JP6893517B2 - ３−（（ヘテロ−）アリール）−アルキル−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体 - Google Patents
３−（（ヘテロ−）アリール）−アルキル−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体 Download PDFInfo
- Publication number
- JP6893517B2 JP6893517B2 JP2018536484A JP2018536484A JP6893517B2 JP 6893517 B2 JP6893517 B2 JP 6893517B2 JP 2018536484 A JP2018536484 A JP 2018536484A JP 2018536484 A JP2018536484 A JP 2018536484A JP 6893517 B2 JP6893517 B2 JP 6893517B2
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenyl
- diazaspiro
- dimethylamino
- sith
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C*C(C)CC1=C[C@@](C)CC=C1 Chemical compound C*C(C)CC1=C[C@@](C)CC=C1 0.000 description 6
- JNVNMRNNXAYZDI-UHFFFAOYSA-N CN(C)C(CC1)(CCC1(CN1)NC1=O)c1ccccc1 Chemical compound CN(C)C(CC1)(CCC1(CN1)NC1=O)c1ccccc1 JNVNMRNNXAYZDI-UHFFFAOYSA-N 0.000 description 1
- MKFQJROZDMTLAJ-BGYRXZFFSA-N CN(C)[C@](CC1)(CC[C@@]1(CN1)N(CC(N(C)C)=O)C1=O)c1ccccc1 Chemical compound CN(C)[C@](CC1)(CC[C@@]1(CN1)N(CC(N(C)C)=O)C1=O)c1ccccc1 MKFQJROZDMTLAJ-BGYRXZFFSA-N 0.000 description 1
- ITFUXLDQVXVYOI-HDICACEKSA-N CN(C)[C@](CC1)(CC[C@@]1(CN1)N(CC(O)=O)C1=O)c1ccccc1 Chemical compound CN(C)[C@](CC1)(CC[C@@]1(CN1)N(CC(O)=O)C1=O)c1ccccc1 ITFUXLDQVXVYOI-HDICACEKSA-N 0.000 description 1
- BHNBGYKHHFLUSJ-PSWAGMNNSA-N CN(C)[C@](CC1)(CC[C@@]1(CN1Cc(cc2)ccc2OC)NC1=O)c1ccccc1 Chemical compound CN(C)[C@](CC1)(CC[C@@]1(CN1Cc(cc2)ccc2OC)NC1=O)c1ccccc1 BHNBGYKHHFLUSJ-PSWAGMNNSA-N 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N OC(C(F)(F)F)=O Chemical compound OC(C(F)(F)F)=O DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16151013.6 | 2016-01-13 | ||
| EP16151013 | 2016-01-13 | ||
| PCT/EP2017/025006 WO2017121648A1 (en) | 2016-01-13 | 2017-01-13 | 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501939A JP2019501939A (ja) | 2019-01-24 |
| JP2019501939A5 JP2019501939A5 (https=) | 2021-04-15 |
| JP6893517B2 true JP6893517B2 (ja) | 2021-06-23 |
Family
ID=55129634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018536484A Expired - Fee Related JP6893517B2 (ja) | 2016-01-13 | 2017-01-13 | ３−（（ヘテロ−）アリール）−アルキル−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体 |
Country Status (28)
| Country | Link |
|---|---|
| US (6) | US20170197947A1 (https=) |
| EP (1) | EP3402784B1 (https=) |
| JP (1) | JP6893517B2 (https=) |
| KR (1) | KR20180098369A (https=) |
| CN (1) | CN108602777B (https=) |
| AR (1) | AR107360A1 (https=) |
| AU (1) | AU2017206909B2 (https=) |
| BR (1) | BR112018014303B1 (https=) |
| CA (1) | CA3011177A1 (https=) |
| CL (1) | CL2018001912A1 (https=) |
| CO (1) | CO2018008444A2 (https=) |
| CY (1) | CY1122818T1 (https=) |
| DK (1) | DK3402784T3 (https=) |
| EA (1) | EA037481B1 (https=) |
| EC (1) | ECSP18060848A (https=) |
| ES (1) | ES2797904T3 (https=) |
| HR (1) | HRP20200837T1 (https=) |
| HU (1) | HUE049813T2 (https=) |
| IL (1) | IL260491B (https=) |
| LT (1) | LT3402784T (https=) |
| MX (1) | MX378994B (https=) |
| PE (1) | PE20181375A1 (https=) |
| PL (1) | PL3402784T3 (https=) |
| PT (1) | PT3402784T (https=) |
| RS (1) | RS60315B1 (https=) |
| SI (1) | SI3402784T1 (https=) |
| TW (1) | TWI636048B (https=) |
