JP2019519491A5 - - Google Patents
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- JP2019519491A5 JP2019519491A5 JP2018558662A JP2018558662A JP2019519491A5 JP 2019519491 A5 JP2019519491 A5 JP 2019519491A5 JP 2018558662 A JP2018558662 A JP 2018558662A JP 2018558662 A JP2018558662 A JP 2018558662A JP 2019519491 A5 JP2019519491 A5 JP 2019519491A5
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- 150000001875 compounds Chemical class 0.000 claims 52
- 150000001408 amides Chemical class 0.000 claims 6
- 150000002148 esters Chemical class 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000011780 sodium chloride Substances 0.000 claims 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- 229920000858 Cyclodextrin Polymers 0.000 claims 4
- 229940097362 Cyclodextrins Drugs 0.000 claims 4
- 150000003983 crown ethers Chemical class 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 150000004032 porphyrins Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 3
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- VSJKWCGYPAHWDS-FQEVSTJZSA-N Camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 2
- 102000001189 Cyclic Peptides Human genes 0.000 claims 2
- 108010069514 Cyclic Peptides Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000005055 alkyl alkoxy group Chemical group 0.000 claims 2
- 210000004027 cells Anatomy 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 2
- 239000000314 lubricant Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 210000001519 tissues Anatomy 0.000 claims 2
- KEKAEHDXIJNAIJ-TWVRELQASA-N (2S,3R)-2-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-hydroxybutanoic ac Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](C(C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@@H]([C@H](O)C)C(O)=O)C1=CC=CC=C1 KEKAEHDXIJNAIJ-TWVRELQASA-N 0.000 claims 1
- AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 1
- 229920002395 Aptamer Polymers 0.000 claims 1
- 229940120638 Avastin Drugs 0.000 claims 1
- DNDCVAGJPBKION-DOPDSADYSA-N Bombesin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1NC2=CC=CC=C2C=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1NC(=O)CC1)C(C)C)C1=CN=CN1 DNDCVAGJPBKION-DOPDSADYSA-N 0.000 claims 1
- 102000013585 Bombesin Human genes 0.000 claims 1
- 108010051479 Bombesin Proteins 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N Docetaxel Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 229960004679 Doxorubicin Drugs 0.000 claims 1
- 229940082789 Erbitux Drugs 0.000 claims 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
- 229940022353 Herceptin Drugs 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N Intaxel Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 101700074108 MLA Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102400000740 Melanocyte-stimulating hormone alpha Human genes 0.000 claims 1
- 229960001592 Paclitaxel Drugs 0.000 claims 1
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temodal Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 125000005159 cyanoalkoxy group Chemical group 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 239000003906 humectant Substances 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002335 preservative Effects 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 229930003347 taxol Natural products 0.000 claims 1
- 229960004964 temozolomide Drugs 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
- LXZZYRPGZAFOLE-UHFFFAOYSA-L transplatin Chemical compound [H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H] LXZZYRPGZAFOLE-UHFFFAOYSA-L 0.000 claims 1
- WHNFPRLDDSXQCL-UAZQEYIDSA-N α-MSH Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(N)=O)NC(=O)[C@H](CO)NC(C)=O)C1=CC=C(O)C=C1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 0.000 claims 1
- WJLROCPIZOQIAS-UHFFFAOYSA-N CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O Chemical compound CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O WJLROCPIZOQIAS-UHFFFAOYSA-N 0.000 description 1
- ZJBDNCHDNHMUKT-QWRGUYRKSA-N C[C@@H](CCC(N[C@@H](CCCOP(NCCCC(O)=O)(O)=O)C(O)=O)=O)C(O)=O Chemical compound C[C@@H](CCC(N[C@@H](CCCOP(NCCCC(O)=O)(O)=O)C(O)=O)=O)C(O)=O ZJBDNCHDNHMUKT-QWRGUYRKSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662333427P | 2016-05-09 | 2016-05-09 | |
| US62/333,427 | 2016-05-09 | ||
| PCT/US2017/031696 WO2017196806A1 (en) | 2016-05-09 | 2017-05-09 | Chemical conjugates of evans blue derivatives and their use as radiotherapy and imaging agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019519491A JP2019519491A (ja) | 2019-07-11 |
| JP2019519491A5 true JP2019519491A5 (pt-PT) | 2020-05-28 |
| JP6946342B2 JP6946342B2 (ja) | 2021-10-06 |
Family
ID=60267260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018558662A Active JP6946342B2 (ja) | 2016-05-09 | 2017-05-09 | エバンスブルー誘導体の化学的コンジュゲート、ならびに放射線治療剤およびイメージング剤としてのそれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10696631B2 (pt-PT) |
