|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
FI903489A7
(fi)
|
1988-11-11 |
1990-07-10 |
Medical Res Council |
Yhden osan sisältävät ligandit, näitä ligandeja sisältävät reseptorit, menetelmiä niiden valmistamiseksi sekä ligandien ja reseptorien käytt ö
|
|
US5198346A
(en)
|
1989-01-06 |
1993-03-30 |
Protein Engineering Corp. |
Generation and selection of novel DNA-binding proteins and polypeptides
|
|
US5096815A
(en)
|
1989-01-06 |
1992-03-17 |
Protein Engineering Corporation |
Generation and selection of novel dna-binding proteins and polypeptides
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
ATE318832T1
(de)
|
1990-06-11 |
2006-03-15 |
Gilead Sciences Inc |
Verfahren zur vervendung von nukleinsäureliganden
|
|
US5763177A
(en)
|
1990-06-11 |
1998-06-09 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
|
|
US5707796A
(en)
|
1990-06-11 |
1998-01-13 |
Nexstar Pharmaceuticals, Inc. |
Method for selecting nucleic acids on the basis of structure
|
|
US5580737A
(en)
|
1990-06-11 |
1996-12-03 |
Nexstar Pharmaceuticals, Inc. |
High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
|
|
US5270163A
(en)
|
1990-06-11 |
1993-12-14 |
University Research Corporation |
Methods for identifying nucleic acid ligands
|
|
US5567588A
(en)
|
1990-06-11 |
1996-10-22 |
University Research Corporation |
Systematic evolution of ligands by exponential enrichment: Solution SELEX
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
EP0548276A4
(en)
|
1990-09-13 |
1993-12-29 |
Children's Hospital Medical Center Of Northern California |
Method for increasing red blood cell production by treatment with activin or activin-related peptides
|
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech, Inc., South San Francisco, Calif. |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
|
EP0590058B1
(en)
|
1991-06-14 |
2003-11-26 |
Genentech, Inc. |
HUMANIZED Heregulin ANTIBODy
|
|
GB9114948D0
(en)
|
1991-07-11 |
1991-08-28 |
Pfizer Ltd |
Process for preparing sertraline intermediates
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
US5288931A
(en)
*
|
1991-12-06 |
1994-02-22 |
Genentech, Inc. |
Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
|
|
CA2372813A1
(en)
|
1992-02-06 |
1993-08-19 |
L.L. Houston |
Biosynthetic binding protein for cancer marker
|
|
US5677196A
(en)
|
1993-05-18 |
1997-10-14 |
University Of Utah Research Foundation |
Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
|
|
US5525490A
(en)
|
1994-03-29 |
1996-06-11 |
Onyx Pharmaceuticals, Inc. |
Reverse two-hybrid method
|
|
US5885574A
(en)
|
1994-07-26 |
1999-03-23 |
Amgen Inc. |
Antibodies which activate an erythropoietin receptor
|
|
US5814565A
(en)
|
1995-02-23 |
1998-09-29 |
University Of Utah Research Foundation |
Integrated optic waveguide immunosensor
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
EP0830459B1
(en)
|
1995-04-11 |
2007-01-24 |
The General Hospital Corporation |
Reverse two-hybrid systems
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US6699843B2
(en)
|
1995-06-07 |
2004-03-02 |
Gilead Sciences, Inc. |
Method for treatment of tumors using nucleic acid ligands to PDGF
|
|
US6423501B2
(en)
|
1996-12-13 |
2002-07-23 |
Beth Israel Deaconess Medical Center |
Calcium-independent negative regulation by CD81 of receptor signaling
