JP2019099677A - アレルゲン低減化組成物 - Google Patents
アレルゲン低減化組成物 Download PDFInfo
- Publication number
- JP2019099677A JP2019099677A JP2017231964A JP2017231964A JP2019099677A JP 2019099677 A JP2019099677 A JP 2019099677A JP 2017231964 A JP2017231964 A JP 2017231964A JP 2017231964 A JP2017231964 A JP 2017231964A JP 2019099677 A JP2019099677 A JP 2019099677A
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- Prior art keywords
- allergen
- materials
- zinc
- allergens
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000013566 allergen Substances 0.000 claims abstract description 88
- 239000000463 material Substances 0.000 claims abstract description 40
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- 150000003751 zinc Chemical class 0.000 claims abstract description 13
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- 239000011701 zinc Substances 0.000 claims description 16
- 229910052725 zinc Inorganic materials 0.000 claims description 12
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- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 6
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- UOURRHZRLGCVDA-UHFFFAOYSA-D pentazinc;dicarbonate;hexahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Zn+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2].[O-]C([O-])=O.[O-]C([O-])=O UOURRHZRLGCVDA-UHFFFAOYSA-D 0.000 description 6
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Abstract
Description
塩基性炭酸亜鉛(堺化学工業株式会社製)42g、ポイズ(登録商標)520(花王株式会社製)2g、イオン交換水236gを混合し、直径1mmのガラスビーズを用いて湿式粉砕を30分間行い、塩基性炭酸亜鉛15%の分散製剤を得て、塩基性炭酸亜鉛分散液とした。
イオン交換水600gにヘキサメタリン酸ナトリウム(米山化学工業株式会社製)3.0gを溶解させ、更に硫酸チタニル(キシダ化学株式会社製)を80g分散させ、沸騰させた湯浴で2時間加熱した。次に70℃まで冷却して25%アンモニア水(和光純薬工業株式会社製)を用いてpHを6.3に調整し、No.5Cのろ紙を敷いた直径12.5cmのヌッチェを用いて吸引ろ過し、さらにイオン交換水で洗浄してケーキ150gを得た。このケーキをイオン交換水100gに分散させ、塩酸(試薬特級、和光純薬工業株式会社製)10gを添加し解膠させた。この分散液に四塩化チタン(和光純薬工業株式会社製)10.7gを添加し、さらに85%リン酸(和光純薬工業株式会社製)2.1gを添加した。2時間撹拌を継続し、再び25%アンモニア水を用いてpHを5.5に調整した。No.5Cのろ紙を敷いた直径12.5cmのヌッチェを用いて吸引ろ過し、さらにイオン交換水で洗浄してケーキ185gを得た。このケーキにイオン交換水120gを添加し、直径1mmのガラスビーズを用いて20分間、湿式粉砕を行い、チタニアゾル(固形分15%)を得た。このチアニアゾルの平均粒子径を、粒度分布測定装置SALD−2100(島津製作所製)を用いて測定したところ、平均粒子径は0.7μmであった。またpHを測定した結果、pHは5.6であった。
アナタース型酸化チタンとしてJA−1(テイカ株式会社製)45g、ポイズ(登録商標)520(花王株式会社製)2.5g、ヘキサメタリン酸ナトリウム(米山化学工業株式会社製)0.6g、ケルザンS(三晶株式会社製)0.3gおよびイオン交換水270gを混合し、直径1mmのガラスビーズを用いて30分間の湿式粉砕を行い、アナタース型酸化チタン濃度15%の分散液を得た。この酸化チタン分散液の平均粒子径を、粒度分布測定装置SALD−2100(島津製作所製)を用いて測定したところ、平均粒子径は0.5μmであった。またpHを測定した結果、pHは8.0であった。
酸化亜鉛(和光純薬工業株式会社製)20g、ポイズ(登録商標)520(花王株式会社製)1g、イオン交換水79gを混合し、直径1mmのガラスビーズを用いて湿式粉砕を10分間行い、酸化亜鉛20%の分散製剤を得て、酸化亜鉛分散液とした。
アレルゲン低減化組成物によるダニアレルゲンの低減化効果の測定
ダニアレルゲンDer f2を含有する、タンパク質量として約900ng/1mL{リン酸緩衝液(pH7.2)}のアレルゲン液に対し、実施例1〜9、比較例1〜6をそれぞれイオン交換水で10倍に希釈した液50μLを反応させた。これら試料について Der f2酵素免疫測定法(ELISA)のサンドイッチ法にてダニアレルゲン低減化効果の測定を行った。まず、リン酸緩衝液(pH7.4)で2μg/mLに希釈した抗Der f2 モノクローナル抗体15E11を、F16 MAXISORP NUNC−IMMUNO MODULEプレート(NUNC社製)の1ウェルあたり100μLずつ添加し、4℃にて3日以上感作させた。感作後、液を捨て、ブロッキング試薬{1重量%牛血清アルブミン+リン酸緩衝液(pH7.2)}を1ウェルあたり200μLずつ添加し、37℃、60分間反応させた。反応後、リン酸緩衝液(pH7.2)にてプレートを洗浄した。
アレルゲン低減化組成物によるスギ花粉アレルゲンの低減化効果の測定
スギ花粉アレルゲンCry j1として約12.5ng/1mL{リン酸緩衝液(pH7.2)}のアレルゲン液に対し、実施例1〜9、比較例1〜6をそれぞれイオン交換水で10倍に希釈した液25μLを反応させた。これら試料についてCry j1酵素免疫測定法(ELISA)のサンドイッチ法にてスギ花粉アレルゲン低減化効果の測定を行った。まず、リン酸緩衝液(pH7.4、0.1重量%NaN3含有)で2μg/mLに希釈したCry j1 モノクローナル抗体013を、F16 MAXISORP NUNC−IMMUNO MODULEプレート(NUNC社製)の1ウェルあたり100μLずつ添加し、4℃にて1日以上感作させた。感作後、液を捨て、ブロッキング試薬{1重量%牛血清アルブミン+リン酸緩衝液(pH7.2、0.1重量%NaN3含有)}を1ウェルあたり200μLずつ添加し、37℃、60分間反応させた。反応後、リン酸緩衝液{pH7.2、0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}にてプレートを洗浄した。
塩ビ壁紙の表面処理剤への加工
塩ビ壁紙表面層として、平均重合度700の塩ビ粉末(PQB83、新第一塩ビ株式会社製)100g、可塑剤ジイソノニルフタレート(DINP、田岡化学工業株式会社製)50g、安定剤としてアデカスタブ(登録商標)FL100(株式会社ADEKA製)3g、イソパラフィン(IPソルベント2028、出光興産株式会社製)7gを、攪拌機を用いて混合した。基材層としてA4サイズのPPC用紙に、調製した表面層液を約200g/m2となるように塗布し、150℃にて1分間加熱し、塩ビ壁紙を得た。
Claims (3)
- (A)水溶性亜鉛塩または炭酸亜鉛、および(B)チタニアゾルを含有することを特徴とするアレルゲン低減化組成物。
- 水溶性亜鉛塩がヒドロキシ酸亜鉛から選択される一種類以上である、請求項1に記載のアレルゲン低減化組成物。
- 請求項1または請求項2に記載のアレルゲン低減化組成物を加工した不織布、壁紙、フィルター材料、繊維または繊維製品、建築用内装材。
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