JP2016528257A5 - - Google Patents
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- JP2016528257A5 JP2016528257A5 JP2016534849A JP2016534849A JP2016528257A5 JP 2016528257 A5 JP2016528257 A5 JP 2016528257A5 JP 2016534849 A JP2016534849 A JP 2016534849A JP 2016534849 A JP2016534849 A JP 2016534849A JP 2016528257 A5 JP2016528257 A5 JP 2016528257A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- independently
- compound
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 7
- 125000004404 heteroalkyl group Chemical group 0.000 claims 7
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 7
- 125000003107 substituted aryl group Chemical group 0.000 claims 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 3
- 229910052796 boron Inorganic materials 0.000 claims 3
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 241000606125 Bacteroides Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- -1 substituted Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 241000588626 Acinetobacter baumannii Species 0.000 claims 1
- 241000588624 Acinetobacter calcoaceticus Species 0.000 claims 1
- 241001148231 Acinetobacter haemolyticus Species 0.000 claims 1
- 241000607528 Aeromonas hydrophila Species 0.000 claims 1
- 241001135322 Bacteroides eggerthii Species 0.000 claims 1
- 241000606124 Bacteroides fragilis Species 0.000 claims 1
- 241000606123 Bacteroides thetaiotaomicron Species 0.000 claims 1
- 241000606219 Bacteroides uniformis Species 0.000 claims 1
- 241000606215 Bacteroides vulgatus Species 0.000 claims 1
- 241000588779 Bordetella bronchiseptica Species 0.000 claims 1
- 241000588780 Bordetella parapertussis Species 0.000 claims 1
- 241000588832 Bordetella pertussis Species 0.000 claims 1
- 241000589969 Borreliella burgdorferi Species 0.000 claims 1
- 241000589513 Burkholderia cepacia Species 0.000 claims 1
- 241000589877 Campylobacter coli Species 0.000 claims 1
- 241000589874 Campylobacter fetus Species 0.000 claims 1
- 241000589875 Campylobacter jejuni Species 0.000 claims 1
- 241000588919 Citrobacter freundii Species 0.000 claims 1
- 241000193163 Clostridioides difficile Species 0.000 claims 1
- 241000186227 Corynebacterium diphtheriae Species 0.000 claims 1
- 241000918600 Corynebacterium ulcerans Species 0.000 claims 1
- 241001600125 Delftia acidovorans Species 0.000 claims 1
- 241000588697 Enterobacter cloacae Species 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 241000194031 Enterococcus faecium Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000589602 Francisella tularensis Species 0.000 claims 1
- 241000606788 Haemophilus haemolyticus Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 241000606822 Haemophilus parahaemolyticus Species 0.000 claims 1
- 241000606766 Haemophilus parainfluenzae Species 0.000 claims 1
- 241000590002 Helicobacter pylori Species 0.000 claims 1
- 241001454354 Kingella Species 0.000 claims 1
- 241000588915 Klebsiella aerogenes Species 0.000 claims 1
- 241000588749 Klebsiella oxytoca Species 0.000 claims 1
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 1
- 241000589242 Legionella pneumophila Species 0.000 claims 1
- 241000186779 Listeria monocytogenes Species 0.000 claims 1
- 241001293418 Mannheimia haemolytica Species 0.000 claims 1
- 241000588621 Moraxella Species 0.000 claims 1
- 241000588655 Moraxella catarrhalis Species 0.000 claims 1
- 241000588772 Morganella morganii Species 0.000 claims 1
- 241000186359 Mycobacterium Species 0.000 claims 1
- 241000186367 Mycobacterium avium Species 0.000 claims 1
- 241000186364 Mycobacterium intracellulare Species 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 claims 1
- 241000588650 Neisseria meningitidis Species 0.000 claims 1
- 241001135232 Odoribacter splanchnicus Species 0.000 claims 1
- 241000606210 Parabacteroides distasonis Species 0.000 claims 1
- 241000606856 Pasteurella multocida Species 0.000 claims 1
- 241000588770 Proteus mirabilis Species 0.000 claims 1
- 241000588767 Proteus vulgaris Species 0.000 claims 1
- 241000576783 Providencia alcalifaciens Species 0.000 claims 1
- 241000588777 Providencia rettgeri Species 0.000 claims 1
- 241000588778 Providencia stuartii Species 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 241000168225 Pseudomonas alcaligenes Species 0.000 claims 1
- 241000589540 Pseudomonas fluorescens Species 0.000 claims 1
- 241000589776 Pseudomonas putida Species 0.000 claims 1
- 241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 claims 1
- 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 claims 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 claims 1
- 241000607715 Serratia marcescens Species 0.000 claims 1
- 241000607764 Shigella dysenteriae Species 0.000 claims 1
- 241000607762 Shigella flexneri Species 0.000 claims 1
- 241000607760 Shigella sonnei Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
- 241000191984 Staphylococcus haemolyticus Species 0.000 claims 1
- 241000192087 Staphylococcus hominis Species 0.000 claims 1
