EA201990915A1 - Новые модуляторы 5-гидрокситриптаминового рецептора 7 и способ их применения - Google Patents

Новые модуляторы 5-гидрокситриптаминового рецептора 7 и способ их применения

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Publication number
EA201990915A1
EA201990915A1 EA201990915A EA201990915A EA201990915A1 EA 201990915 A1 EA201990915 A1 EA 201990915A1 EA 201990915 A EA201990915 A EA 201990915A EA 201990915 A EA201990915 A EA 201990915A EA 201990915 A1 EA201990915 A1 EA 201990915A1
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Eurasian Patent Office
Prior art keywords
receptor
hydroxytriptamine
application
new modulators
modulators
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EA201990915A
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English (en)
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Фармацевтические композиции по настоящему изобретению содержат функционализированные производные лактона, обладающие изменяющим течение заболевания действием при лечении заболеваний, ассоциированных с нарушением регуляции активности 5-гидрокситриптаминового рецептора 7.
EA201990915A 2016-11-15 2017-11-15 Новые модуляторы 5-гидрокситриптаминового рецептора 7 и способ их применения EA201990915A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662422344P 2016-11-15 2016-11-15
PCT/US2017/061677 WO2018093818A1 (en) 2016-11-15 2017-11-15 Novel modulators of the 5-hydroxytryptamine receptor 7 and their method of use

Publications (1)

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EA201990915A1 true EA201990915A1 (ru) 2019-11-29

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US (3) US10858368B2 (ru)
EP (1) EP3541790A4 (ru)
JP (2) JP7107955B2 (ru)
KR (2) KR20230148384A (ru)
CN (1) CN110177776A (ru)
AU (2) AU2017361078B2 (ru)
BR (1) BR112019009908A2 (ru)
CA (1) CA3043319A1 (ru)
CL (1) CL2019001329A1 (ru)
EA (1) EA201990915A1 (ru)
IL (3) IL291029B2 (ru)
MX (2) MX2019005603A (ru)
UA (1) UA125631C2 (ru)
WO (1) WO2018093818A1 (ru)
ZA (1) ZA202105774B (ru)

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EP3738955A1 (en) 2013-03-11 2020-11-18 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
US10544117B2 (en) * 2014-09-10 2020-01-28 Temple University—Of the Commonwealth System of Higher Education 5-hydroxytryptamine receptor 7 activity modulators and their method of use
AU2017361078B2 (en) 2016-11-15 2022-01-06 Praeventix, Llc Novel modulators of the 5-hydroxytryptamine receptor 7 and their method of use
JP7365237B2 (ja) * 2017-03-21 2023-10-19 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション シグマ－２受容体の新規調節物質およびその使用方法
JP7365238B2 (ja) * 2017-03-21 2023-10-19 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション ５－ヒドロキシトリプタミン受容体７調節物質および治療剤としてのその使用
CN114945575A (zh) * 2019-11-13 2022-08-26 英联邦高等教育系统坦普尔大学 作为5-羟色胺受体7调节剂的新型官能化内酯及其使用方法
MX2022005820A (es) * 2019-11-13 2022-08-16 Univ Temple Nuevas lactamas funcionalizadas como moduladores del receptor 7 de 5-hidroxitriptamina y su método de uso.
TW202328148A (zh) * 2021-09-22 2023-07-16 日商塩野義製藥股份有限公司 具有血清素受體結合活性之螺雜環衍生物

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