EA201891609A1 - Производные 3-((гетеро-)арил)алкил-8-амино-2-оксо-1,3-диазаспиро[4.5]декана - Google Patents

Производные 3-((гетеро-)арил)алкил-8-амино-2-оксо-1,3-диазаспиро[4.5]декана

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Publication number
EA201891609A1
EA201891609A1 EA201891609A EA201891609A EA201891609A1 EA 201891609 A1 EA201891609 A1 EA 201891609A1 EA 201891609 A EA201891609 A EA 201891609A EA 201891609 A EA201891609 A EA 201891609A EA 201891609 A1 EA201891609 A1 EA 201891609A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diazaspiro
hetero
oxo
aryl
amino
Prior art date
Application number
EA201891609A
Other languages
English (en)
Other versions
EA037481B1 (ru
Inventor
Свен Кюнерт
Рене Михаэль Кёнигс
Ахим Клесс
Анита Вегерт
Пол Рэтклифф
Рут Йосток
Томас КОХ
Клаус Линц
Вольфганг Шрёдер
Клаус Шине
Инго Конетцки
Original Assignee
Грюненталь Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of EA201891609A1 publication Critical patent/EA201891609A1/ru
Publication of EA037481B1 publication Critical patent/EA037481B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Данное изобретение относится к производным 3-((гетеро-)арил)алкил-8-амино-2-оксо-1,3-диазаспиро[4.5]декана, их получению и применению в медицине, в частности при лечении боли.
EA201891609A 2016-01-13 2017-01-13 Производные 3-((гетеро-)арил)алкил-8-амино-2-оксо-1,3-диазаспиро[4.5]декана EA037481B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16151013 2016-01-13
PCT/EP2017/025006 WO2017121648A1 (en) 2016-01-13 2017-01-13 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

Publications (2)

Publication Number Publication Date
EA201891609A1 true EA201891609A1 (ru) 2019-01-31
EA037481B1 EA037481B1 (ru) 2021-04-01

Family

ID=55129634

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891609A EA037481B1 (ru) 2016-01-13 2017-01-13 Производные 3-((гетеро-)арил)алкил-8-амино-2-оксо-1,3-диазаспиро[4.5]декана

Country Status (28)

Country Link
US (6) US20170197947A1 (ru)
EP (1) EP3402784B1 (ru)
JP (1) JP6893517B2 (ru)
KR (1) KR20180098369A (ru)
CN (1) CN108602777B (ru)
AR (1) AR107360A1 (ru)
AU (1) AU2017206909B2 (ru)
BR (1) BR112018014303B1 (ru)
CA (1) CA3011177A1 (ru)
CL (1) CL2018001912A1 (ru)
CO (1) CO2018008444A2 (ru)
CY (1) CY1122818T1 (ru)
DK (1) DK3402784T3 (ru)
EA (1) EA037481B1 (ru)
EC (1) ECSP18060848A (ru)
ES (1) ES2797904T3 (ru)
HR (1) HRP20200837T1 (ru)
HU (1) HUE049813T2 (ru)
IL (1) IL260491B (ru)
LT (1) LT3402784T (ru)
MX (1) MX2018008644A (ru)
PE (1) PE20181375A1 (ru)
PL (1) PL3402784T3 (ru)
PT (1) PT3402784T (ru)
RS (1) RS60315B1 (ru)
SI (1) SI3402784T1 (ru)
TW (1) TWI636048B (ru)
WO (1) WO2017121648A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3402781T3 (pl) 2016-01-13 2020-09-21 Grünenthal GmbH Pochodne 3-((hetero-)arylo)-8-amino-2-okso-1,3-diazaspiro-[4.5]-dekanu
DK3402785T3 (da) 2016-01-13 2020-04-20 Gruenenthal Gmbh 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decan-derivater
CN108602777B (zh) 2016-01-13 2022-05-03 格吕伦塔尔有限公司 3-((杂-)芳基)-烷基-8-氨基-2-氧代-1，3-氮杂-螺-[4.5]-癸烷衍生物
SI3402783T1 (sl) 2016-01-13 2020-10-30 Gruenenthal Gmbh Derivati 3-(karboksietil)-8-amino-2-okso-1,3-diaza-spiro-(4.5)-dekana
HUE051642T2 (hu) 2016-01-13 2021-03-01 Gruenenthal Gmbh 8-amino-2-oxo-1,3-diaza-spiro-[4,5]-dekán származékok
CA3098428A1 (en) 2018-04-18 2019-10-24 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
CA3100977A1 (en) 2018-05-21 2019-11-28 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof

