KR20160044512A - 선형 펩티드 항생제 - Google Patents
선형 펩티드 항생제 Download PDFInfo
- Publication number
- KR20160044512A KR20160044512A KR1020167006533A KR20167006533A KR20160044512A KR 20160044512 A KR20160044512 A KR 20160044512A KR 1020167006533 A KR1020167006533 A KR 1020167006533A KR 20167006533 A KR20167006533 A KR 20167006533A KR 20160044512 A KR20160044512 A KR 20160044512A
- Authority
- KR
- South Korea
- Prior art keywords
- optionally substituted
- alkyl
- formula
- rti
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC(C(*)C(C)C(C)=O)C(*)N(*)S(=O)=O Chemical compound CC(C(*)C(C)C(C)=O)C(*)N(*)S(=O)=O 0.000 description 14
- UKVNIMDPGXHVES-ZYPSCFAMSA-N CCCCc(cc1)ccc1-c1ccc(C(C(F)(F)F)N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(NC(CC(C)C)C(N[C@H](B(O)O)C)=O)=O)=O)=O)cc1 Chemical compound CCCCc(cc1)ccc1-c1ccc(C(C(F)(F)F)N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(NC(CC(C)C)C(N[C@H](B(O)O)C)=O)=O)=O)=O)cc1 UKVNIMDPGXHVES-ZYPSCFAMSA-N 0.000 description 2
- XUJQNRUTBLBLAX-UHFFFAOYSA-N CB1OCCNCCO1 Chemical compound CB1OCCNCCO1 XUJQNRUTBLBLAX-UHFFFAOYSA-N 0.000 description 1
- DQSZBOPHUQOLRG-UMMYVOPBSA-N CC1(C)[C@H]2C3OB(CNC([C@H](CCCCN)NC(CNC([C@H]4NC([C@H](CCN)NC(CCCCCCCCCCCCCCN)=O)=[O](C)[C@H]4O)=O)=O)=O)OC3C[C@@H]1C2 Chemical compound CC1(C)[C@H]2C3OB(CNC([C@H](CCCCN)NC(CNC([C@H]4NC([C@H](CCN)NC(CCCCCCCCCCCCCCN)=O)=[O](C)[C@H]4O)=O)=O)=O)OC3C[C@@H]1C2 DQSZBOPHUQOLRG-UMMYVOPBSA-N 0.000 description 1
- UPBZFCGPNDDUDQ-QPIXVHDUSA-N CC1(C)[C@H]2C3OB(CNC([C@H](CCCCN)NC(CNC([C@H]4NC([C@H](CCN)NC(CCCCCCCCCCCCN)=O)=[O](C)[C@H]4O)=O)=O)=O)OC3C[C@@H]1C2 Chemical compound CC1(C)[C@H]2C3OB(CNC([C@H](CCCCN)NC(CNC([C@H]4NC([C@H](CCN)NC(CCCCCCCCCCCCN)=O)=[O](C)[C@H]4O)=O)=O)=O)OC3C[C@@H]1C2 UPBZFCGPNDDUDQ-QPIXVHDUSA-N 0.000 description 1
- QEKKXIFJWFCTRJ-YERVVRTASA-N CCCCCCCCN1CC(C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@H](B2O[C@@](C)([C@@H](C3)C(C)(C)[C@@H]3C3)[C@@H]3O2)C)=O)=O)=O)=O)=O)NCC1 Chemical compound CCCCCCCCN1CC(C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@H](B2O[C@@](C)([C@@H](C3)C(C)(C)[C@@H]3C3)[C@@H]3O2)C)=O)=O)=O)=O)=O)NCC1 QEKKXIFJWFCTRJ-YERVVRTASA-N 0.000 description 1
- BAYKNQSTTHRUSX-MFMARWFBSA-N CCCCCCN1CC(C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@H](B2O[C@@](C)([C@@H](C3)C(C)(C)[C@@H]3C3)[C@@H]3O2)C)=O)=O)=O)=O)=O)NCC1 Chemical compound CCCCCCN1CC(C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@H](B2O[C@@](C)([C@@H](C3)C(C)(C)[C@@H]3C3)[C@@H]3O2)C)=O)=O)=O)=O)=O)NCC1 BAYKNQSTTHRUSX-MFMARWFBSA-N 0.000 description 1
