BR112018014303A2 - derivados de 3-((hetero-)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano - Google Patents

derivados de 3-((hetero-)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano

Info

Publication number
BR112018014303A2
BR112018014303A2 BR112018014303-0A BR112018014303A BR112018014303A2 BR 112018014303 A2 BR112018014303 A2 BR 112018014303A2 BR 112018014303 A BR112018014303 A BR 112018014303A BR 112018014303 A2 BR112018014303 A2 BR 112018014303A2
Authority
BR
Brazil
Prior art keywords
diaza
spiro
hetero
oxo
amino
Prior art date
Application number
BR112018014303-0A
Other languages
English (en)
Other versions
BR112018014303B1 (pt
Inventor
Kühnert Sven
Michael Koenigs René
WEGERT Anita
Ratcliffe Paul
Jostock Ruth
Koch Thomas
Linz Klaus
Schröder Wolfgang
Schiene Klaus
Kless Achim
Konetzki Ingo
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of BR112018014303A2 publication Critical patent/BR112018014303A2/pt
Publication of BR112018014303B1 publication Critical patent/BR112018014303B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

derivados de 3-((hetero-)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano a invenção se refere a derivados de 3-((hetero-)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano, sua preparação e seu uso em medicina, particularmente no tratamento de dor.
BR112018014303-0A 2016-01-13 2017-01-13 Derivados de 3-((hetero-)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano BR112018014303B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16151013 2016-01-13
EP16151013.6 2016-01-13
PCT/EP2017/025006 WO2017121648A1 (en) 2016-01-13 2017-01-13 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

Publications (2)

Publication Number Publication Date
BR112018014303A2 true BR112018014303A2 (pt) 2018-12-11
BR112018014303B1 BR112018014303B1 (pt) 2023-10-03

Family

ID=55129634

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018014303-0A BR112018014303B1 (pt) 2016-01-13 2017-01-13 Derivados de 3-((hetero-)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano

Country Status (28)

Country Link
US (6) US20170197947A1 (pt)
EP (1) EP3402784B1 (pt)
JP (1) JP6893517B2 (pt)
KR (1) KR20180098369A (pt)
CN (1) CN108602777B (pt)
AR (1) AR107360A1 (pt)
AU (1) AU2017206909B2 (pt)
BR (1) BR112018014303B1 (pt)
CA (1) CA3011177A1 (pt)
CL (1) CL2018001912A1 (pt)
CO (1) CO2018008444A2 (pt)
CY (1) CY1122818T1 (pt)
DK (1) DK3402784T3 (pt)
EA (1) EA037481B1 (pt)
EC (1) ECSP18060848A (pt)
ES (1) ES2797904T3 (pt)
HR (1) HRP20200837T1 (pt)
HU (1) HUE049813T2 (pt)
IL (1) IL260491B (pt)
LT (1) LT3402784T (pt)
MX (1) MX2018008644A (pt)
PE (1) PE20181375A1 (pt)
PL (1) PL3402784T3 (pt)
PT (1) PT3402784T (pt)
RS (1) RS60315B1 (pt)
SI (1) SI3402784T1 (pt)
TW (1) TWI636048B (pt)
WO (1) WO2017121648A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017207467B2 (en) 2016-01-13 2020-07-16 Grünenthal GmbH 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
PL3402781T3 (pl) 2016-01-13 2020-09-21 Grünenthal GmbH Pochodne 3-((hetero-)arylo)-8-amino-2-okso-1,3-diazaspiro-[4.5]-dekanu
JP6854823B2 (ja) 2016-01-13 2021-04-07 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ３−（カルボキシメチル）−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体
TWI654181B (zh) 2016-01-13 2019-03-21 歌林達有限公司 ８－胺基－２－側氧基－１，３－二氮－螺－［４．５］－癸烷衍生物
ES2797904T3 (es) 2016-01-13 2020-12-04 Gruenenthal Gmbh Derivados de 3-((hetero)aril)alquil-8-amino-2-oxo-1,3-diazaespiro-[4.5]-decano
BR112020021194A2 (pt) 2018-04-18 2021-03-23 Constallation Pharmaceuticals, Inc. moduladores de enzimas modificadoras de metila, composições e usos dos mesmos
CN112262143A (zh) 2018-05-21 2021-01-22 星座制药公司 甲基修饰酶的调节剂、其组合物和用途

