JP2019507756A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019507756A5 JP2019507756A5 JP2018544812A JP2018544812A JP2019507756A5 JP 2019507756 A5 JP2019507756 A5 JP 2019507756A5 JP 2018544812 A JP2018544812 A JP 2018544812A JP 2018544812 A JP2018544812 A JP 2018544812A JP 2019507756 A5 JP2019507756 A5 JP 2019507756A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cyclodextrin
- ophthalmic
- ophthalmic composition
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 258
- 229920000858 Cyclodextrin Polymers 0.000 claims description 220
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 87
- 238000000034 method Methods 0.000 claims description 81
- 239000001116 FEMA 4028 Substances 0.000 claims description 73
- 229960004853 betadex Drugs 0.000 claims description 73
- 229940054534 ophthalmic solution Drugs 0.000 claims description 41
- 239000002997 ophthalmic solution Substances 0.000 claims description 41
- 125000004964 sulfoalkyl group Chemical group 0.000 claims description 33
- -1 carboxyalkyl cyclodextrin Chemical compound 0.000 claims description 27
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 24
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 24
- 239000000872 buffer Substances 0.000 claims description 24
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 24
- 239000013543 active substance Substances 0.000 claims description 22
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims description 16
- 229910019142 PO4 Inorganic materials 0.000 claims description 16
- 208000002205 allergic conjunctivitis Diseases 0.000 claims description 16
- 208000024998 atopic conjunctivitis Diseases 0.000 claims description 16
- 239000010452 phosphate Substances 0.000 claims description 16
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 14
- 206010020751 Hypersensitivity Diseases 0.000 claims description 8
- 239000013566 allergen Substances 0.000 claims description 8
- 208000026935 allergic disease Diseases 0.000 claims description 8
- 230000007815 allergy Effects 0.000 claims description 8
- 239000003963 antioxidant agent Substances 0.000 claims description 8
- 239000002738 chelating agent Substances 0.000 claims description 8
- 239000007951 isotonicity adjuster Substances 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 8
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims description 8
- 239000003755 preservative agent Substances 0.000 claims description 8
- 239000001488 sodium phosphate Substances 0.000 claims description 8
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 8
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical group [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 8
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims description 7
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims description 7
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims description 7
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims description 7
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims description 7
- 239000003906 humectant Substances 0.000 claims description 6
- 239000000314 lubricant Substances 0.000 claims description 6
- 229940097346 sulfobutylether-beta-cyclodextrin Drugs 0.000 claims description 6
- 239000002562 thickening agent Substances 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 2
- 241000208125 Nicotiana Species 0.000 claims description 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims description 2
- 238000003915 air pollution Methods 0.000 claims description 2
- 206010069664 atopic keratoconjunctivitis Diseases 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000002537 cosmetic Substances 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 239000003205 fragrance Substances 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 206010023332 keratitis Diseases 0.000 claims description 2
- 201000010666 keratoconjunctivitis Diseases 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 230000001932 seasonal effect Effects 0.000 claims description 2
- 239000000779 smoke Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 239000000375 suspending agent Substances 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