| EP (1) | EP3455206B1 (pt-PT) |
| JP (1) | JP6946342B2 (pt-PT) |
| CN (1) | CN109153641B (pt-PT) |
| SG (1) | SG11201809982RA (pt-PT) |
| WO (1) | WO2017196806A1 (pt-PT) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3310758A1 (en) | 2015-06-22 | 2018-04-25 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Chemical conjugates of evans blue derivatives and their use in the production of long-acting therapeutics |
| EP3692032B1 (en) | 2017-10-03 | 2024-06-19 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Chemical conjugates of evans blue derivatives and their use as radiotherapy and imaging agents |
| EP3755321A4 (en) | 2018-02-22 | 2021-11-24 | The United States of America, as represented by the Secretary, Department of Health and Human Services | CHEMICAL CONJUGATES OF EVANS BLUE DERIVATIVES AND THEIR USE AS RADIOTHERAPY AND IMAGING AGENTS FOR THE TARGETING OF PROSTATE CANCER |
| TWI745616B (zh) * | 2018-09-10 | 2021-11-11 | 行政院原子能委員會核能研究所 | 放射線標誌長效型靶向性胜肽藥物及其生產方法 |
| CN109485642A (zh) * | 2018-11-21 | 2019-03-19 | 希施生物科技（上海）有限公司 | 一种制备伊文氏蓝衍生物的方法 |
| SG11202108081PA (en) | 2019-01-30 | 2021-08-30 | The United States Of America As Represented By The Secretary | Conjugates of bivalent evans blue dye derivatives and methods of use |
| EP3906947A4 (en) * | 2019-05-24 | 2022-07-13 | Peking University | TARGETED RADIOPHARMACEUTICALS FOR TUMORS AND COMBINATION THERAPY OF TARGETED RADIATION THERAPY THEREOF AND IMMUNOTHERAPY UNDER IMAGE GUIDANCE |
| CA3174082A1 (en) | 2020-03-04 | 2021-09-10 | Nihon Medi-Physics Co., Ltd. | Compound and radioactive labeling compound |
| CN114790193B (zh) * | 2020-12-21 | 2024-05-10 | 苏州药明博锐生物科技有限公司 | 成纤维细胞活化蛋白抑制剂 |
| KR102648429B1 (ko) | 2021-02-10 | 2024-03-18 | 옌타이 란나청 바이오테크놀로지 컴퍼니 리미티드 | 절단형 에반스 블루 변형의 섬유아세포 활성화 단백질 억제제 및 이의 제조 방법과 응용 |
| CN114369084B (zh) * | 2021-02-10 | 2023-02-03 | 烟台蓝纳成生物技术有限公司 | 一种截短型伊文思蓝修饰的成纤维细胞活化蛋白抑制剂及其制备方法和应用 |
| CN113004371A (zh) * | 2021-03-01 | 2021-06-22 | 上海蓝纳成生物技术有限公司 | 一种长循环半衰期的前列腺特异性膜抗原靶向化合物及其制备方法和应用 |
| CN114796532A (zh) * | 2022-04-20 | 2022-07-29 | 北京先通国际医药科技股份有限公司 | 放射性标记的伊文思蓝衍生物药物水溶液及其用途 |
| WO2023236778A1 (zh) * | 2022-06-10 | 2023-12-14 | 北京大学 | 一种三功能化合物及其用途 |
| CN115433261B (zh) * | 2022-11-07 | 2023-01-13 | 烟台蓝纳成生物技术有限公司 | 一种rgd二聚体化合物及其制备方法和应用 |
| CN115583989B (zh) * | 2022-12-09 | 2023-02-28 | 烟台蓝纳成生物技术有限公司 | 一种靶向sstr2的化合物及其制备方法和应用 |
| CN115611779A (zh) * | 2022-12-21 | 2023-01-17 | 北京先通国际医药科技股份有限公司 | 一种放射性药物前体的中间体的制备方法及其用途 |
| CN115838393B (zh) * | 2023-02-16 | 2023-05-05 | 烟台蓝纳成生物技术有限公司 | 用于fapi合成的中间体及其制备方法和应用 |
| CN115850367B (zh) * | 2023-03-02 | 2023-05-23 | 北京先通国际医药科技股份有限公司 | Psma抑制剂的纯化方法及其用途 |
| CN115947775B (zh) * | 2023-03-13 | 2023-06-09 | 北京先通国际医药科技股份有限公司 | 一种制备化合物（i）的方法和化合物（i）及其用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004075925A1 (ja) | 2003-02-27 | 2004-09-10 | Kyushu Tlo Company Limited | Ｍｒｉ用造影剤 |
| WO2006025304A1 (ja) | 2004-08-30 | 2006-03-09 | Kyushu University, National University Corporation | 動脈硬化検知用ｍｒｉ造影剤 |
| CN101623504A (zh) * | 2008-07-07 | 2010-01-13 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 伊文思蓝作为实体肿瘤着色剂的用途 |
| CN103242255B (zh) * | 2013-04-28 | 2015-01-14 | 厦门大学 | 伊文氏蓝配合物及其制备方法和应用 |
| CN104650217B (zh) * | 2015-01-26 | 2018-08-10 | 莎穆(上海)生物科技有限公司 | 伊文氏蓝或其衍生物修饰的Exendin-4及其制备方法和应用 |
| US20160287730A1 (en) | 2015-03-31 | 2016-10-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv | Labeled evans blue dye derivative for in vivo serum albumin labeling |
| EP3310758A1 (en) * | 2015-06-22 | 2018-04-25 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Chemical conjugates of evans blue derivatives and their use in the production of long-acting therapeutics |
| WO2017192874A1 (en) | 2016-05-04 | 2017-11-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Albumin-binding immunomodulatory compositions and methods of use thereof |
| EP3692032B1 (en) | 2017-10-03 | 2024-06-19 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Chemical conjugates of evans blue derivatives and their use as radiotherapy and imaging agents |
| EP3755321A4 (en) | 2018-02-22 | 2021-11-24 | The United States of America, as represented by the Secretary, Department of Health and Human Services | CHEMICAL CONJUGATES OF EVANS BLUE DERIVATIVES AND THEIR USE AS RADIOTHERAPY AND IMAGING AGENTS FOR THE TARGETING OF PROSTATE CANCER |
-
2017
- 2017-05-09 JP JP2018558662A patent/JP6946342B2/ja active Active
- 2017-05-09 SG SG11201809982RA patent/SG11201809982RA/en unknown
- 2017-05-09 EP EP17796666.0A patent/EP3455206B1/en active Active
- 2017-05-09 WO PCT/US2017/031696 patent/WO2017196806A1/en unknown
- 2017-05-09 US US16/099,488 patent/US10696631B2/en active Active
- 2017-05-09 CN CN201780029003.XA patent/CN109153641B/zh active Active
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