JP2019052154A5 - - Google Patents
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- JP2019052154A5 JP2019052154A5 JP2018206892A JP2018206892A JP2019052154A5 JP 2019052154 A5 JP2019052154 A5 JP 2019052154A5 JP 2018206892 A JP2018206892 A JP 2018206892A JP 2018206892 A JP2018206892 A JP 2018206892A JP 2019052154 A5 JP2019052154 A5 JP 2019052154A5
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- Prior art keywords
- pharmaceutical composition
- chemotherapeutic agent
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- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- NTFOSUUWGCDXEF-UHFFFAOYSA-N 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide Chemical compound CC1=CC=C(C)C(C=2N(N=C(C=2)C(F)(F)F)C=2C=CC(=CC=2)S(N)(=O)=O)=C1 NTFOSUUWGCDXEF-UHFFFAOYSA-N 0.000 claims 2
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims 2
- NDTYTMIUWGWIMO-UHFFFAOYSA-N perillyl alcohol Chemical compound CC(=C)C1CCC(CO)=CC1 NDTYTMIUWGWIMO-UHFFFAOYSA-N 0.000 claims 2
- 229960004964 temozolomide Drugs 0.000 claims 2
- 229930007631 (-)-perillyl alcohol Natural products 0.000 claims 1
- 229940126161 DNA alkylating agent Drugs 0.000 claims 1
- 239000012624 DNA alkylating agent Substances 0.000 claims 1
- 230000000340 anti-metabolite Effects 0.000 claims 1
- 229940100197 antimetabolite Drugs 0.000 claims 1
- 239000002256 antimetabolite Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003534 dna topoisomerase inhibitor Substances 0.000 claims 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 claims 1
- 239000002532 enzyme inhibitor Substances 0.000 claims 1
- 229940125532 enzyme inhibitor Drugs 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 235000005693 perillyl alcohol Nutrition 0.000 claims 1
- 150000003058 platinum compounds Chemical class 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- HJORMJIFDVBMOB-UHFFFAOYSA-N rolipram Chemical compound COC1=CC=C(C2CC(=O)NC2)C=C1OC1CCCC1 HJORMJIFDVBMOB-UHFFFAOYSA-N 0.000 claims 1
- 229950005741 rolipram Drugs 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37774710P | 2010-08-27 | 2010-08-27 | |
| US61/377,747 | 2010-08-27 | ||
| US201161471402P | 2011-04-04 | 2011-04-04 | |
| US61/471,402 | 2011-04-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016151115A Division JP6431009B2 (ja) | 2010-08-27 | 2016-08-01 | Ｐｏｈ誘導体を含む医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019052154A JP2019052154A (ja) | 2019-04-04 |
| JP2019052154A5 true JP2019052154A5 (enExample) | 2019-09-26 |
Family
ID=45724091
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527140A Active JP5797755B2 (ja) | 2010-08-27 | 2011-08-26 | Ｐｏｈ誘導体を含む医薬組成物 |
| JP2015006736A Active JP5982507B2 (ja) | 2010-08-27 | 2015-01-16 | Ｐｏｈ誘導体を含む医薬組成物 |
| JP2016151115A Active JP6431009B2 (ja) | 2010-08-27 | 2016-08-01 | Ｐｏｈ誘導体を含む医薬組成物 |
| JP2018206892A Pending JP2019052154A (ja) | 2010-08-27 | 2018-11-01 | Ｐｏｈ誘導体を含む医薬組成物 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527140A Active JP5797755B2 (ja) | 2010-08-27 | 2011-08-26 | Ｐｏｈ誘導体を含む医薬組成物 |
| JP2015006736A Active JP5982507B2 (ja) | 2010-08-27 | 2015-01-16 | Ｐｏｈ誘導体を含む医薬組成物 |
