JP2019005626A5 - - Google Patents
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- JP2019005626A5 JP2019005626A5 JP2018188306A JP2018188306A JP2019005626A5 JP 2019005626 A5 JP2019005626 A5 JP 2019005626A5 JP 2018188306 A JP2018188306 A JP 2018188306A JP 2018188306 A JP2018188306 A JP 2018188306A JP 2019005626 A5 JP2019005626 A5 JP 2019005626A5
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- JP
- Japan
- Prior art keywords
- cells
- chamber
- chambers
- poly
- porous scaffold
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 27
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 4
- 229940072056 alginate Drugs 0.000 claims 4
- 229920000615 alginic acid Polymers 0.000 claims 4
- 235000010443 alginic acid Nutrition 0.000 claims 4
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 108010035532 Collagen Proteins 0.000 claims 3
- 102000008186 Collagen Human genes 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- 210000002808 connective tissue Anatomy 0.000 claims 3
- 210000004153 islets of langerhan Anatomy 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 229920001661 Chitosan Polymers 0.000 claims 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 230000000735 allogeneic effect Effects 0.000 claims 2
- 230000002491 angiogenic effect Effects 0.000 claims 2
- 210000004204 blood vessel Anatomy 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 239000000017 hydrogel Substances 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920001296 polysiloxane Polymers 0.000 claims 2
- -1 polyvinylsiloxane Polymers 0.000 claims 2
- 210000000717 sertoli cell Anatomy 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- 229920001817 Agar Polymers 0.000 claims 1
- 229920000936 Agarose Polymers 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 208000013016 Hypoglycemia Diseases 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims 1
- 108010039918 Polylysine Proteins 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 102000003970 Vinculin Human genes 0.000 claims 1
- 108090000384 Vinculin Proteins 0.000 claims 1
- 239000008272 agar Substances 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 230000003510 anti-fibrotic effect Effects 0.000 claims 1
- 229910052788 barium Inorganic materials 0.000 claims 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960000633 dextran sulfate Drugs 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 230000002218 hypoglycaemic effect Effects 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 108010082117 matrigel Proteins 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 239000002088 nanocapsule Substances 0.000 claims 1
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 claims 1
- 229950004354 phosphorylcholine Drugs 0.000 claims 1
- 229920001308 poly(aminoacid) Polymers 0.000 claims 1
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims 1
- 229920000218 poly(hydroxyvalerate) Polymers 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 229920000656 polylysine Polymers 0.000 claims 1
- 229920006254 polymer film Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23801109P | 2009-08-28 | 2009-08-28 | |
| US61/238,011 | 2009-08-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017199265A Division JP6446111B2 (ja) | 2009-08-28 | 2017-10-13 | 細胞移植のための方法およびデバイス |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020042947A Division JP2020089790A (ja) | 2009-08-28 | 2020-03-12 | 細胞移植のための方法およびデバイス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019005626A JP2019005626A (ja) | 2019-01-17 |
| JP2019005626A5 true JP2019005626A5 (enExample) | 2019-06-13 |
| JP6676719B2 JP6676719B2 (ja) | 2020-04-08 |
Family
ID=43466432
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012527042A Active JP5756108B2 (ja) | 2009-08-28 | 2010-08-27 | 細胞移植のための方法およびデバイス |
| JP2015108394A Active JP5976883B2 (ja) | 2009-08-28 | 2015-05-28 | 細胞移植のための方法およびデバイス |
| JP2016107014A Withdrawn JP2016163768A (ja) | 2009-08-28 | 2016-05-30 | 細胞移植のための方法およびデバイス |
| JP2017199265A Active JP6446111B2 (ja) | 2009-08-28 | 2017-10-13 | 細胞移植のための方法およびデバイス |
