47-cd38双特异性抗体 |
| KR20230110291A (ko) | 2020-11-18 | 2023-07-21 | 노파르티스 아게 | Nlrc4-gof 염증복합체병증의 치료에 사용하기 위한 이중특이적 항체 |
| EP4347640A1 (en) | 2021-05-27 | 2024-04-10 | Sanofi | Fc variant with enhanced affinity to fc receptors and improved thermal stability |
| CN118251411A (zh) * | 2021-09-29 | 2024-06-25 | 摩德斯医疗股份有限公司 | 抗原结合多肽、抗原结合多肽复合物及其使用方法 |
| CA3232365A1 (en) * | 2021-09-29 | 2023-04-06 | Ronnie Rong Wei | Antigen binding polypeptides, antigen binding polypeptide complexes and methods of use thereof in hiv |
| TW202330594A (zh) * | 2021-09-29 | 2023-08-01 | 美商莫德斯醫療公司 | 抗原結合多肽、抗原結合多肽複合物及其使用方法 |
| WO2023060277A1 (en) * | 2021-10-08 | 2023-04-13 | Arbele Limited | Composition of multispecific antibodies targeting cdh17-expressing tumors and method of making and using thereof |
| US20250381223A1 (en) * | 2022-02-16 | 2025-12-18 | Utc Therapeutics (Shanghai) Co., Ltd. | Humanized anti-cd28 antibody and bispecific antibody thereof with anti-cd40 antibody |
| US20240117030A1 (en) * | 2022-03-03 | 2024-04-11 | Pfizer Inc. | Multispecific antibodies and uses thereof |
| US20240228650A9 (en) | 2022-05-06 | 2024-07-11 | Ichnos Sciences SA | CD3/BCMA/CD38 Trispecific Antibodies |
| KR20250017240A (ko) | 2022-05-27 | 2025-02-04 | 사노피 | FC-조작을 갖는 NKp46 및 BCMA 변이체에 결합하는 자연 살해(NK) 세포 관여자 |
| EP4540284A2 (en) | 2022-06-17 | 2025-04-23 | Apogee Therapeutics, Inc. | Antibodies that bind interleukin 13 and methods of use |
| CN119487071A (zh) * | 2022-06-24 | 2025-02-18 | 北京可瑞生物科技有限公司 | 基于t细胞受体的双特异性多肽分子及其用途 |
| CN119923415A (zh) * | 2022-08-05 | 2025-05-02 | 成都恩沐生物科技有限公司 | 靶向可二聚化肿瘤抗原和免疫刺激性抗原的多特异性抗体 |
| EP4640700A1 (en) * | 2022-12-19 | 2025-10-29 | Harbour Biomed (Shanghai) Co., Ltd | "kappa/lambda" fab-fab series-connection multi-specific binding protein, preparation thereof, and use thereof |
| AU2024239150A1 (en) | 2023-03-21 | 2025-10-02 | Biograph 55, Inc. | Cd19/cd38 multispecific antibodies |
| WO2025006794A1 (en) * | 2023-06-29 | 2025-01-02 | Promab Biotechnologies, Inc. | Her-2 -cd3-epsilon bispecific antibodies |
| WO2025027003A1 (en) | 2023-07-31 | 2025-02-06 | Sanofi | Methods and uses for anti-cd38 t cell engagers in treatment of peripheral t-cell lymphomas |
| US20250376537A1 (en) | 2024-05-17 | 2025-12-11 | Sanofi | Methods of treating cancer using trispecific binding proteins targeting her2-expressing tumors |
| WO2026022712A1 (en) | 2024-07-23 | 2026-01-29 | Sanofi | Cereblon ligase modulator and bcma nk cell engager combination therapy |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3850542T2 (de) | 1987-09-23 | 1994-11-24 | Bristol Myers Squibb Co | Antikörper-Heterokonjugate zur Töting von HIV-infizierten Zellen. |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| ATE375365T1 (de) | 1998-04-02 | 2007-10-15 | Genentech Inc | Antikörper varianten und fragmente davon |
| RU2420537C2 (ru) * | 2001-01-17 | 2011-06-10 | Трабьон Фармасьютикалз Инк. | Слитые белки связывающий домен-иммуноглобулин |
| CN1294148C (zh) * | 2001-04-11 | 2007-01-10 | 中国科学院遗传与发育生物学研究所 | 环状单链三特异抗体 |
| NZ544924A (en) | 2003-06-27 | 2009-03-31 | Biogen Idec Inc | Modified binding molecules comprising connecting peptides |
| US9200061B2 (en) | 2004-02-06 | 2015-12-01 | Morpho Sys AG | Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i |
| CN100376599C (zh) | 2004-04-01 | 2008-03-26 | 北京安波特基因工程技术有限公司 | 基因工程重组抗cea抗cd3抗cd28线性单链三特异抗体 |
| EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| CA2726087A1 (en) | 2008-06-03 | 2009-12-10 | Tariq Ghayur | Dual variable domain immunoglobulins and uses thereof |
| CA2774636C (en) | 2009-09-25 | 2019-05-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to hiv-1 and their use |
| SMT202000031T1 (it) * | 2010-06-09 | 2020-03-13 | Genmab As | Anticorpi contro cd38 umano |
| JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| TWI743461B (zh) | 2011-03-28 | 2021-10-21 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| WO2012154312A1 (en) | 2011-05-09 | 2012-11-15 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Neutralizing antibodies to hiv-1 and their use |