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FR2734265B1 (fr) 1995-05-17 1997-06-13 Adir Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant
MXPA03009602A (es) 2001-04-18 2004-04-02 Euro Celtique Sa Analogos de nociceptina.
DE10130020A1 (de) 2001-06-25 2003-12-04 Gruenenthal Gmbh Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
DE10210195B4 (de) 2002-03-07 2005-12-15 Schwarz Pharma Ag Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz
NZ537214A (en) 2002-07-05 2007-08-31 Targacept Inc N-Aryl diazaspiracyclic compounds capable of affecting nicotinic cholinergic receptors and methods of preparation and use thereof
DE10252667A1 (de) 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
EP1628978A2 (en) 2003-05-23 2006-03-01 Zealand Pharma A/S Triaza-spiro compounds as nociceptin analogues and uses thereof
JO2676B1 (en) 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
MX2009003939A (es) 2006-10-19 2009-05-11 Hoffmann La Roche Derivados de imidazolona e imidazolidinona como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa de tipo 1 para diabetes.
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ES2663398T3 (es) * 2008-03-27 2018-04-12 Grünenthal GmbH Derivados de 4-aminociclohexano sustituidos
WO2010151815A2 (en) 2009-06-25 2010-12-29 Abbott Laboratories 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof
TWI582092B (zh) 2010-07-28 2017-05-11 歌林達股份有限公司 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物
US9884844B2 (en) * 2012-12-31 2018-02-06 Sunovion Pharmaceuticals, Inc. Heterocyclic compounds and methods of use thereof
JP2017521488A (ja) 2014-06-13 2017-08-03 パーデュー、ファーマ、リミテッド、パートナーシップ 複素環式モルフィナン誘導体及びその使用
JP6854823B2 (ja) 2016-01-13 2021-04-07 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ３−（カルボキシメチル）−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体
TWI654181B (zh) 2016-01-13 2019-03-21 歌林達有限公司 ８－胺基－２－側氧基－１，３－二氮－螺－［４．５］－癸烷衍生物
BR112018013820A2 (pt) 2016-01-13 2018-12-11 Novo Nordisk A/S análogos de egf(a) com substituintes de ácido graxo
PL3402781T3 (pl) 2016-01-13 2020-09-21 Grünenthal GmbH Pochodne 3-((hetero-)arylo)-8-amino-2-okso-1,3-diazaspiro-[4.5]-dekanu
AR107354A1 (es) 2016-01-13 2018-04-18 Bristol Myers Squibb Co Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock
AU2017207467B2 (en) 2016-01-13 2020-07-16 Grünenthal GmbH 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
ES2797904T3 (es) 2016-01-13 2020-12-04 Gruenenthal Gmbh Derivados de 3-((hetero)aril)alquil-8-amino-2-oxo-1,3-diazaespiro-[4.5]-decano

Also Published As

Publication number Publication date
CY1122818T1 (el) 2021-05-05
US20210179592A1 (en) 2021-06-17
CN108602777A (zh) 2018-09-28
CO2018008444A2 (es) 2018-08-31
HRP20200837T1 (hr) 2020-08-07
EA037481B1 (ru) 2021-04-01
CL2018001912A1 (es) 2018-10-19
AR107360A1 (es) 2018-04-25
US20170197947A1 (en) 2017-07-13
PL3402784T3 (pl) 2020-09-21
AU2017206909B2 (en) 2020-07-09
US20200399252A1 (en) 2020-12-24
CA3011177A1 (en) 2017-07-20
US20230174520A1 (en) 2023-06-08
EA201891609A1 (ru) 2019-01-31
US20180327392A1 (en) 2018-11-15
MX2018008644A (es) 2018-11-19
TW201731822A (zh) 2017-09-16
EP3402784A1 (en) 2018-11-21
PE20181375A1 (es) 2018-08-28
JP6893517B2 (ja) 2021-06-23
AU2017206909A1 (en) 2018-08-30
TWI636048B (zh) 2018-09-21
IL260491B (en) 2021-07-29
PT3402784T (pt) 2020-06-18
WO2017121648A1 (en) 2017-07-20
LT3402784T (lt) 2020-06-10
ES2797904T3 (es) 2020-12-04
BR112018014303B1 (pt) 2023-10-03
DK3402784T3 (da) 2020-05-25
EP3402784B1 (en) 2020-03-11
JP2019501939A (ja) 2019-01-24
HUE049813T2 (hu) 2020-10-28
ECSP18060848A (es) 2018-08-31
CN108602777B (zh) 2022-05-03
KR20180098369A (ko) 2018-09-03
US20200002319A1 (en) 2020-01-02
US10829480B2 (en) 2020-11-10
RS60315B1 (sr) 2020-07-31
SI3402784T1 (sl) 2020-07-31

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/01/2017, OBSERVADAS AS CONDICOES LEGAIS