JP2019511565A5 - - Google Patents
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- JP2019511565A5 JP2019511565A5 JP2018560724A JP2018560724A JP2019511565A5 JP 2019511565 A5 JP2019511565 A5 JP 2019511565A5 JP 2018560724 A JP2018560724 A JP 2018560724A JP 2018560724 A JP2018560724 A JP 2018560724A JP 2019511565 A5 JP2019511565 A5 JP 2019511565A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- composition
- immune checkpoint
- composition according
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 14
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 14
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 14
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 6
- -1 cyano, carboxyl Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 5
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 5
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 5
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 5
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 4
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 4
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 4
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 4
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 102100038078 CD276 antigen Human genes 0.000 claims 3
- 101710185679 CD276 antigen Proteins 0.000 claims 3
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 3
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 3
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 102000002698 KIR Receptors Human genes 0.000 claims 3
- 108010043610 KIR Receptors Proteins 0.000 claims 3
- 102000017578 LAG3 Human genes 0.000 claims 3
- 108010079206 V-Set Domain-Containing T-Cell Activation Inhibitor 1 Proteins 0.000 claims 3
- 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 claims 3
- 125000004442 acylamino group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
- XEDONBRPTABQFB-UHFFFAOYSA-N 4-[(2-formyl-3-hydroxyphenoxy)methyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1COC1=CC=CC(O)=C1C=O XEDONBRPTABQFB-UHFFFAOYSA-N 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 229950009795 tucaresol Drugs 0.000 claims 2
- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010055113 Breast cancer metastatic Diseases 0.000 claims 1
- 239000012275 CTLA-4 inhibitor Substances 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010052360 Colorectal adenocarcinoma Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 239000012270 PD-1 inhibitor Substances 0.000 claims 1
- 239000012668 PD-1-inhibitor Substances 0.000 claims 1
- 239000012271 PD-L1 inhibitor Substances 0.000 claims 1
- 239000012272 PD-L2 inhibitor Substances 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 1
- 229960003852 atezolizumab Drugs 0.000 claims 1
- 201000000053 blastoma Diseases 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000000139 costimulatory effect Effects 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 229960003901 dacarbazine Drugs 0.000 claims 1
- 201000008184 embryoma Diseases 0.000 claims 1
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000010658 metastatic prostate carcinoma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229940121655 pd-1 inhibitor Drugs 0.000 claims 1
- 229940121656 pd-l1 inhibitor Drugs 0.000 claims 1
- 229940121654 pd-l2 inhibitor Drugs 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- UNRCMCRRFYFGFX-TYPNBTCFSA-N plinabulin Chemical compound N1C=NC(\C=C/2C(NC(=C\C=3C=CC=CC=3)/C(=O)N\2)=O)=C1C(C)(C)C UNRCMCRRFYFGFX-TYPNBTCFSA-N 0.000 claims 1
- 229950011498 plinabulin Drugs 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 230000005747 tumor angiogenesis Effects 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022063979A JP2022088662A (ja) | 2016-02-08 | 2022-04-07 | ツカレゾールまたはそのアナログを含む組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662292763P | 2016-02-08 | 2016-02-08 | |
| US62/292,763 | 2016-02-08 | ||
| PCT/US2017/016740 WO2017139231A1 (en) | 2016-02-08 | 2017-02-06 | Compositions containing tucaresol or its analogs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022063979A Division JP2022088662A (ja) | 2016-02-08 | 2022-04-07 | ツカレゾールまたはそのアナログを含む組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019511565A JP2019511565A (ja) | 2019-04-25 |
| JP2019511565A5 true JP2019511565A5 (https=) | 2020-03-19 |
Family
ID=59563990
