FR3014316B1 - Organe bioartificiel - Google Patents

Organe bioartificiel

Info

Publication number
FR3014316B1
FR3014316B1 FR1362342A FR1362342A FR3014316B1 FR 3014316 B1 FR3014316 B1 FR 3014316B1 FR 1362342 A FR1362342 A FR 1362342A FR 1362342 A FR1362342 A FR 1362342A FR 3014316 B1 FR3014316 B1 FR 3014316B1
Authority
FR
France
Prior art keywords
bioartificial organ
layer
biocompatible polymer
membrane
semi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1362342A
Other languages
English (en)
Other versions
FR3014316A1 (fr
Inventor
Aoun Richard Bou
Severine Sigrist
Stefan Sproll
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Defymed SAS
Original Assignee
Defymed SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1362342A priority Critical patent/FR3014316B1/fr
Application filed by Defymed SAS filed Critical Defymed SAS
Priority to JP2016539148A priority patent/JP6424226B2/ja
Priority to EP14809630.8A priority patent/EP3079658B1/fr
Priority to US15/103,108 priority patent/US10022404B2/en
Priority to ES14809630T priority patent/ES2778044T3/es
Priority to CA2932048A priority patent/CA2932048C/fr
Priority to DK14809630.8T priority patent/DK3079658T3/da
Priority to CN201480066624.1A priority patent/CN105813630B/zh
Priority to PCT/EP2014/076955 priority patent/WO2015086550A1/fr
Priority to AU2014363694A priority patent/AU2014363694B2/en
Publication of FR3014316A1 publication Critical patent/FR3014316A1/fr
Application granted granted Critical
Publication of FR3014316B1 publication Critical patent/FR3014316B1/fr
Priority to US16/031,040 priority patent/US10668106B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules

Abstract

L'invention se rapporte à une chambre d'encapsulation pour cellules sécrétrices, comportant une enveloppe fermée réalisée dans une membrane semi-perméable, ladite membrane comprenant au moins une couche de polymère biocompatible poreux, et une couche de polymère biocompatible non-tissé.
FR1362342A 2013-12-10 2013-12-10 Organe bioartificiel Active FR3014316B1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR1362342A FR3014316B1 (fr) 2013-12-10 2013-12-10 Organe bioartificiel
PCT/EP2014/076955 WO2015086550A1 (fr) 2013-12-10 2014-12-09 Chambre d'encapsulation de cellules sécrétrices
US15/103,108 US10022404B2 (en) 2013-12-10 2014-12-09 Chamber for encapsulating secreting cells
ES14809630T ES2778044T3 (es) 2013-12-10 2014-12-09 Una cámara para encapsular células secretoras
CA2932048A CA2932048C (fr) 2013-12-10 2014-12-09 Chambre d'encapsulation de cellules secretrices
DK14809630.8T DK3079658T3 (da) 2013-12-10 2014-12-09 Kammer til indkapsling af secernerende celler
JP2016539148A JP6424226B2 (ja) 2013-12-10 2014-12-09 分泌細胞をカプセル化するためのチャンバー
EP14809630.8A EP3079658B1 (fr) 2013-12-10 2014-12-09 Une chambre d'encapsulation de cellules sécrétrices
AU2014363694A AU2014363694B2 (en) 2013-12-10 2014-12-09 A chamber for encapsulating secreting cells
CN201480066624.1A CN105813630B (zh) 2013-12-10 2014-12-09 用于包封分泌细胞的腔室
US16/031,040 US10668106B2 (en) 2013-12-10 2018-07-10 Chamber for encapsulating secreting cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1362342A FR3014316B1 (fr) 2013-12-10 2013-12-10 Organe bioartificiel

Publications (2)

Publication Number Publication Date
FR3014316A1 FR3014316A1 (fr) 2015-06-12
FR3014316B1 true FR3014316B1 (fr) 2017-01-20

Family

ID=50102060

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1362342A Active FR3014316B1 (fr) 2013-12-10 2013-12-10 Organe bioartificiel

Country Status (10)

