MX378994B - Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano. - Google Patents

Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.

Info

Publication number
MX378994B
MX378994B MX2018008644A MX2018008644A MX378994B MX 378994 B MX378994 B MX 378994B MX 2018008644 A MX2018008644 A MX 2018008644A MX 2018008644 A MX2018008644 A MX 2018008644A MX 378994 B MX378994 B MX 378994B
Authority
MX
Mexico
Prior art keywords
diaza
spiro
hetero
oxo
aryl
Prior art date
Application number
MX2018008644A
Other languages
English (en)
Other versions
MX2018008644A (es
Inventor
Achim Kless
Anita Wegert
Ingo Konetzki
Klaus Linz
Klaus Schiene
Paul Ratcliffe
René Michael Koenigs
Ruth Jostock
Sven Kühnert
Thomas Koch
Wolfgang Schröder
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MX2018008644A publication Critical patent/MX2018008644A/es
Publication of MX378994B publication Critical patent/MX378994B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano, su preparación y su uso en medicamentos, en particular en el tratamiento del dolor.
MX2018008644A 2016-01-13 2017-01-13 Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano. MX378994B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16151013 2016-01-13
PCT/EP2017/025006 WO2017121648A1 (en) 2016-01-13 2017-01-13 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

Publications (2)

Publication Number Publication Date
MX2018008644A MX2018008644A (es) 2018-11-19
MX378994B true MX378994B (es) 2025-03-11

Family

ID=55129634

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018008644A MX378994B (es) 2016-01-13 2017-01-13 Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.

Country Status (28)

Country Link
US (6) US20170197947A1 (es)
EP (1) EP3402784B1 (es)
JP (1) JP6893517B2 (es)
KR (1) KR20180098369A (es)
CN (1) CN108602777B (es)
AR (1) AR107360A1 (es)
AU (1) AU2017206909B2 (es)
BR (1) BR112018014303B1 (es)
CA (1) CA3011177A1 (es)
CL (1) CL2018001912A1 (es)
CO (1) CO2018008444A2 (es)
CY (1) CY1122818T1 (es)
DK (1) DK3402784T3 (es)
EA (1) EA037481B1 (es)
EC (1) ECSP18060848A (es)
ES (1) ES2797904T3 (es)
HR (1) HRP20200837T1 (es)
HU (1) HUE049813T2 (es)
IL (1) IL260491B (es)
LT (1) LT3402784T (es)
MX (1) MX378994B (es)
PE (1) PE20181375A1 (es)
PL (1) PL3402784T3 (es)
PT (1) PT3402784T (es)
RS (1) RS60315B1 (es)
SI (1) SI3402784T1 (es)
TW (1) TWI636048B (es)
WO (1) WO2017121648A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180098369A (ko) 2016-01-13 2018-09-03 그뤼넨탈 게엠베하 3-((헤테로-)아릴)-알킬-8-아미노-2-옥소-1,3-디아자-스피로-[4.5]-데칸 유도체
BR112018014301B1 (pt) 2016-01-13 2023-10-31 Grünenthal GmbH Derivados de 8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano
EP3402783B1 (en) 2016-01-13 2020-03-04 Grünenthal GmbH 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
DK3402781T5 (da) * 2016-01-13 2020-06-02 Gruenenthal Gmbh 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4,5]-decan-derivater
CA3011180A1 (en) 2016-01-13 2017-07-20 Grunenthal Gmbh 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
LT3781561T (lt) 2018-04-18 2024-07-10 Constellation Pharmaceuticals, Inc. Metilą modifikuojančių fermentų moduliatoriai, kompozicijos ir jų naudojimas
WO2019226491A1 (en) 2018-05-21 2019-11-28 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
PE20211733A1 (es) 2019-01-11 2021-09-06 Gruenenthal Chemie Amidas de pirrolidina sustituidas
GB201905721D0 (en) 2019-04-24 2019-06-05 Univ Dundee Compounds
PE20220562A1 (es) 2019-07-24 2022-04-13 Constellation Pharmaceuticals Inc Formas cristalinas de 7-cloro-2-(4-(3-metoxiazetidin-1-il)ciclohexil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-oxo-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioxol-5-carboxamida
WO2024145422A1 (en) * 2022-12-28 2024-07-04 Gilgamesh Pharmaceuticals, Inc. Synthesis of 2-phenyl-2-amino-cyclohexan-1-one derivatives
US20240400537A1 (en) 2023-04-25 2024-12-05 Gruenenthal Gmbh Cis-8-(3,5-difluorophenyl)-8-(dimethylamino)-1,3-diazaspiro[4.5]decan-2-one derivatives

