JP2019500327A5 - - Google Patents

Download PDF

Info

Publication number
JP2019500327A5
JP2019500327A5 JP2018523790A JP2018523790A JP2019500327A5 JP 2019500327 A5 JP2019500327 A5 JP 2019500327A5 JP 2018523790 A JP2018523790 A JP 2018523790A JP 2018523790 A JP2018523790 A JP 2018523790A JP 2019500327 A5 JP2019500327 A5 JP 2019500327A5
Authority
JP
Japan
Prior art keywords
adc
seq
amino acid
acid sequence
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2018523790A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019500327A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/063990 external-priority patent/WO2017095805A1/en
Publication of JP2019500327A publication Critical patent/JP2019500327A/ja
Publication of JP2019500327A5 publication Critical patent/JP2019500327A5/ja
Ceased legal-status Critical Current

Links

JP2018523790A 2015-11-30 2016-11-29 抗huLRRC15抗体薬物コンジュゲート及びその使用方法 Ceased JP2019500327A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562261092P 2015-11-30 2015-11-30
US62/261,092 2015-11-30
US201662417480P 2016-11-04 2016-11-04
US62/417,480 2016-11-04
PCT/US2016/063990 WO2017095805A1 (en) 2015-11-30 2016-11-29 ANTI-huLRRC15 ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE

Publications (2)

Publication Number Publication Date
JP2019500327A JP2019500327A (ja) 2019-01-10
JP2019500327A5 true JP2019500327A5 (OSRAM) 2020-01-16

Family

ID=57614453

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018523790A Ceased JP2019500327A (ja) 2015-11-30 2016-11-29 抗huLRRC15抗体薬物コンジュゲート及びその使用方法

Country Status (7)

Country Link
US (3) US10188660B2 (OSRAM)
EP (1) EP3383909B1 (OSRAM)
JP (1) JP2019500327A (OSRAM)
AU (1) AU2016365114A1 (OSRAM)
CA (1) CA3006596A1 (OSRAM)
ES (1) ES2810755T3 (OSRAM)
WO (1) WO2017095805A1 (OSRAM)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3383909B1 (en) * 2015-11-30 2020-06-17 AbbVie Inc. Anti-human lrrc15 antibody drug conjugates and methods for their use
ES2837755T3 (es) 2016-09-14 2021-07-01 Abbvie Biotherapeutics Inc Anticuerpos anti-PD-1
JP2020523319A (ja) * 2017-06-07 2020-08-06 シルバーバック セラピューティックス インコーポレイテッド 免疫調節化合物の抗体コンジュゲートおよびその使用
IL277049B2 (en) 2018-03-13 2024-02-01 Zymeworks Bc Inc Conjugates of biparatopic anti-HER2 antibody and drug and methods of use
US20210154188A1 (en) 2018-04-02 2021-05-27 Silverback Therapeutics, Inc. Alk5 inhibitors, conjugates, and uses thereof
WO2020086895A1 (en) * 2018-10-24 2020-04-30 Scivera LLC Computer-implemented method for quantifying chemical hazard assessment
EP3935046A1 (en) 2019-03-06 2022-01-12 Silverback Therapeutics, Inc. Cyclic amino-pyrazinecarboxamide compounds and uses thereof
EP3999501A1 (en) 2019-07-16 2022-05-25 Silverback Therapeutics, Inc. Alk5 inhibitors, conjugates, and uses thereof
JP2022542431A (ja) 2019-07-30 2022-10-03 キューエルエスエフ バイオセラピューティクス, インコーポレイテッド 二重特異性抗lrrc15及びcd3イプシロン抗体
JP2022551844A (ja) * 2019-10-04 2022-12-14 ミシク セラピューティクス, インコーポレイテッド 抗原結合タンパク質構築物およびその使用
WO2021102332A1 (en) 2019-11-22 2021-05-27 Silverback Therapeutics, Inc. Tgfbetar2 inhibitor-lrrc15 antibody conjugates and uses thereof
WO2021142086A1 (en) 2020-01-08 2021-07-15 Synthis Therapeutics, Inc. Alk5 inhibitor conjugates and uses thereof
CN115297890A (zh) * 2020-02-03 2022-11-04 国立大学法人东海国立大学机构 用于对患癌的对象处置癌的抗meflin抗体和含有该抗体的药物组合物
KR20220161395A (ko) * 2020-04-01 2022-12-06 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 중간엽 줄기 세포-유래된 암 세포 및 중간엽 줄기 세포 연관된 질환을 표적화하는 이뮤노테라노스틱 작용제
US20230212282A1 (en) * 2020-05-29 2023-07-06 New York Society for the Relief of the Ruptured and Crippled, maintaining the Hospital for Special Methods and compositions for treating, preventing the onset and/or slowing progression of osteoarthritis
AU2022210371A1 (en) 2021-01-22 2023-07-20 Bayer Aktiengesellschaft Lrrc15 antibodies and conjugates thereof
CN113181373B (zh) * 2021-05-10 2024-03-01 深圳安特生物医药科技有限公司 一种抗体药物偶联制剂及其制备方法和应用
JP2024524891A (ja) 2021-06-23 2024-07-09 サイチューン ファーマ インターロイキン-15に基づく免疫サイトカイン
CN117597355A (zh) 2021-06-23 2024-02-23 赛腾制药 白细胞介素15变体
KR20250083225A (ko) * 2022-10-12 2025-06-09 마이틱 테라퓨틱스, 인크. Lrrc15-결합 단백질 작제물 및 이의 용도
CN120548364A (zh) 2023-01-27 2025-08-26 第一三共株式会社 抗lrrc15抗体
WO2025090749A1 (en) * 2023-10-25 2025-05-01 St. Jude Children's Research Hospital, Inc. Chimeric antigen receptors targeting leucine rich repeat containing 15 (lrrc15)
WO2025160129A1 (en) * 2024-01-23 2025-07-31 The Regents Of The University Of California Methods of use of agents targeting mesenchymal stem cell- derived tumors and tumor associated cells