| JP2018188306A Active JP6676719B2 (ja) | 2009-08-28 | 2018-10-03 | 細胞移植のための方法およびデバイス |
| JP2020042947A Pending JP2020089790A (ja) | 2009-08-28 | 2020-03-12 | 細胞移植のための方法およびデバイス |
| JP2022045470A Active JP7416847B2 (ja) | 2009-08-28 | 2022-03-22 | 細胞移植のための方法およびデバイス |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012527042A Active JP5756108B2 (ja) | 2009-08-28 | 2010-08-27 | 細胞移植のための方法およびデバイス |
| JP2015108394A Active JP5976883B2 (ja) | 2009-08-28 | 2015-05-28 | 細胞移植のための方法およびデバイス |
| JP2016107014A Withdrawn JP2016163768A (ja) | 2009-08-28 | 2016-05-30 | 細胞移植のための方法およびデバイス |
| JP2017199265A Active JP6446111B2 (ja) | 2009-08-28 | 2017-10-13 | 細胞移植のための方法およびデバイス |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020042947A Pending JP2020089790A (ja) | 2009-08-28 | 2020-03-12 | 細胞移植のための方法およびデバイス |
| JP2022045470A Active JP7416847B2 (ja) | 2009-08-28 | 2022-03-22 | 細胞移植のための方法およびデバイス |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US9011899B2 (enExample) |
| EP (2) | EP3290061B1 (enExample) |
| JP (7) | JP5756108B2 (enExample) |
| KR (5) | KR102008762B1 (enExample) |
| CN (1) | CN102596273B (enExample) |
| AU (1) | AU2010286531B2 (enExample) |
| BR (1) | BR112012004385B1 (enExample) |
| CA (1) | CA2772375C (enExample) |
| CY (2) | CY1119719T1 (enExample) |
| DK (2) | DK2470228T3 (enExample) |
| EA (3) | EA033785B1 (enExample) |
| ES (2) | ES2806645T3 (enExample) |
| HR (2) | HRP20171926T1 (enExample) |
| HU (2) | HUE036464T2 (enExample) |
| IL (1) | IL218360A (enExample) |
| IN (1) | IN2012DN02668A (enExample) |
| LT (2) | LT2470228T (enExample) |
| MX (3) | MX353390B (enExample) |
| NO (1) | NO2470228T3 (enExample) |
| NZ (2) | NZ598701A (enExample) |
| PL (2) | PL2470228T3 (enExample) |
| PT (2) | PT2470228T (enExample) |
| SG (3) | SG10201405256VA (enExample) |
| SI (2) | SI2470228T1 (enExample) |
| SM (2) | SMT202000363T1 (enExample) |
| WO (1) | WO2011025977A2 (enExample) |
Families Citing this family (45)
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| WO2010057039A2 (en) | 2008-11-14 | 2010-05-20 | Cythera, Inc. | Encapsulation of pancreatic cells derived from human pluripotent stem cells |
| IN2012DN02668A (enExample) | 2009-08-28 | 2015-09-04 | Sernova Corp | |
| EP2404672A1 (en) * | 2010-07-06 | 2012-01-11 | Universiteit Twente | High troughput multiwell system for culturing 3D tissue constructs in-vitro or in-vivo, method for producing said multiwell system and methods for preparing 3D tissue constructs from cells using said multiwell system |
| MX2010013135A (es) * | 2010-11-30 | 2012-05-31 | Val De Bio S De R L De C V | Procedimiento y dispositivo mejorados para favorecer el trasplante de material biológico. |
| US10213746B2 (en) | 2016-04-14 | 2019-02-26 | Lockheed Martin Corporation | Selective interfacial mitigation of graphene defects |
| US9526880B2 (en) * | 2013-03-07 | 2016-12-27 | Viacyte, Inc. | 3-dimensional large capacity cell encapsulation device assembly |
| EP3003215A4 (en) * | 2013-06-07 | 2017-02-22 | The Regents of the University of California | Transplantation device and method of use |
| CN104195105B (zh) * | 2014-08-19 | 2017-10-27 | 杭州安体科技有限公司 | 一种提高人精子活力的体外培养体系试剂盒及其使用方法 |
| US10434122B2 (en) * | 2014-09-24 | 2019-10-08 | The Governors Of The University Of Alberta | Cellular transplant site |
| CA3018694C (en) | 2015-03-23 | 2025-12-30 | The Regents Of The University Of California | Thin film cell encapsulation devices |
| KR20180059429A (ko) * | 2015-08-06 | 2018-06-04 | 록히드 마틴 코포레이션 | 낮은 세포독성을 가진 이식가능한 그래핀 막 |
| US10532127B2 (en) * | 2015-11-19 | 2020-01-14 | Tepha, Inc. | Methods to produce perforated collagen coated surgical meshes |
| US10967102B2 (en) | 2016-09-28 | 2021-04-06 | Boston Scientific Limited | Cell encapsulation membranes, devices and methods |
| WO2018071967A1 (en) * | 2016-10-20 | 2018-04-26 | Australian Foundation for Diabetes Research | Cell associated scaffolds for delivery of agents |