- YKUBHHYXHHMEFB-MROFPOBKSA-N CCCCc(cc1)ccc1-c(cc1)ccc1C(N[C@@H](CCN)C(N[C@@H](C(C)O)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(CCl)=O)=O)=O)=O)=O)=O Chemical compound CCCCc(cc1)ccc1-c(cc1)ccc1C(N[C@@H](CCN)C(N[C@@H](C(C)O)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(CCl)=O)=O)=O)=O)=O)=O YKUBHHYXHHMEFB-MROFPOBKSA-N 0.000 description 1
- MADOSYVMJAMZSG-JQWLQHMOSA-N CCCCc(cc1)ccc1-c1ccc(C(C(F)(F)F)N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@H](B2O[C@@](C)([C@@H](C3)C(C)(C)[C@@H]3C3)[C@@H]3O2)C)=O)=O)=O)=O)cc1 Chemical compound CCCCc(cc1)ccc1-c1ccc(C(C(F)(F)F)N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@H](B2O[C@@](C)([C@@H](C3)C(C)(C)[C@@H]3C3)[C@@H]3O2)C)=O)=O)=O)=O)cc1 MADOSYVMJAMZSG-JQWLQHMOSA-N 0.000 description 1
- ZATYGICVGILNGY-OMCCKGSHSA-N C[C@@H](B1OCCNCCO1)NC([C@H](CCCCN)NC([C@H](N)NC([C@H]([C@@H](C)O)NC([C@H](CN)NC(c(cc1)ccc1-c(cc1)ccc1Cl)=O)=O)=O)=O)=O Chemical compound C[C@@H](B1OCCNCCO1)NC([C@H](CCCCN)NC([C@H](N)NC([C@H]([C@@H](C)O)NC([C@H](CN)NC(c(cc1)ccc1-c(cc1)ccc1Cl)=O)=O)=O)=O)=O ZATYGICVGILNGY-OMCCKGSHSA-N 0.000 description 1
- JGIUDVQQKVEWMI-ACEKRXLCSA-N C[C@H]([C@@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(C(NCC(OC)=O)=O)=O)N)=O)=O)N)=O)NC([C@H](CN)NC(c(cc1)ccc1-c1ccc(C)cc1)=O)=O)O Chemical compound C[C@H]([C@@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(C(NCC(OC)=O)=O)=O)N)=O)=O)N)=O)NC([C@H](CN)NC(c(cc1)ccc1-c1ccc(C)cc1)=O)=O)O JGIUDVQQKVEWMI-ACEKRXLCSA-N 0.000 description 1
- JEPCLNGRAIMPQV-UHFFFAOYSA-N Nc(c(O)ccc1)c1O Chemical compound Nc(c(O)ccc1)c1O JEPCLNGRAIMPQV-UHFFFAOYSA-N 0.000 description 1
- RPHKINMPYFJSCF-UHFFFAOYSA-N Nc1cc(N)cc(N)c1 Chemical compound Nc1cc(N)cc(N)c1 RPHKINMPYFJSCF-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361865980P | 2013-08-14 | 2013-08-14 | |
| US201361865982P | 2013-08-14 | 2013-08-14 | |
| US201361865986P | 2013-08-14 | 2013-08-14 | |
| US61/865,986 | 2013-08-14 | ||
| US61/865,982 | 2013-08-14 | ||
| US61/865,980 | 2013-08-14 | ||
| PCT/US2014/051151 WO2015023898A1 (en) | 2013-08-14 | 2014-08-14 | Linear peptide antibiotcs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20160044512A true KR20160044512A (ko) | 2016-04-25 |
Family
ID=52468711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167006533A Withdrawn KR20160044512A (ko) | 2013-08-14 | 2014-08-14 | 선형 펩티드 항생제 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20160194358A1 (enExample) |
| EP (1) | EP3033352A4 (enExample) |
| JP (1) | JP2016528257A (enExample) |
| KR (1) | KR20160044512A (enExample) |
| CN (1) | CN105636978A (enExample) |
| CA (1) | CA2921082A1 (enExample) |
| MX (1) | MX2016001927A (enExample) |
| RU (1) | RU2016107436A (enExample) |
