CN116531400A - 用环糊精治疗过敏性眼部病状 - Google Patents
用环糊精治疗过敏性眼部病状 Download PDFInfo
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- CN116531400A CN116531400A CN202310746856.2A CN202310746856A CN116531400A CN 116531400 A CN116531400 A CN 116531400A CN 202310746856 A CN202310746856 A CN 202310746856A CN 116531400 A CN116531400 A CN 116531400A
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- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- WHRODDIHRRDWEW-VTHZAVIASA-N sugammadex Chemical compound O([C@@H]([C@@H]([C@H]1O)O)O[C@H]2[C@H](O)[C@H]([C@@H](O[C@@H]3[C@@H](CSCCC(O)=O)O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]3[C@@H](CSCCC(O)=O)O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]3[C@@H](CSCCC(O)=O)O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]3[C@@H](CSCCC(O)=O)O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]3[C@@H](CSCCC(O)=O)O[C@@H]([C@@H]([C@H]3O)O)O3)O[C@@H]2CSCCC(O)=O)O)[C@H](CSCCC(O)=O)[C@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H]3[C@@H](CSCCC(O)=O)O1 WHRODDIHRRDWEW-VTHZAVIASA-N 0.000 description 1
- 229960002257 sugammadex Drugs 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
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- 229940095064 tartrate Drugs 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 229920001664 tyloxapol Polymers 0.000 description 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
- 229960004224 tyloxapol Drugs 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
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- 238000003260 vortexing Methods 0.000 description 1
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- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/16—Cyclodextrin; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Inorganic Chemistry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662300907P | 2016-02-28 | 2016-02-28 | |
| US62/300,907 | 2016-02-28 | ||
| US201662315488P | 2016-03-30 | 2016-03-30 | |
| US62/315,488 | 2016-03-30 | ||
| CN201780023943.8A CN109069530A (zh) | 2016-02-28 | 2017-02-28 | 用环糊精治疗过敏性眼部病状 |
| PCT/US2017/020020 WO2017147617A1 (en) | 2016-02-28 | 2017-02-28 | Treatment of allergic eye conditions with cyclodextrins |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201780023943.8A Division CN109069530A (zh) | 2016-02-28 | 2017-02-28 | 用环糊精治疗过敏性眼部病状 |
Publications (1)
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| CN116531400A true CN116531400A (zh) | 2023-08-04 |
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| CN202310746856.2A Pending CN116531400A (zh) | 2016-02-28 | 2017-02-28 | 用环糊精治疗过敏性眼部病状 |
| CN201780023943.8A Pending CN109069530A (zh) | 2016-02-28 | 2017-02-28 | 用环糊精治疗过敏性眼部病状 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780023943.8A Pending CN109069530A (zh) | 2016-02-28 | 2017-02-28 | 用环糊精治疗过敏性眼部病状 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10426790B2 (https=) |
| EP (1) | EP3419633A4 (https=) |
| JP (2) | JP7450242B2 (https=) |
| KR (1) | KR20180116416A (https=) |
| CN (2) | CN116531400A (https=) |
| AU (1) | AU2017224249A1 (https=) |
| BR (1) | BR112018069533A2 (https=) |
| CA (1) | CA3016759A1 (https=) |
| CL (1) | CL2018002457A1 (https=) |
| CO (1) | CO2018009099A2 (https=) |
| IL (1) | IL261419A (https=) |
| MX (1) | MX2018010292A (https=) |
| WO (1) | WO2017147617A1 (https=) |
Families Citing this family (20)
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| AU2006249866B2 (en) | 2005-05-26 | 2011-10-13 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
| WO2011072141A1 (en) | 2009-12-11 | 2011-06-16 | Neuron Systems, Inc. | Compositions and methods for the treatment of macular degeneration |
| CN117045653A (zh) | 2013-01-23 | 2023-11-14 | 奥尔德拉医疗公司 | 与毒性醛相关的疾病和治疗 |
| US10550085B2 (en) | 2015-08-21 | 2020-02-04 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
| CA3022665A1 (en) | 2016-05-09 | 2017-11-16 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