| JP2016151115A Active JP6431009B2 (ja) | 2010-08-27 | 2016-08-01 | Ｐｏｈ誘導体を含む医薬組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (12) | US9499461B2 (enExample) |
| EP (5) | EP3173080B1 (enExample) |
| JP (4) | JP5797755B2 (enExample) |
| CN (3) | CN103168018B (enExample) |
| BR (1) | BR112013004698B1 (enExample) |
| DK (1) | DK3685835T3 (enExample) |
| ES (4) | ES3034958T3 (enExample) |
| WO (1) | WO2012027693A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9499461B2 (en) * | 2010-08-27 | 2016-11-22 | Neonc Technologies, Inc. | Pharmaceutical compositions comprising POH derivatives |
| WO2015054333A1 (en) * | 2013-10-08 | 2015-04-16 | Neonc Technologies, Inc. | Methods of treating cancer using compositions comprising perillyl alcohol derivative |
| US9913838B2 (en) * | 2010-08-27 | 2018-03-13 | Neonc Technologies, Inc. | Methods of treating cancer using compositions comprising perillyl alcohol derivative |
| US11147809B2 (en) | 2010-08-27 | 2021-10-19 | Neonc Technologies, Inc. | Methods of treating neurofibromatosis with perillyl alcohol |
| WO2018005994A1 (en) * | 2016-07-01 | 2018-01-04 | Neonc Technologies, Inc. | Methods of treating neurofibromatosis with perillyl alcohol |
| WO2012083178A1 (en) | 2010-12-17 | 2012-06-21 | Neo Oncology Inc. | Methods and devices for using isoperillyl alcohol |
| US20160038600A1 (en) * | 2012-08-03 | 2016-02-11 | Neonc Technologies Inc. | Pharmaceutical compositions comprising poh derivatives |
| BR112014006153A2 (pt) | 2011-09-16 | 2020-12-01 | Nanocare Technologies, Inc. | composição farmacêutica, e, método para tratar um distúrbio |
| CN103946202A (zh) * | 2011-11-21 | 2014-07-23 | 尼昂克技术公司 | 包含富含氘的紫苏醇、异紫苏醇及其衍生物的药物组合物 |
| KR101643041B1 (ko) * | 2014-04-25 | 2016-07-28 | 아주대학교산학협력단 | 프로테아좀 저해제 및 디히드로피리딘계 화합물을 유효성분으로 함유하는 암의 예방 또는 치료용 조성물 |
| WO2016064959A1 (en) * | 2014-10-21 | 2016-04-28 | Odin Biotech | Two-layer ocular implant comprising a tyrosine kinase inhibitor |
| TWI677342B (zh) * | 2014-10-27 | 2019-11-21 | 美商尼翁客技術公司 | 紫蘇醇衍生物於製備用於治療鼻咽癌的醫藥組成物之用途 |
| AU2015373915A1 (en) | 2014-12-31 | 2017-08-10 | Nanocare Technologies, Inc. | Jasmonate derivatives and compositions thereof |
| CN107613768B (zh) * | 2015-02-12 | 2020-10-20 | NeOnc技术股份有限公司 | 包含紫苏醇衍生物的药物组合物 |
| US10562901B2 (en) * | 2016-09-22 | 2020-02-18 | The University Of Massachusetts | Temozolomide compounds, polymers prepared therefrom, and method of treating a disease |
| CN110267538B (zh) * | 2016-11-30 | 2022-04-19 | 尼昂克技术公司 | 紫苏醇-3-溴丙酮酸缀合物和治疗癌症的方法 |
| WO2018122724A1 (en) * | 2016-12-27 | 2018-07-05 | Granules India Limited | Temozolomide process |
| US11559508B2 (en) | 2017-04-19 | 2023-01-24 | Neonc Technologies, Inc. | Pharmaceutical compositions comprising POH derivatives and methods of use |
| WO2019014420A1 (en) * | 2017-07-12 | 2019-01-17 | Azhc, Llc | COMPOSITIONS AND METHODS FOR REDUCING MEDICATION ERRORS |
| JP2020531518A (ja) * | 2017-08-24 | 2020-11-05 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | アルデヒドデヒドロゲナーゼ３ａ１のモノテルペン活性化剤およびその使用法 |
| CN107789349A (zh) * | 2017-12-01 | 2018-03-13 | 新乡医学院 | 治疗阿尔海默氏综合症的药物组合物及其应用 |
| JP7325425B2 (ja) | 2018-02-08 | 2023-08-14 | ネオンク テクノロジーズ インク． | 血液脳関門を透過性にする方法 |
| US20210244820A1 (en) * | 2018-06-15 | 2021-08-12 | Neonc Technologies, Inc. | Pharmaceutical compositions comprising poh derivatives |
