JP2024500562A5 - - Google Patents
Info
- Publication number
- JP2024500562A5 JP2024500562A5 JP2023557491A JP2023557491A JP2024500562A5 JP 2024500562 A5 JP2024500562 A5 JP 2024500562A5 JP 2023557491 A JP2023557491 A JP 2023557491A JP 2023557491 A JP2023557491 A JP 2023557491A JP 2024500562 A5 JP2024500562 A5 JP 2024500562A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- substituted
- aryl
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20211730.5 | 2020-12-03 | ||
| EP20211730 | 2020-12-03 | ||
| PCT/EP2021/084089 WO2022117782A1 (en) | 2020-12-03 | 2021-12-03 | Alc1 inhibitors and synergy with parpi |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024500562A JP2024500562A (ja) | 2024-01-09 |
| JP2024500562A5 true JP2024500562A5 (https=) | 2024-12-11 |
Family
ID=73792931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023557491A Pending JP2024500562A (ja) | 2020-12-03 | 2021-12-03 | Ａｌｃ１阻害剤およびｐａｒｐｉとの相乗効果 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20240033363A1 (https=) |
| EP (1) | EP4255910A1 (https=) |
| JP (1) | JP2024500562A (https=) |
| KR (1) | KR20230116832A (https=) |
| CN (1) | CN117120448A (https=) |
| AR (1) | AR124235A1 (https=) |
| AU (1) | AU2021393770A1 (https=) |
| CA (1) | CA3198803A1 (https=) |
| CL (1) | CL2023001587A1 (https=) |
| IL (1) | IL303333A (https=) |
| MX (1) | MX2023006549A (https=) |
| TW (1) | TW202237095A (https=) |
| WO (1) | WO2022117782A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116283828A (zh) * | 2023-02-03 | 2023-06-23 | 广州安岩仁医药科技有限公司 | 一种parp1抑制剂中间体及其制备方法与应用 |
| WO2025088087A1 (en) | 2023-10-25 | 2025-05-01 | Eisbach Bio Gmbh | A pyrido-thieno-pyrimidin derivative as alc1 inhibitor for use in the treatment of homologous recombination deficiency (hrd) cancers |
| AU2024366320A1 (en) | 2023-10-25 | 2026-04-16 | Eisbach Bio Gmbh | Alc1 inhibitors for use in treating cancer by potentiating the effects of several classes of approved cancer drugs |
| WO2025093706A1 (en) | 2023-10-31 | 2025-05-08 | Eisbach Bio Gmbh | Alc1 inhibitors alc1i-1 and alc1i-2 for use in treating pancreatic cancer by potentiating the effect of irinotecan |
| WO2025242703A1 (en) | 2024-05-21 | 2025-11-27 | Eisbach Bio Gmbh | Crystalline forms of an alc1 inhibitor useful in the treatment of cancer |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
| WO2000022110A2 (en) | 1998-10-09 | 2000-04-20 | President And Fellows Of Harvard College | Targeted proteolysis by recruitment to ubiquitin protein ligases |
| US6306663B1 (en) | 1999-02-12 | 2001-10-23 | Proteinex, Inc. | Controlling protein levels in eucaryotic organisms |
| KR100774855B1 (ko) * | 2000-04-27 | 2007-11-08 | 아스텔라스세이야쿠 가부시키가이샤 | 축합 헤테로아릴 유도체 |
| WO2002020740A2 (en) | 2000-09-08 | 2002-03-14 | California Institute Of Technology | Proteolysis targeting chimeric pharmaceutical |
| WO2006010568A2 (de) * | 2004-07-23 | 2006-02-02 | Curacyte Discovery Gmbh | Substituierte pyrido [3',2':4,5]thieno[3,2-d]pyrimidin-2,4(1 h,3h)-diones und -4(3h)-one sowie pyrido [3',2' :4,5] furo[3,2-d]pyrimidin -2,4(1 h,3h)-dione und -4(3h)-one zur verwendung als inhibitoren der tnf-allpha freisetzung |
| WO2010151664A2 (en) * | 2009-06-26 | 2010-12-29 | Massachusetts Institute Of Technology | Compositions and methods for treating cancer and modulating stress granule formation |
| EP2806875B1 (en) * | 2012-01-25 | 2017-07-19 | Proteostasis Therapeutics, Inc. | Proteasome activity modulating compounds |
| RU2738833C9 (ru) | 2014-04-14 | 2022-02-28 | Арвинас, Оперэйшнз, Инк. | Имидные модуляторы протеолиза и способы их применения |
| CN107108613B (zh) | 2014-11-10 | 2020-02-25 | 基因泰克公司 | 布罗莫结构域抑制剂及其用途 |
| MA40940A (fr) | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
| WO2016105518A1 (en) | 2014-12-23 | 2016-06-30 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| US9694084B2 (en) | 2014-12-23 | 2017-07-04 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| WO2017007612A1 (en) | 2015-07-07 | 2017-01-12 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| WO2017024317A2 (en) | 2015-08-06 | 2017-02-09 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| US10154992B2 (en) * | 2016-07-12 | 2018-12-18 | The Regents Of The University Of California | Compounds and methods for treating HIV infection |
-
2021
- 2021-12-01 TW TW110144770A patent/TW202237095A/zh unknown
- 2021-12-02 AR ARP210103350A patent/AR124235A1/es unknown
- 2021-12-03 CA CA3198803A patent/CA3198803A1/en active Pending
- 2021-12-03 AU AU2021393770A patent/AU2021393770A1/en active Pending
- 2021-12-03 EP EP21819146.8A patent/EP4255910A1/en active Pending
- 2021-12-03 US US18/039,740 patent/US20240033363A1/en active Pending
- 2021-12-03 JP JP2023557491A patent/JP2024500562A/ja active Pending
- 2021-12-03 KR KR1020237020848A patent/KR20230116832A/ko active Pending
- 2021-12-03 MX MX2023006549A patent/MX2023006549A/es unknown
- 2021-12-03 CN CN202180081634.2A patent/CN117120448A/zh active Pending
- 2021-12-03 WO PCT/EP2021/084089 patent/WO2022117782A1/en not_active Ceased
- 2021-12-03 IL IL303333A patent/IL303333A/en unknown
-
2023
- 2023-06-01 CL CL2023001587A patent/CL2023001587A1/es unknown
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