JP2019511491A5 - - Google Patents
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- Publication number
- JP2019511491A5 JP2019511491A5 JP2018547320A JP2018547320A JP2019511491A5 JP 2019511491 A5 JP2019511491 A5 JP 2019511491A5 JP 2018547320 A JP2018547320 A JP 2018547320A JP 2018547320 A JP2018547320 A JP 2018547320A JP 2019511491 A5 JP2019511491 A5 JP 2019511491A5
- Authority
- JP
- Japan
- Prior art keywords
- expression
- targeting ligand
- oligomeric compound
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 37
- 230000002401 inhibitory effect Effects 0.000 claims 32
- 239000003446 ligand Substances 0.000 claims 31
- 230000008685 targeting Effects 0.000 claims 30
- 150000003839 salts Chemical class 0.000 claims 19
- 239000003795 chemical substances by application Substances 0.000 claims 13
- 108091030071 RNAI Proteins 0.000 claims 12
- 230000009368 gene silencing by RNA Effects 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 108091081021 Sense strand Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- MSWZFWKMSRAUBD-GASJEMHNSA-N 2-amino-2-deoxy-D-galactopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O MSWZFWKMSRAUBD-GASJEMHNSA-N 0.000 claims 1
- 101100539150 Homo sapiens UBAP1 gene Proteins 0.000 claims 1
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 claims 1
- FVMMQJUBNMOPPR-WLDMJGECSA-N N-[(3R,4R,5R,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]formamide Chemical compound OC[C@H]1OC(O)[C@H](NC=O)[C@@H](O)[C@H]1O FVMMQJUBNMOPPR-WLDMJGECSA-N 0.000 claims 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical group OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 claims 1
- 102100029779 Ubiquitin-associated protein 1 Human genes 0.000 claims 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
- 229930182830 galactose Natural products 0.000 claims 1
- RHLMXWCISNJNDH-UHFFFAOYSA-N n-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]-3-methylbenzamide Chemical compound COC1=CC=C(C=2C=C(C=CC=2)C(=O)N(C)C)C=C1S(=O)(=O)NC(C=1)=CC=CC=1NCCNC(=O)C1=CC=CC(C)=C1 RHLMXWCISNJNDH-UHFFFAOYSA-N 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021189879A JP7485642B2 (ja) | 2016-03-07 | 2021-11-24 | 治療化合物用の標的化リガンド |
| JP2024074913A JP2024097862A (ja) | 2016-03-07 | 2024-05-02 | 治療化合物用の標的化リガンド |
| JP2025092644A JP2025120251A (ja) | 2016-03-07 | 2025-06-03 | 治療化合物用の標的化リガンド |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662304652P | 2016-03-07 | 2016-03-07 | |
| US62/304,652 | 2016-03-07 | ||
| US201662370754P | 2016-08-04 | 2016-08-04 | |
| US62/370,754 | 2016-08-04 | ||
| US201662426916P | 2016-11-28 | 2016-11-28 | |
| US62/426,916 | 2016-11-28 | ||
| PCT/US2017/021175 WO2017156012A1 (en) | 2016-03-07 | 2017-03-07 | Targeting ligands for therapeutic compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021189879A Division JP7485642B2 (ja) | 2016-03-07 | 2021-11-24 | 治療化合物用の標的化リガンド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019511491A JP2019511491A (ja) | 2019-04-25 |
| JP2019511491A5 true JP2019511491A5 (OSRAM) | 2020-04-16 |
| JP6983797B2 JP6983797B2 (ja) | 2021-12-17 |
Family
ID=59723428
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018547320A Active JP6983797B2 (ja) | 2016-03-07 | 2017-03-07 | 治療化合物用の標的化リガンド |
| JP2021189879A Active JP7485642B2 (ja) | 2016-03-07 | 2021-11-24 | 治療化合物用の標的化リガンド |
| JP2024074913A Withdrawn JP2024097862A (ja) | 2016-03-07 | 2024-05-02 | 治療化合物用の標的化リガンド |
| JP2025092644A Pending JP2025120251A (ja) | 2016-03-07 | 2025-06-03 | 治療化合物用の標的化リガンド |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021189879A Active JP7485642B2 (ja) | 2016-03-07 | 2021-11-24 | 治療化合物用の標的化リガンド |
| JP2024074913A Withdrawn JP2024097862A (ja) | 2016-03-07 | 2024-05-02 | 治療化合物用の標的化リガンド |
| JP2025092644A Pending JP2025120251A (ja) | 2016-03-07 | 2025-06-03 | 治療化合物用の標的化リガンド |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US10246709B2 (OSRAM) |
| EP (1) | EP3426261A4 (OSRAM) |
| JP (4) | JP6983797B2 (OSRAM) |
| KR (3) | KR102830443B1 (OSRAM) |
| CN (2) | CN109069529B (OSRAM) |
| AU (3) | AU2017229469B2 (OSRAM) |
| BR (1) | BR112018068230B1 (OSRAM) |
| CA (1) | CA3011946A1 (OSRAM) |
| IL (3) | IL296377A (OSRAM) |
| JO (2) | JOP20170057B1 (OSRAM) |
| MX (3) | MX2018009854A (OSRAM) |
| NZ (2) | NZ744357A (OSRAM) |
| TW (3) | TWI783434B (OSRAM) |
| UY (1) | UY37146A (OSRAM) |
| WO (1) | WO2017156012A1 (OSRAM) |
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