JP2019501939A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019501939A5 JP2019501939A5 JP2018536484A JP2018536484A JP2019501939A5 JP 2019501939 A5 JP2019501939 A5 JP 2019501939A5 JP 2018536484 A JP2018536484 A JP 2018536484A JP 2018536484 A JP2018536484 A JP 2018536484A JP 2019501939 A5 JP2019501939 A5 JP 2019501939A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenyl
- diazaspiro
- dimethylamino
- sith
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CN(C)[C@](*)(CC1)CC[C@@]1(CN1C*)N(CC2(*)CC2)C1=O Chemical compound CN(C)[C@](*)(CC1)CC[C@@]1(CN1C*)N(CC2(*)CC2)C1=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16151013.6 | 2016-01-13 | ||
| EP16151013 | 2016-01-13 | ||
| PCT/EP2017/025006 WO2017121648A1 (en) | 2016-01-13 | 2017-01-13 | 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501939A JP2019501939A (ja) | 2019-01-24 |
| JP2019501939A5 true JP2019501939A5 (enExample) | 2021-04-15 |
| JP6893517B2 JP6893517B2 (ja) | 2021-06-23 |
Family
ID=55129634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018536484A Expired - Fee Related JP6893517B2 (ja) | 2016-01-13 | 2017-01-13 | ３−（（ヘテロ−）アリール）−アルキル−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体 |
Country Status (28)
| Country | Link |
|---|---|
| US (6) | US20170197947A1 (enExample) |
| EP (1) | EP3402784B1 (enExample) |
| JP (1) | JP6893517B2 (enExample) |
| KR (1) | KR20180098369A (enExample) |
| CN (1) | CN108602777B (enExample) |
| AR (1) | AR107360A1 (enExample) |
| AU (1) | AU2017206909B2 (enExample) |
| BR (1) | BR112018014303B1 (enExample) |
| CA (1) | CA3011177A1 (enExample) |
| CL (1) | CL2018001912A1 (enExample) |
| CO (1) | CO2018008444A2 (enExample) |
| CY (1) | CY1122818T1 (enExample) |
| DK (1) | DK3402784T3 (enExample) |
| EA (1) | EA037481B1 (enExample) |
| EC (1) | ECSP18060848A (enExample) |
| ES (1) | ES2797904T3 (enExample) |
| HR (1) | HRP20200837T1 (enExample) |
| HU (1) | HUE049813T2 (enExample) |
| IL (1) | IL260491B (enExample) |
| LT (1) | LT3402784T (enExample) |
| MX (1) | MX378994B (enExample) |
| PE (1) | PE20181375A1 (enExample) |
| PL (1) | PL3402784T3 (enExample) |
| PT (1) | PT3402784T (enExample) |
| RS (1) | RS60315B1 (enExample) |
| SI (1) | SI3402784T1 (enExample) |
| TW (1) | TWI636048B (enExample) |
| WO (1) | WO2017121648A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6893517B2 (ja) | 2016-01-13 | 2021-06-23 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ３−（（ヘテロ−）アリール）−アルキル−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体 |
| TWI635082B (zh) | 2016-01-13 | 2018-09-11 | 歌林達有限公司 | ３－（（雜－）芳基）－８－胺基－２－側氧－１,３－二氮雜－螺－［４.５］－癸烷衍生物 |
| DK3402783T3 (da) | 2016-01-13 | 2020-05-04 | Gruenenthal Gmbh | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decan-derivater |
| MX378995B (es) | 2016-01-13 | 2025-03-11 | Gruenenthal Gmbh | Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano. |
| RS60855B1 (sr) | 2016-01-13 | 2020-10-30 | Gruenenthal Gmbh | Derivati 8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana |
| MX2020010999A (es) | 2018-04-18 | 2021-01-20 | Constellation Pharmaceuticals Inc | Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos. |
| EP3797108B1 (en) | 2018-05-21 | 2022-07-20 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| WO2020144375A1 (en) | 2019-01-11 | 2020-07-16 | Grünenthal GmbH | Substituted pyrrolidine amides iii |
