JP2019501123A5 - - Google Patents
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- Publication number
- JP2019501123A5 JP2019501123A5 JP2018525573A JP2018525573A JP2019501123A5 JP 2019501123 A5 JP2019501123 A5 JP 2019501123A5 JP 2018525573 A JP2018525573 A JP 2018525573A JP 2018525573 A JP2018525573 A JP 2018525573A JP 2019501123 A5 JP2019501123 A5 JP 2019501123A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- independently
- compound according
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 47
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 9
- 125000003107 substituted aryl group Chemical group 0.000 claims 7
- 241000606125 Bacteroides Species 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 241000606790 Haemophilus Species 0.000 claims 3
- 241000191940 Staphylococcus Species 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- -1 substituted Chemical class 0.000 claims 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 241000588807 Bordetella Species 0.000 claims 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 2
- 241000186216 Corynebacterium Species 0.000 claims 2
- 241000588914 Enterobacter Species 0.000 claims 2
- 241000186359 Mycobacterium Species 0.000 claims 2
- 241000606860 Pasteurella Species 0.000 claims 2
- 241000192087 Staphylococcus hominis Species 0.000 claims 2
- 241000607734 Yersinia <bacteria> Species 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 241000588626 Acinetobacter baumannii Species 0.000 claims 1
- 241000588624 Acinetobacter calcoaceticus Species 0.000 claims 1
- 241001148231 Acinetobacter haemolyticus Species 0.000 claims 1
- 241000606124 Bacteroides fragilis Species 0.000 claims 1
- 241000588779 Bordetella bronchiseptica Species 0.000 claims 1
- 241000589969 Borreliella burgdorferi Species 0.000 claims 1
- 241000589513 Burkholderia cepacia Species 0.000 claims 1
- 241000589876 Campylobacter Species 0.000 claims 1
- 241000589877 Campylobacter coli Species 0.000 claims 1
- 241000589875 Campylobacter jejuni Species 0.000 claims 1
- 241000588919 Citrobacter freundii Species 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 241000194031 Enterococcus faecium Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000589602 Francisella tularensis Species 0.000 claims 1
- 241000207201 Gardnerella vaginalis Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 241000606766 Haemophilus parainfluenzae Species 0.000 claims 1
- 241000589989 Helicobacter Species 0.000 claims 1
- 241001454354 Kingella Species 0.000 claims 1
- 241000588749 Klebsiella oxytoca Species 0.000 claims 1
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 1
- 241000589242 Legionella pneumophila Species 0.000 claims 1
- 241000186779 Listeria monocytogenes Species 0.000 claims 1
- 241000588621 Moraxella Species 0.000 claims 1
- 241000588771 Morganella <proteobacterium> Species 0.000 claims 1
- 241000186367 Mycobacterium avium Species 0.000 claims 1
- 241000186364 Mycobacterium intracellulare Species 0.000 claims 1
- 241000588653 Neisseria Species 0.000 claims 1
- 241000588650 Neisseria meningitidis Species 0.000 claims 1
- 241000606210 Parabacteroides distasonis Species 0.000 claims 1
- 241000588770 Proteus mirabilis Species 0.000 claims 1
- 241000588778 Providencia stuartii Species 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 241000589540 Pseudomonas fluorescens Species 0.000 claims 1
- 241000589776 Pseudomonas putida Species 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 claims 1
- 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 claims 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims 1
- 241000607720 Serratia Species 0.000 claims 1
- 241000607768 Shigella Species 0.000 claims 1
