JP2018515525A5 - - Google Patents
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- JP2018515525A5 JP2018515525A5 JP2017559003A JP2017559003A JP2018515525A5 JP 2018515525 A5 JP2018515525 A5 JP 2018515525A5 JP 2017559003 A JP2017559003 A JP 2017559003A JP 2017559003 A JP2017559003 A JP 2017559003A JP 2018515525 A5 JP2018515525 A5 JP 2018515525A5
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- JP
- Japan
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- cycloalkyl
- hydrogen
- Prior art date
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- 0 CC(C)c1c(*)nn[n]1 Chemical compound CC(C)c1c(*)nn[n]1 0.000 description 25
- JPDPRXXLFYTTRV-UHFFFAOYSA-N CC(C)c1c(C)[o]nc1C Chemical compound CC(C)c1c(C)[o]nc1C JPDPRXXLFYTTRV-UHFFFAOYSA-N 0.000 description 4
- VTYLNNZBVOSGTA-UHFFFAOYSA-N CC(C)c([n](C)nn1)c1OC Chemical compound CC(C)c([n](C)nn1)c1OC VTYLNNZBVOSGTA-UHFFFAOYSA-N 0.000 description 3
- DWVFSQVBDSMYJA-UHFFFAOYSA-N CC(C)c([nH]nn1)c1OC Chemical compound CC(C)c([nH]nn1)c1OC DWVFSQVBDSMYJA-UHFFFAOYSA-N 0.000 description 2
- FMSYGTJKIDOBPH-UHFFFAOYSA-N CCc1c(C(C)C)[nH]nn1 Chemical compound CCc1c(C(C)C)[nH]nn1 FMSYGTJKIDOBPH-UHFFFAOYSA-N 0.000 description 2
- MRFNWSQNINZIIA-UHFFFAOYSA-O CC(C)C1=C(C)N(C)N[NH2+]1 Chemical compound CC(C)C1=C(C)N(C)N[NH2+]1 MRFNWSQNINZIIA-UHFFFAOYSA-O 0.000 description 1
- VSNWPYLQRCUJJC-UHFFFAOYSA-O CC(C)C1=C(C)N=N[NH2+]1 Chemical compound CC(C)C1=C(C)N=N[NH2+]1 VSNWPYLQRCUJJC-UHFFFAOYSA-O 0.000 description 1
- MMTJVWTXKUNWCZ-UHFFFAOYSA-N CC(C)c1c(C)nn[n]1C Chemical compound CC(C)c1c(C)nn[n]1C MMTJVWTXKUNWCZ-UHFFFAOYSA-N 0.000 description 1
- UJKAFNFFPBCHLA-UHFFFAOYSA-N CCC1=C(C(C)C)NNN1C Chemical compound CCC1=C(C(C)C)NNN1C UJKAFNFFPBCHLA-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562159991P | 2015-05-12 | 2015-05-12 | |
| US62/159,991 | 2015-05-12 | ||
| US15/150,492 US9725449B2 (en) | 2015-05-12 | 2016-05-10 | Tricyclic compounds as anticancer agents |
| US15/150,492 | 2016-05-10 | ||
| PCT/US2016/031707 WO2016183118A1 (en) | 2015-05-12 | 2016-05-11 | Tricyclic compounds as anticancer agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515525A JP2018515525A (ja) | 2018-06-14 |
| JP2018515525A5 true JP2018515525A5 (https=) | 2019-06-13 |
| JP6843767B2 JP6843767B2 (ja) | 2021-03-17 |
Family
ID=56117957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559003A Active JP6843767B2 (ja) | 2015-05-12 | 2016-05-11 | 抗がん剤としての三環式化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9725449B2 (https=) |
| EP (1) | EP3294739B1 (https=) |
| JP (1) | JP6843767B2 (https=) |
| CN (1) | CN107709322B (https=) |
| ES (1) | ES2746131T3 (https=) |
| TW (1) | TW201713657A (https=) |
| UY (1) | UY36677A (https=) |
| WO (1) | WO2016183118A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108137589B (zh) * | 2016-01-20 | 2021-03-26 | 宁波文达医药科技有限公司 | 作为布罗莫区结构域抑制剂的咔啉衍生物 |
| US20190040063A1 (en) * | 2016-02-05 | 2019-02-07 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Tricyclic compound for bromodomain-containing protein inhibitor and preparation pharmaceutical composition, and application thereof |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| WO2019080941A1 (en) * | 2017-10-27 | 2019-05-02 | Jacobio-Beta Pharmaceuticals Co., Ltd. | NEW TRICYCLIC COMPOUNDS |
