JP2019519464A5 - - Google Patents
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- Publication number
- JP2019519464A5 JP2019519464A5 JP2018524188A JP2018524188A JP2019519464A5 JP 2019519464 A5 JP2019519464 A5 JP 2019519464A5 JP 2018524188 A JP2018524188 A JP 2018524188A JP 2018524188 A JP2018524188 A JP 2018524188A JP 2019519464 A5 JP2019519464 A5 JP 2019519464A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- disease
- carbon
- activation
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims description 21
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 16
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 7
- 150000002923 oximes Chemical class 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 32
- 239000008194 pharmaceutical composition Substances 0.000 claims 24
- 150000003648 triterpenes Chemical class 0.000 claims 17
- 230000004913 activation Effects 0.000 claims 16
- 201000010099 disease Diseases 0.000 claims 16
- 208000035475 disorder Diseases 0.000 claims 16
- 230000037361 pathway Effects 0.000 claims 16
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 12
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 9
- 206010012601 diabetes mellitus Diseases 0.000 claims 8
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 4
- 200000000007 Arterial disease Diseases 0.000 claims 4
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 4
- 208000033626 Renal failure acute Diseases 0.000 claims 4
- 206010063837 Reperfusion injury Diseases 0.000 claims 4
- 206010052428 Wound Diseases 0.000 claims 4
- 208000027418 Wounds and injury Diseases 0.000 claims 4
- 201000011040 acute kidney failure Diseases 0.000 claims 4
- 206010069351 acute lung injury Diseases 0.000 claims 4
- 230000001684 chronic effect Effects 0.000 claims 4
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 4
- 208000014674 injury Diseases 0.000 claims 4
- 208000031225 myocardial ischemia Diseases 0.000 claims 4
- 230000004770 neurodegeneration Effects 0.000 claims 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims 4
- 210000000056 organ Anatomy 0.000 claims 4
- 238000002054 transplantation Methods 0.000 claims 4
- 230000008733 trauma Effects 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 102000003951 Erythropoietin Human genes 0.000 claims 3
- 108090000394 Erythropoietin Proteins 0.000 claims 3
- 208000006011 Stroke Diseases 0.000 claims 3
- 150000001336 alkenes Chemical class 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 206010008129 cerebral palsy Diseases 0.000 claims 3
- 229940105423 erythropoietin Drugs 0.000 claims 3
- 150000007857 hydrazones Chemical class 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 230000036470 plasma concentration Effects 0.000 claims 3
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 206010033799 Paralysis Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16193684.4 | 2016-10-13 | ||
| EP16193684 | 2016-10-13 | ||
| PCT/EP2017/075042 WO2018069086A1 (en) | 2016-10-13 | 2017-10-03 | Hydroxamate triterpenoid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019519464A JP2019519464A (ja) | 2019-07-11 |
| JP2019519464A5 true JP2019519464A5 (https=) | 2019-10-17 |
| JP6598224B2 JP6598224B2 (ja) | 2019-10-30 |
Family
ID=57136723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018524188A Active JP6598224B2 (ja) | 2016-10-13 | 2017-10-03 | ヒドロキサメートトリテルペノイド誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10766855B2 (https=) |
| EP (1) | EP3365351B1 (https=) |