| GB201905721D0 (en) | 2019-04-24 | 2019-06-05 | Univ Dundee | Compounds |
| PE20220562A1 (es) | 2019-07-24 | 2022-04-13 | Constellation Pharmaceuticals Inc | Formas cristalinas de 7-cloro-2-(4-(3-metoxiazetidin-1-il)ciclohexil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-oxo-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioxol-5-carboxamida |
| IL321707A (en) * | 2022-12-28 | 2025-08-01 | Gilgamesh Pharmaceuticals Inc | Synthesis of 2-phenyl-2-amino-cyclohexan-1-one history |
| US20240400537A1 (en) | 2023-04-25 | 2024-12-05 | Gruenenthal Gmbh | Cis-8-(3,5-difluorophenyl)-8-(dimethylamino)-1,3-diazaspiro[4.5]decan-2-one derivatives |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2734265B1 (fr) | 1995-05-17 | 1997-06-13 | Adir | Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant |
| RU2268883C2 (ru) | 2001-04-18 | 2006-01-27 | Эро-Селтик, С.А. | Аналоги ноницептина и фармацевтическая композиция на их основе |
| DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
| DE10210195B4 (de) | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
| PT1519939E (pt) | 2002-07-05 | 2010-02-10 | Targacept Inc | Compostos n-arildiazaspirocíclicos e métodos para a sua preparação e utilização |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| ZA200510329B (en) | 2003-05-23 | 2007-04-25 | Zealand Pharma As | Triaza-spiro compounds as nociceptin analogues and uses thereof |
| JO2676B1 (en) | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
| AU2007312391B2 (en) | 2006-10-19 | 2012-06-21 | F. Hoffmann-La Roche Ag | Imidazolone and imidazolidinone derivatives as 11b-HSD1 inhibitors for diabetes |
| EP2150552B1 (en) | 2007-04-09 | 2013-01-02 | Janssen Pharmaceutica NV | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression |
| KR20120075500A (ko) * | 2008-03-27 | 2012-07-06 | 그뤼넨탈 게엠베하 | 치환된 4-아미노사이클로헥산 유도체 |
| US8268853B2 (en) | 2009-06-25 | 2012-09-18 | Abbott Laboratories | 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof |
| TWI582092B (zh) | 2010-07-28 | 2017-05-11 | 歌林達股份有限公司 | 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物 |
| WO2014106238A1 (en) * | 2012-12-31 | 2014-07-03 | Fang, Qun, Kevin | Heterocyclic compounds and methods of use thereof |
| EP3154971A4 (en) | 2014-06-13 | 2017-11-01 | Purdue Pharma L.P. | Heterocyclic morphinan derivatives and use thereof |
| MX378995B (es) | 2016-01-13 | 2025-03-11 | Gruenenthal Gmbh | Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano. |
| JP6893517B2 (ja) | 2016-01-13 | 2021-06-23 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ３−（（ヘテロ−）アリール）−アルキル−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体 |
| DK3402783T3 (da) | 2016-01-13 | 2020-05-04 | Gruenenthal Gmbh | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decan-derivater |
| TWI730032B (zh) | 2016-01-13 | 2021-06-11 | 美商必治妥美雅史谷比公司 | 作為ｒｏｃｋ抑制劑之螺庚烷水楊酸醯胺及相關化合物 |
| TWI635082B (zh) | 2016-01-13 | 2018-09-11 | 歌林達有限公司 | ３－（（雜－）芳基）－８－胺基－２－側氧－１,３－二氮雜－螺－［４.５］－癸烷衍生物 |
| RS60855B1 (sr) | 2016-01-13 | 2020-10-30 | Gruenenthal Gmbh | Derivati 8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana |
| RU2747877C2 (ru) | 2016-01-13 | 2021-05-17 | Ново Нордиск А/С | Аналоги эфр(а) с заместителями - жирными кислотами |
-
2017
- 2017-01-13 JP JP2018536484A patent/JP6893517B2/ja not_active Expired - Fee Related
