JP2019501222A5 - - Google Patents
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- JP2019501222A5 JP2019501222A5 JP2018554640A JP2018554640A JP2019501222A5 JP 2019501222 A5 JP2019501222 A5 JP 2019501222A5 JP 2018554640 A JP2018554640 A JP 2018554640A JP 2018554640 A JP2018554640 A JP 2018554640A JP 2019501222 A5 JP2019501222 A5 JP 2019501222A5
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- 0 C*[C@@]1COCC1 Chemical compound C*[C@@]1COCC1 0.000 description 13
- LVEIJLGSXRYDEY-UHFFFAOYSA-N CC(C)c1c[nH]nn1 Chemical compound CC(C)c1c[nH]nn1 LVEIJLGSXRYDEY-UHFFFAOYSA-N 0.000 description 1
- ZLVYAWVDOLLMSD-UHFFFAOYSA-N CN(C)CCN(C)c(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c(cc2)c(cc[nH]3)c3c2C(N)=O)ccn1 Chemical compound CN(C)CCN(C)c(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c(cc2)c(cc[nH]3)c3c2C(N)=O)ccn1 ZLVYAWVDOLLMSD-UHFFFAOYSA-N 0.000 description 1
- XFSTWIDWOQOLIQ-UHFFFAOYSA-N CN(C)CCN(C)c(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c2c(cc[n]3C)c3cc(C(N)=O)c2)ccn1 Chemical compound CN(C)CCN(C)c(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c2c(cc[n]3C)c3cc(C(N)=O)c2)ccn1 XFSTWIDWOQOLIQ-UHFFFAOYSA-N 0.000 description 1
- RHSWKSOLSABYHY-UHFFFAOYSA-N CN(C)CCN(C)c(cc(c(Nc(nc1)nc(-c2c(cc[n]3C)c3cc(C(N)=O)c2)c1Cl)c1)OC)c1NC(C=C)=O Chemical compound CN(C)CCN(C)c(cc(c(Nc(nc1)nc(-c2c(cc[n]3C)c3cc(C(N)=O)c2)c1Cl)c1)OC)c1NC(C=C)=O RHSWKSOLSABYHY-UHFFFAOYSA-N 0.000 description 1
- BSKHPKMHTQYZBB-UHFFFAOYSA-N Cc1ccccn1 Chemical compound Cc1ccccn1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 description 1
- YBOQHGVVMRFVDJ-UHFFFAOYSA-N SC1COCC1 Chemical compound SC1COCC1 YBOQHGVVMRFVDJ-UHFFFAOYSA-N 0.000 description 1
- JRKNQYISGWCMNB-UHFFFAOYSA-N SCC1COCC1 Chemical compound SCC1COCC1 JRKNQYISGWCMNB-UHFFFAOYSA-N 0.000 description 1
- RMVRSNDYEFQCLF-UHFFFAOYSA-N Sc1ccccc1 Chemical compound Sc1ccccc1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276221P | 2016-01-07 | 2016-01-07 | |
| US62/276,221 | 2016-01-07 | ||
| US201662399730P | 2016-09-26 | 2016-09-26 | |
| US62/399,730 | 2016-09-26 | ||
| PCT/US2017/012466 WO2017120429A1 (en) | 2016-01-07 | 2017-01-06 | Selective inhibitors of clinically important mutants of the egfr tyrosine kinase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021029700A Division JP2021091703A (ja) | 2016-01-07 | 2021-02-26 | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019501222A JP2019501222A (ja) | 2019-01-17 |
| JP2019501222A5 true JP2019501222A5 (OSRAM) | 2020-01-23 |
Family
ID=59274526
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018554640A Withdrawn JP2019501222A (ja) | 2016-01-07 | 2017-01-06 | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
| JP2021029700A Ceased JP2021091703A (ja) | 2016-01-07 | 2021-02-26 | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021029700A Ceased JP2021091703A (ja) | 2016-01-07 | 2021-02-26 | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10435388B2 (OSRAM) |
| EP (1) | EP3399968B8 (OSRAM) |
| JP (2) | JP2019501222A (OSRAM) |
| KR (1) | KR20180105161A (OSRAM) |
| CN (1) | CN109328059B (OSRAM) |
| TW (1) | TWI726968B (OSRAM) |
| WO (1) | WO2017120429A1 (OSRAM) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106117185B (zh) * | 2015-08-31 | 2017-11-07 | 广州必贝特医药技术有限公司 | 2,4‑二含氮基团取代嘧啶类化合物及其制备方法和应用 |
| JP2019501222A (ja) | 2016-01-07 | 2019-01-17 | シーエス ファーマテック リミテッド | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
