CN113767090A - 三环化合物及其制备方法和医药用途 - Google Patents

三环化合物及其制备方法和医药用途 Download PDF

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CN113767090A
CN113767090A CN202080032427.3A CN202080032427A CN113767090A CN 113767090 A CN113767090 A CN 113767090A CN 202080032427 A CN202080032427 A CN 202080032427A CN 113767090 A CN113767090 A CN 113767090A
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cycloalkyl
alkyl
amino
heterocyclyl
heteroaryl
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CN113767090B (zh
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殷惠军
闫旭
刘国标
史建新
陈士柱
任思洋
冯亚东
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National Institutes of Pharmaceutical R&D Co Ltd
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Abstract

一种通式(I)所示的三环化合物，含有其的药物组合物，及其制备方法和医药用途被公开。该化合物可用于预防和治疗由毒性醛引发的多种疾病。

Description

PCT国内申请，说明书已公开。

Claims (9)

  1. PCT国内申请，权利要求书已公开。
CN202080032427.3A 2019-12-30 2020-12-29 三环化合物及其制备方法和医药用途 Active CN113767090B (zh)

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CN2019113918885 2019-12-30
CN201911391888 2019-12-30
PCT/CN2020/140710 WO2021136244A1 (zh) 2019-12-30 2020-12-29 三环化合物及其制备方法和医药用途

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EP (1) EP4086241A4 (zh)
JP (1) JP2023507900A (zh)
KR (1) KR20220122978A (zh)
CN (1) CN113767090B (zh)
AU (1) AU2020419515A1 (zh)
CA (1) CA3159453A1 (zh)
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WO2022267930A1 (zh) * 2021-06-25 2022-12-29 中国医药研究开发中心有限公司 三环化合物及其制备方法和医药用途

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN108135867A (zh) * 2015-08-21 2018-06-08 奥尔德拉医疗公司 醛结合物和其用途

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US7973025B2 (en) * 2005-05-26 2011-07-05 Neuron Systems, Inc. Compositions and methods of treating retinal disease
CN117045653A (zh) * 2013-01-23 2023-11-14 奥尔德拉医疗公司 与毒性醛相关的疾病和治疗
US10111862B2 (en) * 2013-01-25 2018-10-30 Aldeyra Therapeutics, Inc. Traps in the treatment of macular degeneration
BR112018003250A2 (pt) * 2015-08-21 2018-09-25 Aldeyra Therapeutics Inc compostos deuterados e usos dos mesmos
WO2018039197A1 (en) * 2016-08-22 2018-03-01 Aldeyra Therapeutics, Inc. Aldehyde trapping compounds and methods of use thereof
US20180050989A1 (en) * 2016-08-22 2018-02-22 Aldeyra Therapeutics, Inc. Aldehyde trapping compounds and uses thereof

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CN108135867A (zh) * 2015-08-21 2018-06-08 奥尔德拉医疗公司 醛结合物和其用途

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KR20220122978A (ko) 2022-09-05
EP4086241A1 (en) 2022-11-09
WO2021136244A1 (zh) 2021-07-08
JP2023507900A (ja) 2023-02-28
AU2020419515A1 (en) 2022-05-19
TW202138362A (zh) 2021-10-16
CA3159453A1 (en) 2021-07-08
EP4086241A4 (en) 2024-02-07
CN113767090B (zh) 2024-05-28
US20230021669A1 (en) 2023-01-26

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