- 241000238711 Pyroglyphidae Species 0.000 claims 1
- 229960004784 allergens Drugs 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 229940046533 house dust mites Drugs 0.000 claims 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 3
- 239000000428 dust Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022014231A JP2022048282A (ja) | 2016-02-28 | 2022-02-01 | シクロデキストリンを用いるアレルギーの眼の状態の処置 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662300907P | 2016-02-28 | 2016-02-28 | |
| US62/300,907 | 2016-02-28 | ||
| US201662315488P | 2016-03-30 | 2016-03-30 | |
| US62/315,488 | 2016-03-30 | ||
| PCT/US2017/020020 WO2017147617A1 (en) | 2016-02-28 | 2017-02-28 | Treatment of allergic eye conditions with cyclodextrins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022014231A Division JP2022048282A (ja) | 2016-02-28 | 2022-02-01 | シクロデキストリンを用いるアレルギーの眼の状態の処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507756A JP2019507756A (ja) | 2019-03-22 |
| JP2019507756A5 true JP2019507756A5 (https=) | 2020-04-09 |
| JP7450242B2 JP7450242B2 (ja) | 2024-03-15 |
Family
ID=59685756
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018544812A Active JP7450242B2 (ja) | 2016-02-28 | 2017-02-28 | シクロデキストリンを用いるアレルギーの眼の状態の処置 |
| JP2022014231A Pending JP2022048282A (ja) | 2016-02-28 | 2022-02-01 | シクロデキストリンを用いるアレルギーの眼の状態の処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022014231A Pending JP2022048282A (ja) | 2016-02-28 | 2022-02-01 | シクロデキストリンを用いるアレルギーの眼の状態の処置 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10426790B2 (https=) |
| EP (1) | EP3419633A4 (https=) |
| JP (2) | JP7450242B2 (https=) |
| KR (1) | KR20180116416A (https=) |
| CN (2) | CN116531400A (https=) |
| AU (1) | AU2017224249A1 (https=) |
| BR (1) | BR112018069533A2 (https=) |
| CA (1) | CA3016759A1 (https=) |
| CL (1) | CL2018002457A1 (https=) |
| CO (1) | CO2018009099A2 (https=) |
| IL (1) | IL261419A (https=) |
| MX (1) | MX2018010292A (https=) |
| WO (1) | WO2017147617A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006249866B2 (en) | 2005-05-26 | 2011-10-13 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
| WO2011072141A1 (en) | 2009-12-11 | 2011-06-16 | Neuron Systems, Inc. | Compositions and methods for the treatment of macular degeneration |
| CN117045653A (zh) | 2013-01-23 | 2023-11-14 | 奥尔德拉医疗公司 | 与毒性醛相关的疾病和治疗 |
| US10550085B2 (en) | 2015-08-21 | 2020-02-04 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
| CA3022665A1 (en) | 2016-05-09 | 2017-11-16 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
| CA3054811A1 (en) | 2017-03-16 | 2018-09-20 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| WO2019075136A1 (en) | 2017-10-10 | 2019-04-18 | Aldeyra Therapeutics, Inc. | TREATMENT OF INFLAMMATORY DISORDERS |
| WO2020018498A1 (en) * | 2018-07-16 | 2020-01-23 | Aldeyra Therapeutics, Inc. | Cyclodextrin formulations |
| AU2019319740A1 (en) | 2018-08-06 | 2021-03-25 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| EP3856478A4 (en) * | 2018-09-25 | 2022-06-08 | Aldeyra Therapeutics, Inc. | FORMULATIONS FOR THE TREATMENT OF DRY EYE |
| WO2020072621A1 (en) * | 2018-10-02 | 2020-04-09 | Aldeyra Therapeutics, Inc. | Contact lens solutions and kits |
| CN109646684B (zh) * | 2019-02-18 | 2021-05-28 | 天津医科大学总医院 | 环孢菌素h环糊精及其用途 |
| US11786518B2 (en) | 2019-03-26 | 2023-10-17 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations and uses thereof |
| JP2022530967A (ja) | 2019-05-02 | 2022-07-05 | アルデイラ セラピューティクス， インコーポレイテッド | 多形化合物およびその使用 |
| WO2020223717A1 (en) | 2019-05-02 | 2020-11-05 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| US10744153B1 (en) * | 2019-07-01 | 2020-08-18 | Cloudbreak Therapeutics Llc | Compositions and methods for treating meibomian gland dysfunction |
| CN110752039A (zh) * | 2019-10-30 | 2020-02-04 | 湖南财政经济学院 | 通过电子病历判断过敏原与预测过敏情况的定量评分系统 |
| KR102945395B1 (ko) * | 2019-12-09 | 2026-03-27 | 니치유 가부시키가이샤 | 소프트 콘택트렌즈용 화분 흡착 억제제 및 화분 단백 흡착 억제제 |
| WO2021231792A1 (en) | 2020-05-13 | 2021-11-18 | Aldeyra Therapeutics, Inc. | Pharmaceutical formulations and uses thereof |