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FR2734265B1 (fr) 1995-05-17 1997-06-13 Adir Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant
MXPA03009602A (es) 2001-04-18 2004-04-02 Euro Celtique Sa Analogos de nociceptina.
DE10130020A1 (de) 2001-06-25 2003-12-04 Gruenenthal Gmbh Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
DE10210195B4 (de) 2002-03-07 2005-12-15 Schwarz Pharma Ag Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz
EP1519939B9 (en) 2002-07-05 2011-04-06 Targacept, Inc. N-aryl diazaspirocyclic compounds and methods of preparation and use thereof
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
ZA200510329B (en) 2003-05-23 2007-04-25 Zealand Pharma As Triaza-spiro compounds as nociceptin analogues and uses thereof
JO2676B1 (en) 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
EP2104665A2 (en) 2006-10-19 2009-09-30 F. Hoffmann-Roche AG Imidazolone and imidazolidinone derivatives as 11b-hsd1 inhibitors for diabetes
CN101679430B (zh) 2007-04-09 2013-12-25 詹森药业有限公司 用于治疗焦虑和抑郁症的作为orl-1受体的配体的1,3,8-三取代-1,3,8-三氮杂-螺[4.5]癸-4-酮衍生物
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EP3154971A4 (en) 2014-06-13 2017-11-01 Purdue Pharma L.P. Heterocyclic morphinan derivatives and use thereof
HUE051642T2 (hu) 2016-01-13 2021-03-01 Gruenenthal Gmbh 8-amino-2-oxo-1,3-diaza-spiro-[4,5]-dekán származékok
SI3402783T1 (sl) 2016-01-13 2020-10-30 Gruenenthal Gmbh Derivati 3-(karboksietil)-8-amino-2-okso-1,3-diaza-spiro-(4.5)-dekana
CN108602777B (zh) 2016-01-13 2022-05-03 格吕伦塔尔有限公司 3-((杂-)芳基)-烷基-8-氨基-2-氧代-1，3-氮杂-螺-[4.5]-癸烷衍生物
PL3402781T3 (pl) 2016-01-13 2020-09-21 Grünenthal GmbH Pochodne 3-((hetero-)arylo)-8-amino-2-okso-1,3-diazaspiro-[4.5]-dekanu
TWI730032B (zh) 2016-01-13 2021-06-11 美商必治妥美雅史谷比公司 作為ｒｏｃｋ抑制劑之螺庚烷水楊酸醯胺及相關化合物
HRP20220720T1 (hr) 2016-01-13 2022-09-30 Novo Nordisk A/S Analozi egf(a) s masnim kiselinama kao supstituentima
DK3402785T3 (da) 2016-01-13 2020-04-20 Gruenenthal Gmbh 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decan-derivater

Also Published As

Publication number Publication date
BR112018014303A2 (pt) 2018-12-11
IL260491B (en) 2021-07-29
PT3402784T (pt) 2020-06-18
HUE049813T2 (hu) 2020-10-28
AU2017206909A1 (en) 2018-08-30
CL2018001912A1 (es) 2018-10-19
CY1122818T1 (el) 2021-05-05
JP6893517B2 (ja) 2021-06-23
DK3402784T3 (da) 2020-05-25
AU2017206909B2 (en) 2020-07-09
BR112018014303B1 (pt) 2023-10-03
ECSP18060848A (es) 2018-08-31
AR107360A1 (es) 2018-04-25
RS60315B1 (sr) 2020-07-31
US20170197947A1 (en) 2017-07-13
ES2797904T3 (es) 2020-12-04
EP3402784B1 (en) 2020-03-11
US20210179592A1 (en) 2021-06-17
JP2019501939A (ja) 2019-01-24
CN108602777B (zh) 2022-05-03
US10829480B2 (en) 2020-11-10
US20200399252A1 (en) 2020-12-24
WO2017121648A1 (en) 2017-07-20
PE20181375A1 (es) 2018-08-28
LT3402784T (lt) 2020-06-10
KR20180098369A (ko) 2018-09-03
EP3402784A1 (en) 2018-11-21
US20230174520A1 (en) 2023-06-08
MX2018008644A (es) 2018-11-19
US20200002319A1 (en) 2020-01-02
TWI636048B (zh) 2018-09-21
US20180327392A1 (en) 2018-11-15
TW201731822A (zh) 2017-09-16
CN108602777A (zh) 2018-09-28
CO2018008444A2 (es) 2018-08-31
EA037481B1 (ru) 2021-04-01
PL3402784T3 (pl) 2020-09-21
HRP20200837T1 (hr) 2020-08-07
CA3011177A1 (en) 2017-07-20
SI3402784T1 (sl) 2020-07-31

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