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2734265B1 (fr) 1995-05-17 1997-06-13 Adir Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant
JP4380992B2 (ja) 2001-04-18 2009-12-09 ユーロ−セルティーク エス．エイ． ノシセプチン類似体
DE10130020A1 (de) 2001-06-25 2003-12-04 Gruenenthal Gmbh Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
DE10210195B4 (de) 2002-03-07 2005-12-15 Schwarz Pharma Ag Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz
BR0312414A (pt) 2002-07-05 2005-05-10 Targacept Inc Compostos de n-aril diazaespirociclico e métodos para a preparação e uso dos mesmos
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
ZA200510329B (en) 2003-05-23 2007-04-25 Zealand Pharma As Triaza-spiro compounds as nociceptin analogues and uses thereof
JO2676B1 (en) 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
AU2007312391B2 (en) 2006-10-19 2012-06-21 F. Hoffmann-La Roche Ag Imidazolone and imidazolidinone derivatives as 11b-HSD1 inhibitors for diabetes
MX2009011006A (es) 2007-04-09 2009-11-02 Janssen Pharmaceutica Nv Derivados de 1,3,8-trisustituido-1,3,8-triaza-espiro[4.5]decano-4- ona como ligandos del receptor de orl-1 para el tratamiento de ansiedad y depresion.
AR074615A1 (es) * 2008-03-27 2011-02-02 Gruenenthal Chemie Derivados de 4- aminociclohexano sustituido
US8268853B2 (en) 2009-06-25 2012-09-18 Abbott Laboratories 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof
TWI582092B (zh) 2010-07-28 2017-05-11 歌林達股份有限公司 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物
AU2013369649B2 (en) * 2012-12-31 2018-07-26 Sunovion Pharmaceuticals Inc. Heterocyclic compounds and methods of use thereof
MA40170A (fr) 2014-06-13 2017-04-19 Purdue Pharma Lp Dérivés hétérocycliques de morphinan et leur utilisation
DK3402781T5 (da) 2016-01-13 2020-06-02 Gruenenthal Gmbh 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4,5]-decan-derivater
RU2747877C2 (ru) 2016-01-13 2021-05-17 Ново Нордиск А/С Аналоги эфр(а) с заместителями - жирными кислотами
BR112018014301B1 (pt) 2016-01-13 2023-10-31 Grünenthal GmbH Derivados de 8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano
CA3011180A1 (en) 2016-01-13 2017-07-20 Grunenthal Gmbh 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
EP3402783B1 (en) 2016-01-13 2020-03-04 Grünenthal GmbH 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
KR20180098369A (ko) 2016-01-13 2018-09-03 그뤼넨탈 게엠베하 3-((헤테로-)아릴)-알킬-8-아미노-2-옥소-1,3-디아자-스피로-[4.5]-데칸 유도체
TWI730032B (zh) 2016-01-13 2021-06-11 美商必治妥美雅史谷比公司 作為ｒｏｃｋ抑制劑之螺庚烷水楊酸醯胺及相關化合物

Also Published As

Publication number Publication date
TWI636048B (zh) 2018-09-21
MX2018008644A (es) 2018-11-19
CN108602777A (zh) 2018-09-28
CO2018008444A2 (es) 2018-08-31
TW201731822A (zh) 2017-09-16
PT3402784T (pt) 2020-06-18
US10829480B2 (en) 2020-11-10
HUE049813T2 (hu) 2020-10-28
US20200399252A1 (en) 2020-12-24
DK3402784T3 (da) 2020-05-25
EA201891609A1 (ru) 2019-01-31
US20170197947A1 (en) 2017-07-13
PE20181375A1 (es) 2018-08-28
SI3402784T1 (sl) 2020-07-31
EA037481B1 (ru) 2021-04-01
RS60315B1 (sr) 2020-07-31
BR112018014303B1 (pt) 2023-10-03
US20230174520A1 (en) 2023-06-08
AR107360A1 (es) 2018-04-25
AU2017206909B2 (en) 2020-07-09
IL260491B (en) 2021-07-29
HRP20200837T1 (hr) 2020-08-07
CA3011177A1 (en) 2017-07-20
AU2017206909A1 (en) 2018-08-30
PL3402784T3 (pl) 2020-09-21
US20210179592A1 (en) 2021-06-17
JP6893517B2 (ja) 2021-06-23
LT3402784T (lt) 2020-06-10
KR20180098369A (ko) 2018-09-03
CL2018001912A1 (es) 2018-10-19
ES2797904T3 (es) 2020-12-04
US20200002319A1 (en) 2020-01-02
BR112018014303A2 (pt) 2018-12-11
EP3402784A1 (en) 2018-11-21
US20180327392A1 (en) 2018-11-15
WO2017121648A1 (en) 2017-07-20
ECSP18060848A (es) 2018-08-31
NZ745188A (en) 2024-05-31
JP2019501939A (ja) 2019-01-24
EP3402784B1 (en) 2020-03-11
CY1122818T1 (el) 2021-05-05
CN108602777B (zh) 2022-05-03

Similar Documents

Publication Publication Date Title
ECSP18060848A (es) Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[ 4.5]-decano
CO2018008447A2 (es) Derivados de 3-((hetero-)aril)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano
CL2018001909A1 (es) Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano
CL2018001910A1 (es) Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano
ECSP18060820A (es) Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]- decano
MX390014B (es) Compuestos de dinucleótidos cíclicos y métodos de uso.
MX2022007994A (es) Derivados de arilciclohexilamina y su uso en el tratamiento de trastornos psiquiátricos.
MX390630B (es) Derivados de maitansinoide, conjugados de los mismos y metodos de uso.
MX386328B (es) Derivados de maitansinoide, conjugados de los mismos, y metodos de uso.
UY36544A (es) Derivados de 4h-pirrol[3,2-c]piridin-4-ona
CL2015002835A1 (es) Nuevos derivados de piridina
CL2015002897A1 (es) Inhibidores de bace1
MX2018005987A (es) Compuestos heterociclicos para el tratamiento de enfermedades.
MX390441B (es) Formulaciones liquidas de fosfaplatino.
LT3867244T (lt) 4-pirazin-2-ilmetil-morfolino dariniai ir jų naudojimas kaip vaisto
IL273242B1 (en) 6chloro-3-(2,4-dichloro-5-methoxyphenyl)-2-mercapto-7- methoxyquinazolin-4(3h)-one and derivative compounds, compositions comprising same and uses thereof
EA202091403A1 (ru) Производные 2-оксо-1-пирролидинилимидазотиадиазола