|
CA2861066C
(en)
|
2012-01-12 |
2024-01-02 |
Yale University |
Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an e3 ubiquitin ligase
|
|
US9765039B2
(en)
|
2012-11-21 |
2017-09-19 |
Zenith Epigenetics Ltd. |
Biaryl derivatives as bromodomain inhibitors
|
|
US9073878B2
(en)
|
2012-11-21 |
2015-07-07 |
Zenith Epigenetics Corp. |
Cyclic amines as bromodomain inhibitors
|
|
AU2013365926B9
(en)
|
2012-12-21 |
2019-01-17 |
Zenith Epigenetics Ltd. |
Novel heterocyclic compounds as bromodomain inhibitors
|
|
CN105189488B
(zh)
|
2013-02-27 |
2018-07-24 |
百时美施贵宝公司 |
用作溴区结构域抑制剂的咔唑化合物
|
|
EP2970312B1
(en)
|
2013-03-11 |
2017-11-15 |
The Regents of The University of Michigan |
Bet bromodomain inhibitors and therapeutic methods using the same
|
|
MX366703B
(es)
|
2013-03-15 |
2019-07-22 |
Incyte Holdings Corp |
Heterociclos tricíclicos como inhibidores de la proteína bet.
|
|
EP3010918B1
(en)
|
2013-06-21 |
2018-08-15 |
Zenith Epigenetics Ltd. |
Novel substituted bicyclic compounds as bromodomain inhibitors
|
|
CA2915838C
(en)
|
2013-06-21 |
2023-04-18 |
Zenith Epigenetics Corp. |
Bicyclic bromodomain inhibitors
|
|
AR096837A1
(es)
|
2013-07-08 |
2016-02-03 |
Incyte Corp |
Heterociclos tricíclicos como inhibidores de proteínas bet
|
|
JP6542212B2
(ja)
|
2013-07-31 |
2019-07-10 |
ゼニス・エピジェネティクス・リミテッドZenith Epigenetics Ltd. |
ブロモドメイン阻害剤としての新規キナゾリノン
|
|
US9399640B2
(en)
|
2013-11-26 |
2016-07-26 |
Incyte Corporation |
Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors
|
|
WO2015081189A1
(en)
|
2013-11-26 |
2015-06-04 |
Incyte Corporation |
Bicyclic heterocycles as bet protein inhibitors
|
|
WO2015095492A1
(en)
|
2013-12-19 |
2015-06-25 |
Incyte Corporation |
Tricyclic heterocycles as bet protein inhibitors
|
|
US9458156B2
(en)
|
2014-12-23 |
2016-10-04 |
Bristol-Myers Squibb Company |
Tricyclic compounds as anticancer agents
|
|
ES2857848T3
(es)
*
|
2013-12-24 |
2021-09-29 |
Bristol Myers Squibb Co |
Compuestos tricíclicos como agentes antineoplásicos
|
|
US9580430B2
(en)
|
2014-02-28 |
2017-02-28 |
The Regents Of The University Of Michigan |
9H-pyrimido[4,5-B]indoles and related analogs as BET bromodomain inhibitors
|
|
US20180228907A1
(en)
|
2014-04-14 |
2018-08-16 |
Arvinas, Inc. |
Cereblon ligands and bifunctional compounds comprising the same
|
|
EA034972B1
(ru)
|
2014-04-23 |
2020-04-13 |
Инсайт Корпорейшн |
1h-пирроло[2,3-c]пиридин-7(6h)-оны в качестве ингибиторов белков bet
|
|
CA2947970A1
(en)
*
|
2014-05-08 |
2015-11-12 |
Oncoethix Gmbh |
Method of treating triple-negative breast cancer using thienotriazolodiazepine compounds
|
|
US9527864B2
(en)
|
2014-09-15 |
2016-12-27 |
Incyte Corporation |
Tricyclic heterocycles as BET protein inhibitors
|
|
AU2015326910B2
(en)
*
|
2014-10-02 |
2018-03-01 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Compound
|
|
EP3227281A4
(en)
|
2014-12-01 |
2018-05-30 |
Zenith Epigenetics Ltd. |
Substituted pyridinones as bromodomain inhibitors
|
|
HK1246273B
(en)
|
2014-12-01 |
2019-12-06 |
恒翼生物医药(上海)股份有限公司 |