|
|
US6011577A
(en)
|
1997-06-30 |
2000-01-04 |
Polaroid Corporation |
Modular optical print head assembly
|
|
US6953662B2
(en)
|
1997-08-29 |
2005-10-11 |
Human Genome Sciences, Inc. |
Follistatin-3
|
|
AU8921698A
(en)
|
1997-08-29 |
1999-03-16 |
Human Genome Sciences, Inc. |
Follistatin-3
|
|
US6610833B1
(en)
|
1997-11-24 |
2003-08-26 |
The Institute For Human Genetics And Biochemistry |
Monoclonal human natural antibodies
|
|
WO1999029888A1
(en)
|
1997-12-05 |
1999-06-17 |
The Scripps Research Institute |
Humanization of murine antibody
|
|
US6335155B1
(en)
|
1998-06-26 |
2002-01-01 |
Sunesis Pharmaceuticals, Inc. |
Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
|
|
CA2355215A1
(en)
|
1998-12-28 |
2000-07-06 |
Jim Wells |
Identifying small organic molecule ligands for binding
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
JP2003517580A
(ja)
|
1999-01-21 |
2003-05-27 |
メタモーフイクス・インコーポレーテツド |
増殖分化因子インヒビター及びそれらの用途
|
|
GB9912350D0
(en)
*
|
1999-05-26 |
1999-07-28 |
European Molecular Biology Lab Embl |
Modified cytokine
|
|
DE60042021D1
(de)
|
1999-07-29 |
2009-05-28 |
Gilead Sciences Inc |
Nukleinsäureliganden für den hepatozytischen wachstumsfaktor/dispersionsfaktor (hgf/sf) und seines c-met rezeptors
|
|
JP2003516755A
(ja)
|
1999-12-15 |
2003-05-20 |
ジェネンテック・インコーポレーテッド |
ショットガン走査、すなわち機能性タンパク質エピトープをマッピングするための組み合わせ方法
|
|
PT2857516T
(pt)
|
2000-04-11 |
2017-08-28 |
Genentech Inc |
Anticorpos multivalentes e utilizações dos mesmos
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
DE60131456T2
(de)
|
2000-11-30 |
2008-07-10 |
Medarex, Inc., Milpitas |
Transchromosomale transgen-nagetiere zur herstellung von humanen antikörpern
|
|
PL374966A1
(en)
|
2002-02-21 |
2005-11-14 |
Wyeth |
Follistatin domain containing proteins
|
|
EP1513879B1
(en)
|
2002-06-03 |
2018-08-22 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
|
MXPA05003889A
(es)
|
2002-10-15 |
2005-06-22 |
Celgene Corp |
Farmacos inhibidores de citosina selectiva para tratar sindrome mielodisplastico.
|
|
US20040223966A1
(en)
|
2002-10-25 |
2004-11-11 |
Wolfman Neil M. |
ActRIIB fusion polypeptides and uses therefor
|
|
AU2004205631A1
(en)
|
2003-01-16 |
2004-08-05 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
|
WO2005028517A2
(en)
|
2003-05-09 |
2005-03-31 |
The General Hospital Corporation |
SOLUBLE TGF-β TYPE III RECEPTOR FUSION PROTEINS
|
|
WO2005025601A1
(en)
|
2003-09-15 |
2005-03-24 |
Monash University |
Follistatin isoforms and uses thereof
|
|
CN1961003B
(zh)
|
2004-03-31 |
2013-03-27 |
健泰科生物技术公司 |
人源化抗TGF-β抗体
|
|
US7785903B2
(en)
|
2004-04-09 |
2010-08-31 |
Genentech, Inc. |
Variable domain library and uses
|
|
WO2005100402A1
(en)
|
2004-04-13 |
2005-10-27 |
F.Hoffmann-La Roche Ag |
Anti-p-selectin antibodies
|
|
JP2008507288A
(ja)
|
2004-07-23 |
2008-03-13 |
アクセルロン ファーマ インコーポレーテッド |
ActRII受容体ポリペプチド、方法、および組成物
|
|
MX2007000976A
(es)
|
2004-08-12 |
2007-04-10 |
Wyeth Corp |
Tratamiento combinado para diabetes, obesidad y enfermedades cardiovasculares utilizando inhibidores del factor 8 de crecimiento y diferenciacion.
|
|
TWI309240B
(en)
|
2004-09-17 |
2009-05-01 |
Hoffmann La Roche |
Anti-ox40l antibodies
|
|
TR201808537T4
(tr)
|
2004-09-23 |
2018-07-23 |
Genentech Inc |
Sistein değiştirilmiş antikorlar ve konjugatlar.
