EA201891612A1 - Производные 3-(карбоксиметил)-8-амино-2-оксо-1,3-диазаспиро[4.5]декана - Google Patents

Производные 3-(карбоксиметил)-8-амино-2-оксо-1,3-диазаспиро[4.5]декана

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Publication number
EA201891612A1
EA201891612A1 EA201891612A EA201891612A EA201891612A1 EA 201891612 A1 EA201891612 A1 EA 201891612A1 EA 201891612 A EA201891612 A EA 201891612A EA 201891612 A EA201891612 A EA 201891612A EA 201891612 A1 EA201891612 A1 EA 201891612A1
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EA
Eurasian Patent Office
Prior art keywords
diazaspiro
carboxymethyl
oxo
derivatives
amino
Prior art date
Application number
EA201891612A
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English (en)
Other versions
EA034904B1 (ru
Inventor
Свен Кюнерт
Рене Михаэль Кёнигс
Флориан Якоб
Ахим Клесс
Пол Рэтклифф
Рут Йосток
Томас КОХ
Клаус Линц
Вольфганг Шрёдер
Клаус Шине
Анита Вегерт
Original Assignee
Грюненталь Гмбх
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Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of EA201891612A1 publication Critical patent/EA201891612A1/ru
Publication of EA034904B1 publication Critical patent/EA034904B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Abstract

Данное изобретение относится к производным 3-(карбоксиметил)-8-амино-2-оксо-1,3-диазаспиро[4.5]декана, их получению и их применению в медицине, в частности при лечении боли.
EA201891612A 2016-01-13 2017-01-13 Производные 3-(карбоксиметил)-8-амино-2-оксо-1,3-диазаспиро-[4.5]-декана EA034904B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16151014 2016-01-13
PCT/EP2017/025007 WO2017121649A1 (en) 2016-01-13 2017-01-13 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

Publications (2)

Publication Number Publication Date
EA201891612A1 true EA201891612A1 (ru) 2019-01-31
EA034904B1 EA034904B1 (ru) 2020-04-03

Family

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EA201891612A EA034904B1 (ru) 2016-01-13 2017-01-13 Производные 3-(карбоксиметил)-8-амино-2-оксо-1,3-диазаспиро-[4.5]-декана

Country Status (29)

Country Link
US (7) US20170197971A1 (ru)
EP (1) EP3402785B1 (ru)
JP (1) JP6854823B2 (ru)
KR (1) KR20180097733A (ru)
CN (1) CN108779075B (ru)
AR (1) AR107358A1 (ru)
AU (1) AU2017206910B2 (ru)
BR (1) BR112018014296B1 (ru)
CA (1) CA3011180A1 (ru)
CL (1) CL2018001910A1 (ru)
CO (1) CO2018008449A2 (ru)
CY (1) CY1122892T1 (ru)
DK (1) DK3402785T3 (ru)
EA (1) EA034904B1 (ru)
EC (1) ECSP18060864A (ru)
ES (1) ES2793384T3 (ru)
HR (1) HRP20200809T1 (ru)
HU (1) HUE049134T2 (ru)
IL (1) IL260497B (ru)
LT (1) LT3402785T (ru)
MX (1) MX2018008646A (ru)
NZ (1) NZ745184A (ru)
PL (1) PL3402785T3 (ru)
PT (1) PT3402785T (ru)
RS (1) RS60224B1 (ru)
SI (1) SI3402785T1 (ru)
TW (1) TWI640514B (ru)
WO (1) WO2017121649A1 (ru)
ZA (1) ZA201805358B (ru)

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AU2017207467B2 (en) 2016-01-13 2020-07-16 Grünenthal GmbH 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
PL3402781T3 (pl) 2016-01-13 2020-09-21 Grünenthal GmbH Pochodne 3-((hetero-)arylo)-8-amino-2-okso-1,3-diazaspiro-[4.5]-dekanu
JP6854823B2 (ja) 2016-01-13 2021-04-07 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ３−（カルボキシメチル）−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体
TWI654181B (zh) 2016-01-13 2019-03-21 歌林達有限公司 ８－胺基－２－側氧基－１，３－二氮－螺－［４．５］－癸烷衍生物
ES2797904T3 (es) 2016-01-13 2020-12-04 Gruenenthal Gmbh Derivados de 3-((hetero)aril)alquil-8-amino-2-oxo-1,3-diazaespiro-[4.5]-decano
WO2019039855A2 (ko) 2017-08-22 2019-02-28 주식회사 엘지화학 방열 소재의 혼합 방법

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TWI654181B (zh) 2016-01-13 2019-03-21 歌林達有限公司 ８－胺基－２－側氧基－１，３－二氮－螺－［４．５］－癸烷衍生物
JP6854823B2 (ja) 2016-01-13 2021-04-07 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ３−（カルボキシメチル）−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体
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PL3402781T3 (pl) 2016-01-13 2020-09-21 Grünenthal GmbH Pochodne 3-((hetero-)arylo)-8-amino-2-okso-1,3-diazaspiro-[4.5]-dekanu
AR107354A1 (es) 2016-01-13 2018-04-18 Bristol Myers Squibb Co Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock
AU2017207467B2 (en) 2016-01-13 2020-07-16 Grünenthal GmbH 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
ES2797904T3 (es) 2016-01-13 2020-12-04 Gruenenthal Gmbh Derivados de 3-((hetero)aril)alquil-8-amino-2-oxo-1,3-diazaespiro-[4.5]-decano

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TWI640514B (zh) 2018-11-11
US20190382407A1 (en) 2019-12-19
ZA201805358B (en) 2024-03-27
RS60224B1 (sr) 2020-06-30
CN108779075A (zh) 2018-11-09
US20170197971A1 (en) 2017-07-13
JP2019501940A (ja) 2019-01-24
BR112018014296B1 (pt) 2023-10-31
AU2017206910A1 (en) 2018-08-30
CO2018008449A2 (es) 2018-09-10
US20190106430A1 (en) 2019-04-11
HUE049134T2 (hu) 2020-08-28
BR112018014296A2 (pt) 2019-01-22
SI3402785T1 (sl) 2020-07-31
US20200399280A1 (en) 2020-12-24
IL260497B (en) 2020-08-31
WO2017121649A1 (en) 2017-07-20
AU2017206910B2 (en) 2020-07-16
EP3402785A1 (en) 2018-11-21
PT3402785T (pt) 2020-05-15
DK3402785T3 (da) 2020-04-20
NZ745184A (en) 2024-03-22
AR107358A1 (es) 2018-04-25
CL2018001910A1 (es) 2018-10-19
US20210179627A1 (en) 2021-06-17
CA3011180A1 (en) 2017-07-20
US10807989B2 (en) 2020-10-20
HRP20200809T1 (hr) 2020-08-07
ES2793384T3 (es) 2020-11-13
MX2018008646A (es) 2018-11-19
JP6854823B2 (ja) 2021-04-07
US20230174540A1 (en) 2023-06-08
CN108779075B (zh) 2022-01-11
LT3402785T (lt) 2020-04-10
EP3402785B1 (en) 2020-02-26
KR20180097733A (ko) 2018-08-31
CY1122892T1 (el) 2021-10-29
EA034904B1 (ru) 2020-04-03
ECSP18060864A (es) 2018-08-31
TW201731823A (zh) 2017-09-16
US20180282341A1 (en) 2018-10-04
PL3402785T3 (pl) 2020-07-27

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