| WO2024091659A1 (en) * | 2022-10-28 | 2024-05-02 | Aldeyra Therapeutics, Inc. | Modified cyclodextrins and ophthalmic uses thereof |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ225045A (en) | 1987-07-01 | 1990-06-26 | Janssen Pharmaceutica Nv | Antiviral pharmaceutical compositions containing cyclodextrin and an antiviral agent |
| US5002935A (en) | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| BR9106193A (pt) | 1990-10-22 | 1993-03-23 | Bausch & Lomb | Metodo e composicao para limpar lentes de contato |
| US5472954A (en) | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
| TW401300B (en) * | 1992-12-25 | 2000-08-11 | Senju Pharma Co | Antiallergic composition for ophthalmic or nasal use |
| JP2746832B2 (ja) * | 1993-05-14 | 1998-05-06 | 大鵬薬品工業株式会社 | 眼局所抗アレルギー剤 |
| US5767109A (en) | 1993-10-20 | 1998-06-16 | Sanchez; Robert A. | Complexing urushiols |
| US5576311A (en) | 1994-11-30 | 1996-11-19 | Pharmos Corporation | Cyclodextrins as suspending agents for pharmaceutical suspensions |
| JP3297969B2 (ja) | 1994-12-26 | 2002-07-02 | ライオン株式会社 | 点眼剤 |
| FR2742053B1 (fr) * | 1995-12-06 | 1998-03-06 | Chauvin Lab Sa | Compositions pharmaceutiques a base de mequitazine |
| JP3736916B2 (ja) | 1996-02-19 | 2006-01-18 | 株式会社サンコンタクトレンズ | 含水性ソフトコンタクトレンズの消毒用組成物とその用途 |
| JP4748289B2 (ja) | 2000-06-23 | 2011-08-17 | ライオン株式会社 | 点眼剤、眼科用組成物及び吸着抑制方法 |
| US20040198828A1 (en) * | 2003-01-17 | 2004-10-07 | Abelson Mark B. | Combinational use of long-acting and short-acting anti-histamines for ocular allergies |
| EP3326623A1 (en) | 2003-03-14 | 2018-05-30 | University of Washington | Retinoid replacements and opsin agonists and methods for the use thereof |
| US20060111318A1 (en) | 2003-04-18 | 2006-05-25 | Advanced Medicine Research Institute | Agent for treating eye diseases |
| EP1621199B8 (en) | 2003-04-18 | 2011-01-19 | Advanced Medicine Research Institute | Remedies for diseases to be applied to eye |
| US7083803B2 (en) | 2003-09-19 | 2006-08-01 | Advanced Ocular Systems Limited | Ocular solutions |
| CA2546042A1 (en) | 2003-11-20 | 2005-06-09 | Othera Pharmaceuticals, Inc. | Amelioration of macular degeneration and other ophthalmic diseases |
| JP2005187407A (ja) * | 2003-12-25 | 2005-07-14 | Lion Corp | アレルギー眼疾患用眼科組成物 |
| US20050197292A1 (en) | 2004-01-30 | 2005-09-08 | Glennda Smithson | Compositions and methods for treating T-cell mediated pathological conditions |
| US20050234018A1 (en) | 2004-04-15 | 2005-10-20 | Allergan, Inc. | Drug delivery to the back of the eye |
| JP2006008568A (ja) * | 2004-06-24 | 2006-01-12 | Cyclochem:Kk | ＩｇＥ抗体抑制剤および食品 |
| AU2006249866B2 (en) | 2005-05-26 | 2011-10-13 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
| JP4466875B2 (ja) | 2006-04-05 | 2010-05-26 | ライオン株式会社 | ソフトコンタクトレンズ用点眼剤 |
| JP5194218B2 (ja) | 2006-06-05 | 2013-05-08 | 株式会社メニコンネクト | 含水性コンタクトレンズの保存方法ならびに該保存方法により保存された含水性コンタクトレンズ |
| US8158609B1 (en) | 2006-11-02 | 2012-04-17 | Novartis Ag | Use of cyclodextrins as an active ingredient for treating dry AMD and solubilizing drusen |
| US20090118503A1 (en) | 2007-06-20 | 2009-05-07 | Kevin Sprott | Faah inhibitors |
| CN103553945B (zh) | 2007-10-05 | 2015-01-07 | 奥克塞拉有限公司 | 用于治疗疾病的烷氧基化合物 |
| AU2009282076A1 (en) | 2008-08-12 | 2010-02-18 | Sirtris Pharmaceuticals, Inc. | Benzoxazoles, benzthiazoles and related analogs as sirtuin modulators |
| CA2754996A1 (en) | 2009-03-17 | 2010-09-23 | Aciex Therapeutics, Inc. | Ophthalmic formulations of ketotifen and methods of use |
| WO2011072141A1 (en) | 2009-12-11 | 2011-06-16 | Neuron Systems, Inc. | Compositions and methods for the treatment of macular degeneration |
| US10463687B2 (en) * | 2011-01-20 | 2019-11-05 | Cornell University | Treatments for retinal disorders |
| TWI544922B (zh) * | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物 |
| US20130165419A1 (en) | 2011-12-21 | 2013-06-27 | Insite Vision Incorporated | Combination anti-inflammatory ophthalmic compositions |
| MX373894B (es) | 2012-11-08 | 2020-07-09 | Clearside Biomedical Inc | Métodos y dispositivos para el tratamiento de trastornos oculares en sujetos humanos. |