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4299216A (en) 1979-10-17 1981-11-10 The United States Of America As Represented By The Secretary Of The Interior Self-contained closed circuit breathing apparatus having a balanced breathing resistance system
US4444887A (en) 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4816457A (en) 1980-12-23 1989-03-28 Baldwin John J Aralkylaminoethanol heterocyclic compounds
US4716111A (en) 1982-08-11 1987-12-29 Trustees Of Boston University Process for producing human antibodies
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
AU631802B2 (en) 1988-06-14 1992-12-10 Cetus Oncology Corporation Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
DE69133566T2 (de) 1990-01-12 2007-12-06 Amgen Fremont Inc. Bildung von xenogenen Antikörpern
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
MX9204374A (es) 1991-07-25 1993-03-01 Idec Pharma Corp Anticuerpo recombinante y metodo para su produccion.
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
ATE408012T1 (de) 1991-12-02 2008-09-15 Medical Res Council Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
JP4312259B2 (ja) 1995-04-27 2009-08-12 アムジェン フレモント インク. 免疫したゼノマウス(XenoMouse)に由来するヒト抗体
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
WO1997034631A1 (en) 1996-03-18 1997-09-25 Board Of Regents, The University Of Texas System Immunoglobin-like domains with increased half lives
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
DE69738539T2 (de) 1996-12-03 2009-03-26 Amgen Fremont Inc. Vollkommen humane Antikörper die EGFR binden
BRPI9809391B8 (pt) 1997-04-14 2021-05-25 Amgen Res Munich Gmbh processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
JP2002530081A (ja) 1998-11-18 2002-09-17 ジェネンテック・インコーポレーテッド 親抗体より高度な結合親和性を持つ抗体変異体
PT1355919E (pt) 2000-12-12 2011-03-02 Medimmune Llc Moléculas com semivida longa, composições que as contêm e suas utilizações
EP1243276A1 (en) 2001-03-23 2002-09-25 Franciscus Marinus Hendrikus De Groot Elongated and multiple spacers containing activatible prodrugs
CA2802205C (en) 2002-07-31 2016-01-19 Seattle Genetics, Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
WO2004019993A1 (en) 2002-08-30 2004-03-11 Ramot At Tel Aviv University Ltd. Self-immolative dendrimers releasing many active moieties upon a single activating event
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
CA2506080A1 (en) 2002-11-14 2004-05-27 Syntarga B.V. Prodrugs built as multiple self-elimination-release spacers
WO2004073656A2 (en) 2003-02-20 2004-09-02 Seattle Genetics, Inc. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
WO2005037999A2 (en) * 2003-10-14 2005-04-28 Biogen Idec Ma Inc. Treatment of cancer using antibodies to lrrc15
NZ583292A (en) * 2003-11-06 2012-03-30 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
AU2005216251B2 (en) 2004-02-23 2011-03-10 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
US7399469B2 (en) 2004-03-26 2008-07-15 Pdl Biopharma, Inc. Anti-LFL2 antibodies for the diagnosis, prognosis and treatment of cancer
WO2005123780A2 (en) 2004-04-09 2005-12-29 Protein Design Labs, Inc. Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
ES2579805T3 (es) 2004-09-23 2016-08-16 Genentech, Inc. Anticuerpos y conjugados modificados por ingeniería genética con cisteína
PT3248613T (pt) 2005-07-18 2022-03-16 Seagen Inc Conjugados de ligante de fármaco e beta-glucuronida
BRPI0707426A2 (pt) 2006-02-02 2011-05-03 Syntarga Bv composto, conjugado, uso de um composto, composição farmacêutica, processo para preparar uma composição farmacêutica, e, métodos de tratamento de um mamìfero estando em necessidade do mesmo, e de tratamento ou prevenção de um tumor em um mamìfero
ES2523915T5 (es) 2006-12-01 2022-05-26 Seagen Inc Agentes de unión a la diana variantes y usos de los mismos
JP5557746B2 (ja) 2007-11-28 2014-07-23 メルサナ セラピューティックス,インク. 生体適合性生分解性フマギリンアナログ複合体
US20100152725A1 (en) 2008-12-12 2010-06-17 Angiodynamics, Inc. Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation
US8524214B2 (en) 2009-05-28 2013-09-03 Mersana Therapeutics, Inc. Polyal drug conjugates comprising variable rate-releasing linkers
WO2011120053A1 (en) 2010-03-26 2011-09-29 Mersana Therapeutics, Inc. Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
NZ602932A (en) 2010-04-15 2014-08-29 Seattle Genetics Inc Targeted pyrrolobenzodiazapine conjugates
KR101972303B1 (ko) 2011-06-10 2019-04-25 메르사나 테라퓨틱스, 인코포레이티드 단백질-중합체-약물 접합체
BR112014013526A8 (pt) 2011-12-05 2017-06-13 Igenica Biotherapeutics Inc conjugados de anticorpo-fármaco e compostos, composições e métodos relacionados
TW201332574A (zh) 2011-12-23 2013-08-16 Mersana Therapeutics Inc 煙曲黴素衍生物-phf共軛物之醫藥調配物
ES2812849T3 (es) 2012-02-24 2021-03-18 Abbvie Stemcentrx Llc Anticuerpos anti-DLL3 y procedimientos de utilización de los mismos
US9504756B2 (en) 2012-05-15 2016-11-29 Seattle Genetics, Inc. Self-stabilizing linker conjugates
US20140017265A1 (en) 2012-07-05 2014-01-16 Mersana Therapeutics, Inc. Terminally Modified Polymers and Conjugates Thereof
EP2928504B1 (en) 2012-12-10 2019-02-20 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
US10226535B2 (en) 2012-12-10 2019-03-12 Mersana Therapeutics, Inc. Auristatin compounds and conjugates thereof
US9872918B2 (en) 2012-12-12 2018-01-23 Mersana Therapeutics, Inc. Hydroxyl-polymer-drug-protein conjugates
US10195209B2 (en) * 2015-11-30 2019-02-05 Abbvie Inc. Anti-huLRRC15 antibody drug conjugates and methods for their use
EP3383909B1 (en) * 2015-11-30 2020-06-17 AbbVie Inc. Anti-human lrrc15 antibody drug conjugates and methods for their use