| CN109311858B (zh) | 2016-05-26 | 2021-12-03 | 里科瑞尔姆Ip控股有限责任公司 | Egfr抑制剂化合物 |
| CN108602802B (zh) | 2016-07-26 | 2020-01-21 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白酪氨酸激酶活性的氨基嘧啶类化合物 |
| MA46191A (fr) | 2016-09-09 | 2021-04-21 | Incyte Corp | Dérivés de pyrazolopyridine comme modulateurs de hpk1 et leurs utilisations pour le traitement du cancer |
| US20180072718A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| MY199042A (en) * | 2017-06-13 | 2023-10-11 | Beijing Adamadle Biotechnology Llc | Aminopyrimidine compound, preparation method therefor and use thereof |
| CA3068854A1 (en) * | 2017-07-05 | 2019-01-10 | Cs Pharmatech Limited | Selective inhibitors of clinically important mutants of the egfr tyrosine kinase |
| WO2019022487A1 (en) * | 2017-07-28 | 2019-01-31 | Yuhan Corporation | INTERMEDIATES USEFUL FOR THE SYNTHESIS OF A SELECTIVE INHIBITOR TO PROTEIN KINASE AND METHODS FOR THEIR PREPARATION |
| CA3071345A1 (en) * | 2017-07-28 | 2019-01-31 | Yale University | Anticancer drugs and methods of making and using same |
| EP3653622B1 (en) * | 2017-08-30 | 2022-12-28 | Shenzhen TargetRx, Inc. | Aminopyrimidine compound and composition comprising same and use thereof |
| CN109503573A (zh) * | 2017-09-14 | 2019-03-22 | 昆明圣加南生物科技有限公司 | 2-取代苯胺基嘧啶衍生物及其用途 |
| CN107827875B (zh) * | 2017-09-25 | 2021-07-09 | 文韬创新药物研究（北京）有限责任公司 | 一种苯并咪唑类衍生物作为周期蛋白依赖性激酶4/6抑制剂的应用 |
| WO2019154177A1 (zh) * | 2018-02-12 | 2019-08-15 | 恩瑞生物医药科技（上海）有限公司 | 嘧啶类化合物、其制备方法及其医药用途 |
| EP3755337A4 (en) * | 2018-02-20 | 2021-11-03 | Dana-Farber Cancer Institute, Inc. | EGFR INHIBITOR PHARMACEUTICAL COMBINATIONS AND METHODS OF USE |
| US20200375999A1 (en) * | 2018-02-20 | 2020-12-03 | Dana-Farber Cancer Institute, Inc. | Pharmaceutical combinations of egfr inhibitors and methods of use thereof |
| SMT202200294T1 (it) | 2018-02-20 | 2022-11-18 | Incyte Corp | Derivati di n-(fenil)-2-(fenil)pirimidina-4-carbossammide e composti correlati come inibitori di hpk1 per trattare il cancro |
| WO2019236884A1 (en) | 2018-06-07 | 2019-12-12 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 |
| CN112543757A (zh) | 2018-06-15 | 2021-03-23 | 卡迪拉保健有限公司 | 对结核菌具有抗菌活性的缩合氮杂杂芳基化合物 |
| CN110790749B (zh) * | 2018-08-03 | 2023-07-14 | 北京普祺医药科技股份有限公司 | 一种含氮杂环化合物、药物组合物以及其用途 |
| US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
| CN110857292A (zh) * | 2018-08-22 | 2020-03-03 | 上海艾力斯医药科技有限公司 | 一种egfr激酶抑制剂及其制备方法和应用 |
| CA3123215C (en) | 2018-12-19 | 2024-04-02 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 in combination with neuroprotective agents |
| CN113227073B (zh) * | 2019-01-05 | 2022-09-16 | 山东轩竹医药科技有限公司 | Egfr酪氨酸激酶的选择性抑制剂的盐及其晶型 |
| CN111410651B (zh) * | 2019-01-05 | 2021-06-04 | 山东轩竹医药科技有限公司 | 酪氨酸激酶抑制剂的盐及其晶型 |
| MA55380A (fr) | 2019-03-19 | 2022-01-26 | B2Sbio Inc | Dérivé hétéroaryle, son procédé de production et composition pharmaceutique le comprenant en tant que constituant efficace |
| US12157730B2 (en) | 2019-03-19 | 2024-12-03 | Voronoi Inc. | Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component |
| CN111825658B (zh) * | 2019-04-18 | 2024-11-08 | 华东理工大学 | Egfr三突变抑制剂及其应用 |
| CN112174961A (zh) * | 2019-07-04 | 2021-01-05 | 微境生物医药科技(上海)有限公司 | 一类抑制egfr激酶的化合物及其制备方法和用途 |
| WO2021018017A1 (zh) * | 2019-07-26 | 2021-02-04 | 南京明德新药研发有限公司 | 作用于egfr和erbb2的嘧啶类化合物 |
| KR20220059480A (ko) | 2019-08-06 | 2022-05-10 | 인사이트 코포레이션 | 고체 형태의 hpk1 억제제 |
