JP2019038820A5 - - Google Patents
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- Publication number
- JP2019038820A5 JP2019038820A5 JP2018196401A JP2018196401A JP2019038820A5 JP 2019038820 A5 JP2019038820 A5 JP 2019038820A5 JP 2018196401 A JP2018196401 A JP 2018196401A JP 2018196401 A JP2018196401 A JP 2018196401A JP 2019038820 A5 JP2019038820 A5 JP 2019038820A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- dimethylcyclohex
- piperazin
- pyrrolo
- yloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 4-{[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl Chemical group 0.000 claims 85
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 46
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 30
- 150000003839 salts Chemical class 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 19
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 3
- 208000005777 Lupus Nephritis Diseases 0.000 claims 3
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 3
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 3
- 206010041067 Small cell lung cancer Diseases 0.000 claims 3
- 208000000277 Splenic Neoplasms Diseases 0.000 claims 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims 3
- 201000006491 bone marrow cancer Diseases 0.000 claims 3
- 201000010881 cervical cancer Diseases 0.000 claims 3
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 201000004101 esophageal cancer Diseases 0.000 claims 3
- 201000003444 follicular lymphoma Diseases 0.000 claims 3
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 3
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 3
- 208000003747 lymphoid leukemia Diseases 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 208000025113 myeloid leukemia Diseases 0.000 claims 3
- 201000000050 myeloid neoplasm Diseases 0.000 claims 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 3
- 201000002471 spleen cancer Diseases 0.000 claims 3
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims 3
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 2
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- TYERRNIXCPPQQD-UHFFFAOYSA-N N-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide Chemical compound C(C1=CC=CC=C1)(=O)NOC=1C=C2C(=NC=1)NC=C2 TYERRNIXCPPQQD-UHFFFAOYSA-N 0.000 claims 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000005443 oral cavity cancer Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361781070P | 2013-03-14 | 2013-03-14 | |
| US61/781,070 | 2013-03-14 | ||
| US14/176,506 US20140275082A1 (en) | 2013-03-14 | 2014-02-10 | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US14/176,506 | 2014-02-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500337A Division JP6449222B2 (ja) | 2013-03-14 | 2014-02-21 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020118278A Division JP2020180145A (ja) | 2013-03-14 | 2020-07-09 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019038820A JP2019038820A (ja) | 2019-03-14 |
| JP2019038820A5 true JP2019038820A5 (cg-RX-API-DMAC7.html) | 2019-06-13 |
Family
ID=51529947
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500337A Active JP6449222B2 (ja) | 2013-03-14 | 2014-02-21 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
| JP2018196401A Pending JP2019038820A (ja) | 2013-03-14 | 2018-10-18 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
| JP2020118278A Pending JP2020180145A (ja) | 2013-03-14 | 2020-07-09 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
| JP2021109903A Pending JP2021167330A (ja) | 2013-03-14 | 2021-07-01 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500337A Active JP6449222B2 (ja) | 2013-03-14 | 2014-02-21 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020118278A Pending JP2020180145A (ja) | 2013-03-14 | 2020-07-09 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
| JP2021109903A Pending JP2021167330A (ja) | 2013-03-14 | 2021-07-01 | 癌並びに免疫疾患及び自己免疫疾患の治療用としてのアポトーシス誘導剤 |
Country Status (35)
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