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018560724A Pending JP2019511565A (ja) | 2016-02-08 | 2017-02-06 | ツカレゾールまたはそのアナログを含む組成物 |
| JP2022063979A Pending JP2022088662A (ja) | 2016-02-08 | 2022-04-07 | ツカレゾールまたはそのアナログを含む組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022063979A Pending JP2022088662A (ja) | 2016-02-08 | 2022-04-07 | ツカレゾールまたはそのアナログを含む組成物 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10912748B2 (https=) |
| EP (1) | EP3413885A4 (https=) |
| JP (2) | JP2019511565A (https=) |
| KR (1) | KR20180105685A (https=) |
| CN (1) | CN108778267A (https=) |
| AU (1) | AU2017217426B2 (https=) |
| BR (1) | BR112018016054A2 (https=) |
| CA (1) | CA3013467A1 (https=) |
| CO (1) | CO2018009096A2 (https=) |
| EC (1) | ECSP18067631A (https=) |
| IL (1) | IL260933B2 (https=) |
| MX (1) | MX388474B (https=) |
| MY (1) | MY192703A (https=) |
| NZ (1) | NZ744854A (https=) |
| PH (1) | PH12018501669A1 (https=) |
| RU (1) | RU2753543C1 (https=) |
| SG (1) | SG11201806583XA (https=) |
| WO (1) | WO2017139231A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016219204B2 (en) * | 2015-02-12 | 2021-01-21 | Beyondspring Pharmaceuticals, Inc. | Use of Plinabulin in combination with immune checkpoint inhibitors |
| HK1249051A1 (zh) | 2015-03-06 | 2018-10-26 | BeyondSpring Pharmaceuticals Inc. | 治疗脑肿瘤的方法 |
| MX383691B (es) | 2015-03-06 | 2025-03-14 | Beyondspring Pharmaceuticals Inc | Método de tratamiento de cáncer asociado con una mutación de ras. |
| US10155748B2 (en) | 2015-07-13 | 2018-12-18 | Beyondspring Pharmaceuticals, Inc. | Plinabulin compositions |
| WO2017139231A1 (en) | 2016-02-08 | 2017-08-17 | Beyondspring Pharmaceuticals, Inc. | Compositions containing tucaresol or its analogs |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| RU2760348C2 (ru) | 2016-06-06 | 2021-11-24 | Бейондспринг Фармасьютикалс, Инк. | Способ уменьшения нейтропении |
| JP2020503363A (ja) | 2017-01-06 | 2020-01-30 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | チューブリン結合化合物およびその治療的使用 |
| BR112019015974A2 (pt) | 2017-02-01 | 2020-03-31 | Beyondspring Pharmaceuticals, Inc. | Método para reduzir neutropenia |
| AU2018236168B2 (en) * | 2017-03-13 | 2024-02-29 | Beyondspring Pharmaceuticals, Inc. | Compositions of plinabulin and use thereof |
| CN109420167B (zh) * | 2017-08-28 | 2022-02-11 | 四川九章生物科技有限公司 | 一种治疗肿瘤的联合用药物 |
| KR20200112881A (ko) | 2018-01-24 | 2020-10-05 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법 |
| KR20210131316A (ko) | 2019-02-27 | 2021-11-02 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | Sumo-활성화 효소 저해제 및 관문 저해제의 투여 |
| BR112021018186A2 (pt) * | 2019-03-14 | 2021-11-30 | Engene Inc | Expressão localizada à base de poliplex de quitosana de il-12 sozinho ou em combinação com indutores ifn tipo-i para tratamento de cânceres de mucosa |
| AU2020343329C1 (en) * | 2019-09-03 | 2026-02-12 | Intra-Cellular Therapies, Inc. | Methods of treatment |
| CN112778155B (zh) * | 2019-11-11 | 2023-08-11 | 大连万春布林医药有限公司 | 妥卡雷琐衍生物及其用途 |
| KR20230006568A (ko) * | 2020-05-04 | 2023-01-10 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 낮은 면역원성을 갖는 암에서 암세포 사멸을 강화하기 위한 삼중 병용 요법 |
| CA3215047A1 (en) | 2021-04-09 | 2022-10-13 | Lan Huang | Therapeutic compositions and methods for treating tumors |
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2017
- 2017-02-06 WO PCT/US2017/016740 patent/WO2017139231A1/en not_active Ceased
- 2017-02-06 SG SG11201806583XA patent/SG11201806583XA/en unknown
- 2017-02-06 AU AU2017217426A patent/AU2017217426B2/en active Active
- 2017-02-06 KR KR1020187024294A patent/KR20180105685A/ko not_active Ceased
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- 2017-02-06 JP JP2018560724A patent/JP2019511565A/ja active Pending
- 2017-02-06 US US16/075,942 patent/US10912748B2/en active Active
- 2017-02-06 BR BR112018016054-7A patent/BR112018016054A2/pt not_active Application Discontinuation
- 2017-02-06 NZ NZ744854A patent/NZ744854A/en unknown
- 2017-02-06 MX MX2018009413A patent/MX388474B/es unknown
- 2017-02-06 EP EP17750611.0A patent/EP3413885A4/en not_active Withdrawn
- 2017-02-06 CN CN201780018762.6A patent/CN108778267A/zh active Pending
- 2017-02-06 RU RU2018128290A patent/RU2753543C1/ru active
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- 2017-02-06 CA CA3013467A patent/CA3013467A1/en active Pending
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2021
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