RU2761476C2 - Макроциклические антибиотики широкого спектра действия - Google Patents

Макроциклические антибиотики широкого спектра действия Download PDF

Info

Publication number
RU2761476C2
RU2761476C2 RU2018122498A RU2018122498A RU2761476C2 RU 2761476 C2 RU2761476 C2 RU 2761476C2 RU 2018122498 A RU2018122498 A RU 2018122498A RU 2018122498 A RU2018122498 A RU 2018122498A RU 2761476 C2 RU2761476 C2 RU 2761476C2
Authority
RU
Russia
Prior art keywords
alkyl
compound
formula
another embodiment
optionally substituted
Prior art date
Application number
RU2018122498A
Other languages
English (en)
Russian (ru)
Other versions
RU2018122498A (ru
RU2018122498A3 (enExample
Inventor
Юньшэнь ЧЭНЬ
Петер Эндрю Смит
Такер Карран Робертс
Роберт И. Хигучи
Прасуна Параселли
Майкл Ф.Т. КЕЛЕР
Джейкоб Бредли ШВАРЦ
Джеймс Джон Кроуфорд
Куонг Ц. ЛЮ
Хуайонг ХУ
Чжиоюн ЮЙ
Original Assignee
АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК.
Дженетек, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК., Дженетек, Инк. filed Critical АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК.
Publication of RU2018122498A publication Critical patent/RU2018122498A/ru
Publication of RU2018122498A3 publication Critical patent/RU2018122498A3/ru
Application granted granted Critical
Publication of RU2761476C2 publication Critical patent/RU2761476C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RU2018122498A 2015-11-20 2016-11-21 Макроциклические антибиотики широкого спектра действия RU2761476C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2015/095165 2015-11-20
CNPCT/CN2015/095165 2015-11-20
CNPCT/CN2016/105043 2016-11-08
CNPCT/CN2016/105043 2016-11-08
PCT/CN2016/106597 WO2017084629A1 (en) 2015-11-20 2016-11-21 Macrocyclic broad spectrum antibiotics

Publications (3)

Publication Number Publication Date
RU2018122498A RU2018122498A (ru) 2019-12-26
RU2018122498A3 RU2018122498A3 (enExample) 2020-02-28
RU2761476C2 true RU2761476C2 (ru) 2021-12-08

Family

ID=58231314

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018122498A RU2761476C2 (ru) 2015-11-20 2016-11-21 Макроциклические антибиотики широкого спектра действия

Country Status (12)

Country Link
US (1) US11072635B2 (enExample)
EP (1) EP3377474B1 (enExample)
JP (1) JP6873993B2 (enExample)
KR (1) KR20180109858A (enExample)
CN (1) CN109219596B (enExample)
AU (1) AU2016357926B2 (enExample)
BR (1) BR112018010267A2 (enExample)
CA (1) CA3005551A1 (enExample)
IL (1) IL259429B (enExample)
MX (1) MX387476B (enExample)
RU (1) RU2761476C2 (enExample)
WO (1) WO2017084629A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
KR20170027721A (ko) 2014-05-20 2017-03-10 알큐엑스 파마슈티컬스, 인크. 마크로시클릭 광범위 항생제
KR20180109858A (ko) 2015-11-20 2018-10-08 알큐엑스 파마슈티컬스, 인크. 마크로시클릭 광범위 항생제
UA126027C2 (uk) * 2017-02-15 2022-08-03 АрКьюЕкс ФАРМАСЬЮТІКЛС, ІНК. Макроциклічні антибіотики широкого спектра
JP2020536072A (ja) * 2017-09-29 2020-12-10 ジェネンテック， インコーポレイテッド ペプチド抗生物質複合体およびその使用方法
IL288294B (en) * 2019-05-28 2022-09-01 Hoffmann La Roche A broad-spectrum macrocyclic antibiotic

