JP2020523351A5 - - Google Patents
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- Publication number
- JP2020523351A5 JP2020523351A5 JP2019568599A JP2019568599A JP2020523351A5 JP 2020523351 A5 JP2020523351 A5 JP 2020523351A5 JP 2019568599 A JP2019568599 A JP 2019568599A JP 2019568599 A JP2019568599 A JP 2019568599A JP 2020523351 A5 JP2020523351 A5 JP 2020523351A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- heterocycloalkyl
- cycloalkyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*(C)C1(C)*c2nc(I)nc(N(*)**=C)c2**1 Chemical compound C*(C)C1(C)*c2nc(I)nc(N(*)**=C)c2**1 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023060086A JP7636460B2 (ja) | 2017-06-15 | 2023-04-03 | Ａｌｋ２キナーゼのイミダゾール含有阻害剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762520150P | 2017-06-15 | 2017-06-15 | |
| US62/520,150 | 2017-06-15 | ||
| PCT/US2018/037503 WO2018232094A1 (en) | 2017-06-15 | 2018-06-14 | Imidazole-containing inhibitors of alk2 kinase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023060086A Division JP7636460B2 (ja) | 2017-06-15 | 2023-04-03 | Ａｌｋ２キナーゼのイミダゾール含有阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020523351A JP2020523351A (ja) | 2020-08-06 |
| JP2020523351A5 true JP2020523351A5 (enExample) | 2021-07-26 |
| JP7257338B2 JP7257338B2 (ja) | 2023-04-13 |
Family
ID=64659499
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019568599A Active JP7257338B2 (ja) | 2017-06-15 | 2018-06-14 | Ａｌｋ２キナーゼのイミダゾール含有阻害剤 |
| JP2023060086A Active JP7636460B2 (ja) | 2017-06-15 | 2023-04-03 | Ａｌｋ２キナーゼのイミダゾール含有阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023060086A Active JP7636460B2 (ja) | 2017-06-15 | 2023-04-03 | Ａｌｋ２キナーゼのイミダゾール含有阻害剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US11661426B2 (enExample) |
| EP (1) | EP3638229A4 (enExample) |
| JP (2) | JP7257338B2 (enExample) |
| KR (2) | KR102659955B1 (enExample) |
| CN (2) | CN110913855B (enExample) |
| AR (1) | AR112027A1 (enExample) |
| AU (2) | AU2018283053C1 (enExample) |
| BR (1) | BR112019026517A2 (enExample) |
| CA (1) | CA3066164A1 (enExample) |
| CL (1) | CL2019003669A1 (enExample) |
| CO (1) | CO2020000194A2 (enExample) |
| EA (1) | EA202090052A1 (enExample) |
| IL (2) | IL271109B2 (enExample) |
| MA (1) | MA49401A (enExample) |
| MX (2) | MX2019015226A (enExample) |
| MY (1) | MY204609A (enExample) |
| PH (1) | PH12019502781A1 (enExample) |
| SG (1) | SG10202112496SA (enExample) |
| TW (2) | TWI833696B (enExample) |
| WO (1) | WO2018232094A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10202356B2 (en) | 2013-03-14 | 2019-02-12 | Tolero Pharmaceuticals, Inc. | JAK2 and ALK2 inhibitors and methods for their use |
| AR112027A1 (es) | 2017-06-15 | 2019-09-11 | Biocryst Pharm Inc | Inhibidores de alk 2 quinasa que contienen imidazol |
| EP3826684A4 (en) | 2018-07-26 | 2022-04-06 | Sumitomo Dainippon Pharma Oncology, Inc. | METHODS OF TREATMENT OF DISEASES ASSOCIATED WITH ABNORMAL ACVR1 EXPRESSION AND ACVR1 INHIBITORS FOR USE IN THE SAME |
| US11111247B2 (en) * | 2018-09-25 | 2021-09-07 | Incyte Corporation | Pyrazolopyrimidine compounds and uses thereof |
| EP3870181B1 (en) | 2018-10-26 | 2024-08-14 | Keros Therapeutics, Inc. | Crystal forms of an alk2 inhibitor |
| EP3919484B1 (en) * | 2019-01-29 | 2023-05-24 | Shandong Xuanzhu Pharma Co., Ltd. | Hexone glucokinase inhibitor and use thereof |
| KR20200133188A (ko) * | 2019-05-17 | 2020-11-26 | 보로노이바이오 주식회사 | 헤테로고리 융합 피리미딘 유도체 및 이의 용도 |
| AU2020279686B2 (en) * | 2019-05-21 | 2025-08-28 | Voronoi Inc. | N-containing heteroaryl derivative and pharmaceutical composition comprising same as active ingredient for prevention or treatment of cancer |
