ECSP18060864A - Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]- decano - Google Patents
Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]- decanoInfo
- Publication number
- ECSP18060864A ECSP18060864A ECSENADI201860864A ECDI201860864A ECSP18060864A EC SP18060864 A ECSP18060864 A EC SP18060864A EC SENADI201860864 A ECSENADI201860864 A EC SENADI201860864A EC DI201860864 A ECDI201860864 A EC DI201860864A EC SP18060864 A ECSP18060864 A EC SP18060864A
- Authority
- EC
- Ecuador
- Prior art keywords
- diaza
- decane
- spiro
- oxo
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
Abstract
Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano, su preparación y su uso en medicamentos, en particular en el tratamiento del dolor.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16151014 | 2016-01-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP18060864A true ECSP18060864A (es) | 2018-08-31 |
Family
ID=55129635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSENADI201860864A ECSP18060864A (es) | 2016-01-13 | 2018-08-13 | Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]- decano |
Country Status (29)
Country | Link |
---|---|
US (7) | US20170197971A1 (es) |
EP (1) | EP3402785B1 (es) |
JP (1) | JP6854823B2 (es) |
KR (1) | KR20180097733A (es) |
CN (1) | CN108779075B (es) |
AR (1) | AR107358A1 (es) |
AU (1) | AU2017206910B2 (es) |
BR (1) | BR112018014296B1 (es) |
CA (1) | CA3011180A1 (es) |
CL (1) | CL2018001910A1 (es) |
CO (1) | CO2018008449A2 (es) |
CY (1) | CY1122892T1 (es) |
DK (1) | DK3402785T3 (es) |
EA (1) | EA034904B1 (es) |
EC (1) | ECSP18060864A (es) |
ES (1) | ES2793384T3 (es) |
HR (1) | HRP20200809T1 (es) |
HU (1) | HUE049134T2 (es) |
IL (1) | IL260497B (es) |
LT (1) | LT3402785T (es) |
MX (1) | MX2018008646A (es) |
NZ (1) | NZ745184A (es) |
PL (1) | PL3402785T3 (es) |
PT (1) | PT3402785T (es) |
RS (1) | RS60224B1 (es) |
SI (1) | SI3402785T1 (es) |
TW (1) | TWI640514B (es) |
WO (1) | WO2017121649A1 (es) |
ZA (1) | ZA201805358B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017121650A1 (en) | 2016-01-13 | 2017-07-20 | Grünenthal GmbH | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
CA3011180A1 (en) | 2016-01-13 | 2017-07-20 | Grunenthal Gmbh | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
RS60223B1 (sr) | 2016-01-13 | 2020-06-30 | Gruenenthal Gmbh | Derivati 3-(karboksietil)-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana |
EP3402784B1 (en) | 2016-01-13 | 2020-03-11 | Grünenthal GmbH | 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
EA037598B1 (ru) | 2016-01-13 | 2021-04-20 | Грюненталь Гмбх | Производные 3-((гетеро-)арил)-8-амино-2-оксо-1,3-диазаспиро[4,5]декана |
WO2019039855A2 (ko) | 2017-08-22 | 2019-02-28 | 주식회사 엘지화학 | 방열 소재의 혼합 방법 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2734265B1 (fr) | 1995-05-17 | 1997-06-13 | Adir | Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant |
KR100729242B1 (ko) | 2001-04-18 | 2007-06-15 | 유로-셀티크 소시에떼 아노뉨 | 노시셉틴 유사체 |
DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
DE10210195B4 (de) | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
DE60330456D1 (de) | 2002-07-05 | 2010-01-21 | Targacept Inc | N-aryl diazaspirozyklische verbindungen, deren verwendung und das verfahren zu ihren herstellung |
DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
EP1628978A2 (en) | 2003-05-23 | 2006-03-01 | Zealand Pharma A/S | Triaza-spiro compounds as nociceptin analogues and uses thereof |
JO2676B1 (en) | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
DE102005023784A1 (de) | 2005-05-19 | 2006-11-30 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
DE102005044813A1 (de) | 2005-05-19 | 2007-10-04 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
DE102005030051A1 (de) | 2005-06-27 | 2006-12-28 | Grünenthal GmbH | Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
DE102006019597A1 (de) | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
CA2666489C (en) | 2006-10-19 | 2012-10-02 | F. Hoffmann-La Roche Ag | Imidazolone and imidazolidinone derivatives as 11b-hsd1 inhibitors for diabetes |
WO2008124209A1 (en) | 2007-04-09 | 2008-10-16 | Janssen Pharmaceutica, N.V. | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression |
CN102046595B (zh) | 2008-03-27 | 2014-03-05 | 格吕伦塔尔有限公司 | 取代的4-氨基环己烷衍生物 |
TW201038572A (en) | 2009-03-25 | 2010-11-01 | Gruenenthal Gmbh | Substituted spiro-amide compounds |
WO2010151815A2 (en) | 2009-06-25 | 2010-12-29 | Abbott Laboratories | 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof |
TWI582092B (zh) * | 2010-07-28 | 2017-05-11 | 歌林達股份有限公司 | 順式-四氫-螺旋(環己烷-1,1’-吡啶[3,4-b]吲哚)-4-胺-衍生物 |
EP3154971A4 (en) * | 2014-06-13 | 2017-11-01 | Purdue Pharma L.P. | Heterocyclic morphinan derivatives and use thereof |