- 2017-01-13 PE PE2018001302A patent/PE20181375A1/es unknown
- 2017-01-13 CN CN201780006494.6A patent/CN108602777B/zh not_active Expired - Fee Related
- 2017-01-13 DK DK17701638.3T patent/DK3402784T3/da active
- 2017-01-13 BR BR112018014303-0A patent/BR112018014303B1/pt not_active IP Right Cessation
- 2017-01-13 MX MX2018008644A patent/MX378994B/es unknown
- 2017-01-13 HU HUE17701638A patent/HUE049813T2/hu unknown
- 2017-01-13 TW TW106101125A patent/TWI636048B/zh not_active IP Right Cessation
- 2017-01-13 EA EA201891609A patent/EA037481B1/ru unknown
- 2017-01-13 PT PT177016383T patent/PT3402784T/pt unknown
- 2017-01-13 KR KR1020187021562A patent/KR20180098369A/ko active Pending
- 2017-01-13 HR HRP20200837TT patent/HRP20200837T1/hr unknown
- 2017-01-13 PL PL17701638T patent/PL3402784T3/pl unknown
- 2017-01-13 LT LTEP17701638.3T patent/LT3402784T/lt unknown
- 2017-01-13 ES ES17701638T patent/ES2797904T3/es active Active
- 2017-01-13 US US15/405,896 patent/US20170197947A1/en not_active Abandoned
- 2017-01-13 SI SI201730268T patent/SI3402784T1/sl unknown
- 2017-01-13 EP EP17701638.3A patent/EP3402784B1/en active Active
- 2017-01-13 AU AU2017206909A patent/AU2017206909B2/en not_active Ceased
- 2017-01-13 CA CA3011177A patent/CA3011177A1/en active Pending
- 2017-01-13 AR ARP170100095A patent/AR107360A1/es unknown
- 2017-01-13 RS RS20200585A patent/RS60315B1/sr unknown
- 2017-01-13 WO PCT/EP2017/025006 patent/WO2017121648A1/en not_active Ceased
-
2018
- 2018-05-21 US US15/984,919 patent/US20180327392A1/en not_active Abandoned
- 2018-07-09 IL IL260491A patent/IL260491B/en unknown
- 2018-07-13 CL CL2018001912A patent/CL2018001912A1/es unknown
- 2018-08-13 CO CONC2018/0008444A patent/CO2018008444A2/es unknown
- 2018-08-13 EC ECSENADI201860848A patent/ECSP18060848A/es unknown
-
2019
- 2019-02-01 US US16/265,080 patent/US10829480B2/en active Active
-
2020
- 2020-05-04 CY CY20201100402T patent/CY1122818T1/el unknown
- 2020-08-31 US US17/007,258 patent/US20200399252A1/en not_active Abandoned
-
2021
- 2021-03-01 US US17/188,743 patent/US20210179592A1/en not_active Abandoned
-
2023
- 2023-01-30 US US18/103,180 patent/US20230174520A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20200837T1 (hr) | Derivati 3-((hetero-)aril)-alkil-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana | |
| JP5628363B2 (ja) | 造影剤 | |
| JP6505153B2 (ja) | がん細胞の転移を予防するための化合物、組成物および方法 | |
| CN113214198B (zh) | 用于治疗或预防与痛风或高尿酸血症相关的症状的化合物、组合物和方法 | |
| JP2024546951A5 (enExample) | ||
| JP2021529812A5 (enExample) | ||
| JP2019501937A5 (enExample) | ||
| JP2022515369A5 (enExample) | ||
| JP2018534301A5 (enExample) | ||
| JPH0222066B2 (enExample) | ||
| JP2013510883A5 (enExample) | ||
| JP2016537389A5 (enExample) | ||
| JP2018502867A (ja) | がんの画像化及び治療用のヘテロ環式化合物ならびにそれらの使用方法 | |
| JP2022548250A5 (enExample) | ||
| JP2022504620A5 (enExample) | ||
| JP2024500562A5 (enExample) | ||
| JP2024502175A5 (enExample) | ||
| JP2019501936A5 (enExample) | ||
| JP2022542140A5 (enExample) | ||
| US11401234B2 (en) | Deuterated compounds and uses thereof | |
| EP1492776B1 (en) | Iodinated triglyceride analogs | |
| RU2004111787A (ru) | Ретиноидные агонисты (1), производные алкилмочевины | |
| US11261166B2 (en) | Lipophilic macrocyclic ligands, complexes thereof, and uses of same | |
| JP2025507732A5 (enExample) | ||
| JP2022521474A5 (enExample) |