| WO (1) | WO2017121648A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3402784T1 (sl) | 2016-01-13 | 2020-07-31 | Gruenenthal Gmbh | Derivati 3-((hetero)aril)-alkil-8-amino-2-okso-1,3-diaza-spiro-(4.5)-dekana |
| SI3402782T1 (sl) | 2016-01-13 | 2020-11-30 | Grunenthal Gmbh | 8-amino-2-okso-1,3-diaza-spiro-(4,5)-dekanski derivati |
| CA3011176C (en) | 2016-01-13 | 2023-09-19 | Grunenthal Gmbh | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| CA3011180A1 (en) | 2016-01-13 | 2017-07-20 | Grunenthal Gmbh | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| BR112018014302B1 (pt) | 2016-01-13 | 2023-10-17 | Grünenthal GmbH | Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
| HRP20240793T1 (hr) | 2018-04-18 | 2024-09-13 | Constellation Pharmaceuticals, Inc. | Modulatori enzima koji modificiraju metil, njihovi pripravci i upotreba |
| EP3797108B1 (en) | 2018-05-21 | 2022-07-20 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| BR112021013557A2 (pt) | 2019-01-11 | 2021-09-21 | Grünenthal GmbH | Amidas de pirrolidina substituídas iii |
| GB201905721D0 (en) | 2019-04-24 | 2019-06-05 | Univ Dundee | Compounds |
| LT4003532T (lt) | 2019-07-24 | 2024-11-11 | Constellation Pharmaceuticals, Inc. | 7-chlor-2- (4-(3-metoksiazetidin-1-il)cikloheksil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-okso-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioksol-5-karboksamido kristalinės formos |
| CN120858088A (zh) * | 2022-12-28 | 2025-10-28 | 吉尔伽美什制药公司 | 2-苯基-2-氨基-环己-1-酮衍生物的合成 |
| US20240400537A1 (en) | 2023-04-25 | 2024-12-05 | Gruenenthal Gmbh | Cis-8-(3,5-difluorophenyl)-8-(dimethylamino)-1,3-diazaspiro[4.5]decan-2-one derivatives |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2734265B1 (fr) | 1995-05-17 | 1997-06-13 | Adir | Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant |
| RU2268883C2 (ru) | 2001-04-18 | 2006-01-27 | Эро-Селтик, С.А. | Аналоги ноницептина и фармацевтическая композиция на их основе |
| DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
| DE10210195B4 (de) | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
| DK1519939T5 (da) | 2002-07-05 | 2011-01-24 | Targacept Inc | N-Aryl-diazaspirocykliske forbindelser og fremgangsmåder til fremstilling og anvendelse deraf |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| EP1628978A2 (en) | 2003-05-23 | 2006-03-01 | Zealand Pharma A/S | Triaza-spiro compounds as nociceptin analogues and uses thereof |
| JO2676B1 (en) | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
| CN101553474B (zh) | 2006-10-19 | 2013-02-27 | 霍夫曼-拉罗奇有限公司 | 作为糖尿病用11b-HSD1抑制剂的咪唑啉酮和咪唑烷酮衍生物 |
| CA2683598C (en) | 2007-04-09 | 2015-11-17 | Janssen Pharmaceutica Nv | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression |
| CA2719735A1 (en) * | 2008-03-27 | 2009-10-01 | Gruenenthal Gmbh | Substituted 4-aminocyclohexane derivatives |
| WO2010151815A2 (en) | 2009-06-25 | 2010-12-29 | Abbott Laboratories | 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof |
| TWI582092B (zh) | 2010-07-28 | 2017-05-11 | 歌林達股份有限公司 | 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物 |
| WO2014106238A1 (en) * | 2012-12-31 | 2014-07-03 | Fang, Qun, Kevin | Heterocyclic compounds and methods of use thereof |
| WO2015192039A1 (en) | 2014-06-13 | 2015-12-17 | Purdue Pharma L.P. | Heterocyclic morphinan derivatives and use thereof |
