CL2018001912A1 - Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano - Google Patents

Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano

Info

Publication number
CL2018001912A1
CL2018001912A1 CL2018001912A CL2018001912A CL2018001912A1 CL 2018001912 A1 CL2018001912 A1 CL 2018001912A1 CL 2018001912 A CL2018001912 A CL 2018001912A CL 2018001912 A CL2018001912 A CL 2018001912A CL 2018001912 A1 CL2018001912 A1 CL 2018001912A1
Authority
CL
Chile
Prior art keywords
diaza
hetero
oxo
amino
spiro
Prior art date
Application number
CL2018001912A
Other languages
English (en)
Inventor
Ingo Konetzki
Sven Kühnert
Achim Kless
Anita Wegert
Paul Ratcliffe
Ruth Jostock
Thomas Koch
Klaus Linz
Wolfgang Schröder
Klaus Schiene
René Michael Koenigs
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of CL2018001912A1 publication Critical patent/CL2018001912A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADOS DE 3-((HETERO)ARIL)-ALQUIL-8-AMINO-2-OXO-1,3-DIAZA-ESPIRO-[4.5]-DECANO, SU PREPARACIÓN Y SU USO EN MEDICAMENTOS, EN PARTICULAR EN EL TRATAMIENTO DEL DOLOR.
CL2018001912A 2016-01-13 2018-07-13 Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano CL2018001912A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16151013 2016-01-13

Publications (1)

Publication Number Publication Date
CL2018001912A1 true CL2018001912A1 (es) 2018-10-19

Family

ID=55129634

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018001912A CL2018001912A1 (es) 2016-01-13 2018-07-13 Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano

Country Status (28)

Country Link
US (6) US20170197947A1 (es)
EP (1) EP3402784B1 (es)
JP (1) JP6893517B2 (es)
KR (1) KR20180098369A (es)
CN (1) CN108602777B (es)
AR (1) AR107360A1 (es)
AU (1) AU2017206909B2 (es)
BR (1) BR112018014303B1 (es)
CA (1) CA3011177A1 (es)
CL (1) CL2018001912A1 (es)
CO (1) CO2018008444A2 (es)
CY (1) CY1122818T1 (es)
DK (1) DK3402784T3 (es)
EA (1) EA037481B1 (es)
EC (1) ECSP18060848A (es)
ES (1) ES2797904T3 (es)
HR (1) HRP20200837T1 (es)
HU (1) HUE049813T2 (es)
IL (1) IL260491B (es)
LT (1) LT3402784T (es)
MX (1) MX2018008644A (es)
PE (1) PE20181375A1 (es)
PL (1) PL3402784T3 (es)
PT (1) PT3402784T (es)
RS (1) RS60315B1 (es)
SI (1) SI3402784T1 (es)
TW (1) TWI636048B (es)
WO (1) WO2017121648A1 (es)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10793556B2 (en) 2016-01-13 2020-10-06 Gruenenthal Gmbh 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
US10807988B2 (en) 2016-01-13 2020-10-20 Grünenthal GmbH 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
US10807989B2 (en) 2016-01-13 2020-10-20 Grünenthal GmbH 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
US10829480B2 (en) 2016-01-13 2020-11-10 Gruenenthal Gmbh 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3402783T1 (sl) 2016-01-13 2020-10-30 Gruenenthal Gmbh Derivati 3-(karboksietil)-8-amino-2-okso-1,3-diaza-spiro-(4.5)-dekana
CA3098428A1 (en) 2018-04-18 2019-10-24 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
CA3100977A1 (en) 2018-05-21 2019-11-28 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2734265B1 (fr) 1995-05-17 1997-06-13 Adir Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant
MXPA03009602A (es) 2001-04-18 2004-04-02 Euro Celtique Sa Analogos de nociceptina.
DE10130020A1 (de) 2001-06-25 2003-12-04 Gruenenthal Gmbh Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
DE10210195B4 (de) 2002-03-07 2005-12-15 Schwarz Pharma Ag Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz
EP1519939B9 (en) 2002-07-05 2011-04-06 Targacept, Inc. N-aryl diazaspirocyclic compounds and methods of preparation and use thereof
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
ZA200510329B (en) 2003-05-23 2007-04-25 Zealand Pharma As Triaza-spiro compounds as nociceptin analogues and uses thereof
JO2676B1 (en) 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
EP2104665A2 (en) 2006-10-19 2009-09-30 F. Hoffmann-Roche AG Imidazolone and imidazolidinone derivatives as 11b-hsd1 inhibitors for diabetes
CN101679430B (zh) 2007-04-09 2013-12-25 詹森药业有限公司 用于治疗焦虑和抑郁症的作为orl-1受体的配体的1,3,8-三取代-1,3,8-三氮杂-螺[4.5]癸-4-酮衍生物
NZ600207A (en) * 2008-03-27 2013-09-27 Gruenenthal Chemie Substituted 4-aminocyclohexane derivatives
US8268853B2 (en) 2009-06-25 2012-09-18 Abbott Laboratories 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof
TWI582092B (zh) 2010-07-28 2017-05-11 歌林達股份有限公司 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物
US9884844B2 (en) * 2012-12-31 2018-02-06 Sunovion Pharmaceuticals, Inc. Heterocyclic compounds and methods of use thereof
EP3154971A4 (en) 2014-06-13 2017-11-01 Purdue Pharma L.P. Heterocyclic morphinan derivatives and use thereof
HUE051642T2 (hu) 2016-01-13 2021-03-01 Gruenenthal Gmbh 8-amino-2-oxo-1,3-diaza-spiro-[4,5]-dekán származékok
SI3402783T1 (sl) 2016-01-13 2020-10-30 Gruenenthal Gmbh Derivati 3-(karboksietil)-8-amino-2-okso-1,3-diaza-spiro-(4.5)-dekana
CN108602777B (zh) 2016-01-13 2022-05-03 格吕伦塔尔有限公司 3-((杂-)芳基)-烷基-8-氨基-2-氧代-1，3-氮杂-螺-[4.5]-癸烷衍生物
PL3402781T3 (pl) 2016-01-13 2020-09-21 Grünenthal GmbH Pochodne 3-((hetero-)arylo)-8-amino-2-okso-1,3-diazaspiro-[4.5]-dekanu
TWI730032B (zh) 2016-01-13 2021-06-11 美商必治妥美雅史谷比公司 作為ｒｏｃｋ抑制劑之螺庚烷水楊酸醯胺及相關化合物
HRP20220720T1 (hr) 2016-01-13 2022-09-30 Novo Nordisk A/S Analozi egf(a) s masnim kiselinama kao supstituentima
DK3402785T3 (da) 2016-01-13 2020-04-20 Gruenenthal Gmbh 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decan-derivater