| WO2012158818A2 (en) * | 2011-05-16 | 2012-11-22 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
| CN103797029B (zh) | 2011-05-17 | 2016-08-17 | 洛克菲勒大学 | 人类免疫缺陷病毒中和抗体及其使用方法 |
| BR112014010823B1 (pt) | 2011-11-07 | 2021-02-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | anticorpos que se ligam a gp41 e neutralizam o vírus da imunodeficiência humana tipo 1 (hiv-1), seus usos, molécula de ácido nucleico, vetor de expressão, composição, kit, bem como métodos de detecção de infecção pelo hiv-1 e de teste de imunógeno potencial |
| EP2788376B1 (en) | 2011-12-08 | 2018-10-03 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Neutralizing antibodies to hiv-1 and their use |
| WO2013163427A1 (en) | 2012-04-25 | 2013-10-31 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Antibodies to treat hiv-1 infection |
| JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
| AU2013322710A1 (en) * | 2012-09-25 | 2015-04-16 | Glenmark Pharmaceuticals S.A. | Purification of hetero-dimeric immunoglobulins |
| US20140213772A1 (en) * | 2012-12-28 | 2014-07-31 | Abbvie, Inc. | Cross-over dual variable domain immunoglobulin constructs |
| US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
| WO2014116846A2 (en) * | 2013-01-23 | 2014-07-31 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
| LT2961771T (lt) | 2013-02-26 | 2020-03-10 | Roche Glycart Ag | Bispecifinės t ląstelę aktyvinančios antigeną surišančios molekulės, specifinės cd3 ir cea antigenams |
| US20140302037A1 (en) * | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| CN105209491A (zh) | 2013-03-15 | 2015-12-30 | 艾伯维公司 | 针对TNFα的双重特异性结合蛋白 |
| JP2016538275A (ja) | 2013-11-04 | 2016-12-08 | グレンマーク ファーマシューティカルズ, エセ.アー. | T細胞再標的化ヘテロ二量体免疫グロブリン(hetero−dimeric immunoglobulin)の製造 |
| EP3699195A3 (en) | 2014-03-28 | 2020-11-04 | Xencor, Inc. | Bispecific antibodies that bind to cd38 and cd3 |
| CN106687584B (zh) | 2014-09-04 | 2021-08-13 | 干细胞技术公司 | 用于t细胞或nk细胞活化和扩增的可溶性抗体复合物 |
| CN120988137A (zh) | 2015-01-23 | 2025-11-21 | 赛诺菲 | 抗cd3抗体、抗cd123抗体和与cd3和/或cd123特异性结合的双特异性抗体 |
| WO2016196740A1 (en) | 2015-06-02 | 2016-12-08 | The Rockefeller University | Tri-specific antibodies for hiv therapy |
| MX2018003463A (es) | 2015-09-22 | 2018-09-06 | Univ Pennsylvania | Método de redireccionamiento de células t para tratar la infección por virus de inmunodeficiencia humana (vih). |
| RS62437B1 (sr) | 2015-10-25 | 2021-11-30 | Sanofi Sa | Trispecifični i/ili trivalentni vezujući proteini za prevenciju ili lečenje hiv infekcije |
| CN105837688B (zh) | 2015-11-20 | 2019-02-26 | 北京大学深圳研究生院 | 单域抗体及其编码基因,免疫毒素及其编码基因、制备方法、表达载体、应用,及宿主细胞 |
| JP6732915B2 (ja) | 2015-12-15 | 2020-07-29 | ギリアード サイエンシーズ, インコーポレイテッド | ヒト免疫不全ウイルス中和抗体 |
| CA3020633A1 (en) | 2016-04-13 | 2017-10-19 | Sanofi | Trispecific and/or trivalent binding proteins |
| WO2018120842A1 (zh) | 2016-12-30 | 2018-07-05 | 上海欣百诺生物科技有限公司 | 一种双功能分子及其应用 |
| WO2018151841A1 (en) | 2017-02-17 | 2018-08-23 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
| KR102654105B1 (ko) | 2017-02-17 | 2024-04-04 | 사노피 | 디스트로글리칸 및 라미닌-2에 대한 특이성을 갖는 다중특이적 결합 분자 |
| BR112020007002A2 (pt) | 2017-10-10 | 2020-11-17 | Sanofi | anticorpos anti-cd38 e métodos de uso |
| JP7462621B2 (ja) | 2018-10-09 | 2024-04-05 | サノフイ | 三重特異性抗cd38、抗cd28、および抗cd3結合タンパク質ならびにウイルス感染を処置するための使用方法 |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
-
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- 2017-04-13 CN CN201780036515.9A patent/CN109476732B/zh active Active
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- 2017-04-18 UY UY0001037206A patent/UY37206A/es not_active Application Discontinuation
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2018
- 2018-10-10 CL CL2018002883A patent/CL2018002883A1/es unknown
- 2018-10-11 PH PH12018502182A patent/PH12018502182A1/en unknown
- 2018-10-12 DO DO2018000225A patent/DOP2018000225A/es unknown
- 2018-11-09 CO CONC2018/0012107A patent/CO2018012107A2/es unknown
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2020
- 2020-11-16 US US17/099,439 patent/US11192960B2/en active Active
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