- 241000607762 Shigella flexneri Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241000191984 Staphylococcus haemolyticus Species 0.000 claims 1
- 241000191980 Staphylococcus intermedius Species 0.000 claims 1
- 241000122973 Stenotrophomonas maltophilia Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 241000193996 Streptococcus pyogenes Species 0.000 claims 1
- 241000607626 Vibrio cholerae Species 0.000 claims 1
- 241000607272 Vibrio parahaemolyticus Species 0.000 claims 1
- 241000607481 Yersinia intermedia Species 0.000 claims 1
- 241000607479 Yersinia pestis Species 0.000 claims 1
- 230000037006 agalactosis Effects 0.000 claims 1
- 210000003555 cloaca Anatomy 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000001848 dysentery Diseases 0.000 claims 1
- 229940032049 enterococcus faecalis Drugs 0.000 claims 1
- 229940118764 francisella tularensis Drugs 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 230000002949 hemolytic effect Effects 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229940115932 legionella pneumophila Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940037649 staphylococcus haemolyticus Drugs 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 229940118696 vibrio cholerae Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2015/095165 | 2015-11-20 | ||
| CNPCT/CN2015/095165 | 2015-11-20 | ||
| CNPCT/CN2016/105043 | 2016-11-08 | ||
| CNPCT/CN2016/105043 | 2016-11-08 | ||
| PCT/CN2016/106597 WO2017084629A1 (en) | 2015-11-20 | 2016-11-21 | Macrocyclic broad spectrum antibiotics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501123A JP2019501123A (ja) | 2019-01-17 |
| JP2019501123A5 true JP2019501123A5 (enExample) | 2020-01-09 |
| JP6873993B2 JP6873993B2 (ja) | 2021-05-19 |
Family
ID=58231314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525573A Active JP6873993B2 (ja) | 2015-11-20 | 2016-11-21 | 大環状広域抗生物質 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11072635B2 (enExample) |
| EP (1) | EP3377474B1 (enExample) |
| JP (1) | JP6873993B2 (enExample) |
| KR (1) | KR20180109858A (enExample) |
| CN (1) | CN109219596B (enExample) |
| AU (1) | AU2016357926B2 (enExample) |
| BR (1) | BR112018010267A2 (enExample) |
| CA (1) | CA3005551A1 (enExample) |
| IL (1) | IL259429B (enExample) |
| MX (1) | MX387476B (enExample) |
| RU (1) | RU2761476C2 (enExample) |
| WO (1) | WO2017084629A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10501493B2 (en) | 2011-05-27 | 2019-12-10 | Rqx Pharmaceuticals, Inc. | Broad spectrum antibiotics |
| KR20170027721A (ko) | 2014-05-20 | 2017-03-10 | 알큐엑스 파마슈티컬스, 인크. | 마크로시클릭 광범위 항생제 |
| KR20180109858A (ko) | 2015-11-20 | 2018-10-08 | 알큐엑스 파마슈티컬스, 인크. | 마크로시클릭 광범위 항생제 |
| UA126027C2 (uk) * | 2017-02-15 | 2022-08-03 | АрКьюЕкс ФАРМАСЬЮТІКЛС, ІНК. | Макроциклічні антибіотики широкого спектра |
| JP2020536072A (ja) * | 2017-09-29 | 2020-12-10 | ジェネンテック， インコーポレイテッド | ペプチド抗生物質複合体およびその使用方法 |
| IL288294B (en) * | 2019-05-28 | 2022-09-01 | Hoffmann La Roche | A broad-spectrum macrocyclic antibiotic |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3128280A (en) | 1959-10-23 | 1964-04-07 | Searle & Co | 1-(alkoxylated/halogenated phenyl)-3-pyridylmethylureas |
| US5204328A (en) | 1990-06-26 | 1993-04-20 | Merck & Co., Inc. | Peptides having atrial natriuretic factor activity |
| JPH11514527A (ja) | 1995-11-03 | 1999-12-14 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | バキルス エスピー（Ｂａｃｉｌｌｕｓ ｓｐ．）用の陽性選択ベクター |
| NZ335276A (en) | 1996-10-18 | 2000-09-29 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease |
| EP0895999A1 (en) | 1997-08-06 | 1999-02-10 | Pfizer Products Inc. | C-4" substituted macrolide antibiotics |
| GB9902399D0 (en) | 1999-02-03 | 1999-03-24 | Smithkline Beecham Plc | Compounds |