| CR20200347A (es) | 2018-02-13 | 2020-09-23 | Gilead Sciences Inc | Inhibidores pd-1/pd-l1 |
| AU2019295983B2 (en) * | 2018-06-25 | 2021-09-30 | Jacobio Pharmaceuticals Co., Ltd. | Tricyclic compounds |
| SG11202012425QA (en) | 2018-07-13 | 2021-01-28 | Gilead Sciences Inc | Pd-1/pd-l1 inhibitors |
| WO2020200284A1 (zh) * | 2019-04-04 | 2020-10-08 | 上海华汇拓医药科技有限公司 | 三环类化合物制备方法及其在医药领域的应用 |
| US10947253B2 (en) | 2019-08-05 | 2021-03-16 | Ankh Life Sciences Limited | Fused polycyclic dimers |
| EP4051663B1 (en) * | 2019-10-30 | 2024-02-21 | Janssen Sciences Ireland Unlimited Company | Synthesis of 3-nitro-n-(2,2,2-trifluoroethyl)-4-pyridinamine |
| US12129265B2 (en) | 2020-07-21 | 2024-10-29 | Ankh Life Sciences Limited | Therapeutic agents and uses thereof |
| WO2022156757A1 (en) * | 2021-01-22 | 2022-07-28 | Jingrui Biopharma Co., Ltd. | Tricyclic compounds as anticancer agents |
| WO2024099441A1 (en) * | 2022-11-11 | 2024-05-16 | Jingrui Biopharma (Shandong) Co., Ltd. | Bromodomain and extra-terminal (bet) protein degrader |
| US12173005B1 (en) | 2023-12-21 | 2024-12-24 | King Faisal University | Pyrimido[1′,6′:1,5]pyrazolo[4,3-b][1,7]naphthyridine compounds as CK2 inhibitors |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE504828C2 (sv) | 1990-04-11 | 1997-05-12 | Sandvik Ab | Hammaranordning där kolv och borrkrona har omvänd design relativt varandra vad gäller impedans |
| TWI380996B (zh) | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | 抗ｏｘ４０ｌ抗體 |
| PT2343320T (pt) | 2005-03-25 | 2018-01-23 | Gitr Inc | Anticorpos anti-gitr e as suas utilizações |
| PL1879573T3 (pl) | 2005-05-10 | 2013-05-31 | Incyte Holdings Corp | Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania |
| PT1907424E (pt) | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| US8450351B2 (en) | 2005-12-20 | 2013-05-28 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| WO2008036642A2 (en) | 2006-09-19 | 2008-03-27 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| US8591886B2 (en) | 2007-07-12 | 2013-11-26 | Gitr, Inc. | Combination therapies employing GITR binding molecules |
| EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
| US10047066B2 (en) | 2007-11-30 | 2018-08-14 | Newlink Genetics Corporation | IDO inhibitors |
| EA201001030A1 (ru) | 2007-12-19 | 2011-02-28 | Амген Инк. | Конденсированные соединения пиридина, пиримидина и триазина в качестве ингибиторов клеточного цикла |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| EP3255060A1 (en) | 2008-12-09 | 2017-12-13 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| CN102257076B (zh) | 2008-12-18 | 2014-07-30 | 纳幕尔杜邦公司 | 具有新颜料的粉末涂料组合物 |
| KR101790802B1 (ko) | 2009-09-03 | 2017-10-27 | 머크 샤프 앤드 돔 코포레이션 | 항-ｇｉｔｒ 항체 |
| EP2493862B1 (en) | 2009-10-28 | 2016-10-05 | Newlink Genetics Corporation | Imidazole derivatives as ido inhibitors |
| ES2722300T3 (es) | 2009-12-10 | 2019-08-09 | Hoffmann La Roche | Anticuerpos que se unen preferentemente al dominio extracelular 4 de CSF1R y su uso |