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10793556B2 (en) 2016-01-13 2020-10-06 Gruenenthal Gmbh 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
US10807988B2 (en) 2016-01-13 2020-10-20 Grünenthal GmbH 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
US10807989B2 (en) 2016-01-13 2020-10-20 Grünenthal GmbH 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
US10829480B2 (en) 2016-01-13 2020-11-10 Gruenenthal Gmbh 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives

Also Published As

Publication number Publication date
BR112018014303A2 (pt) 2018-12-11
IL260491B (en) 2021-07-29
PT3402784T (pt) 2020-06-18
HUE049813T2 (hu) 2020-10-28
AU2017206909A1 (en) 2018-08-30
CY1122818T1 (el) 2021-05-05
JP6893517B2 (ja) 2021-06-23
DK3402784T3 (da) 2020-05-25
AU2017206909B2 (en) 2020-07-09
BR112018014303B1 (pt) 2023-10-03
ECSP18060848A (es) 2018-08-31
AR107360A1 (es) 2018-04-25
RS60315B1 (sr) 2020-07-31
US20170197947A1 (en) 2017-07-13
ES2797904T3 (es) 2020-12-04
EP3402784B1 (en) 2020-03-11
US20210179592A1 (en) 2021-06-17
JP2019501939A (ja) 2019-01-24
CN108602777B (zh) 2022-05-03
US10829480B2 (en) 2020-11-10
US20200399252A1 (en) 2020-12-24
WO2017121648A1 (en) 2017-07-20
PE20181375A1 (es) 2018-08-28
LT3402784T (lt) 2020-06-10
KR20180098369A (ko) 2018-09-03
EP3402784A1 (en) 2018-11-21
US20230174520A1 (en) 2023-06-08
MX2018008644A (es) 2018-11-19
US20200002319A1 (en) 2020-01-02
TWI636048B (zh) 2018-09-21
US20180327392A1 (en) 2018-11-15
EA201891609A1 (ru) 2019-01-31
TW201731822A (zh) 2017-09-16
CN108602777A (zh) 2018-09-28
CO2018008444A2 (es) 2018-08-31
EA037481B1 (ru) 2021-04-01
PL3402784T3 (pl) 2020-09-21
HRP20200837T1 (hr) 2020-08-07
CA3011177A1 (en) 2017-07-20
SI3402784T1 (sl) 2020-07-31

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