JP2007517885A5 - - Google Patents

Info

Publication number

JP2007517885A5

JP2007517885A5 JP2006549374A JP2006549374A JP2007517885A5 JP 2007517885 A5 JP2007517885 A5 JP 2007517885A5 JP 2006549374 A JP2006549374 A JP 2006549374A JP 2006549374 A JP2006549374 A JP 2006549374A JP 2007517885 A5 JP2007517885 A5 JP 2007517885A5

Authority

JP

Japan

Prior art keywords

composition

adamantane

component

eye

neuroprotective

Prior art date

2005-01-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
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• ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical compound C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 claims 66
• 239000000203 mixture Substances 0.000 claims 41
• 230000000324 neuroprotective effect Effects 0.000 claims 38
• 241001465754 Metazoa Species 0.000 claims 13
• 230000000694 effects Effects 0.000 claims 11
• 210000001525 retina Anatomy 0.000 claims 8
• 229920002845 Poly(methacrylic acid) Polymers 0.000 claims 6
• 229920002125 Sokalan® Polymers 0.000 claims 6
• 239000000783 alginic acid Substances 0.000 claims 6
• 235000010443 alginic acid Nutrition 0.000 claims 6
• 229920000615 alginic acid Polymers 0.000 claims 6
• 229960001126 alginic acid Drugs 0.000 claims 6
• 150000004781 alginic acids Chemical class 0.000 claims 6
• 239000004584 polyacrylic acid Substances 0.000 claims 6
• 238000011200 topical administration Methods 0.000 claims 6
• 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 5
• BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims 5
• 229960004640 memantine Drugs 0.000 claims 5
• 150000001412 amines Chemical group 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 3
• UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 claims 3
• 108010010803 Gelatin Proteins 0.000 claims 3
• 241000282412 Homo Species 0.000 claims 3
• 229920000805 Polyaspartic acid Polymers 0.000 claims 3
• DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 3
• 229960003805 amantadine Drugs 0.000 claims 3
• 229920006321 anionic cellulose Polymers 0.000 claims 3
• 229920006320 anionic starch Chemical class 0.000 claims 3
• 239000008365 aqueous carrier Substances 0.000 claims 3
• 229920000159 gelatin Polymers 0.000 claims 3
• 239000008273 gelatin Substances 0.000 claims 3
• 229940014259 gelatin Drugs 0.000 claims 3
• 235000019322 gelatine Nutrition 0.000 claims 3
• 235000011852 gelatine desserts Nutrition 0.000 claims 3
• 229920002674 hyaluronan Polymers 0.000 claims 3
• 229960003160 hyaluronic acid Drugs 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 235000019426 modified starch Nutrition 0.000 claims 3
• 108010064470 polyaspartate Proteins 0.000 claims 3
• 229960000888 rimantadine Drugs 0.000 claims 3
• 238000011282 treatment Methods 0.000 claims 3
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
• 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 2
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims 2
• 231100000252 nontoxic Toxicity 0.000 claims 2
• 230000003000 nontoxic effect Effects 0.000 claims 2
• 125000001424 substituent group Chemical group 0.000 claims 2
• 230000000699 topical effect Effects 0.000 claims 2
• 208000003098 Ganglion Cysts Diseases 0.000 claims 1
• 208000005400 Synovial Cyst Diseases 0.000 claims 1
• 230000001154 acute effect Effects 0.000 claims 1
• 230000006727 cell loss Effects 0.000 claims 1
• 239000004615 ingredient Substances 0.000 claims 1
• 230000007794 irritation Effects 0.000 claims 1
• 125000005647 linker group Chemical group 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 210000005036 nerve Anatomy 0.000 claims 1
• 230000004770 neurodegeneration Effects 0.000 claims 1
• 208000015122 neurodegenerative disease Diseases 0.000 claims 1
• 229910052757 nitrogen Inorganic materials 0.000 claims 1
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
• 229920000447 polyanionic polymer Polymers 0.000 claims 1
• 238000011321 prophylaxis Methods 0.000 claims 1
• 230000001681 protective effect Effects 0.000 claims 1