|
|
WO2006052842A2
(en)
|
2004-11-09 |
2006-05-18 |
The Trustees Of The University Of Pennsylvania |
Methods for diagnosis of myelodysplastic syndromes (mds)
|
|
US8067562B2
(en)
|
2005-11-01 |
2011-11-29 |
Amgen Inc. |
Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
|
|
EP1957531B1
(en)
|
2005-11-07 |
2016-04-13 |
Genentech, Inc. |
Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
|
|
BRPI0618947B1
(pt)
|
2005-11-23 |
2022-07-19 |
Acceleron Pharma Inc |
Polipeptídeo actriia que se liga à ativina, polinucleotídeo isolado, polinucleotídeo recombinante, métodopara preparar um polipeptídeo actriia que se liga à ativina, preparação farmacêutica e uso de uma proteína de fusão actriia-fc para promover o crescimento ósseo e inibir a ressorção óssea
|
|
WO2007064919A2
(en)
|
2005-12-02 |
2007-06-07 |
Genentech, Inc. |
Binding polypeptides with restricted diversity sequences
|
|
EP2016101A2
(en)
|
2006-05-09 |
2009-01-21 |
Genentech, Inc. |
Binding polypeptides with optimized scaffolds
|
|
WO2008030367A2
(en)
|
2006-09-01 |
2008-03-13 |
The General Hospital Corporation |
Selective myostatin inhibitors
|
|
WO2008073292A2
(en)
|
2006-12-08 |
2008-06-19 |
Caritas St. Elizabeth's Medical Center Of Boston, Inc. |
Method for protecting renal tubular epithelial cells from radiocontrast nephro parhy (rcn)
|
|
CA2672758C
(en)
|
2006-12-18 |
2019-07-30 |
Acceleron Pharma Inc. |
Activin-actrii antagonists and uses for increasing red blood cell levels
|
|
US8895016B2
(en)
|
2006-12-18 |
2014-11-25 |
Acceleron Pharma, Inc. |
Antagonists of activin-actriia and uses for increasing red blood cell levels
|
|
US20100028332A1
(en)
*
|
2006-12-18 |
2010-02-04 |
Acceleron Pharma Inc. |
Antagonists of actriib and uses for increasing red blood cell levels
|
|
AU2013221910B2
(en)
|
2006-12-18 |
2016-11-17 |
Acceleron Pharma Inc. |
Activin-ActRII antagonists and uses for increasing red blood cell levels
|
|
TWI584815B
(zh)
|
2007-02-01 |
2017-06-01 |
艾瑟勒朗法瑪公司 |
活化素-ActRIIa拮抗劑及其治療或預防乳癌之用途
|
|
TW201627320A
(zh)
|
2007-02-02 |
2016-08-01 |
艾瑟勒朗法瑪公司 |
衍生自ActRIIB的變體與其用途
|
|
CN100592373C
(zh)
|
2007-05-25 |
2010-02-24 |
群康科技(深圳)有限公司 |
液晶显示面板驱动装置及其驱动方法
|
|
EP3663318A1
(en)
|
2008-01-07 |
2020-06-10 |
Amgen Inc. |
Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
|
|
KR20110031951A
(ko)
|
2008-06-26 |
2011-03-29 |
악셀레론 파마 인코포레이티드 |
액티빈-actriia의 길항물질 및 적혈구 수준을 증가시키기 위한 이들의 용도
|
|
EP2315602A4
(en)
|
2008-06-26 |
2011-11-02 |
Acceleron Pharma Inc |
METHOD OF DOSING AN ACTRIIB ANTAGONIST AND MONITORING TREATED PATIENTS
|
|
DK3750552T5
(da)
|
2008-08-14 |
2024-08-26 |
Acceleron Pharma Inc |
Gdf-fælder
|
|
US8216997B2
(en)
*
|
2008-08-14 |
2012-07-10 |
