TWI636048B - ３－（（雜－）芳基）－烷基－８－胺基－２－側氧－１,３－二氮雜－螺－［４.５］－癸烷衍生物 - Google Patents

３－（（雜－）芳基）－烷基－８－胺基－２－側氧－１,３－二氮雜－螺－［４.５］－癸烷衍生物 Download PDF

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Publication number
TWI636048B
TWI636048B TW106101125A TW106101125A TWI636048B TW I636048 B TWI636048 B TW I636048B TW 106101125 A TW106101125 A TW 106101125A TW 106101125 A TW106101125 A TW 106101125A TW I636048 B TWI636048 B TW I636048B
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Taiwan
Prior art keywords
methyl
phenyl
cis
dec
diazaspiro
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TW106101125A
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English (en)
Chinese (zh)
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TW201731822A (zh
Inventor
斯凡 柯奈特
萊寧 米歇爾 柯以尼斯
亞錫姆 克雷斯
Achim Kless
阿妮塔 偉格特
Anita Wegert
保爾 拉特克里弗
Paul Ratcliffe
路斯 喬斯托克
Ruth Jostock
湯瑪士 寇和
Thomas Koch
克勞斯 林茲
Klaus Linz
沃夫岡 施羅德
克勞斯 施能
Klaus Schiene
英葛 柯奈茲奇
Ingo Konetzki
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歌林達有限公司
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Publication of TW201731822A publication Critical patent/TW201731822A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW106101125A 2016-01-13 2017-01-13 ３－（（雜－）芳基）－烷基－８－胺基－２－側氧－１,３－二氮雜－螺－［４.５］－癸烷衍生物 TWI636048B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16151013.6 2016-01-13
EP16151013 2016-01-13

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TW201731822A TW201731822A (zh) 2017-09-16
TWI636048B true TWI636048B (zh) 2018-09-21

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EP (1) EP3402784B1 (enExample)
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KR (1) KR20180098369A (enExample)
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PL (1) PL3402784T3 (enExample)
PT (1) PT3402784T (enExample)
RS (1) RS60315B1 (enExample)
SI (1) SI3402784T1 (enExample)
TW (1) TWI636048B (enExample)
WO (1) WO2017121648A1 (enExample)

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JP6893517B2 (ja) 2016-01-13 2021-06-23 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ３−（（ヘテロ−）アリール）−アルキル−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体
TWI635082B (zh) 2016-01-13 2018-09-11 歌林達有限公司 ３－（（雜－）芳基）－８－胺基－２－側氧－１,３－二氮雜－螺－［４.５］－癸烷衍生物
DK3402783T3 (da) 2016-01-13 2020-05-04 Gruenenthal Gmbh 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decan-derivater
MX378995B (es) 2016-01-13 2025-03-11 Gruenenthal Gmbh Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.
RS60855B1 (sr) 2016-01-13 2020-10-30 Gruenenthal Gmbh Derivati 8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana
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IL321707A (en) * 2022-12-28 2025-08-01 Gilgamesh Pharmaceuticals Inc Synthesis of 2-phenyl-2-amino-cyclohexan-1-one history
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PL3402784T3 (pl) 2020-09-21
NZ745188A (en) 2024-05-31
CY1122818T1 (el) 2021-05-05
TW201731822A (zh) 2017-09-16
JP6893517B2 (ja) 2021-06-23
WO2017121648A1 (en) 2017-07-20
SI3402784T1 (sl) 2020-07-31
US20200399252A1 (en) 2020-12-24
PT3402784T (pt) 2020-06-18
KR20180098369A (ko) 2018-09-03
EP3402784A1 (en) 2018-11-21
AU2017206909A1 (en) 2018-08-30
RS60315B1 (sr) 2020-07-31
PE20181375A1 (es) 2018-08-28
DK3402784T3 (da) 2020-05-25
HUE049813T2 (hu) 2020-10-28
US20170197947A1 (en) 2017-07-13
JP2019501939A (ja) 2019-01-24
MX2018008644A (es) 2018-11-19
AR107360A1 (es) 2018-04-25
EA037481B1 (ru) 2021-04-01
US10829480B2 (en) 2020-11-10
EP3402784B1 (en) 2020-03-11
CN108602777B (zh) 2022-05-03
MX378994B (es) 2025-03-11
BR112018014303B1 (pt) 2023-10-03
IL260491B (en) 2021-07-29
HRP20200837T1 (hr) 2020-08-07
US20230174520A1 (en) 2023-06-08
AU2017206909B2 (en) 2020-07-09
ES2797904T3 (es) 2020-12-04
US20180327392A1 (en) 2018-11-15
CL2018001912A1 (es) 2018-10-19
US20210179592A1 (en) 2021-06-17
CN108602777A (zh) 2018-09-28
CO2018008444A2 (es) 2018-08-31
LT3402784T (lt) 2020-06-10
BR112018014303A2 (pt) 2018-12-11
EA201891609A1 (ru) 2019-01-31
CA3011177A1 (en) 2017-07-20
ECSP18060848A (es) 2018-08-31
US20200002319A1 (en) 2020-01-02

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