CN108602777B - 3-((杂-)芳基)-烷基-8-氨基-2-氧代-1，3-氮杂-螺-[4.5]-癸烷衍生物 - Google Patents

3-((杂-)芳基)-烷基-8-氨基-2-氧代-1，3-氮杂-螺-[4.5]-癸烷衍生物 Download PDF

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Publication number
CN108602777B
CN108602777B CN201780006494.6A CN201780006494A CN108602777B CN 108602777 B CN108602777 B CN 108602777B CN 201780006494 A CN201780006494 A CN 201780006494A CN 108602777 B CN108602777 B CN 108602777B
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methyl
phenyl
cis
diazaspiro
dimethylamino
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Expired - Fee Related
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CN201780006494.6A
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English (en)
Chinese (zh)
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CN108602777A (zh
Inventor
S.屈纳特
R.M.克尼希斯
A.克莱斯
A.韦格特
P.拉特克利费
R.约施托克
T.科克
K.林茨
W.施勒德
K.席内
I.科内茨基
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Grünenthal GmbH
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Grünenthal GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201780006494.6A 2016-01-13 2017-01-13 3-((杂-)芳基)-烷基-8-氨基-2-氧代-1，3-氮杂-螺-[4.5]-癸烷衍生物 Expired - Fee Related CN108602777B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16151013.6 2016-01-13
EP16151013 2016-01-13
PCT/EP2017/025006 WO2017121648A1 (en) 2016-01-13 2017-01-13 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

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CN108602777A CN108602777A (zh) 2018-09-28
CN108602777B true CN108602777B (zh) 2022-05-03

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US (6) US20170197947A1 (enExample)
EP (1) EP3402784B1 (enExample)
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RS (1) RS60315B1 (enExample)
SI (1) SI3402784T1 (enExample)
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TWI635082B (zh) 2016-01-13 2018-09-11 歌林達有限公司 ３－（（雜－）芳基）－８－胺基－２－側氧－１,３－二氮雜－螺－［４.５］－癸烷衍生物
DK3402783T3 (da) 2016-01-13 2020-05-04 Gruenenthal Gmbh 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decan-derivater
MX378995B (es) 2016-01-13 2025-03-11 Gruenenthal Gmbh Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.
RS60855B1 (sr) 2016-01-13 2020-10-30 Gruenenthal Gmbh Derivati 8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana
MX2020010999A (es) 2018-04-18 2021-01-20 Constellation Pharmaceuticals Inc Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos.
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PL3402784T3 (pl) 2020-09-21
NZ745188A (en) 2024-05-31
CY1122818T1 (el) 2021-05-05
TW201731822A (zh) 2017-09-16
JP6893517B2 (ja) 2021-06-23
WO2017121648A1 (en) 2017-07-20
SI3402784T1 (sl) 2020-07-31
US20200399252A1 (en) 2020-12-24
PT3402784T (pt) 2020-06-18
KR20180098369A (ko) 2018-09-03
EP3402784A1 (en) 2018-11-21
AU2017206909A1 (en) 2018-08-30
RS60315B1 (sr) 2020-07-31
PE20181375A1 (es) 2018-08-28
DK3402784T3 (da) 2020-05-25
HUE049813T2 (hu) 2020-10-28
US20170197947A1 (en) 2017-07-13
JP2019501939A (ja) 2019-01-24
MX2018008644A (es) 2018-11-19
AR107360A1 (es) 2018-04-25
EA037481B1 (ru) 2021-04-01
US10829480B2 (en) 2020-11-10
EP3402784B1 (en) 2020-03-11
MX378994B (es) 2025-03-11
BR112018014303B1 (pt) 2023-10-03
IL260491B (en) 2021-07-29
HRP20200837T1 (hr) 2020-08-07
US20230174520A1 (en) 2023-06-08
AU2017206909B2 (en) 2020-07-09
ES2797904T3 (es) 2020-12-04
US20180327392A1 (en) 2018-11-15
CL2018001912A1 (es) 2018-10-19
US20210179592A1 (en) 2021-06-17
CN108602777A (zh) 2018-09-28
CO2018008444A2 (es) 2018-08-31
LT3402784T (lt) 2020-06-10
BR112018014303A2 (pt) 2018-12-11
EA201891609A1 (ru) 2019-01-31
TWI636048B (zh) 2018-09-21
CA3011177A1 (en) 2017-07-20
ECSP18060848A (es) 2018-08-31
US20200002319A1 (en) 2020-01-02

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