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012166665A2 (en) * 2011-05-27 2012-12-06 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
WO2013138187A1 (en) * 2012-03-14 2013-09-19 The Scripps Research Institute Broad spectrum antibiotic arylomycin analogs
RU2012142832A (ru) * 2010-03-09 2014-04-20 Мерк Шарп Энд Домэ Корп. Мостиковые липогликопептиды, усиливающие активность бета-лактамных антибактериальных агентов
WO2014081886A1 (en) * 2012-11-21 2014-05-30 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3128280A (en) 1959-10-23 1964-04-07 Searle & Co 1-(alkoxylated/halogenated phenyl)-3-pyridylmethylureas
US5204328A (en) 1990-06-26 1993-04-20 Merck & Co., Inc. Peptides having atrial natriuretic factor activity
JPH11514527A (ja) 1995-11-03 1999-12-14 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー バキルス エスピー（Ｂａｃｉｌｌｕｓ ｓｐ．）用の陽性選択ベクター
NZ335276A (en) 1996-10-18 2000-09-29 Vertex Pharma Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease
EP0895999A1 (en) 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics
GB9902399D0 (en) 1999-02-03 1999-03-24 Smithkline Beecham Plc Compounds
US6660832B1 (en) 1999-08-20 2003-12-09 Isis Pharmaceuticals, Inc. Macrocyclic compounds and preparation methods thereof
US6951840B2 (en) 2001-08-31 2005-10-04 Eli Lilly And Company Lipoglycopeptide antibiotics
DE10226921A1 (de) 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
JP2007536200A (ja) 2003-07-17 2007-12-13 ミジェニックス インコーポレイテッド リポペプチド抗生物質誘導体の組成物およびその使用方法
DE10358824A1 (de) 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014245A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
DE102005014247A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
BR112012021806A2 (pt) 2010-03-01 2015-09-08 Myrexis Inc compostos e seus usos terapêusticos.
WO2011120071A1 (en) 2010-04-01 2011-10-06 The University Of Queensland Oxytocin peptide analogues
MX2013003035A (es) 2010-09-15 2013-12-16 Scripps Research Inst Analogos de arilomicina como antibióticos de amplio espectro.
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
CN103159830B (zh) 2011-12-15 2017-06-20 上海来益生物药物研究开发中心有限责任公司 脂肽类化合物
FR2986154B1 (fr) 2012-01-31 2017-08-04 Pierre Fabre Dermo Cosmetique Nouveau systeme photoprotecteur
CN103788176A (zh) * 2012-10-31 2014-05-14 上海来益生物药物研究开发中心有限责任公司 一种arylomycin类化合物及其制备方法和应用
KR20170027721A (ko) 2014-05-20 2017-03-10 알큐엑스 파마슈티컬스, 인크. 마크로시클릭 광범위 항생제
ITUB20154591A1 (it) 2015-10-12 2017-04-12 Crestoptics S R L Apparato di microscopia confocale e relativo procedimento di acquisizione ed elaborazione di immagini
KR20180109858A (ko) 2015-11-20 2018-10-08 알큐엑스 파마슈티컬스, 인크. 마크로시클릭 광범위 항생제
TWI725075B (zh) 2015-11-20 2021-04-21 美商Ｒｑｘ製藥公司 巨環廣效抗生素
UA126027C2 (uk) 2017-02-15 2022-08-03 АрКьюЕкс ФАРМАСЬЮТІКЛС, ІНК. Макроциклічні антибіотики широкого спектра
MX386696B (es) 2017-03-27 2025-03-19 Hoffmann La Roche Proceso para producir analogos de anillo de arilomicina
JP2020536072A (ja) 2017-09-29 2020-12-10 ジェネンテック， インコーポレイテッド ペプチド抗生物質複合体およびその使用方法
IL288294B (en) 2019-05-28 2022-09-01 Hoffmann La Roche A broad-spectrum macrocyclic antibiotic

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2012142832A (ru) * 2010-03-09 2014-04-20 Мерк Шарп Энд Домэ Корп. Мостиковые липогликопептиды, усиливающие активность бета-лактамных антибактериальных агентов
WO2012166665A2 (en) * 2011-05-27 2012-12-06 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
WO2013138187A1 (en) * 2012-03-14 2013-09-19 The Scripps Research Institute Broad spectrum antibiotic arylomycin analogs
WO2014081886A1 (en) * 2012-11-21 2014-05-30 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics

Also Published As

Publication number Publication date
RU2018122498A (ru) 2019-12-26
MX2018006199A (es) 2019-01-10
JP6873993B2 (ja) 2021-05-19
CN109219596B (zh) 2022-04-19
AU2016357926A1 (en) 2018-06-14
RU2018122498A3 (enExample) 2020-02-28
IL259429A (en) 2018-07-31
CN109219596A (zh) 2019-01-15
EP3377474A1 (en) 2018-09-26
WO2017084629A1 (en) 2017-05-26
MX387476B (es) 2025-03-18
KR20180109858A (ko) 2018-10-08
CA3005551A1 (en) 2017-05-26
IL259429B (en) 2021-12-01
JP2019501123A (ja) 2019-01-17
US20200239519A1 (en) 2020-07-30
US11072635B2 (en) 2021-07-27
EP3377474C0 (en) 2023-08-16
EP3377474B1 (en) 2023-08-16
BR112018010267A2 (pt) 2018-11-27
AU2016357926B2 (en) 2021-05-27

Similar Documents

Publication Publication Date Title
JP7148652B2 (ja) 大環状広域スペクトル抗生物質
US20230133817A1 (en) Macrocyclic broad spectrum antibiotics
JP6662960B2 (ja) 大環状広域抗生物質
EP3377474B1 (en) Macrocyclic broad spectrum antibiotics
US20160194358A1 (en) Linear peptide antibiotcs
HK1205736A1 (en) Linear peptide antibiotics
WO2018149419A1 (en) Macrocyclic broad spectrum antibiotics
HK40002868A (en) Macrocyclic broad spectrum antibiotics
HK40002868B (en) Macrocyclic broad spectrum antibiotics