| CN119638704A (zh) * | 2019-08-13 | 2025-03-18 | 缆图药品公司 | 活化素受体样激酶抑制剂的盐和晶体形式 |
| AU2021207804A1 (en) | 2020-01-13 | 2022-09-01 | Verge Analytics, Inc. | Substituted pyrazolo-pyrimidines and uses thereof |
| EP4118087A1 (en) * | 2020-03-09 | 2023-01-18 | Verge Analytics, Inc. | Substituted furo[3,2-d]pyrimidines and uses thereof |
| GB202006382D0 (en) | 2020-04-30 | 2020-06-17 | Spermatech As | Use |
| WO2022098812A1 (en) | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating iron overload |
| UY39578A (es) * | 2020-12-21 | 2022-07-29 | Biocryst Pharm Inc | Regímenes de dosificación de inhibidores orales de alk2 |
| BR112023024537A2 (pt) * | 2021-05-25 | 2024-02-06 | Biocryst Pharm Inc | Inibidores de alk2 cinase contendo imidazol, seus usos, composição farmacêutica, e kit |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
| AU2023249795A1 (en) | 2022-04-08 | 2024-10-17 | Shy Therapeutics, Llc | Compounds that interact with ras superfamily proteins for treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
| CN116478145B (zh) * | 2022-04-13 | 2024-02-02 | 杭州邦顺制药有限公司 | Alk2激酶抑制剂 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| LU86084A1 (fr) | 1985-09-20 | 1987-04-02 | Faco Sa | Apparei de massage electrique |
| US5102417A (en) | 1985-11-07 | 1992-04-07 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
| US4800882A (en) | 1987-03-13 | 1989-01-31 | Cook Incorporated | Endovascular stent and delivery system |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4886062A (en) | 1987-10-19 | 1989-12-12 | Medtronic, Inc. | Intravascular radially expandable stent and method of implant |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| WO1990013332A1 (en) | 1989-05-11 | 1990-11-15 | Cedars-Sinai Medical Center | Stent with sustained drug delivery |
| DE69110787T2 (de) | 1990-02-28 | 1996-04-04 | Medtronic, Inc., Minneapolis, Minn. | Intraluminale prothese mit wirkstoffeluierung. |
| PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| US5419760A (en) | 1993-01-08 | 1995-05-30 | Pdt Systems, Inc. | Medicament dispensing stent for prevention of restenosis of a blood vessel |
| US5429634A (en) | 1993-09-09 | 1995-07-04 | Pdt Systems | Biogenic implant for drug delivery and method |
| US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
| US6335324B1 (en) | 1998-06-25 | 2002-01-01 | Bristol-Myers Squibb Co. | Beta lactam compounds and their use as inhibitors of tryptase |
| CA2386955A1 (en) * | 1999-11-22 | 2001-05-31 | Warner-Lambert Company | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes |
| EE200200715A (et) | 2000-06-28 | 2004-08-16 | Astrazeneca Ab | Asendatud kinasoliini derivaadid ja nende kasutamine inhibiitoritena |
| WO2002022605A1 (en) | 2000-09-15 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| WO2003022214A2 (en) | 2001-09-06 | 2003-03-20 | Millennium Pharmaceuticals, Inc. | Piperazine and homopiperazine compounds |
| AU2003220300A1 (en) | 2002-03-15 | 2003-09-29 | Binch, Hayley | Compositions useful as inhibitors of protein kinases |
| US6770729B2 (en) | 2002-09-30 | 2004-08-03 | Medtronic Minimed, Inc. | Polymer compositions containing bioactive agents and methods for their use |
| WO2004081000A1 (en) | 2003-03-10 | 2004-09-23 | Astrazeneca Ab | Quinazoline derivatives |
| MY145634A (en) | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
| US20070244114A1 (en) | 2004-07-06 | 2007-10-18 | Myriad Genetics, Incorporated | Compounds and therapeutical use thereof |