| WO (1) | WO2015023898A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3464336T1 (sl) | 2016-06-01 | 2022-06-30 | Athira Pharma, Inc. | Spojine |
| RU2698328C1 (ru) * | 2019-02-27 | 2019-08-26 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) | Серебряные соли 5,6-диарил-4-[4-(ацетиламиносульфонил)фенил]-3,5-дигидропирроло[3,4-с]пиразол-3-онов, проявляющие противомикробную активность |
| CN111978371B (zh) * | 2019-05-22 | 2022-05-13 | 成都诺和晟泰生物科技有限公司 | 一种多肽类衍生物及其在医药领域的用途 |
| US20220289698A1 (en) * | 2019-07-30 | 2022-09-15 | Karl-Franzens-Universität Graz | Inhibitors of human atgl |
| CN110606825A (zh) * | 2019-10-30 | 2019-12-24 | 成都海杰亚医药科技有限公司 | 一种制备吡啶-2-硫醇的方法 |
| CN110790817A (zh) * | 2019-11-12 | 2020-02-14 | 成都诺和晟泰生物科技有限公司 | 一种多肽类化合物、制剂、药物组合物及制备方法、应用 |
| EP4284804A1 (en) | 2021-01-26 | 2023-12-06 | Schrödinger, Inc. | Tricyclic compounds useful in the treatment of cancer, autoimmune and inflammatory disorders |
| CN116444378A (zh) * | 2023-02-14 | 2023-07-18 | 广东优康精细化工有限公司 | 一种n-甲基异丙基胺的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1136498A1 (en) * | 1996-10-18 | 2001-09-26 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus NS3 protease |
| NZ335276A (en) * | 1996-10-18 | 2000-09-29 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease |
| CN103159830B (zh) * | 2011-12-15 | 2017-06-20 | 上海来益生物药物研究开发中心有限责任公司 | 脂肽类化合物 |
| KR20140132367A (ko) * | 2012-02-16 | 2014-11-17 | 알큐엑스 파마슈티컬스, 인크. | 선형 펩티드 항생제 |
-
2014
- 2014-08-14 WO PCT/US2014/051151 patent/WO2015023898A1/en not_active Ceased
- 2014-08-14 KR KR1020167006533A patent/KR20160044512A/ko not_active Withdrawn
- 2014-08-14 CA CA2921082A patent/CA2921082A1/en not_active Abandoned
- 2014-08-14 EP EP14836261.9A patent/EP3033352A4/en not_active Withdrawn
- 2014-08-14 RU RU2016107436A patent/RU2016107436A/ru not_active Application Discontinuation
- 2014-08-14 MX MX2016001927A patent/MX2016001927A/es unknown
- 2014-08-14 CN CN201480056420.XA patent/CN105636978A/zh active Pending
- 2014-08-14 JP JP2016534849A patent/JP2016528257A/ja active Pending
- 2014-08-14 US US14/911,823 patent/US20160194358A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20160194358A1 (en) | 2016-07-07 |
| MX2016001927A (es) | 2016-09-08 |
| RU2016107436A3 (enExample) | 2018-05-22 |
| WO2015023898A1 (en) | 2015-02-19 |
| CA2921082A1 (en) | 2015-02-19 |
| RU2016107436A (ru) | 2017-09-19 |
| EP3033352A4 (en) | 2017-04-19 |
| JP2016528257A (ja) | 2016-09-15 |
| CN105636978A (zh) | 2016-06-01 |
| EP3033352A1 (en) | 2016-06-22 |
| WO2015023898A8 (en) | 2016-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20160311 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |