CN108368150B - 氧肟酸三萜系化合物衍生物 - Google Patents

氧肟酸三萜系化合物衍生物 Download PDF

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CN108368150B
CN108368150B CN201780004882.0A CN201780004882A CN108368150B CN 108368150 B CN108368150 B CN 108368150B CN 201780004882 A CN201780004882 A CN 201780004882A CN 108368150 B CN108368150 B CN 108368150B
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carbon
hydroxy
olean
double bond
methylene
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CN108368150A (zh
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爱德华多·穆尼奥斯布兰科
阿尔贝托·米纳西
玛丽亚·卢斯·贝利多卡韦略德阿尔瓦
乔瓦尼·阿彭迪诺
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Vivacell Biotechnology Espana SL
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    • C07C259/08—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
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    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780004882.0A 2016-10-13 2017-10-03 氧肟酸三萜系化合物衍生物 Expired - Fee Related CN108368150B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16193684.4 2016-10-13
EP16193684 2016-10-13
PCT/EP2017/075042 WO2018069086A1 (en) 2016-10-13 2017-10-03 Hydroxamate triterpenoid derivatives

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CN108368150A CN108368150A (zh) 2018-08-03
CN108368150B true CN108368150B (zh) 2022-02-25

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US (1) US10766855B2 (https=)
EP (1) EP3365351B1 (https=)
JP (1) JP6598224B2 (https=)
KR (1) KR102038930B1 (https=)
CN (1) CN108368150B (https=)
AU (1) AU2017341257B2 (https=)
BR (1) BR112018068996A2 (https=)
CA (1) CA3020387C (https=)
ES (1) ES2774198T3 (https=)
HK (1) HK1254200A1 (https=)
IL (1) IL259391B (https=)
MX (2) MX364919B (https=)
RU (1) RU2018136782A (https=)
WO (1) WO2018069086A1 (https=)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
WO2020157494A1 (en) * 2019-01-30 2020-08-06 Rothamsted Research Ltd Cylodimer of dehydrosalicortin and derivatives thereof isolated from plant of the genus salix for use in cancer therapy
CN114805469A (zh) * 2021-01-27 2022-07-29 中国科学院上海药物研究所 含吡唑的白桦脂酸类衍生物，其制备方法及用途
CN117567544A (zh) * 2021-04-27 2024-02-20 中国医学科学院药物研究所 一类具有α,β-不饱和酮结构五环三萜类化合物在预防和治疗神经退行性疾病中的用途
WO2024145502A1 (en) * 2022-12-29 2024-07-04 The Board Of Regents Of The University Of Texas System Synthetic triterpenoids and compositions thereof in weight management, skeletal muscle function, and appetite suppression
CN119504913B (zh) * 2024-11-18 2025-09-26 南京中医药大学 一类五环三萜衍生物及其医药用途

Citations (5)

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CN101367861A (zh) * 2007-08-15 2009-02-18 中国药科大学 2-羟基-3-脱氧五环三萜类化合物及其衍生物、其制备方法及用途
WO2009146216A2 (en) * 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
CN101965184A (zh) * 2008-01-11 2011-02-02 里亚塔医药公司 合成三萜类化合物及用以治病之方法
CN102499925A (zh) * 2011-10-21 2012-06-20 上海中医药大学 一种中性粒细胞弹性蛋白酶抑制剂
US8324264B1 (en) * 2011-07-22 2012-12-04 Sequoia Sciences, Inc. Inhibitors of bacterial biofilms and related methods

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JP2002322068A (ja) * 2001-02-26 2002-11-08 Japan Science & Technology Corp 血管再生促進剤
KR100821649B1 (ko) * 2006-01-24 2008-04-11 서울시립대학교 산학협력단 클리오퀴놀을 유효성분으로 포함하는 ＨＩＦ-1α 활성제
US20100144688A1 (en) * 2008-12-10 2010-06-10 Advanced Life Sciences, Inc. 23-Substituted Derivatives of Lupane-type Pentacyclic Triterpenoids
KR101811462B1 (ko) * 2010-01-11 2018-01-25 피닉스 바이오테크놀러지 인코포레이티드. 협죽도 추출물을 포함하는 신경질환 치료용 조성물
CN102180939B (zh) 2011-03-30 2013-02-20 沈阳化工大学 一种抗肿瘤活性的熊果酸化学修饰物及其制备方法

Patent Citations (5)

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CN101367861A (zh) * 2007-08-15 2009-02-18 中国药科大学 2-羟基-3-脱氧五环三萜类化合物及其衍生物、其制备方法及用途
CN101965184A (zh) * 2008-01-11 2011-02-02 里亚塔医药公司 合成三萜类化合物及用以治病之方法
WO2009146216A2 (en) * 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
US8324264B1 (en) * 2011-07-22 2012-12-04 Sequoia Sciences, Inc. Inhibitors of bacterial biofilms and related methods
CN102499925A (zh) * 2011-10-21 2012-06-20 上海中医药大学 一种中性粒细胞弹性蛋白酶抑制剂

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Betulinic acid derived hydroxamates and betulin derived carbamates are interesting scaffolds for the synthesis of novel cytotoxic compounds;Jana Wiemann et al.;《European Journal of Medicinal Chemistry》;20151105;第106卷;第194-210页 *
Betulinic acid inhibits the expression of hypoxia-inducible factor 1a and vascular endothelial growth factor in human endometrial adenocarcinoma cells;Ewa Karna et al.;《Mol Cell Biochem》;20100221;第340卷;第15-20页 *
Hypoxic Regulation of Inducible Nitric Oxide Synthase via Hypoxia Inducible Factor-1 in Cardiac Myocytes;Frank Jung et al.;《Circulation Research》;20000218;第86卷;第319-325页 *
Maslinic Acid Induces Mitochondrial Apoptosis and Suppresses HIF-1α Expression in A549 Lung Cancer Cells under Normoxic and Hypoxic Conditions;Te-Chun Hsia et al.;《Molecules》;20141128;第19卷;第19892-19906页 *
Maslinic acid inhibits the metastatic capacity of DU145 human prostate cancer cells: possible mediation via hypoxia-inducible factor-1a signalling;So Young Park et al.;《British Journal of Nutrition》;20120413;第109卷;第210-222页 *
Oleanolic acid enhances the radiosensitivity of tumor cells under mimetic hypoxia through the reduction in intracellular GSH content and HIF-1α expression;RONGXIN QI et al.;《ONCOLOGY REPORTS》;20141231;第31卷;第2399-2406页 *
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KR102038930B1 (ko) 2019-11-05
AU2017341257A1 (en) 2018-11-01
AU2017341257B2 (en) 2019-08-08
IL259391A (en) 2018-07-31
MX2019005448A (es) 2019-07-04
CN108368150A (zh) 2018-08-03
RU2018136782A (ru) 2020-04-20
US10766855B2 (en) 2020-09-08
WO2018069086A1 (en) 2018-04-19
MX2018006429A (es) 2018-09-27
CA3020387C (en) 2020-07-28
IL259391B (en) 2019-10-31
RU2018136782A3 (https=) 2020-04-20
BR112018068996A2 (pt) 2019-01-22
KR20180117700A (ko) 2018-10-29
ES2774198T3 (es) 2020-07-17
EP3365351B1 (en) 2019-12-04
EP3365351A1 (en) 2018-08-29
US20190367447A1 (en) 2019-12-05
CA3020387A1 (en) 2018-04-19
JP6598224B2 (ja) 2019-10-30
MX364919B (es) 2019-05-13
JP2019519464A (ja) 2019-07-11
HK1254200A1 (zh) 2019-07-12

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