| JP2008525422A (ja) | 2004-12-23 | 2008-07-17 | ファイザー・プロダクツ・インク | 抗癌剤として有用な複素芳香族誘導体 |
| US7572809B2 (en) | 2005-12-19 | 2009-08-11 | Hoffmann-La Roche Inc. | Isoquinoline aminopyrazole derivatives |
| EP2041138B1 (en) * | 2006-07-07 | 2014-06-25 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| US7531539B2 (en) | 2006-08-09 | 2009-05-12 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| US20100311965A1 (en) | 2007-12-28 | 2010-12-09 | Carna Biosciences Inc. | 2-aminoquinazoline derivative |
| TW201018693A (en) * | 2008-09-30 | 2010-05-16 | Astrazeneca Ab | Chemical compounds 496-1p |
| HRP20230248T1 (hr) * | 2009-06-12 | 2023-04-14 | Abivax | Spojevi korisni za liječenje preranog starenja, te naročito progerije |
| AR079814A1 (es) * | 2009-12-31 | 2012-02-22 | Otsuka Pharma Co Ltd | Compuestos heterociclicos, composiciones farmaceuticas que los contienen y sus usos |
| US8470820B2 (en) | 2010-01-22 | 2013-06-25 | Hoffman-La Roche Inc. | Nitrogen-containing heteroaryl derivatives |
| JP6121658B2 (ja) | 2011-06-29 | 2017-04-26 | 大塚製薬株式会社 | 治療用化合物、及び関連する使用の方法 |
| WO2014105958A2 (en) | 2012-12-26 | 2014-07-03 | Medivation Technologies, Inc. | Fused pyrimidine compounds and use thereof |
| US10202356B2 (en) * | 2013-03-14 | 2019-02-12 | Tolero Pharmaceuticals, Inc. | JAK2 and ALK2 inhibitors and methods for their use |
| GB201416754D0 (en) | 2014-09-23 | 2014-11-05 | Mission Therapeutics Ltd | Novel compounds |
| CN108239071B (zh) | 2016-12-27 | 2020-12-04 | 沈阳药科大学 | 酰胺及硫代酰胺类衍生物及其制备方法和应用 |
| AR112027A1 (es) * | 2017-06-15 | 2019-09-11 | Biocryst Pharm Inc | Inhibidores de alk 2 quinasa que contienen imidazol |
-
2018
- 2018-06-13 AR ARP180101628A patent/AR112027A1/es unknown
- 2018-06-14 MX MX2019015226A patent/MX2019015226A/es unknown
- 2018-06-14 KR KR1020207001054A patent/KR102659955B1/ko active Active
- 2018-06-14 BR BR112019026517-1A patent/BR112019026517A2/pt not_active Application Discontinuation
- 2018-06-14 AU AU2018283053A patent/AU2018283053C1/en active Active
- 2018-06-14 WO PCT/US2018/037503 patent/WO2018232094A1/en not_active Ceased
- 2018-06-14 KR KR1020247012786A patent/KR20240063970A/ko active Pending
- 2018-06-14 IL IL271109A patent/IL271109B2/en unknown
- 2018-06-14 EA EA202090052A patent/EA202090052A1/ru unknown
- 2018-06-14 MA MA049401A patent/MA49401A/fr unknown
- 2018-06-14 CN CN201880052585.8A patent/CN110913855B/zh active Active
- 2018-06-14 JP JP2019568599A patent/JP7257338B2/ja active Active
- 2018-06-14 SG SG10202112496SA patent/SG10202112496SA/en unknown
- 2018-06-14 MY MYPI2019007421A patent/MY204609A/en unknown
- 2018-06-14 TW TW107120504A patent/TWI833696B/zh active
- 2018-06-14 TW TW113104734A patent/TW202436303A/zh unknown
- 2018-06-14 US US16/622,816 patent/US11661426B2/en active Active
- 2018-06-14 EP EP18816547.6A patent/EP3638229A4/en active Pending
- 2018-06-14 CA CA3066164A patent/CA3066164A1/en active Pending
- 2018-06-14 IL IL312670A patent/IL312670B1/en unknown
- 2018-06-14 CN CN202411166057.9A patent/CN119060060A/zh active Pending
-
2019
- 2019-12-10 PH PH12019502781A patent/PH12019502781A1/en unknown
- 2019-12-13 MX MX2023004309A patent/MX2023004309A/es unknown
- 2019-12-13 CL CL2019003669A patent/CL2019003669A1/es unknown
-
2020
- 2020-01-09 CO CONC2020/0000194A patent/CO2020000194A2/es unknown
-
2022
- 2022-08-29 AU AU2022221581A patent/AU2022221581B2/en active Active
-
2023
- 2023-02-13 US US18/168,055 patent/US12054492B2/en active Active
- 2023-04-03 JP JP2023060086A patent/JP7636460B2/ja active Active
-
2024
- 2024-04-26 US US18/647,310 patent/US20240376117A1/en active Pending