Country Link
US (2) US10022404B2 (fr)
EP (1) EP3079658B1 (fr)
JP (1) JP6424226B2 (fr)
CN (1) CN105813630B (fr)
AU (1) AU2014363694B2 (fr)
CA (1) CA2932048C (fr)
DK (1) DK3079658T3 (fr)
ES (1) ES2778044T3 (fr)
FR (1) FR3014316B1 (fr)
WO (1) WO2015086550A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2470228T1 (en) 2009-08-28 2018-02-28 Sernova Corporation Cell transplantation procedures and devices
FR3014316B1 (fr) * 2013-12-10 2017-01-20 Defymed Organe bioartificiel
CN114344244A (zh) 2015-03-23 2022-04-15 加利福尼亚大学董事会 薄膜细胞包囊装置
EP3095509A1 (fr) 2015-05-18 2016-11-23 Defymed Membranes fonctionnalisées pour organes bioartificiels
KR20190022563A (ko) * 2016-06-28 2019-03-06 고쿠리츠겐큐가이하츠호징 노우교 · 쇼쿠힝 산교기쥬츠 소고겐큐기코 세포 봉입용 디바이스 및 그 사용
EP3318294A1 (fr) 2016-11-08 2018-05-09 Defymed Kit d'administration in situ d'un composé d'intérêt
EP3428264A1 (fr) 2017-07-12 2019-01-16 Defymed Poche non pliable pour former un organe artificiel implantable
EP3427692A1 (fr) 2017-07-12 2019-01-16 Defymed Kit de verrouillage pour organe artificiel implantable
EP3677289A4 (fr) 2017-08-30 2020-08-26 FUJIFILM Corporation Agent angiogénique et procédé de production de ce dernier
WO2019044990A1 (fr) * 2017-08-30 2019-03-07 富士フイルム株式会社 Dispositif de greffe de cellules et procédé de fabrication associé
CA3077412A1 (fr) * 2017-09-29 2019-04-04 Semma Therapeutics, Inc. Dispositif de logement de cellules
CN112654331A (zh) * 2018-08-22 2021-04-13 波士顿科学国际有限公司 包括多孔管的细胞包封装置
SG11202102784TA (en) * 2018-10-01 2021-04-29 The Electrospinning Company Ltd Membrane
EP3975926A1 (fr) * 2019-05-31 2022-04-06 W.L. Gore & Associates, Inc. Composite à membrane biocompatible
CA3139292A1 (fr) * 2019-05-31 2020-12-03 Timothy M. BRUHN Dispositifs d'encapsulation de cellules presentant des distances de diffusion d'oxygene regulees
EP3892259A1 (fr) 2020-04-09 2021-10-13 Defymed Membranes pour dispositifs médicaux
CN115697300A (zh) 2020-04-09 2023-02-03 帝梵麦德公司 用于医疗装置的膜
CN114949369B (zh) * 2021-02-19 2023-09-05 清华大学 一种人工组织器官的封装装置及其制备方法和应用
CN113786521B (zh) * 2021-08-06 2022-07-19 深圳华源再生医学有限公司 一种组合式支架及其制备方法与应用
WO2023157727A1 (fr) * 2022-02-15 2023-08-24 国立大学法人神戸大学 Procédé de préparation de cellules de type leydig issues de cellules souches pluripotentes humaines, et population de cellules de type leydig issues de cellules souches pluripotentes humaines

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FR2597391B1 (fr) 1986-03-25 1989-02-24 Univ Catholique Louvain Procede de realisation de perforations dans un materiau solide en feuille, dispositif d'irradiation pour la mise en oeuvre du procede et materiau perfore ainsi obtenu
US5236447A (en) * 1990-06-29 1993-08-17 Nissho Corporation Artificial tubular organ
DE19536033C2 (de) 1995-09-28 1997-08-28 Oxyphen Gmbh Dresden Hydrophobe Kapillarporenmembran und Verfahren zur Herstellung
US6361771B1 (en) * 1999-04-06 2002-03-26 Neurotech S.A. ARPE-19 as a platform cell line for encapsulated cell-based delivery
FR2820057A1 (fr) 2001-01-30 2002-08-02 Ct De Transfert De Technologie Membrane pour chambre d'encapsulation de cellules produisant au moins une substance biologiquement active et organe bio-artificiel comprenant une telle membrane
JP2003265594A (ja) * 2002-03-19 2003-09-24 Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho 宿主内埋め込み用構造体および繁殖方法
US20040197374A1 (en) * 2003-04-02 2004-10-07 Alireza Rezania Implantable pouch seeded with insulin-producing cells to treat diabetes
US20060067917A1 (en) * 2004-09-20 2006-03-30 Athanassios Sambanis Insulin delivery system
WO2008103101A1 (fr) 2007-02-19 2008-08-28 Ticapex Ab Ensemble d'implant
KR101666228B1 (ko) * 2007-09-28 2016-10-13 인트렉손 코포레이션 생물치료학적 분자를 발현시키기 위한 치료학적 유전자-스위치 작제물 및 생물반응기, 및 이의 용도
CH701975A1 (de) 2009-10-02 2011-04-15 Oxyphen Ag Lithium-Ionen Batterie mit Separator.
FR2960783B1 (fr) * 2010-06-04 2012-07-27 Ass Pour Les Transferts De Technologies Du Mans Membrane fonctionnalisee pour chambre d'encapsulation de cellules produisant au moins une substance d'interet therapeutique et organe bioartificiel comprenant une telle membrane
FR2962898B1 (fr) 2010-07-22 2012-08-17 Statice Sante Poche pour former un organe artificiel implantable
EP2988699B1 (fr) 2013-04-24 2020-05-27 Société des Produits Nestlé S.A. Dispositif d'encapsulation
FR3014316B1 (fr) * 2013-12-10 2017-01-20 Defymed Organe bioartificiel

Also Published As

Publication number Publication date
CN105813630B (zh) 2019-11-08
DK3079658T3 (da) 2020-04-27
CA2932048A1 (fr) 2015-06-18
EP3079658A1 (fr) 2016-10-19
JP6424226B2 (ja) 2018-11-14
ES2778044T3 (es) 2020-08-07
CA2932048C (fr) 2022-02-22
AU2014363694A1 (en) 2016-06-16
CN105813630A (zh) 2016-07-27
JP2017502008A (ja) 2017-01-19
US10022404B2 (en) 2018-07-17
US10668106B2 (en) 2020-06-02
US20180311282A1 (en) 2018-11-01
US20160310541A1 (en) 2016-10-27
FR3014316A1 (fr) 2015-06-12
AU2014363694B2 (en) 2020-03-05
WO2015086550A1 (fr) 2015-06-18
EP3079658B1 (fr) 2020-02-05

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