| SI3402782T1 (sl) | 2016-01-13 | 2020-11-30 | Grunenthal Gmbh | 8-amino-2-okso-1,3-diaza-spiro-(4,5)-dekanski derivati |
| AR107354A1 (es) | 2016-01-13 | 2018-04-18 | Bristol Myers Squibb Co | Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock |
| BR112018014302B1 (pt) | 2016-01-13 | 2023-10-17 | Grünenthal GmbH | Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
| SI3402784T1 (sl) | 2016-01-13 | 2020-07-31 | Gruenenthal Gmbh | Derivati 3-((hetero)aril)-alkil-8-amino-2-okso-1,3-diaza-spiro-(4.5)-dekana |
| SI3402811T1 (sl) | 2016-01-13 | 2022-06-30 | Novo Nordisk A/S | Analogi EGF(A) z maščobnokislinskimi substituenti |
| CA3011180A1 (en) | 2016-01-13 | 2017-07-20 | Grunenthal Gmbh | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| CA3011176C (en) | 2016-01-13 | 2023-09-19 | Grunenthal Gmbh | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
-
2017
- 2017-01-13 SI SI201730268T patent/SI3402784T1/sl unknown
- 2017-01-13 WO PCT/EP2017/025006 patent/WO2017121648A1/en not_active Ceased
- 2017-01-13 HR HRP20200837TT patent/HRP20200837T1/hr unknown
- 2017-01-13 DK DK17701638.3T patent/DK3402784T3/da active
- 2017-01-13 HU HUE17701638A patent/HUE049813T2/hu unknown
- 2017-01-13 PE PE2018001302A patent/PE20181375A1/es unknown
- 2017-01-13 KR KR1020187021562A patent/KR20180098369A/ko active Pending
- 2017-01-13 CA CA3011177A patent/CA3011177A1/en active Pending
- 2017-01-13 EA EA201891609A patent/EA037481B1/ru unknown
- 2017-01-13 PT PT177016383T patent/PT3402784T/pt unknown
- 2017-01-13 CN CN201780006494.6A patent/CN108602777B/zh not_active Expired - Fee Related
- 2017-01-13 RS RS20200585A patent/RS60315B1/sr unknown
- 2017-01-13 LT LTEP17701638.3T patent/LT3402784T/lt unknown
- 2017-01-13 EP EP17701638.3A patent/EP3402784B1/en active Active
- 2017-01-13 AU AU2017206909A patent/AU2017206909B2/en not_active Ceased
- 2017-01-13 ES ES17701638T patent/ES2797904T3/es active Active
- 2017-01-13 TW TW106101125A patent/TWI636048B/zh active
- 2017-01-13 US US15/405,896 patent/US20170197947A1/en not_active Abandoned
- 2017-01-13 MX MX2018008644A patent/MX378994B/es unknown
- 2017-01-13 JP JP2018536484A patent/JP6893517B2/ja not_active Expired - Fee Related
- 2017-01-13 PL PL17701638T patent/PL3402784T3/pl unknown
- 2017-01-13 BR BR112018014303-0A patent/BR112018014303B1/pt not_active IP Right Cessation
- 2017-01-13 AR ARP170100095A patent/AR107360A1/es unknown
-
2018
- 2018-05-21 US US15/984,919 patent/US20180327392A1/en not_active Abandoned
- 2018-07-09 IL IL260491A patent/IL260491B/en unknown
- 2018-07-13 CL CL2018001912A patent/CL2018001912A1/es unknown
- 2018-08-13 EC ECSENADI201860848A patent/ECSP18060848A/es unknown
- 2018-08-13 CO CONC2018/0008444A patent/CO2018008444A2/es unknown
-
2019
- 2019-02-01 US US16/265,080 patent/US10829480B2/en active Active
-
2020
- 2020-05-04 CY CY20201100402T patent/CY1122818T1/el unknown
- 2020-08-31 US US17/007,258 patent/US20200399252A1/en not_active Abandoned
-
2021
- 2021-03-01 US US17/188,743 patent/US20210179592A1/en not_active Abandoned
-
2023
- 2023-01-30 US US18/103,180 patent/US20230174520A1/en not_active Abandoned
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