| CN112469401A (zh) * | 2018-06-15 | 2021-03-09 | 尼昂克技术公司 | 包含poh衍生物的药物组合物 |
| CN116615197A (zh) * | 2020-11-12 | 2023-08-18 | NeOnc技术股份有限公司 | 用紫苏醇治疗复发性胶质母细胞瘤 |
| TWI843989B (zh) | 2021-02-19 | 2024-06-01 | 美商美威高能離子醫療系統公司 | 用於粒子治療系統之支架 |
| EP4323070A4 (en) * | 2021-04-16 | 2025-03-26 | University Of Southern California | PHARMACEUTICAL COMPOSITIONS CONTAINING POH DERIVATIVES |
| EP4329722A4 (en) * | 2021-04-28 | 2025-03-26 | University of Southern California | USE OF PERILLYL ALCOHOL TO ENHANCE LEVO-DOPA RELEASE |
| TWI849808B (zh) * | 2022-03-18 | 2024-07-21 | 共信醫藥科技股份有限公司 | 藥物組成物及化療劑用於製備治療癌症之藥物的用途 |
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2011
- 2011-08-26 US US13/818,972 patent/US9499461B2/en active Active
- 2011-08-26 CN CN201180050187.0A patent/CN103168018B/zh active Active
- 2011-08-26 CN CN201510569791.4A patent/CN105078973B/zh active Active
- 2011-08-26 EP EP16184092.1A patent/EP3173080B1/en active Active
- 2011-08-26 EP EP15153140.7A patent/EP2883543B1/en active Active
- 2011-08-26 CN CN201910611300.6A patent/CN110464718A/zh active Pending
- 2011-08-26 ES ES19214554T patent/ES3034958T3/es active Active
- 2011-08-26 JP JP2013527140A patent/JP5797755B2/ja active Active
- 2011-08-26 EP EP11820740.6A patent/EP2609064B1/en active Active
- 2011-08-26 ES ES11820740.6T patent/ES2600928T3/es active Active
- 2011-08-26 ES ES15153140.7T patent/ES2610425T3/es active Active
- 2011-08-26 ES ES15153141.5T patent/ES2610810T3/es active Active
- 2011-08-26 WO PCT/US2011/049392 patent/WO2012027693A2/en not_active Ceased
- 2011-08-26 DK DK19214554.8T patent/DK3685835T3/da active
- 2011-08-26 BR BR112013004698-8A patent/BR112013004698B1/pt active IP Right Grant
- 2011-08-26 EP EP19214554.8A patent/EP3685835B1/en active Active
- 2011-08-26 EP EP15153141.5A patent/EP2898883B1/en active Active
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2012
- 2012-08-03 US US13/566,731 patent/US8916545B2/en active Active
- 2012-11-21 US US14/359,366 patent/US20160039731A1/en not_active Abandoned
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2014
- 2014-08-08 US US14/455,293 patent/US9663428B2/en active Active
- 2014-08-08 US US14/455,371 patent/US9580372B2/en active Active
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2015
- 2015-01-16 JP JP2015006736A patent/JP5982507B2/ja active Active
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2016
- 2016-08-01 JP JP2016151115A patent/JP6431009B2/ja active Active
- 2016-10-12 US US15/291,847 patent/US20170128578A1/en not_active Abandoned
-
2017
- 2017-01-18 US US15/408,866 patent/US10092562B2/en active Active
- 2017-04-07 US US15/482,451 patent/US20170369408A1/en not_active Abandoned
-
2018
- 2018-09-06 US US16/123,729 patent/US11077104B2/en active Active
- 2018-11-01 JP JP2018206892A patent/JP2019052154A/ja active Pending
-
2019
- 2019-04-15 US US16/384,534 patent/US20200078355A1/en not_active Abandoned
-
2021
- 2021-05-06 US US17/313,258 patent/US20210283127A1/en not_active Abandoned
-
2022
- 2022-01-12 US US17/573,693 patent/US20220133712A1/en not_active Abandoned
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