- 241000191982 Staphylococcus hyicus Species 0.000 claims 1
- 241000191980 Staphylococcus intermedius Species 0.000 claims 1
- 241001464905 Staphylococcus saccharolyticus Species 0.000 claims 1
- 241001147691 Staphylococcus saprophyticus Species 0.000 claims 1
- 241000122973 Stenotrophomonas maltophilia Species 0.000 claims 1
- 241000193985 Streptococcus agalactiae Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 241000193996 Streptococcus pyogenes Species 0.000 claims 1
- 241000607626 Vibrio cholerae Species 0.000 claims 1
- 241000607272 Vibrio parahaemolyticus Species 0.000 claims 1
- 241000607447 Yersinia enterocolitica Species 0.000 claims 1
- 241000607481 Yersinia intermedia Species 0.000 claims 1
- 241000607479 Yersinia pestis Species 0.000 claims 1
- 241000607477 Yersinia pseudotuberculosis Species 0.000 claims 1
- 241000606834 [Haemophilus] ducreyi Species 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940092559 enterobacter aerogenes Drugs 0.000 claims 1
- 229940032049 enterococcus faecalis Drugs 0.000 claims 1
- 229940118764 francisella tularensis Drugs 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 229940037467 helicobacter pylori Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229940115932 legionella pneumophila Drugs 0.000 claims 1
- 229940076266 morganella morganii Drugs 0.000 claims 1
- 229940051027 pasteurella multocida Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940007042 proteus vulgaris Drugs 0.000 claims 1
- 229940007046 shigella dysenteriae Drugs 0.000 claims 1
- 229940115939 shigella sonnei Drugs 0.000 claims 1
- 229940037649 staphylococcus haemolyticus Drugs 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 229940118696 vibrio cholerae Drugs 0.000 claims 1
- 229940098232 yersinia enterocolitica Drugs 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361865980P | 2013-08-14 | 2013-08-14 | |
| US201361865982P | 2013-08-14 | 2013-08-14 | |
| US201361865986P | 2013-08-14 | 2013-08-14 | |
| US61/865,986 | 2013-08-14 | ||
| US61/865,982 | 2013-08-14 | ||
| US61/865,980 | 2013-08-14 | ||
| PCT/US2014/051151 WO2015023898A1 (en) | 2013-08-14 | 2014-08-14 | Linear peptide antibiotcs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016528257A JP2016528257A (ja) | 2016-09-15 |
| JP2016528257A5 true JP2016528257A5 (enExample) | 2017-10-05 |
Family
ID=52468711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016534849A Pending JP2016528257A (ja) | 2013-08-14 | 2014-08-14 | 直鎖ペプチド抗生物質 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20160194358A1 (enExample) |
| EP (1) | EP3033352A4 (enExample) |
| JP (1) | JP2016528257A (enExample) |
| KR (1) | KR20160044512A (enExample) |
| CN (1) | CN105636978A (enExample) |
| CA (1) | CA2921082A1 (enExample) |
| MX (1) | MX2016001927A (enExample) |
| RU (1) | RU2016107436A (enExample) |
| WO (1) | WO2015023898A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3464336T1 (sl) | 2016-06-01 | 2022-06-30 | Athira Pharma, Inc. | Spojine |
| RU2698328C1 (ru) * | 2019-02-27 | 2019-08-26 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) | Серебряные соли 5,6-диарил-4-[4-(ацетиламиносульфонил)фенил]-3,5-дигидропирроло[3,4-с]пиразол-3-онов, проявляющие противомикробную активность |
| CN111978371B (zh) * | 2019-05-22 | 2022-05-13 | 成都诺和晟泰生物科技有限公司 | 一种多肽类衍生物及其在医药领域的用途 |
| US20220289698A1 (en) * | 2019-07-30 | 2022-09-15 | Karl-Franzens-Universität Graz | Inhibitors of human atgl |
| CN110606825A (zh) * | 2019-10-30 | 2019-12-24 | 成都海杰亚医药科技有限公司 | 一种制备吡啶-2-硫醇的方法 |
| CN110790817A (zh) * | 2019-11-12 | 2020-02-14 | 成都诺和晟泰生物科技有限公司 | 一种多肽类化合物、制剂、药物组合物及制备方法、应用 |
| EP4284804A1 (en) | 2021-01-26 | 2023-12-06 | Schrödinger, Inc. | Tricyclic compounds useful in the treatment of cancer, autoimmune and inflammatory disorders |
| CN116444378A (zh) * | 2023-02-14 | 2023-07-18 | 广东优康精细化工有限公司 | 一种n-甲基异丙基胺的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1136498A1 (en) * | 1996-10-18 | 2001-09-26 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus NS3 protease |
| NZ335276A (en) * | 1996-10-18 | 2000-09-29 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease |
| CN103159830B (zh) * | 2011-12-15 | 2017-06-20 | 上海来益生物药物研究开发中心有限责任公司 | 脂肽类化合物 |
| KR20140132367A (ko) * | 2012-02-16 | 2014-11-17 | 알큐엑스 파마슈티컬스, 인크. | 선형 펩티드 항생제 |
-
2014
- 2014-08-14 WO PCT/US2014/051151 patent/WO2015023898A1/en not_active Ceased
- 2014-08-14 KR KR1020167006533A patent/KR20160044512A/ko not_active Withdrawn
- 2014-08-14 CA CA2921082A patent/CA2921082A1/en not_active Abandoned
- 2014-08-14 EP EP14836261.9A patent/EP3033352A4/en not_active Withdrawn
- 2014-08-14 RU RU2016107436A patent/RU2016107436A/ru not_active Application Discontinuation
- 2014-08-14 MX MX2016001927A patent/MX2016001927A/es unknown
- 2014-08-14 CN CN201480056420.XA patent/CN105636978A/zh active Pending
- 2014-08-14 JP JP2016534849A patent/JP2016528257A/ja active Pending
- 2014-08-14 US US14/911,823 patent/US20160194358A1/en not_active Abandoned
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