| TW202128670A (zh) * | 2019-11-26 | 2021-08-01 | 大陸商上海翰森生物醫藥科技有限公司 | 含氮多環類衍生物抑制劑、其製備方法和應用 |
| CN113045475A (zh) * | 2019-12-27 | 2021-06-29 | 上海泓博智源医药股份有限公司 | 一种5-溴-7-甲基吲哚的制备方法 |
| CN113493419A (zh) * | 2020-03-18 | 2021-10-12 | 南京药石科技股份有限公司 | Egfr酪氨酸激酶抑制剂及其用途 |
| WO2021243596A1 (en) * | 2020-06-03 | 2021-12-09 | InventisBio Co., Ltd. | Aminopyrimidine compounds, preparation methods and uses thereof |
| WO2022063212A1 (zh) * | 2020-09-24 | 2022-03-31 | 广州费米子科技有限责任公司 | 嘧啶基衍生物、其制备方法及其用途 |
| CA3195035A1 (en) * | 2020-10-12 | 2022-04-21 | Dana Farber Cancer Institute, Inc. | Covalent egfr inhibitors and methods of use thereof |
| WO2022090481A1 (en) * | 2020-11-02 | 2022-05-05 | Boehringer Ingelheim International Gmbh | Substituted 1h-pyrazolo[4,3-c]pyridines and derivatives as egfr inhibitors |
| CN114539269B (zh) * | 2020-11-19 | 2023-04-28 | 上海医药工业研究院有限公司 | 一种含氮大环化合物、其制备方法及其应用 |
| US20240002378A1 (en) * | 2020-11-30 | 2024-01-04 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Merged scaffold taf1 inhibitors |
| US20240109885A1 (en) * | 2020-12-02 | 2024-04-04 | Abbisko Therapeutics Co., Ltd | 2,3-dihydro-1h-pyrrolo[3,2-b]pyridine derivative, preparation method therefor, and application thereof |
| CN117836287A (zh) * | 2021-06-23 | 2024-04-05 | 缆图药品公司 | 表皮生长因子受体抑制剂的盐和晶体形式 |
| AU2022299172A1 (en) * | 2021-06-23 | 2024-01-18 | Blueprint Medicines Corporation | Process for preparing egfr inhibitors |
| CN115701429B (zh) * | 2021-08-02 | 2024-03-12 | 上海和誉生物医药科技有限公司 | 4-(1h-吲哚-1-基)嘧啶-2-氨基衍生物及其制备方法和应用 |
| AU2022323373B2 (en) * | 2021-08-06 | 2025-02-13 | Abbisko Therapeutics Co., Ltd. | Pyrimidine or pyridine derivative, preparation method therefor, and application thereof in pharmacy |
| CN115703760B (zh) * | 2021-08-11 | 2024-05-31 | 山东大学 | 2,4-二取代嘧啶类细胞周期蛋白依赖性激酶酶抑制剂及其制备方法和应用 |
| CN116283914A (zh) * | 2021-12-01 | 2023-06-23 | 上海艾力斯医药科技股份有限公司 | 一类嘧啶类化合物、其制备方法及应用 |
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| CN106117185B (zh) | 2015-08-31 | 2017-11-07 | 广州必贝特医药技术有限公司 | 2,4‑二含氮基团取代嘧啶类化合物及其制备方法和应用 |
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| JP2019501222A (ja) | 2016-01-07 | 2019-01-17 | シーエス ファーマテック リミテッド | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
| CN106279160B (zh) | 2016-03-18 | 2017-09-26 | 海南越康生物医药有限公司 | N‑苯基‑2‑氨基嘧啶类化合物制备方法和用途 |
| WO2017190637A1 (zh) | 2016-05-06 | 2017-11-09 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白酪氨酸激酶活性的稠合嘧啶类化合物 |
| TW201740951A (zh) | 2016-05-11 | 2017-12-01 | 貝達醫藥公司 | 做為用於治療腦癌的治療劑之2-苯胺嘧啶 |
| CN108602802B (zh) | 2016-07-26 | 2020-01-21 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白酪氨酸激酶活性的氨基嘧啶类化合物 |
| CA3068854A1 (en) | 2017-07-05 | 2019-01-10 | Cs Pharmatech Limited | Selective inhibitors of clinically important mutants of the egfr tyrosine kinase |
-
2017
- 2017-01-06 JP JP2018554640A patent/JP2019501222A/ja not_active Withdrawn
- 2017-01-06 KR KR1020187022731A patent/KR20180105161A/ko not_active Withdrawn
- 2017-01-06 CN CN201780016875.2A patent/CN109328059B/zh active Active
- 2017-01-06 WO PCT/US2017/012466 patent/WO2017120429A1/en not_active Ceased
- 2017-01-06 EP EP17736401.5A patent/EP3399968B8/en not_active Not-in-force
- 2017-01-06 US US16/068,559 patent/US10435388B2/en active Active
- 2017-01-06 TW TW106100545A patent/TWI726968B/zh not_active IP Right Cessation
-
2021
- 2021-02-26 JP JP2021029700A patent/JP2021091703A/ja not_active Ceased
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