| AU2013361314A1 (en) | 2012-12-20 | 2015-07-02 | Aldeyra Therapeutics, Inc. | Peri-carbinols |
| CN117045653A (zh) | 2013-01-23 | 2023-11-14 | 奥尔德拉医疗公司 | 与毒性醛相关的疾病和治疗 |
| US10111862B2 (en) | 2013-01-25 | 2018-10-30 | Aldeyra Therapeutics, Inc. | Traps in the treatment of macular degeneration |
| US20160151410A1 (en) * | 2013-07-02 | 2016-06-02 | The Trustees Of Columbia University In The City Of New York | Clearance of bioactive lipids from membrane structures by cyclodextrins |
| KR20180073553A (ko) | 2015-08-21 | 2018-07-02 | 알데이라 테라퓨틱스, 아이엔씨. | 알데히드 접합체 및 이의 용도 |
| US10550085B2 (en) | 2015-08-21 | 2020-02-04 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
| CA3022665A1 (en) | 2016-05-09 | 2017-11-16 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
| WO2018039192A1 (en) | 2016-08-22 | 2018-03-01 | Aldeyra Therapeutics, Inc. | Aldehyde trapping compounds and uses thereof |
| CA3032609A1 (en) | 2016-08-22 | 2018-03-01 | Aldeyra Therapeutics, Inc. | Aldehyde trapping compounds and methods of use thereof |
| CA3054811A1 (en) | 2017-03-16 | 2018-09-20 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
-
2017
- 2017-02-28 KR KR1020187028238A patent/KR20180116416A/ko not_active Withdrawn
- 2017-02-28 US US15/445,802 patent/US10426790B2/en active Active
- 2017-02-28 MX MX2018010292A patent/MX2018010292A/es unknown
- 2017-02-28 EP EP17757445.6A patent/EP3419633A4/en not_active Withdrawn
- 2017-02-28 CN CN202310746856.2A patent/CN116531400A/zh active Pending
- 2017-02-28 BR BR112018069533-5A patent/BR112018069533A2/pt not_active Application Discontinuation
- 2017-02-28 WO PCT/US2017/020020 patent/WO2017147617A1/en not_active Ceased
- 2017-02-28 CA CA3016759A patent/CA3016759A1/en not_active Abandoned
- 2017-02-28 CN CN201780023943.8A patent/CN109069530A/zh active Pending
- 2017-02-28 JP JP2018544812A patent/JP7450242B2/ja active Active
- 2017-02-28 AU AU2017224249A patent/AU2017224249A1/en not_active Abandoned
-
2018
- 2018-08-28 IL IL261419A patent/IL261419A/en unknown
- 2018-08-28 CL CL2018002457A patent/CL2018002457A1/es unknown
- 2018-08-29 CO CONC2018/0009099A patent/CO2018009099A2/es unknown
-
2022
- 2022-02-01 JP JP2022014231A patent/JP2022048282A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019507756A5 (https=) | ||
| JP5519001B2 (ja) | コルチコステロイドおよびシクロデキストリンを含む局所用溶液処方物 | |
| EP4374851A3 (en) | Ophthalmic composition for treatment of dry eye disease | |
| CU20100200A7 (es) | Una composición farmacéutica que comprende n-(3,4-difluoro-2-4-iodofenilamino)-6-metoxifenil)-l-(2,3-dihidroxipropil)ciclopropano-l-sulfonamida, útil para el tratamiento y prevención del cáncer y de enfermedades inflamatorias | |
| JP6313599B2 (ja) | 眼科用水性組成物 | |
| JP2013525501A5 (https=) | ||
| JP2012520880A (ja) | ケトチフェンの眼科用製剤および使用方法 | |
| JP2015007136A5 (https=) | ||
| GT200900173A (es) | Dispersión sólida de un antagonista de neuroquinina | |
| EA202090029A1 (ru) | Твердая композиция карипразина для орального введения | |
| SA522431498B1 (ar) | مشتقات 3، 6-داي أمينو-بيريدازين-3-يل، تركيبات صيدلية تحتوي عليها واستخدامها في صورة عوامل مساعدة على تلاشي الخلايا | |
| MX388073B (es) | Composición farmacéutica, preparación y usos de la misma. | |
| JP2013535472A5 (https=) | ||
| DE60319221T2 (de) | Quaternisierte ammoniumcyclodextrinverbindungen | |
| JP2018529666A5 (https=) | ||
| UY38055A (es) | Composiciones oftálmicas de compuestos de bencimidazol para uso unico diario | |
| EA201791138A1 (ru) | Фармацевтическая композиция, ее приготовление и применения | |
| ATE412402T1 (de) | Ophthalmische suspension aus einem ophthalmischen arzneimittel, einem poloxamin und glykol- tonizitätsanpassenden mittel, verwendung der zusammensetzung zur herstellung eines medikaments zur behandlung von augenerkrankungen | |
| AR092691A1 (es) | Composicion farmaceutica que comprende rebamipida | |
| JP2001097865A (ja) | 眼科用組成物 | |
| JP2020527138A5 (https=) | ||
| JP2014534215A5 (https=) | ||
| JP6931257B2 (ja) | レバミピドを含有する新規ドライアイ治療用点眼組成物及びその可溶化及び安定化方法 | |
| JP2007517885A5 (https=) | ||
| IL274149B1 (en) | Extended release formulations for intra-articular applications |