EA202190281A1 - Производные 3-((гетеро-)арил)-8-амино-2-оксо-1,3-диаза-спиро[4,5]декана - Google Patents

Производные 3-((гетеро-)арил)-8-амино-2-оксо-1,3-диаза-спиро[4,5]декана

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Publication number
EA202190281A1
EA202190281A1 EA202190281A EA202190281A EA202190281A1 EA 202190281 A1 EA202190281 A1 EA 202190281A1 EA 202190281 A EA202190281 A EA 202190281A EA 202190281 A EA202190281 A EA 202190281A EA 202190281 A1 EA202190281 A1 EA 202190281A1
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EA
Eurasian Patent Office
Prior art keywords
diaza
decane
spiro
hetero
oxo
Prior art date
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EA202190281A
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English (en)
Inventor
Свен Кюнерт
Рене Михаэль Кёнигс
Ахим Клесс
Анита Вегерт
Инго Конетцки
Пол Рэтклифф
Рут Йосток
Томас КОХ
Клаус Линц
Вольфганг Шрёдер
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Грюненталь Гмбх
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Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of EA202190281A1 publication Critical patent/EA202190281A1/ru

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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

Изобретение относится к производным 3-((гетеро-)арил)-8-амино-2-оксо-1,3-диаза-спиро[4,5]декана, их получению и их применению в медицине, особенно при лечении боли.
EA202190281A 2016-01-13 2017-01-13 Производные 3-((гетеро-)арил)-8-амино-2-оксо-1,3-диаза-спиро[4,5]декана EA202190281A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16151012 2016-01-13

Publications (1)

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EA202190281A1 true EA202190281A1 (ru) 2021-09-01

Family

ID=55129633

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EA201891611A EA037598B1 (ru) 2016-01-13 2017-01-13 Производные 3-((гетеро-)арил)-8-амино-2-оксо-1,3-диазаспиро[4,5]декана
EA202190281A EA202190281A1 (ru) 2016-01-13 2017-01-13 Производные 3-((гетеро-)арил)-8-амино-2-оксо-1,3-диаза-спиро[4,5]декана

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EA201891611A EA037598B1 (ru) 2016-01-13 2017-01-13 Производные 3-((гетеро-)арил)-8-амино-2-оксо-1,3-диазаспиро[4,5]декана

Country Status (30)

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US (7) US20170197970A1 (ru)
EP (2) EP3402781B1 (ru)
JP (2) JP6893516B2 (ru)
KR (1) KR20180097732A (ru)
CN (2) CN114149413A (ru)
AR (2) AR107434A1 (ru)
AU (1) AU2017206908B2 (ru)
BR (1) BR112018014305B1 (ru)
CA (1) CA3011176C (ru)
CL (1) CL2018001911A1 (ru)
CO (1) CO2018008447A2 (ru)
CY (1) CY1122923T1 (ru)
DK (1) DK3402781T5 (ru)
EA (2) EA037598B1 (ru)
EC (1) ECSP18060834A (ru)
ES (1) ES2807549T3 (ru)
HR (1) HRP20200782T1 (ru)
HU (1) HUE049771T2 (ru)
IL (2) IL260496B (ru)
LT (1) LT3402781T (ru)
MX (1) MX2018008643A (ru)
NZ (1) NZ745185A (ru)
PE (1) PE20221732A1 (ru)
PL (1) PL3402781T3 (ru)
PT (1) PT3402781T (ru)
RS (1) RS60307B1 (ru)
SI (1) SI3402781T1 (ru)
TW (1) TWI635082B (ru)
WO (1) WO2017121647A1 (ru)
ZA (1) ZA201805356B (ru)

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