Similar Documents

Publication Publication Date Title
JP2019500327A5 (OSRAM)
JP2012136541A5 (OSRAM)
JP2013517277A5 (OSRAM)
JP2018510132A5 (OSRAM)
JP2019524645A5 (OSRAM)
JP2015531750A5 (OSRAM)
JP2021504430A5 (OSRAM)
JP2014237714A5 (OSRAM)
FI3430027T3 (fi) Peptidi käytettäväksi ei-pienisoluisen keuhkosyövän ja pienisoluisen keuhkosyövän hoidossa
JP2011219478A5 (OSRAM)
FI4084791T3 (fi) Spesifisiä tryptamiinejä käytettäviksi mielialahäiriöiden hoidossa
JP2014516991A5 (OSRAM)
JP2020097577A5 (OSRAM)
JP2019172710A5 (OSRAM)
WO2020056198A3 (en) Substituted benzazepine compounds, conjugates, and uses thereof
FI3083694T3 (fi) Kaninisoituja hiiren anti-koira-pd-1 -vasta-aineita
JP2014129395A5 (OSRAM)
JP2006527762A5 (OSRAM)
JP2015527319A5 (OSRAM)
JP2015528818A5 (OSRAM)
JP2019523214A5 (OSRAM)
IL281277B1 (en) Compositions and methods for the treatment of viral infections
RU2015146614A (ru) Конъюгированная вакцина на основе пептида антигена wt1
JP2019504086A5 (OSRAM)
JP2012522802A5 (OSRAM)