JP2019501973A5 - - Google Patents
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- Publication number
- JP2019501973A5 JP2019501973A5 JP2018555314A JP2018555314A JP2019501973A5 JP 2019501973 A5 JP2019501973 A5 JP 2019501973A5 JP 2018555314 A JP2018555314 A JP 2018555314A JP 2018555314 A JP2018555314 A JP 2018555314A JP 2019501973 A5 JP2019501973 A5 JP 2019501973A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antibody
- cancer
- cell
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 34
- 210000001744 T-lymphocyte Anatomy 0.000 claims 13
- 101000686985 Mouse mammary tumor virus (strain C3H) Protein PR73 Proteins 0.000 claims 11
- 231100000617 superantigen Toxicity 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 8
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 230000000091 immunopotentiator Effects 0.000 claims 5
- 230000004913 activation Effects 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 230000011664 signaling Effects 0.000 claims 4
- 230000008685 targeting Effects 0.000 claims 4
- 101710160107 Outer membrane protein A Proteins 0.000 claims 3
- 239000003623 enhancer Substances 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 229960003852 atezolizumab Drugs 0.000 claims 2
- 230000005754 cellular signaling Effects 0.000 claims 2
- 229950009791 durvalumab Drugs 0.000 claims 2
- 231100000655 enterotoxin Toxicity 0.000 claims 2
- 230000001900 immune effect Effects 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276955P | 2016-01-10 | 2016-01-10 | |
| US62/276,955 | 2016-01-10 | ||
| PCT/IB2017/000511 WO2017122098A2 (en) | 2016-01-10 | 2017-01-10 | Methods and compositions for enhancing the potency of superantigen mediated cancer immunotherapy. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501973A JP2019501973A (ja) | 2019-01-24 |
| JP2019501973A5 true JP2019501973A5 (enExample) | 2020-02-20 |
| JP7161938B2 JP7161938B2 (ja) | 2022-10-27 |
Family
ID=58737690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018555314A Active JP7161938B2 (ja) | 2016-01-10 | 2017-01-10 | スーパー抗原媒介性癌免疫療法の能力を増強するための方法および組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10314910B2 (enExample) |
| EP (1) | EP3411409B1 (enExample) |
| JP (1) | JP7161938B2 (enExample) |
| KR (2) | KR20250071286A (enExample) |
| CN (2) | CN109195988B (enExample) |
| AU (1) | AU2017206656B2 (enExample) |
| CA (1) | CA3010678A1 (enExample) |
| EA (1) | EA201891601A1 (enExample) |
| ES (1) | ES3052659T3 (enExample) |
| IL (1) | IL260423B2 (enExample) |
| MX (1) | MX2018008383A (enExample) |
| WO (1) | WO2017122098A2 (enExample) |
| ZA (1) | ZA201804565B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3411409B1 (en) * | 2016-01-10 | 2025-10-08 | Neotx Therapeutics Ltd. | Anti pd-1/anti-pd-l1 antibodies for enhancing the potency of superantigen mediated cancer immunotherapy |
| CN112423778A (zh) * | 2018-05-16 | 2021-02-26 | 杜克大学 | 利用免疫毒素和检查点抑制剂组合的新辅助癌症治疗 |
| CN108840923B (zh) * | 2018-06-22 | 2021-08-03 | 上海交通大学医学院附属仁济医院 | 一种靶向pd-l1的多肽及其应用 |
| AU2020275142A1 (en) * | 2019-05-15 | 2021-12-16 | Neotx Therapeutics Ltd. | Cancer treatment |
| US12514927B2 (en) | 2019-10-30 | 2026-01-06 | Duke University | Immunotherapy with combination therapy comprising an immunotoxin |
| JP2023517011A (ja) * | 2020-03-05 | 2023-04-21 | ネオティーエックス セラピューティクス リミテッド | 免疫細胞を用いて癌を治療するための方法および組成物 |
| KR20230085904A (ko) * | 2020-07-20 | 2023-06-14 | 네오티엑스 테라퓨틱스 엘티디. | 암을 치료하기 위한 방법 및 조성물에 사용하기 위한 초항원 접합체 |
| WO2022037323A1 (zh) * | 2020-08-19 | 2022-02-24 | 上海易慕峰生物科技有限公司 | 人源化抗体、嵌合抗原受体、核酸、载体、细胞及应用 |
| EP4326775A1 (en) * | 2021-04-22 | 2024-02-28 | Neotx Therapeutics Ltd. | Methods and compositions for treating glioblastoma |
| EP4536278A4 (en) | 2022-06-07 | 2026-08-12 | Actinium Pharmaceuticals Inc | CHELETARIANS AND BIFUNCTIONAL CONJUGATES |
| CN116284448B (zh) * | 2023-02-14 | 2024-06-21 | 浙江大学 | 一种超抗原参与的三功能t细胞衔接器及其应用 |
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| DE68923027D1 (de) | 1988-03-04 | 1995-07-20 | Cancer Res Campaign Tech | Antigene. |
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| US5220007A (en) | 1990-02-15 | 1993-06-15 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of RNA and production of encoded polypeptides |
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| SE9102074D0 (sv) | 1991-07-03 | 1991-07-03 | Kabi Pharmacia Ab | Tomour antigen specific antibody |
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| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| WO1993011794A1 (en) | 1991-12-13 | 1993-06-24 | Xoma Corporation | Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof |
| US5869619A (en) | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
| DE69233035D1 (de) | 1991-12-24 | 2003-06-05 | Harvard College | Gezielte punkt-mutagenese von dna |