Substituted pyridines as bromodomain inhibitors
|
|
EP3230277B1
(en)
|
2014-12-11 |
2019-09-18 |
Zenith Epigenetics Ltd. |
Substituted heterocycles as bromodomain inhibitors
|
|
HK1245247A1
(zh)
|
2014-12-17 |
2018-08-24 |
恒翼生物医药科技(上海)有限公司 |
溴结构域的抑制剂
|
|
US10730870B2
(en)
|
2015-03-18 |
2020-08-04 |
Arvinas Operations, Inc. |
Compounds and methods for the enhanced degradation of targeted proteins
|
|
GB201504694D0
(en)
|
2015-03-19 |
2015-05-06 |
Glaxosmithkline Ip Dev Ltd |
Covalent conjugates
|
|
EP3294736B1
(en)
*
|
2015-05-11 |
2020-07-22 |
Bristol-Myers Squibb Company |
Tricyclic compounds as anticancer agents
|
|
EP3307740B1
(en)
|
2015-05-12 |
2019-12-18 |
Bristol-Myers Squibb Company |
5h-pyrido[3,2-b]indole compounds as anticancer agents
|
|
US9725449B2
(en)
*
|
2015-05-12 |
2017-08-08 |
Bristol-Myers Squibb Company |
Tricyclic compounds as anticancer agents
|
|
WO2017011371A1
(en)
|
2015-07-10 |
2017-01-19 |
Arvinas, Inc |
Mdm2-based modulators of proteolysis and associated methods of use
|
|
EP3337476A4
(en)
|
2015-08-19 |
2019-09-04 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of bromodomain-containing proteins
|
|
TW201722966A
(zh)
|
2015-10-29 |
2017-07-01 |
英塞特公司 |
Bet蛋白質抑制劑之非晶固體形式
|
|
US10550091B2
(en)
|
2016-03-25 |
2020-02-04 |
St. Jude Children's Research Hospital |
1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
|
|
WO2017172914A1
(en)
|
2016-03-30 |
2017-10-05 |
Wisconsin Alumni Research Foundation |
Methods and compositions for modulating frataxin expression
|
|
US20170281784A1
(en)
|
2016-04-05 |
2017-10-05 |
Arvinas, Inc. |
Protein-protein interaction inducing technology
|
|
KR102643344B1
(ko)
|
2016-06-20 |
2024-03-07 |
인사이트 코포레이션 |
Bet 저해제의 결정질 고체 형태
|
|
BR112019015484A2
(pt)
|
2017-01-31 |
2020-04-28 |
Arvinas Operations Inc |
ligantes de cereblon e compostos bifuncionais compreendendo os mesmos
|
|
WO2018183679A1
(en)
|
2017-03-29 |
2018-10-04 |
Wisconsin Alumni Research Foundation |
Methods and compositions for modulating gene expression
|
|
US11220515B2
(en)
|
2018-01-26 |
2022-01-11 |
Yale University |
Imide-based modulators of proteolysis and associated methods of use
|
|
CA3165168A1
(en)
|
2019-12-19 |
2021-06-24 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of androgen receptor
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
CN111809182B
(zh)
*
|
2020-07-08 |
2025-04-18 |
江苏和达电子科技有限公司 |
一种用于铜/钼(铌)/igzo膜层的刻蚀液及其制备方法和应用
|
|
US12016847B2
(en)
|
2021-03-12 |
2024-06-25 |
Bristol-Myers Squibb Company |
Methods of treating prostate cancer
|
|
AU2023273729A1
(en)
*
|
2022-05-20 |
2024-12-05 |
University Of Puerto Rico |
1,4,5-trisubstituted-1,2,3-triazoles and uses thereof
|
|
WO2025049555A1
(en)
|
2023-08-31 |
2025-03-06 |
Oerth Bio Llc |
Compositions and methods for targeted inhibition and degradation of proteins in an insect cell
|
|
US20260092058A1
(en)
|
2024-09-30 |
2026-04-02 |
St. Jude Children's Research Hospital, Inc. |
Small Molecule Degraders and Fluorescent Probes of PXR
|