| EP2542256B1 (en) | 2010-03-04 | 2019-05-22 | MacroGenics, Inc. | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| JP5989547B2 (ja) | 2010-03-05 | 2016-09-07 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ヒトｃｓｆ−１ｒに対する抗体及びその使用 |
| US9169323B2 (en) | 2010-03-05 | 2015-10-27 | Hoffmann-La Roche Inc. | Antibodies against human CSF-1R |
| HRP20190047T1 (hr) | 2010-05-04 | 2019-02-22 | Five Prime Therapeutics, Inc. | Protutijela koja se vežu na csf1r |
| MX337040B (es) | 2010-09-09 | 2016-02-09 | Pfizer | Moleculas de union a 4-1bb. |
| US8580399B2 (en) | 2011-04-08 | 2013-11-12 | Universal Display Corporation | Substituted oligoazacarbazoles for light emitting diodes |
| NO2694640T3 (https=) | 2011-04-15 | 2018-03-17 | ||
| JP6072771B2 (ja) | 2011-04-20 | 2017-02-01 | メディミューン，エルエルシー | Ｂ７−ｈ１およびｐｄ−１に結合する抗体およびその他の分子 |
| WO2013046635A1 (ja) | 2011-09-28 | 2013-04-04 | 出光興産株式会社 | 有機エレクトロルミネッセンス素子用材料及びそれを用いた有機エレクトロルミネッセンス素子 |
| KR101764096B1 (ko) | 2011-11-28 | 2017-08-02 | 메르크 파텐트 게엠베하 | 항-ｐｄ-ｌ1 항체 및 그의 용도 |
| RU2658603C2 (ru) | 2011-12-15 | 2018-06-21 | Ф.Хоффманн-Ля Рош Аг | Антитела против человеческого csf-1r и их применения |
| KR20140127855A (ko) | 2012-02-06 | 2014-11-04 | 제넨테크, 인크. | Csf1r 억제제를 사용하는 조성물 및 방법 |
| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
| RU2670743C9 (ru) | 2012-05-11 | 2018-12-19 | Файв Прайм Терапьютикс, Инк. | Способы лечения состояний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r) |
| UY34887A (es) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
| CN107759690A (zh) | 2012-08-31 | 2018-03-06 | 戊瑞治疗有限公司 | 用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法 |
| UA115576C2 (uk) | 2012-12-06 | 2017-11-27 | Байєр Фарма Акцієнгезелльшафт | Похідні бензимідазолу як антагоністи ер4 |
| EP2961747B1 (en) | 2013-02-27 | 2017-11-15 | Bristol-Myers Squibb Company | Carbazole compounds useful as bromodomain inhibitors |
| US9492460B2 (en) | 2013-02-27 | 2016-11-15 | Bristol-Myers Squibb Company | Carbazole compounds useful as bromodomain inhibitors |
| EP2970312B1 (en) | 2013-03-11 | 2017-11-15 | The Regents of The University of Michigan | Bet bromodomain inhibitors and therapeutic methods using the same |
| KR102457145B1 (ko) | 2013-12-24 | 2022-10-19 | 브리스톨-마이어스 스큅 컴퍼니 | 항암제로서의 트리시클릭 화합물 |
| US9458156B2 (en) | 2014-12-23 | 2016-10-04 | Bristol-Myers Squibb Company | Tricyclic compounds as anticancer agents |
| WO2015110263A1 (en) | 2014-01-21 | 2015-07-30 | Ac Immune Sa | Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyolid-like proteins |
| WO2015131005A1 (en) | 2014-02-28 | 2015-09-03 | The Regents Of The University Of Michigan | 9h-pyrimido[4,5-b]indoles and related analogs as bet bromodomain inhibitors |
-
2016
- 2016-05-10 US US15/150,492 patent/US9725449B2/en active Active
- 2016-05-11 WO PCT/US2016/031707 patent/WO2016183118A1/en not_active Ceased
- 2016-05-11 CN CN201680039269.8A patent/CN107709322B/zh active Active
- 2016-05-11 JP JP2017559003A patent/JP6843767B2/ja active Active
- 2016-05-11 UY UY0001036677A patent/UY36677A/es unknown
- 2016-05-11 EP EP16728765.5A patent/EP3294739B1/en active Active
- 2016-05-11 ES ES16728765T patent/ES2746131T3/es active Active
- 2016-05-11 TW TW105114608A patent/TW201713657A/zh unknown
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