| JP (1) | JP6598224B2 (https=) |
| KR (1) | KR102038930B1 (https=) |
| CN (1) | CN108368150B (https=) |
| AU (1) | AU2017341257B2 (https=) |
| BR (1) | BR112018068996A2 (https=) |
| CA (1) | CA3020387C (https=) |
| ES (1) | ES2774198T3 (https=) |
| HK (1) | HK1254200A1 (https=) |
| IL (1) | IL259391B (https=) |
| MX (2) | MX364919B (https=) |
| RU (1) | RU2018136782A (https=) |
| WO (1) | WO2018069086A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020157494A1 (en) * | 2019-01-30 | 2020-08-06 | Rothamsted Research Ltd | Cylodimer of dehydrosalicortin and derivatives thereof isolated from plant of the genus salix for use in cancer therapy |
| CN114805469A (zh) * | 2021-01-27 | 2022-07-29 | 中国科学院上海药物研究所 | 含吡唑的白桦脂酸类衍生物，其制备方法及用途 |
| CN117567544A (zh) * | 2021-04-27 | 2024-02-20 | 中国医学科学院药物研究所 | 一类具有α,β-不饱和酮结构五环三萜类化合物在预防和治疗神经退行性疾病中的用途 |
| WO2024145502A1 (en) * | 2022-12-29 | 2024-07-04 | The Board Of Regents Of The University Of Texas System | Synthetic triterpenoids and compositions thereof in weight management, skeletal muscle function, and appetite suppression |
| CN119504913B (zh) * | 2024-11-18 | 2025-09-26 | 南京中医药大学 | 一类五环三萜衍生物及其医药用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002322068A (ja) * | 2001-02-26 | 2002-11-08 | Japan Science & Technology Corp | 血管再生促進剤 |
| KR100821649B1 (ko) * | 2006-01-24 | 2008-04-11 | 서울시립대학교 산학협력단 | 클리오퀴놀을 유효성분으로 포함하는 ＨＩＦ-1α 활성제 |
| CN101367861A (zh) * | 2007-08-15 | 2009-02-18 | 中国药科大学 | 2-羟基-3-脱氧五环三萜类化合物及其衍生物、其制备方法及用途 |
| PL2252283T3 (pl) * | 2008-01-11 | 2019-09-30 | Reata Pharmaceuticals, Inc. | Syntetyczne triterpenoidy i sposoby zastosowania w leczeniu choroby |
| WO2009146216A2 (en) * | 2008-04-18 | 2009-12-03 | Reata Pharmaceuticals. Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| US20100144688A1 (en) * | 2008-12-10 | 2010-06-10 | Advanced Life Sciences, Inc. | 23-Substituted Derivatives of Lupane-type Pentacyclic Triterpenoids |
| KR101811462B1 (ko) * | 2010-01-11 | 2018-01-25 | 피닉스 바이오테크놀러지 인코포레이티드. | 협죽도 추출물을 포함하는 신경질환 치료용 조성물 |
| CN102180939B (zh) | 2011-03-30 | 2013-02-20 | 沈阳化工大学 | 一种抗肿瘤活性的熊果酸化学修饰物及其制备方法 |
| US8324264B1 (en) * | 2011-07-22 | 2012-12-04 | Sequoia Sciences, Inc. | Inhibitors of bacterial biofilms and related methods |
| CN102499925B (zh) * | 2011-10-21 | 2015-11-11 | 上海中医药大学 | 一种中性粒细胞弹性蛋白酶抑制剂 |
-
2017
- 2017-10-03 EP EP17790966.0A patent/EP3365351B1/en active Active
- 2017-10-03 WO PCT/EP2017/075042 patent/WO2018069086A1/en not_active Ceased
- 2017-10-03 US US16/099,800 patent/US10766855B2/en active Active
- 2017-10-03 KR KR1020187028923A patent/KR102038930B1/ko not_active Expired - Fee Related
- 2017-10-03 CN CN201780004882.0A patent/CN108368150B/zh not_active Expired - Fee Related
- 2017-10-03 CA CA3020387A patent/CA3020387C/en active Active
- 2017-10-03 MX MX2018006429A patent/MX364919B/es active IP Right Grant
- 2017-10-03 BR BR112018068996A patent/BR112018068996A2/pt not_active Application Discontinuation
- 2017-10-03 ES ES17790966T patent/ES2774198T3/es active Active
- 2017-10-03 JP JP2018524188A patent/JP6598224B2/ja active Active
- 2017-10-03 HK HK18113340.0A patent/HK1254200A1/zh unknown
- 2017-10-03 AU AU2017341257A patent/AU2017341257B2/en active Active
- 2017-10-03 RU RU2018136782A patent/RU2018136782A/ru not_active Application Discontinuation
-
2018
- 2018-05-15 IL IL25939118A patent/IL259391B/en active IP Right Grant
- 2018-05-24 MX MX2019005448A patent/MX2019005448A/es unknown
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