| US6660832B1 (en) | 1999-08-20 | 2003-12-09 | Isis Pharmaceuticals, Inc. | Macrocyclic compounds and preparation methods thereof |
| US6951840B2 (en) | 2001-08-31 | 2005-10-04 | Eli Lilly And Company | Lipoglycopeptide antibiotics |
| DE10226921A1 (de) | 2002-06-17 | 2003-12-24 | Bayer Ag | Antibakterielle Amid-Makrozyklen |
| JP2007536200A (ja) | 2003-07-17 | 2007-12-13 | ミジェニックス インコーポレイテッド | リポペプチド抗生物質誘導体の組成物およびその使用方法 |
| DE10358824A1 (de) | 2003-12-16 | 2005-07-21 | Bayer Healthcare Ag | Antibakterielle Makrozyklen mit substituiertem Biphenyl |
| DE102005014245A1 (de) | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Antibakterielle Amid-Makrozyklen V |
| DE102005014247A1 (de) | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Antibakterielle Amid-Makrozyklen VI |
| BR112012021806A2 (pt) | 2010-03-01 | 2015-09-08 | Myrexis Inc | compostos e seus usos terapêusticos. |
| CN102939095A (zh) * | 2010-03-09 | 2013-02-20 | 默沙东公司 | 增强β-内酰胺抗菌药物的活性的桥联脂糖肽类 |
| WO2011120071A1 (en) | 2010-04-01 | 2011-10-06 | The University Of Queensland | Oxytocin peptide analogues |
| MX2013003035A (es) | 2010-09-15 | 2013-12-16 | Scripps Research Inst | Analogos de arilomicina como antibióticos de amplio espectro. |
| WO2012166665A2 (en) | 2011-05-27 | 2012-12-06 | Rqx Pharmaceuticals, Inc. | Broad spectrum antibiotics |
| US10501493B2 (en) | 2011-05-27 | 2019-12-10 | Rqx Pharmaceuticals, Inc. | Broad spectrum antibiotics |
| CN103159830B (zh) | 2011-12-15 | 2017-06-20 | 上海来益生物药物研究开发中心有限责任公司 | 脂肽类化合物 |
| FR2986154B1 (fr) | 2012-01-31 | 2017-08-04 | Pierre Fabre Dermo Cosmetique | Nouveau systeme photoprotecteur |
| KR20140140580A (ko) * | 2012-03-14 | 2014-12-09 | 더 스크립스 리서치 인스티튜트 | 광범위 항생제 아릴로마이신 유사체 |
| CN103788176A (zh) * | 2012-10-31 | 2014-05-14 | 上海来益生物药物研究开发中心有限责任公司 | 一种arylomycin类化合物及其制备方法和应用 |
| CA2892027A1 (en) | 2012-11-21 | 2014-05-30 | Rqx Pharmaceuticals, Inc. | Macrocyclic broad spectrum antibiotics |
| KR20170027721A (ko) | 2014-05-20 | 2017-03-10 | 알큐엑스 파마슈티컬스, 인크. | 마크로시클릭 광범위 항생제 |
| ITUB20154591A1 (it) | 2015-10-12 | 2017-04-12 | Crestoptics S R L | Apparato di microscopia confocale e relativo procedimento di acquisizione ed elaborazione di immagini |
| KR20180109858A (ko) | 2015-11-20 | 2018-10-08 | 알큐엑스 파마슈티컬스, 인크. | 마크로시클릭 광범위 항생제 |
| TWI725075B (zh) | 2015-11-20 | 2021-04-21 | 美商Ｒｑｘ製藥公司 | 巨環廣效抗生素 |
| UA126027C2 (uk) | 2017-02-15 | 2022-08-03 | АрКьюЕкс ФАРМАСЬЮТІКЛС, ІНК. | Макроциклічні антибіотики широкого спектра |
| MX386696B (es) | 2017-03-27 | 2025-03-19 | Hoffmann La Roche | Proceso para producir analogos de anillo de arilomicina |
| JP2020536072A (ja) | 2017-09-29 | 2020-12-10 | ジェネンテック， インコーポレイテッド | ペプチド抗生物質複合体およびその使用方法 |
| IL288294B (en) | 2019-05-28 | 2022-09-01 | Hoffmann La Roche | A broad-spectrum macrocyclic antibiotic |
-
2016
- 2016-11-21 KR KR1020187017097A patent/KR20180109858A/ko not_active Ceased
- 2016-11-21 CA CA3005551A patent/CA3005551A1/en not_active Abandoned
- 2016-11-21 CN CN201680079520.3A patent/CN109219596B/zh active Active
- 2016-11-21 AU AU2016357926A patent/AU2016357926B2/en not_active Ceased
- 2016-11-21 WO PCT/CN2016/106597 patent/WO2017084629A1/en not_active Ceased
- 2016-11-21 JP JP2018525573A patent/JP6873993B2/ja active Active
- 2016-11-21 US US15/777,509 patent/US11072635B2/en active Active
- 2016-11-21 MX MX2018006199A patent/MX387476B/es unknown
- 2016-11-21 EP EP16843251.6A patent/EP3377474B1/en active Active
- 2016-11-21 BR BR112018010267A patent/BR112018010267A2/pt not_active Application Discontinuation
- 2016-11-21 RU RU2018122498A patent/RU2761476C2/ru active
-
2018
- 2018-05-16 IL IL259429A patent/IL259429B/en unknown
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