| DE69308573T2 (de) | 1992-08-17 | 1997-08-07 | Genentech Inc | Bispezifische immunoadhesine |
| US5389514A (en) | 1992-08-28 | 1995-02-14 | Fox Chase Cancer Center | Method for specifically altering the nucleotide sequence of RNA |
| US5545716A (en) | 1992-09-08 | 1996-08-13 | University Of Florida | Superantigen agonist and antagonist peptides |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US6066718A (en) | 1992-09-25 | 2000-05-23 | Novartis Corporation | Reshaped monoclonal antibodies against an immunoglobulin isotype |
| US5519114A (en) | 1993-10-29 | 1996-05-21 | University Of Florida Research Foundation, Inc. | Retroviral superantigens, superantigen peptides, and methods of use |
| SE9402430L (sv) | 1994-07-11 | 1996-01-12 | Pharmacia Ab | Konjugat mellan modifierat superantigen och en målsökande förening samt användning av konjugaten |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| AU723116B2 (en) | 1995-06-07 | 2000-08-17 | Regents Of The University Of Minnesota | Mutants of streptococcal toxin A and methods of use |
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| JPH09208491A (ja) * | 1996-01-31 | 1997-08-12 | Asahi Optical Co Ltd | 免疫賦活剤 |
| SE9601245D0 (sv) | 1996-03-29 | 1996-03-29 | Pharmacia Ab | Chimeric superantigens and their use |
| US6447777B1 (en) | 1996-03-29 | 2002-09-10 | David S. Terman | Polymerized staphylococcal protein a for treatment of diseases |
| TW517061B (en) | 1996-03-29 | 2003-01-11 | Pharmacia & Amp Upjohn Ab | Modified/chimeric superantigens and their use |
| BR9713679A (pt) | 1996-12-06 | 2001-07-17 | Univ Minnesota | Mutantes de toxina c de estreptococo e métodos de uso |
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| US6774218B2 (en) | 1996-12-06 | 2004-08-10 | Regents Of The University Of Minnesota | Mutants of streptococcal toxin C and methods of use |
| WO1998026747A2 (en) | 1996-12-17 | 1998-06-25 | Terman David S | Superantigen based methods and compositions for treatment of diseases |
| US7087235B2 (en) | 1997-06-25 | 2006-08-08 | The United States Of America As Represented By The Secretary Of The Army | Fusion protein of streptococcal pyrogenic exotoxins |
| US6713284B2 (en) | 1997-06-25 | 2004-03-30 | The United States Of America As Represented By The Secretary Of The Army | Bacterial superantigen vaccines |
| DE69837706T2 (de) | 1997-07-21 | 2008-01-10 | Active Biotech Ab | Zytolyse der geeigneten zielzellen mit superantigen konjugate mittels der induktion von t-zell aktivierung |
| US6872518B2 (en) | 1997-09-22 | 2005-03-29 | University Of Rochester | Methods for selecting polynucleotides encoding T cell epitopes |
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| WO2014006217A1 (en) * | 2012-07-06 | 2014-01-09 | Genmab B.V. | Dimeric protein with triple mutations |
| CN112587671A (zh) * | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
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| US20170002060A1 (en) * | 2014-01-08 | 2017-01-05 | Moderna Therapeutics, Inc. | Polynucleotides for the in vivo production of antibodies |
| SG11201704056XA (en) * | 2014-11-20 | 2017-06-29 | Hoffmann La Roche | Combination therapy of t cell activating bispecific antigen binding molecules cd3 abd folate receptor 1 (folr1) and pd-1 axis binding antagonists |
| EP3411409B1 (en) * | 2016-01-10 | 2025-10-08 | Neotx Therapeutics Ltd. | Anti pd-1/anti-pd-l1 antibodies for enhancing the potency of superantigen mediated cancer immunotherapy |
-
2017
- 2017-01-10 EP EP17724437.3A patent/EP3411409B1/en active Active
- 2017-01-10 AU AU2017206656A patent/AU2017206656B2/en active Active
- 2017-01-10 WO PCT/IB2017/000511 patent/WO2017122098A2/en not_active Ceased
- 2017-01-10 EA EA201891601A patent/EA201891601A1/ru unknown
- 2017-01-10 JP JP2018555314A patent/JP7161938B2/ja active Active
- 2017-01-10 CN CN201780016492.5A patent/CN109195988B/zh active Active
- 2017-01-10 ES ES17724437T patent/ES3052659T3/es active Active
- 2017-01-10 US US15/402,888 patent/US10314910B2/en active Active
- 2017-01-10 KR KR1020257014967A patent/KR20250071286A/ko not_active Ceased
- 2017-01-10 CA CA3010678A patent/CA3010678A1/en active Pending
- 2017-01-10 MX MX2018008383A patent/MX2018008383A/es unknown
- 2017-01-10 CN CN202311526574.8A patent/CN117679499A/zh active Pending
- 2017-01-10 KR KR1020187022673A patent/KR20180100412A/ko not_active Ceased
-
2018
- 2018-07-04 IL IL260423A patent/IL260423B2/en unknown
- 2018-07-09 ZA ZA2018/04565A patent/ZA201804565B/en unknown
-
2019
- 2019-05-14 US US16/411,276 patent/US11202829B2/en active Active
- 2019-12-11 US US16/710,432 patent/US11607452B2/en active Active
-
2023
- 2023-02-09 US US18/166,938 patent/US20240100156A1/en active Pending
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