JP2024502175A5 - - Google Patents
Info
- Publication number
- JP2024502175A5 JP2024502175A5 JP2023541658A JP2023541658A JP2024502175A5 JP 2024502175 A5 JP2024502175 A5 JP 2024502175A5 JP 2023541658 A JP2023541658 A JP 2023541658A JP 2023541658 A JP2023541658 A JP 2023541658A JP 2024502175 A5 JP2024502175 A5 JP 2024502175A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- haloalkyl
- alkylene
- groups
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163134747P | 2021-01-07 | 2021-01-07 | |
| US63/134,747 | 2021-01-07 | ||
| PCT/CA2022/050016 WO2022147622A1 (en) | 2021-01-07 | 2022-01-07 | Isoindolinone aminopyrimidine compounds as inhibitors of nuak kinases, compositions and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024502175A JP2024502175A (ja) | 2024-01-17 |
| JP2024502175A5 true JP2024502175A5 (https=) | 2024-12-10 |
Family
ID=82357069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023541658A Pending JP2024502175A (ja) | 2021-01-07 | 2022-01-07 | Ｎｕａｋキナーゼの阻害剤としてのイソインドリノンアミノピリミジン化合物、その組成物及び使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240092763A1 (https=) |
| EP (1) | EP4277902A4 (https=) |
| JP (1) | JP2024502175A (https=) |
| CN (1) | CN116940565A (https=) |
| AU (1) | AU2022206470A1 (https=) |
| CA (1) | CA3204401A1 (https=) |
| WO (1) | WO2022147622A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102939283B1 (ko) * | 2022-05-03 | 2026-03-13 | 한국화학연구원 | 5-클로로-2,4-다이아미노피리미딘을 포함하는 키나아제 억제 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
| US20260085036A1 (en) * | 2022-09-12 | 2026-03-26 | Mihkal Gmbh | Novel nootropic prodrugs of henethylamine |
| KR20240156074A (ko) * | 2023-04-21 | 2024-10-29 | (주)엠디바이오팜 | Hpk1 및 mlk3 저해제 및 이를 함유하는 항암용 조성물 |
| CN116947764B9 (zh) * | 2023-07-13 | 2025-07-25 | 特科罗生物科技(成都)有限公司 | 一种嘧啶胺类nuak抑制剂及其制备方法和用途 |
| KR20250041906A (ko) * | 2023-09-19 | 2025-03-26 | (주)엠디바이오팜 | Hpk1 및 mlk3 저해 활성을 갖는 신규한 화합물 및 이를 함유하는 항암용 조성물 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1660458E (pt) * | 2003-08-15 | 2012-04-27 | Novartis Ag | 2,4-pirimidinodiaminas úteis no tratamento de doenças neoplásicas, desordens inflamatórias e do sistema imunitário |
| US7521457B2 (en) * | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
| GB0419161D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| CA2634646C (en) * | 2005-12-21 | 2012-04-10 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| ES2555803T3 (es) * | 2006-10-23 | 2016-01-08 | Cephalon, Inc. | Fusión de derivados bicíclicos 2,4-diaminopirimidina como utilizar inhibidores ALK y c-Met |
| HUE030912T2 (en) * | 2008-02-15 | 2017-06-28 | Rigel Pharmaceuticals Inc | Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases |
| MX353308B (es) * | 2008-05-21 | 2018-01-08 | Ariad Pharma Inc | Derivados fosforosos como inhibidores de cinasa. |
| JP5781943B2 (ja) * | 2009-01-21 | 2015-09-24 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 炎症性疾患、自己免疫疾患または増殖性疾患の治療に有用なｎ２−（３−ピリジルまたはフェニル）−ｎ４−（４−ピペリジル）−２，４−ピリミジンジアミン誘導体 |
| PH12012501556A1 (en) * | 2009-12-30 | 2012-10-22 | Arqule Inc | Substituted naphthalenyl-pyrimidine compounds |
| WO2012051587A1 (en) * | 2010-10-14 | 2012-04-19 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in egfr-driven cancers |
| EP3789386A1 (en) * | 2017-01-26 | 2021-03-10 | Hanmi Pharm. Co., Ltd. | Pyrimidine compound and pharmaceutical use thereof |
| MX2021010323A (es) * | 2019-03-01 | 2021-12-10 | Revolution Medicines Inc | Compuestos bicíclicos de heterociclilo y usos de este. |
| WO2021239133A1 (zh) * | 2020-05-29 | 2021-12-02 | 南京正大天晴制药有限公司 | 作为axl抑制剂的嘧啶类化合物 |
-
2022
- 2022-01-07 WO PCT/CA2022/050016 patent/WO2022147622A1/en not_active Ceased
- 2022-01-07 JP JP2023541658A patent/JP2024502175A/ja active Pending
- 2022-01-07 AU AU2022206470A patent/AU2022206470A1/en not_active Abandoned
- 2022-01-07 CA CA3204401A patent/CA3204401A1/en active Pending
- 2022-01-07 CN CN202280019578.4A patent/CN116940565A/zh active Pending
- 2022-01-07 US US18/271,103 patent/US20240092763A1/en active Pending
- 2022-01-07 EP EP22736481.7A patent/EP4277902A4/en not_active Withdrawn
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