| CA3054811A1 (en) | 2017-03-16 | 2018-09-20 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| WO2019075136A1 (en) | 2017-10-10 | 2019-04-18 | Aldeyra Therapeutics, Inc. | TREATMENT OF INFLAMMATORY DISORDERS |
| WO2020018498A1 (en) * | 2018-07-16 | 2020-01-23 | Aldeyra Therapeutics, Inc. | Cyclodextrin formulations |
| AU2019319740A1 (en) | 2018-08-06 | 2021-03-25 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| EP3856478A4 (en) * | 2018-09-25 | 2022-06-08 | Aldeyra Therapeutics, Inc. | FORMULATIONS FOR THE TREATMENT OF DRY EYE |
| WO2020072621A1 (en) * | 2018-10-02 | 2020-04-09 | Aldeyra Therapeutics, Inc. | Contact lens solutions and kits |
| CN109646684B (zh) * | 2019-02-18 | 2021-05-28 | 天津医科大学总医院 | 环孢菌素h环糊精及其用途 |
| US11786518B2 (en) | 2019-03-26 | 2023-10-17 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations and uses thereof |
| JP2022530967A (ja) | 2019-05-02 | 2022-07-05 | アルデイラ セラピューティクス， インコーポレイテッド | 多形化合物およびその使用 |
| WO2020223717A1 (en) | 2019-05-02 | 2020-11-05 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| US10744153B1 (en) * | 2019-07-01 | 2020-08-18 | Cloudbreak Therapeutics Llc | Compositions and methods for treating meibomian gland dysfunction |
| CN110752039A (zh) * | 2019-10-30 | 2020-02-04 | 湖南财政经济学院 | 通过电子病历判断过敏原与预测过敏情况的定量评分系统 |
| KR102945395B1 (ko) * | 2019-12-09 | 2026-03-27 | 니치유 가부시키가이샤 | 소프트 콘택트렌즈용 화분 흡착 억제제 및 화분 단백 흡착 억제제 |
| WO2021231792A1 (en) | 2020-05-13 | 2021-11-18 | Aldeyra Therapeutics, Inc. | Pharmaceutical formulations and uses thereof |
| WO2024091659A1 (en) * | 2022-10-28 | 2024-05-02 | Aldeyra Therapeutics, Inc. | Modified cyclodextrins and ophthalmic uses thereof |
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| WO2006000421A2 (en) * | 2004-06-24 | 2006-01-05 | Wacker-Chemie Gmbh | Ige antibody repressing agent comprising alpha cyclodextrin |
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-
2017
- 2017-02-28 KR KR1020187028238A patent/KR20180116416A/ko not_active Withdrawn
- 2017-02-28 US US15/445,802 patent/US10426790B2/en active Active
- 2017-02-28 MX MX2018010292A patent/MX2018010292A/es unknown
- 2017-02-28 EP EP17757445.6A patent/EP3419633A4/en not_active Withdrawn
- 2017-02-28 CN CN202310746856.2A patent/CN116531400A/zh active Pending
- 2017-02-28 BR BR112018069533-5A patent/BR112018069533A2/pt not_active Application Discontinuation
- 2017-02-28 WO PCT/US2017/020020 patent/WO2017147617A1/en not_active Ceased
- 2017-02-28 CA CA3016759A patent/CA3016759A1/en not_active Abandoned
- 2017-02-28 CN CN201780023943.8A patent/CN109069530A/zh active Pending
- 2017-02-28 JP JP2018544812A patent/JP7450242B2/ja active Active
- 2017-02-28 AU AU2017224249A patent/AU2017224249A1/en not_active Abandoned
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2018
- 2018-08-28 IL IL261419A patent/IL261419A/en unknown
- 2018-08-28 CL CL2018002457A patent/CL2018002457A1/es unknown
- 2018-08-29 CO CONC2018/0009099A patent/CO2018009099A2/es unknown
-
2022
- 2022-02-01 JP JP2022014231A patent/JP2022048282A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006000421A2 (en) * | 2004-06-24 | 2006-01-05 | Wacker-Chemie Gmbh | Ige antibody repressing agent comprising alpha cyclodextrin |
Non-Patent Citations (1)
| Title |
|---|
| R A RAJEWSKI等: "Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery", 《JOURNAL OF PHARMACEUTICAL SCIENCES》, vol. 85, no. 85, pages 1142 - 1169, XP000629515, DOI: 10.1021/js960075u * |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2018010292A (es) | 2018-09-27 |
| EP3419633A1 (en) | 2019-01-02 |
| JP2019507756A (ja) | 2019-03-22 |
| EP3419633A4 (en) | 2019-10-30 |
| CO2018009099A2 (es) | 2018-10-10 |
| JP2022048282A (ja) | 2022-03-25 |
| US20170266220A1 (en) | 2017-09-21 |
| CL2018002457A1 (es) | 2018-11-09 |
| WO2017147617A1 (en) | 2017-08-31 |
| BR112018069533A2 (pt) | 2019-04-16 |
| CA3016759A1 (en) | 2017-08-31 |
| US10426790B2 (en) | 2019-10-01 |
| IL261419A (en) | 2018-10-31 |
| AU2017224249A1 (en) | 2018-09-13 |
| KR20180116416A (ko) | 2018-10-24 |
| CN109069530A (zh) | 2018-12-21 |
| JP7450242B2 (ja) | 2024-03-15 |
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