| WO2018085714A1 (en) | 2016-11-03 | 2018-05-11 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Encapsulation device systems with oxygen sensors with or without exogenous oxygen delivery |
| EP3534793B1 (en) * | 2016-11-03 | 2025-12-31 | Arizona Board of Regents on behalf of the University of Arizona | IMPLANTABLE METHODS, SYSTEMS AND DEVICES FOR IMPROVING BLOOD GLUCOSE REGULATION |
| KR20220149620A (ko) | 2016-11-03 | 2022-11-08 | 아리조나 보드 오브 리전츠 온 비해프 오브 더 유니버시티 오브 아리조나 | 산소 전달을 수반 또는 비-수반하는 적층형 조직 캡슐화 장치 시스템 |
| CN115322880A (zh) | 2016-11-03 | 2022-11-11 | 代表亚利桑那大学的亚利桑那董事会 | 用于在移植前后实时评估包封装置中细胞的方法和系统 |
| US11052230B2 (en) * | 2016-11-08 | 2021-07-06 | W. L. Gore & Associates, Inc. | Implantable encapsulation devices |
| US11623023B2 (en) | 2016-11-10 | 2023-04-11 | Viacyte, Inc. | PDX1 pancreatic endoderm cells in cell delivery devices and methods thereof |
| JP6557717B2 (ja) * | 2016-12-23 | 2019-08-07 | インスコビー・インコーポレイテッドＩｎｓｃｏｂｅｅ，Ｉｎｃ． | 生体植立用インプラント及びその製造方法 |
| US12016327B2 (en) | 2017-03-20 | 2024-06-25 | Boston Scientific Medical Device Limited | Cell encapsulation device |
| KR101952762B1 (ko) * | 2017-05-08 | 2019-02-27 | 강원대학교산학협력단 | 알긴산과 콜라겐의 조합으로 생성된 줄기세포를 캡슐화하는 미세캡슐 조성물 및 그 제조방법 |
| RU2663470C2 (ru) * | 2017-05-11 | 2018-08-06 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Казанский государственный медицинский университет" | Способ стимулирования ангиогенеза с использованием генетически модифицированных клеток крови пуповины |
| EP3409239A1 (en) | 2017-05-29 | 2018-12-05 | University College Dublin, National University of Ireland, Dublin | An implantable active agent encapsulating device |
| CN107376033B (zh) * | 2017-07-26 | 2019-03-26 | 湖南赛诺生物科技股份有限公司 | 一种细胞移植增效保护装置及其制备方法 |
| JP7101377B2 (ja) | 2017-09-15 | 2022-07-15 | 株式会社日立製作所 | 細胞培養基材、細胞培養容器、及び細胞培養方法 |
| CA3116829A1 (en) | 2017-10-17 | 2019-04-25 | The Methodist Hospital System | Delivery devices |
| GB201717885D0 (en) * | 2017-10-31 | 2017-12-13 | Hothouse Medical Ltd | Prothesis and method of manufacture |
| WO2019108973A2 (en) * | 2017-11-30 | 2019-06-06 | Duke University | Compositions and methods for ablating niche cells in testis and other epithelial cells and methods relating thereto |
| CN112203667A (zh) * | 2018-03-01 | 2021-01-08 | 塞拉克西斯股份有限公司 | 大包封的治疗性细胞、装置及其使用方法 |
| RU2682160C2 (ru) * | 2018-05-28 | 2019-03-15 | Игорь Валерьевич Саматошенков | Способ регенерации нервных волокон кровеносных сосудов |
| WO2020023957A1 (en) * | 2018-07-27 | 2020-01-30 | Washington University | Cell-embedded vascular graft for transplantation |
| CN113286564A (zh) * | 2018-08-02 | 2021-08-20 | 乔治敦大学 | 细胞移植物的方法和组成 |
| EP3840693A1 (en) | 2018-08-22 | 2021-06-30 | Boston Scientific Scimed Inc. | Cell encapsulation device including a porous tube |
| US20210401564A1 (en) * | 2018-09-24 | 2021-12-30 | Arizona Board Regents On Behalf Of The University Of Arizona | Methods and systems for implantable medical devices and vascularization membranes |
| WO2020138028A1 (ja) * | 2018-12-25 | 2020-07-02 | 富士フイルム株式会社 | 細胞移植キット、袋状構造物の製造方法、および糖尿病治療剤 |
| US12515028B2 (en) * | 2019-04-03 | 2026-01-06 | Vertex Pharmaceuticals Incorporated | Multicompartment macroencapsulation devices |
| WO2020223670A1 (en) | 2019-05-01 | 2020-11-05 | Sernova Corporation | Methods of treating diabetes using devices for cellular transplantation |
| EP4034174A4 (en) * | 2019-09-27 | 2023-11-01 | Isla Technologies, Inc. | BIOARTIFICIAL PANCREAS |
| WO2021072190A1 (en) * | 2019-10-10 | 2021-04-15 | W.L. Gore & Associates, Inc. | Cell encapsulation devices |
| CA3162806A1 (en) * | 2020-01-13 | 2022-07-22 | Incube Labs, Llc | Cell delivery articles and methods of administration |
| CN115443142A (zh) * | 2020-02-10 | 2022-12-06 | 优美佳生物技术有限公司 | 胰岛移植装置、套件和方法 |
| AU2021372247A1 (en) | 2020-10-30 | 2023-06-22 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods and systems for encapsulation devices for housing cells and agents |
| KR20250075649A (ko) * | 2022-09-30 | 2025-05-28 | 더블유. 엘. 고어 앤드 어소시에이트스, 인코포레이티드 | 이식 가능한 멤브레인 구조체 및 이를 포함하는 캡슐화 장치 |
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