JP2016528257A - 直鎖ペプチド抗生物質 - Google Patents

直鎖ペプチド抗生物質 Download PDF

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Publication number
JP2016528257A
JP2016528257A JP2016534849A JP2016534849A JP2016528257A JP 2016528257 A JP2016528257 A JP 2016528257A JP 2016534849 A JP2016534849 A JP 2016534849A JP 2016534849 A JP2016534849 A JP 2016534849A JP 2016528257 A JP2016528257 A JP 2016528257A
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JP
Japan
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optionally substituted
formula
alkyl
independently
compound
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JP2016534849A
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English (en)
Japanese (ja)
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JP2016528257A5 (enExample
Inventor
スミス，ピーター，アンドリュー
ロバーツ，タッカー，カラン
ヒグチ，ロバート，アイ．
パラセッリ，プラスナ
ケーラー，マイケル，エフ．，ティー．
クロフォード，ジェイムス，ジョン
Original Assignee
アールキューエックス ファーマシューティカルズ，インク．
アールキューエックス ファーマシューティカルズ，インク．
ジェネンテック， インク．
ジェネンテック， インク．
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Application filed by アールキューエックス ファーマシューティカルズ，インク．, アールキューエックス ファーマシューティカルズ，インク．, ジェネンテック， インク．, ジェネンテック， インク． filed Critical アールキューエックス ファーマシューティカルズ，インク．
Publication of JP2016528257A publication Critical patent/JP2016528257A/ja
Publication of JP2016528257A5 publication Critical patent/JP2016528257A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
JP2016534849A 2013-08-14 2014-08-14 直鎖ペプチド抗生物質 Pending JP2016528257A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361865980P 2013-08-14 2013-08-14
US201361865982P 2013-08-14 2013-08-14
US201361865986P 2013-08-14 2013-08-14
US61/865,986 2013-08-14
US61/865,982 2013-08-14
US61/865,980 2013-08-14
PCT/US2014/051151 WO2015023898A1 (en) 2013-08-14 2014-08-14 Linear peptide antibiotcs

Publications (2)

Publication Number Publication Date
JP2016528257A true JP2016528257A (ja) 2016-09-15
JP2016528257A5 JP2016528257A5 (enExample) 2017-10-05

Family

ID=52468711

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016534849A Pending JP2016528257A (ja) 2013-08-14 2014-08-14 直鎖ペプチド抗生物質

Country Status (9)

Country Link
US (1) US20160194358A1 (enExample)
EP (1) EP3033352A4 (enExample)
JP (1) JP2016528257A (enExample)
KR (1) KR20160044512A (enExample)
CN (1) CN105636978A (enExample)
CA (1) CA2921082A1 (enExample)
MX (1) MX2016001927A (enExample)
RU (1) RU2016107436A (enExample)
WO (1) WO2015023898A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022542613A (ja) * 2019-07-30 2022-10-05 カール－フランツェンス－ウニベルシテート グラーツ ヒトａｔｇｌの阻害剤

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3464336T1 (sl) 2016-06-01 2022-06-30 Athira Pharma, Inc. Spojine
RU2698328C1 (ru) * 2019-02-27 2019-08-26 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) Серебряные соли 5,6-диарил-4-[4-(ацетиламиносульфонил)фенил]-3,5-дигидропирроло[3,4-с]пиразол-3-онов, проявляющие противомикробную активность
CN111978371B (zh) * 2019-05-22 2022-05-13 成都诺和晟泰生物科技有限公司 一种多肽类衍生物及其在医药领域的用途
CN110606825A (zh) * 2019-10-30 2019-12-24 成都海杰亚医药科技有限公司 一种制备吡啶-2-硫醇的方法
CN110790817A (zh) * 2019-11-12 2020-02-14 成都诺和晟泰生物科技有限公司 一种多肽类化合物、制剂、药物组合物及制备方法、应用
EP4284804A1 (en) 2021-01-26 2023-12-06 Schrödinger, Inc. Tricyclic compounds useful in the treatment of cancer, autoimmune and inflammatory disorders
CN116444378A (zh) * 2023-02-14 2023-07-18 广东优康精细化工有限公司 一种n-甲基异丙基胺的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017679A1 (en) * 1996-10-18 1998-04-30 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
CN103159830A (zh) * 2011-12-15 2013-06-19 上海来益生物药物研究开发中心有限责任公司 脂肽类化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1136498A1 (en) * 1996-10-18 2001-09-26 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis c virus NS3 protease
KR20140132367A (ko) * 2012-02-16 2014-11-17 알큐엑스 파마슈티컬스, 인크. 선형 펩티드 항생제

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017679A1 (en) * 1996-10-18 1998-04-30 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
CN103159830A (zh) * 2011-12-15 2013-06-19 上海来益生物药物研究开发中心有限责任公司 脂肽类化合物

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BIOORG. MED. CHEM. LETT., 2009, VOL.19, PP.2880-2883, JPN6018031777, ISSN: 0004134066 *
CHEMISTRY & BIOLOGY, 2010, VOL.17, PP.1223-1231, JPN6018031798, ISSN: 0004134072 *
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2011, VOL.19, PP.3437-3449, JPN6018031781, ISSN: 0004134067 *
J. AM. CHEM. SOC., 2011, VOL.133, PP.17869-17877, JPN6018031800, ISSN: 0004134073 *
JOURNAL OF PEPTIDE SCIENCE, 2000, VOL.6, PP.11-18, JPN6018031787, ISSN: 0004134069 *
JOURNAL OF PEPTIDE SCIENCE, 2005, VOL.11, PP.142-152, JPN6018031791, ISSN: 0004134070 *
ORG. LETT., 2001, VOL.3, NO.3, PP.337-340, JPN6018031784, ISSN: 0004134068 *
TETRAHEDRON LETTERS, 1998, VOL.39, PP.9675-9678, JPN6018031794, ISSN: 0004134071 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022542613A (ja) * 2019-07-30 2022-10-05 カール－フランツェンス－ウニベルシテート グラーツ ヒトａｔｇｌの阻害剤

Also Published As

Publication number Publication date
US20160194358A1 (en) 2016-07-07
MX2016001927A (es) 2016-09-08
RU2016107436A3 (enExample) 2018-05-22
WO2015023898A1 (en) 2015-02-19
CA2921082A1 (en) 2015-02-19
RU2016107436A (ru) 2017-09-19
EP3033352A4 (en) 2017-04-19
CN105636978A (zh) 2016-06-01
KR20160044512A (ko) 2016-04-25
EP3033352A1 (en) 2016-06-22
WO2015023898A8 (en) 2016-03-24

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