JP2019501939A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019501939A5 JP2019501939A5 JP2018536484A JP2018536484A JP2019501939A5 JP 2019501939 A5 JP2019501939 A5 JP 2019501939A5 JP 2018536484 A JP2018536484 A JP 2018536484A JP 2018536484 A JP2018536484 A JP 2018536484A JP 2019501939 A5 JP2019501939 A5 JP 2019501939A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenyl
- diazaspiro
- dimethylamino
- sith
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CN(C)[C@](*)(CC1)CC[C@@]1(CN1C*)N(CC2(*)CC2)C1=O Chemical compound CN(C)[C@](*)(CC1)CC[C@@]1(CN1C*)N(CC2(*)CC2)C1=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16151013.6 | 2016-01-13 | ||
| EP16151013 | 2016-01-13 | ||
| PCT/EP2017/025006 WO2017121648A1 (en) | 2016-01-13 | 2017-01-13 | 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501939A JP2019501939A (ja) | 2019-01-24 |
| JP2019501939A5 true JP2019501939A5 (https=) | 2021-04-15 |
| JP6893517B2 JP6893517B2 (ja) | 2021-06-23 |
Family
ID=55129634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018536484A Expired - Fee Related JP6893517B2 (ja) | 2016-01-13 | 2017-01-13 | ３−（（ヘテロ−）アリール）−アルキル−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体 |
Country Status (28)
| Country | Link |
|---|---|
| US (6) | US20170197947A1 (https=) |
| EP (1) | EP3402784B1 (https=) |
| JP (1) | JP6893517B2 (https=) |
| KR (1) | KR20180098369A (https=) |
| CN (1) | CN108602777B (https=) |
| AR (1) | AR107360A1 (https=) |
| AU (1) | AU2017206909B2 (https=) |
| BR (1) | BR112018014303B1 (https=) |
| CA (1) | CA3011177A1 (https=) |
| CL (1) | CL2018001912A1 (https=) |
| CO (1) | CO2018008444A2 (https=) |
| CY (1) | CY1122818T1 (https=) |
| DK (1) | DK3402784T3 (https=) |
| EA (1) | EA037481B1 (https=) |
| EC (1) | ECSP18060848A (https=) |
| ES (1) | ES2797904T3 (https=) |
| HR (1) | HRP20200837T1 (https=) |
| HU (1) | HUE049813T2 (https=) |
| IL (1) | IL260491B (https=) |
| LT (1) | LT3402784T (https=) |
| MX (1) | MX378994B (https=) |
| PE (1) | PE20181375A1 (https=) |
| PL (1) | PL3402784T3 (https=) |
| PT (1) | PT3402784T (https=) |
| RS (1) | RS60315B1 (https=) |
| SI (1) | SI3402784T1 (https=) |
| TW (1) | TWI636048B (https=) |
| WO (1) | WO2017121648A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3402784T1 (sl) | 2016-01-13 | 2020-07-31 | Gruenenthal Gmbh | Derivati 3-((hetero)aril)-alkil-8-amino-2-okso-1,3-diaza-spiro-(4.5)-dekana |
| SI3402782T1 (sl) | 2016-01-13 | 2020-11-30 | Grunenthal Gmbh | 8-amino-2-okso-1,3-diaza-spiro-(4,5)-dekanski derivati |
| CA3011176C (en) | 2016-01-13 | 2023-09-19 | Grunenthal Gmbh | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| CA3011180A1 (en) | 2016-01-13 | 2017-07-20 | Grunenthal Gmbh | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| BR112018014302B1 (pt) | 2016-01-13 | 2023-10-17 | Grünenthal GmbH | Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
| HRP20240793T1 (hr) | 2018-04-18 | 2024-09-13 | Constellation Pharmaceuticals, Inc. | Modulatori enzima koji modificiraju metil, njihovi pripravci i upotreba |
| EP3797108B1 (en) | 2018-05-21 | 2022-07-20 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| BR112021013557A2 (pt) | 2019-01-11 | 2021-09-21 | Grünenthal GmbH | Amidas de pirrolidina substituídas iii |
| GB201905721D0 (en) | 2019-04-24 | 2019-06-05 | Univ Dundee | Compounds |
| LT4003532T (lt) | 2019-07-24 | 2024-11-11 | Constellation Pharmaceuticals, Inc. | 7-chlor-2- (4-(3-metoksiazetidin-1-il)cikloheksil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-okso-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioksol-5-karboksamido kristalinės formos |
| CN120858088A (zh) * | 2022-12-28 | 2025-10-28 | 吉尔伽美什制药公司 | 2-苯基-2-氨基-环己-1-酮衍生物的合成 |
| US20240400537A1 (en) | 2023-04-25 | 2024-12-05 | Gruenenthal Gmbh | Cis-8-(3,5-difluorophenyl)-8-(dimethylamino)-1,3-diazaspiro[4.5]decan-2-one derivatives |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2734265B1 (fr) | 1995-05-17 | 1997-06-13 | Adir | Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant |
| RU2268883C2 (ru) | 2001-04-18 | 2006-01-27 | Эро-Селтик, С.А. | Аналоги ноницептина и фармацевтическая композиция на их основе |
| DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
| DE10210195B4 (de) | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