AR107354A1 (es) | 2016-01-13 | 2018-04-18 | Bristol Myers Squibb Co | Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock |
RS60223B1 (sr) | 2016-01-13 | 2020-06-30 | Gruenenthal Gmbh | Derivati 3-(karboksietil)-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana |
KR102417487B1 (ko) | 2016-01-13 | 2022-07-06 | 노보 노르디스크 에이/에스 | 지방산 치환기를 가진 egf(a) 유사체 |
CA3011180A1 (en) | 2016-01-13 | 2017-07-20 | Grunenthal Gmbh | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
EP3402784B1 (en) | 2016-01-13 | 2020-03-11 | Grünenthal GmbH | 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
WO2017121650A1 (en) | 2016-01-13 | 2017-07-20 | Grünenthal GmbH | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
EA037598B1 (ru) | 2016-01-13 | 2021-04-20 | Грюненталь Гмбх | Производные 3-((гетеро-)арил)-8-амино-2-оксо-1,3-диазаспиро[4,5]декана |
-
2017
- 2017-01-13 CA CA3011180A patent/CA3011180A1/en active Pending
- 2017-01-13 BR BR112018014296-4A patent/BR112018014296B1/pt active IP Right Grant
- 2017-01-13 EA EA201891612A patent/EA034904B1/ru not_active IP Right Cessation
- 2017-01-13 LT LTEP17702003.9T patent/LT3402785T/lt unknown
- 2017-01-13 ES ES17702003T patent/ES2793384T3/es active Active
- 2017-01-13 NZ NZ745184A patent/NZ745184A/en unknown
- 2017-01-13 MX MX2018008646A patent/MX2018008646A/es unknown
- 2017-01-13 CN CN201780006526.2A patent/CN108779075B/zh active Active
- 2017-01-13 PL PL17702003T patent/PL3402785T3/pl unknown
- 2017-01-13 AR ARP170100093A patent/AR107358A1/es unknown
- 2017-01-13 DK DK17702003.9T patent/DK3402785T3/da active
- 2017-01-13 RS RS20200532A patent/RS60224B1/sr unknown
- 2017-01-13 TW TW106101126A patent/TWI640514B/zh active
- 2017-01-13 EP EP17702003.9A patent/EP3402785B1/en active Active
- 2017-01-13 SI SI201730265T patent/SI3402785T1/sl unknown
- 2017-01-13 AU AU2017206910A patent/AU2017206910B2/en active Active
- 2017-01-13 HU HUE17702003A patent/HUE049134T2/hu unknown
- 2017-01-13 KR KR1020187021555A patent/KR20180097733A/ko not_active Application Discontinuation
- 2017-01-13 US US15/405,919 patent/US20170197971A1/en not_active Abandoned
- 2017-01-13 WO PCT/EP2017/025007 patent/WO2017121649A1/en active Application Filing
- 2017-01-13 PT PT177020039T patent/PT3402785T/pt unknown
- 2017-01-13 JP JP2018536503A patent/JP6854823B2/ja active Active
-
2018
- 2018-05-15 US US15/980,181 patent/US20180282341A1/en not_active Abandoned
- 2018-07-09 IL IL260497A patent/IL260497B/en active IP Right Grant
- 2018-07-13 CL CL2018001910A patent/CL2018001910A1/es unknown
- 2018-08-10 ZA ZA2018/05358A patent/ZA201805358B/en unknown
- 2018-08-13 EC ECSENADI201860864A patent/ECSP18060864A/es unknown
- 2018-08-13 CO CONC2018/0008449A patent/CO2018008449A2/es unknown
- 2018-12-07 US US16/212,723 patent/US20190106430A1/en not_active Abandoned
-
2019
- 2019-06-27 US US16/454,489 patent/US10807989B2/en active Active
-
2020
- 2020-05-11 CY CY20201100430T patent/CY1122892T1/el unknown
- 2020-05-18 HR HRP20200809TT patent/HRP20200809T1/hr unknown
- 2020-08-31 US US17/007,557 patent/US20200399280A1/en not_active Abandoned
-
2021
- 2021-03-01 US US17/188,884 patent/US20210179627A1/en not_active Abandoned
-
2023
- 2023-01-30 US US18/103,319 patent/US20230174540A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP18060864A (es) | Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]- decano | |
ECSP18060848A (es) | Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[ 4.5]-decano | |
ECSP18060875A (es) | Derivados de 8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano | |
ECSP18060820A (es) | Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]- decano | |
MX2020003661A (es) | Formas de dosificacion de liquidos, metodos de fabricacion y uso. | |
ECSP18060834A (es) | Derivados de 3-((hetero)aril)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]- decano | |
CL2015002835A1 (es) | Nuevos derivados de piridina | |
CL2019001329A1 (es) | Composiciones farmacéuticas moduladoras del receptor 7 de 5-hidroxitritpina y métodos de uso. | |
ES2966644T3 (es) | Fluorofenil beta-hidroxietilaminas y su uso en el tratamiento de la hiperglucemia | |
ECSP16086247A (es) | (s)-pirlindole y sus sales farmacéuticamente aceptables para uso en medicina | |
ECSP16086232A (es) | (r) -pirlindole y sus sales farmacéuticamente aceptables para uso en medicina | |
EA202090270A1 (ru) | Новые замещенные производные ксантина | |
PH12018502139A1 (en) | Phosphaplatin liquid formulations | |
IL282142A (en) | The history of 4-pyrazine-2-ylmethyl-morpholine and its use as a medicine | |
IT201700035757A1 (it) | Composizioni contenenti principi attivi naturali, loro preparazione ed uso nel trattamento della stipsi | |
NZ784118A (en) | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | |
CL2016000822A1 (es) | Tratamiento del cáncer con una combinación de plinabulina y taxano |