Acceleron Pharma, Inc. |
Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
|
|
KR102170682B1
(ko)
*
|
2009-08-13 |
2020-10-28 |
악셀레론 파마 인코포레이티드 |
적혈구 수준을 증가시키기 위한 gdf 트랩과 에리트로포이에틴 수용체 활성인자의 병용
|
|
WO2012027065A2
(en)
*
|
2010-08-27 |
2012-03-01 |
Celgene Corporation |
Combination therapy for treatment of disease
|
|
AU2010363329A1
(en)
|
2010-11-07 |
2013-05-09 |
Targegen, Inc. |
Compositions and methods for treating myelofibrosis
|
|
JP6472999B2
(ja)
|
2011-07-01 |
2019-02-20 |
ノバルティス アーゲー |
代謝障害を治療するための方法
|
|
DK3520805T3
(da)
|
2011-10-17 |
2021-04-19 |
Acceleron Pharma Inc |
Sammensætninger til behandling af myelofibrose
|
|
JP6401172B2
(ja)
|
2012-10-24 |
2018-10-10 |
セルジーン コーポレイション |
貧血の治療方法
|
|
CA2889209C
(en)
|
2012-10-24 |
2023-08-22 |
Celgene Corporation |
Biomarker for use in treating anemia
|
|
KR20150136061A
(ko)
|
2013-02-01 |
2015-12-04 |
산타 마리아 바이오테라퓨틱스, 인코포레이티드 |
대상에 항-액티빈-a 화합물의 투여
|
|
WO2015081127A2
(en)
*
|
2013-11-26 |
2015-06-04 |
Gilead Sciences, Inc. |
Therapies for treating myeloproliferative disorders
|
|
JP2017509647A
(ja)
*
|
2014-03-21 |
2017-04-06 |
アクセルロン ファーマ, インコーポレイテッド |
アクチビンbおよび/またはgdf11の阻害によって赤血球レベルを増大させ、無効赤血球生成を処置する方法
|
|
EP3131931B1
(en)
|
2014-04-18 |
2020-10-21 |
Acceleron Pharma Inc. |
Methods for increasing red blood cell levels and treating sickle-cell disease
|
|
CN114699529A
(zh)
*
|
2014-06-13 |
2022-07-05 |
阿塞勒隆制药公司 |
用于治疗溃疡的方法和组合物
|
|
EP3227675B1
(en)
|
2014-12-03 |
2023-03-15 |
Celgene Corporation |
Activin-actrii antagonists and uses for treating myelodysplastic syndrome
|
|
MA41119A
(fr)
|
2014-12-03 |
2017-10-10 |
Acceleron Pharma Inc |
Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique
|
|
CA2983440C
(en)
|
2015-04-22 |
2024-03-12 |
Alivegen Usa Inc. |
Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases
|
|
TWI814187B
(zh)
|
2015-05-13 |
2023-09-01 |
美商西建公司 |
使用ACTRII配位體捕捉以治療β-地中海型貧血
|
|
WO2017024171A1
(en)
|
2015-08-04 |
2017-02-09 |
Acceleron Pharma Inc. |
Methods for treating myeloproliferative disorders
|
|
EP3370754B1
(en)
|
2015-11-04 |
2026-04-29 |
Acceleron Pharma, Inc. |
Methods for increasing red blood cell levels and treating ineffective erythropoiesis
|
|
JP7072507B2
(ja)
|
2015-11-23 |
2022-05-20 |
アクセルロン ファーマ インコーポレイテッド |
眼の障害を処置するための方法
|
|
AU2017296040C1
(en)
|
2016-07-15 |
2023-06-22 |
Acceleron Pharma Inc. |
Compositions and methods for treating pulmonary hypertension
|
|
LT3490582T
(lt)
|
2016-07-27 |
2024-07-25 |
Acceleron Pharma Inc. |
Kompozicijos, skirtos naudoti gydant mielofibrozę
|
|
WO2018231905A1
(en)
*
|
2017-06-14 |
2018-12-20 |
Celgene Corporation |
Methods for treating myeloproliferative neoplasm-associated myelofibrosis and anemia
|