| DK1519939T5 (da) | 2002-07-05 | 2011-01-24 | Targacept Inc | N-Aryl-diazaspirocykliske forbindelser og fremgangsmåder til fremstilling og anvendelse deraf |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| EP1628978A2 (en) | 2003-05-23 | 2006-03-01 | Zealand Pharma A/S | Triaza-spiro compounds as nociceptin analogues and uses thereof |
| JO2676B1 (en) | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
| CN101553474B (zh) | 2006-10-19 | 2013-02-27 | 霍夫曼-拉罗奇有限公司 | 作为糖尿病用11b-HSD1抑制剂的咪唑啉酮和咪唑烷酮衍生物 |
| CA2683598C (en) | 2007-04-09 | 2015-11-17 | Janssen Pharmaceutica Nv | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression |
| CA2719735A1 (en) * | 2008-03-27 | 2009-10-01 | Gruenenthal Gmbh | Substituted 4-aminocyclohexane derivatives |
| WO2010151815A2 (en) | 2009-06-25 | 2010-12-29 | Abbott Laboratories | 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof |
| TWI582092B (zh) | 2010-07-28 | 2017-05-11 | 歌林達股份有限公司 | 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物 |
| WO2014106238A1 (en) * | 2012-12-31 | 2014-07-03 | Fang, Qun, Kevin | Heterocyclic compounds and methods of use thereof |
| WO2015192039A1 (en) | 2014-06-13 | 2015-12-17 | Purdue Pharma L.P. | Heterocyclic morphinan derivatives and use thereof |
| SI3402782T1 (sl) | 2016-01-13 | 2020-11-30 | Grunenthal Gmbh | 8-amino-2-okso-1,3-diaza-spiro-(4,5)-dekanski derivati |
| AR107354A1 (es) | 2016-01-13 | 2018-04-18 | Bristol Myers Squibb Co | Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock |
| BR112018014302B1 (pt) | 2016-01-13 | 2023-10-17 | Grünenthal GmbH | Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
| SI3402784T1 (sl) | 2016-01-13 | 2020-07-31 | Gruenenthal Gmbh | Derivati 3-((hetero)aril)-alkil-8-amino-2-okso-1,3-diaza-spiro-(4.5)-dekana |
| SI3402811T1 (sl) | 2016-01-13 | 2022-06-30 | Novo Nordisk A/S | Analogi EGF(A) z maščobnokislinskimi substituenti |
| CA3011180A1 (en) | 2016-01-13 | 2017-07-20 | Grunenthal Gmbh | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| CA3011176C (en) | 2016-01-13 | 2023-09-19 | Grunenthal Gmbh | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
-
2017
- 2017-01-13 SI SI201730268T patent/SI3402784T1/sl unknown
- 2017-01-13 WO PCT/EP2017/025006 patent/WO2017121648A1/en not_active Ceased
- 2017-01-13 HR HRP20200837TT patent/HRP20200837T1/hr unknown
- 2017-01-13 DK DK17701638.3T patent/DK3402784T3/da active
- 2017-01-13 HU HUE17701638A patent/HUE049813T2/hu unknown
- 2017-01-13 PE PE2018001302A patent/PE20181375A1/es unknown
- 2017-01-13 KR KR1020187021562A patent/KR20180098369A/ko active Pending
- 2017-01-13 CA CA3011177A patent/CA3011177A1/en active Pending
- 2017-01-13 EA EA201891609A patent/EA037481B1/ru unknown
- 2017-01-13 PT PT177016383T patent/PT3402784T/pt unknown
- 2017-01-13 CN CN201780006494.6A patent/CN108602777B/zh not_active Expired - Fee Related
- 2017-01-13 RS RS20200585A patent/RS60315B1/sr unknown
- 2017-01-13 LT LTEP17701638.3T patent/LT3402784T/lt unknown
- 2017-01-13 EP EP17701638.3A patent/EP3402784B1/en active Active
- 2017-01-13 AU AU2017206909A patent/AU2017206909B2/en not_active Ceased
- 2017-01-13 ES ES17701638T patent/ES2797904T3/es active Active
- 2017-01-13 TW TW106101125A patent/TWI636048B/zh active
- 2017-01-13 US US15/405,896 patent/US20170197947A1/en not_active Abandoned
- 2017-01-13 MX MX2018008644A patent/MX378994B/es unknown
- 2017-01-13 JP JP2018536484A patent/JP6893517B2/ja not_active Expired - Fee Related
- 2017-01-13 PL PL17701638T patent/PL3402784T3/pl unknown
- 2017-01-13 BR BR112018014303-0A patent/BR112018014303B1/pt not_active IP Right Cessation
- 2017-01-13 AR ARP170100095A patent/AR107360A1/es unknown
-
2018
- 2018-05-21 US US15/984,919 patent/US20180327392A1/en not_active Abandoned
- 2018-07-09 IL IL260491A patent/IL260491B/en unknown
- 2018-07-13 CL CL2018001912A patent/CL2018001912A1/es unknown
- 2018-08-13 EC ECSENADI201860848A patent/ECSP18060848A/es unknown
- 2018-08-13 CO CONC2018/0008444A patent/CO2018008444A2/es unknown
-
2019
- 2019-02-01 US US16/265,080 patent/US10829480B2/en active Active
-
2020
- 2020-05-04 CY CY20201100402T patent/CY1122818T1/el unknown
- 2020-08-31 US US17/007,258 patent/US20200399252A1/en not_active Abandoned
-
2021
- 2021-03-01 US US17/188,743 patent/US20210179592A1/en not_active Abandoned
-
2023
- 2023-01-30 US US18/103,180 patent/US20230174520A1/en not_active Abandoned